QUANTIFYING FUNCTIONAL OUTCOME IN SPINAL TUMOUR SURGERY

Abstract

Background: Intramedullary spinal cord tumours (ISCT) are rare with an annual incidence of less than 1 per 100,000 population. This makes assessing the efficacy of any treatment regimen difficult. Goals of management currently focus on obtaining a histological diagnosis for prognostic and therapeutic planning, and long-term tumour control. However, current outcome measures are crude and the quality of life outcome after surgery for intramedullary spinal cord tumours remains uncertain.

Aim: The aims of this study are to assess disability and outcome in patients undergoing surgery for ISCT. We aim to provide prospective quality of life data on patients with spinal cord tumours.

Patients and Methods: Data was collected prospectively on patients undergoing surgery for ISCT between 1995–2006 under the care of the senior author. The Short Form 36 (SF36) Health Survey Questionnaire was self-administered prior to surgery and again at 3, 12 and 24 months after surgery. All patients were also classified using the Frankel disability score. SF36 data were analysed using the Friedman test with Dunn’s post-test for multiple comparisons and the Wilcoxon signed rank test for matched pairs.

Results: Sixty-five patients (35 men, 30 women) had surgical interventions for ISCT. The mean age at first operation was 43y and median follow-up time was 60 months. 15% had astrocytomas, 45% ependymomas, 7 haemangioblastomas and 19 miscellaneous tumours.

Seventy-two percent of patients (47/65) were graded Frankel D pre-operatively and 65% (42/65) remained so after surgery. SF36 data were obtained for 17 patients. Pre-operatively, patients with ISCT had significantly lower SF36 physical domain scores when compared with normative data from age-matched population controls (p=0.0096). There was no difference between post-operative scores and those of normal controls. Matched pairs analysis on the patients with complete SF36 data sets (n=12) demonstrated a significant improvement in physical function post-operatively. Eleven of these 12 did not show an improvement in their Frankel grade, remaining Grade D pre- and post-operatively.

Conclusion: From this preliminary study it appears that patients with spinal cord tumours have significantly impaired physical function compared to the normal population. More importantly, we have demonstrated that the SF36 can detect changes in function associated with spinal cord tumour surgery that other, cruder measures, cannot.