Aims

Though the pathogenesis of Legg-Calve-Perthes disease (LCPD) is unknown, repetitive microtrauma resulting in deformity has been postulated. The purpose of this study is to trial a novel upright MRI scanner, to determine whether any deformation occurs in femoral heads affected by LCPD with weightbearing.

The unwell child with an acutely irritable hip poses a diagnostic dilemma. Recent studies indicate that pericapsular myositis may be at least as common as joint infection in the septic child. MRI might therefore be a critical first step to avoid unnecessary hip drainage surgery in the septic child with hip symptoms. We reviewed our own experience with MR imaging in this setting. We searched our PACS system to retrieve MRI scans performed for children with suspected hip sepsis from August 2008 to August 2014 using the following terms: hip, septic arthritis, osteomyelitis, mysositis, abscess, femur, acetabulum. 56 cases fulfilled inclusion criteria that included acute presentation with hip symptoms and 2 or more Kocher criteria for septic arthritis. Recent unsuccessful hip washout was not a contra-indication. 56 patients presented with acute infection around the hip. 47 (84%) had MRI scans before any surgical intervention and 9 (16%) had scans promptly following unsatisfactory hip washout with failure to improve. 20 (36%) were found to have pericapsular myositis. In this group, the infection commonly involved the iliopsoas (4), gluteal (4), piriformis (5) or obturator (7) muscles. 15 (27%) children had proximal femoral or acetabular osteomyelitis and 8 (14%) were diagnosed with septic arthritis. The 13 (23%) remaining scans did not show infection around the hip. This study confirms a high rate of extracapsular foci in septic children presenting with hip irritability. Less than 20% had actual septic arthritis in this series. While drainage of a septic joint should never be delayed in the face of a large joint effusion with debris on US, there is a clear role for MRI scanning in the acute setting when the diagnosis is less certain

Purpose. In children presenting with irritable hip symptoms we wished to determine the incidence of hip septic arthritis, pathogen characteristics and the functional outcome. Methods. Between May 2007 and January 2010, children presenting to our institution with irritable hip symptoms were eligible to participate. Exclusion criteria were history of trauma to the hip, systemic inflammatory diseases. Data collected included; demographics, clinical symptoms, temperature, haematological profile, ultrasound and culture reports, microorganism isolated and outcome. The minimum follow up was 6 months (6–24). Results. Out of 210 children, 199 (135 males) met the inclusion criteria (mean age 5.3 years (0.15–15)). On U/S 72 children had a positive result for hip effusion. 60 children required admission and 41 cases had arthrotomy and washout, with a mean WCC of 10.4 × 10∗9/L (4.85–15.8) and CRP of 118(< 5 to 312). The mean length of hospital stay was 4.4 days (1–32). 25 of the samples cultured showed no growth, 3 of which were positive for gram+cocci on staining. The remaining 16 grew staphylococcus aureus, sensitive to flucloxacillin. 4 cases had positive radiological signs of disease sequelae on follow-up imaging (1 grade II heterotrophic ossification of the hip, 1 minor degenerative changes and 2 major avascular necrosis of the femoral head). Functional sparing was common among this group of cases with preservation of excellent function in all but the 2 cases with major avascular necrosis, which had good/fair function, with 1 and 1.5cm leg length discrepancy. Conclusion. Of 210 consecutive patients, 41 (20.6%) cases required hip arthrotomy and 19 (9.5%) had a positive culture with 2 cases of functional limitation. The most common pathogen isolated was staph. aureous. K. kingae species, which cannot be cultured by standard methods, was isolated from 1 case, highlighting the need for culturing hip aspirates in blood vials in all cases

Purpose This was an observational study to determine the prevalence of 25-hydroxyvitamin D (25[OH]D deficiency in our paediatric orthopaedic patient population. Methods We have measured serum 25(OH)D levels in 44 paediatric patients who presented with bone pain. None of these patients had a pre-existing diagnosis of 25(OH)D deficiency. The age of patients ranged from 11 months to 16.5 years. There were 23 female and 21 male patients. The range of diagnoses included hip pain/irritable hip (4), Blount's disease (4), developmental hip dysplasia (7), genu valgum (3), Legg Calve Perthes’ disease (6), slipped capital femoral epiphysis (11), knee pain (3), other (6). Those found to be 25(OH)D deficient underwent further biochemical investigation and were referred for paediatric endocrinology review with a view to vitamin D supplementation. Results We found 9 patients (20%) with serum 25(OH)D levels of <20ng/mL indicating 25(OH)D deficiency. 17 patients (39%) had serum 25(OH)D levels in the range 20-30ng/mL indicating possible deficiency. The remaining 18 patients (41%) had a normal level of 25(OH)D. There was no association between low serum 25(OH)D level and any specific diagnosis, nor with gender or age of patient. There was, however, a statistically significant difference between the serum 25(OH)D level in those patients with unexplained joint pain (mean 22.5ng/mL) and those with other diagnoses (mean 30.7ng/ml) (P<0.05). Conclusion Our results are consistent with other recent prevalence studies showing a concerning level of 25(OH)D deficiency among the paediatric population, and may suggest an increasing burden of disease in the coming years arising from the problem

Clinical prediction algorithms are used to differentiate transient synovitis from septic arthritis. These algorithms typically include the erythrocyte sedimentation rate (ESR), although in clinical practice measurement of the C-reactive protein (CRP) has largely replaced the ESR. We evaluated the use of CRP in a predictive algorithm.

The records of 311 children with an effusion of the hip, which was confirmed on ultrasound, were reviewed (mean age 5.3 years (0.2 to 15.1)). Of these, 269 resolved without intervention and without long-term sequelae and were considered to have had transient synovitis. The remaining 42 underwent arthrotomy because of suspicion of septic arthritis. Infection was confirmed in 29 (18 had micro-organisms isolated and 11 had a high synovial fluid white cell count). In the remaining 13 no evidence of infection was found and they were also considered to have had transient synovitis. In total 29 hips were categorised as septic arthritis and 282 as transient synovitis. The temperature, weight-bearing status, peripheral white blood cell count and CRP was reviewed in each patient.

A CRP > 20 mg/l was the strongest independent risk factor for septic arthritis (odds ratio 81.9, p < 0.001). A multivariable prediction model revealed that only two determinants (weight-bearing status and CRP > 20 mg/l) were independent in differentiating septic arthritis from transient synovitis. Individuals with neither predictor had a < 1% probability of septic arthritis, but those with both had a 74% probability of septic arthritis. A two-variable algorithm can therefore quantify the risk of septic arthritis, and is an excellent negative predictor.

We retrospectively reviewed the records of 16 children treated for spondylodiscitis at our hospital between 2000 and 2007. The mean follow-up was 24 months (12 to 38). There was a mean delay in diagnosis in hospital of 25 days in the ten children aged less than 24 months. At presentation only five of the 16 children presented with localising signs and symptoms. Common presenting symptoms were a refusal to walk or sit in nine children, unexplained fever in six, irritability in five, and limping in four. Plain radiography showed changes in only seven children. The ESR was the most useful investigation when following the clinical course of the disease. Positive blood cultures were obtained in seven children with Staphylococcus aureus being isolated in five. Antibiotics were used in 14 children and spinal bracing in six. Children with spondylodiscitis often present with a confusing clinical picture leading to late diagnosis.

The early use of MRI in the investigation of children with an atypical picture may avoid unnecessary delay in starting treatment and possibly prevent long-term problems. All except one of our children had made a complete clinical recovery at final follow-up. However, all six children in the > 24-month age group showed radiological evidence of degenerative changes which might cause problems in the future.

The crucial differentiation between septic arthritis and transient synovitis of the hip in children can be difficult. In 1999, Kocher et al introduced four clinical predictors which were highly predictive (99.6%) of septic arthritis. These included fever (temperature ≥ 38.5°C), inability to bear weight, white blood-cell count > 12.0 × 10. 9. cells/L and ESR ≥ 40 mm/hr; CRP ≥ 20 mg/L was later added as a fifth predictor. We retrospectively evaluated these predictors to differentiate septic arthritis from transient synovitis of the hip in children over a four-year period in a primary referral general hospital. When all five were positive, the predicted probability of septic arthritis in this study was only 59.9%, with fever being the best predictor. When applied to low-prevalence diseases, even highly specific tests yield a high number of false positives and the predictive value is thereby diminished. Clinical predictors should be applied with caution when assessing a child with an irritable hip, and a high index of suspicion, and close observation of patients at risk should be maintained

Purpose: The aim of the study was to assess the usefulness of ultrasound in the management of Irritable hips in children’s. Materials and Methods: Retrospective analysis was performed for 168 patients with irritable hip from January 2004 to December 2005. The right hip was affected in 86 patients and the left hip was affected in 85 patients. Bilateral hip affection was seen in 3 patients. All the patients presented with pain in the hip joint. Most had pain on internal rotation. Majority had limp lasting 0 – 3 days. All patients were older than 1 year. White Blood Cell count (WBC), C-Reactive Protein (CRP) and Ultrasound of the hip was performed on all the patients as per the Irritable hip protocol. Temperature and associated medical condition were also recorded. Patients were divided into two groups, Group A who could weight bear involved 146 patients and Group B who could not weight bear had 22 patients. Results: Ultrasound examination showed no effusion in 77 patients in Group A and 11 patients in Group B. Remainder of patients in both the groups had hip joint effusion ranging from 2mm – 7mm. All the patients were treated conservatively. None needed aspirations of the effusion in the hip joint or secondary operative procedure. In group A (Weight bearing patients), 30 patients had mild temperature and 1 had moderate temperature. All of these 31 patients had normal WBC, CRP and their ultrasound showed effusion from 0 – 7mm. 12/31 patients had URTI. In group B (Non weight bearing patients), 5 patients had mild temperature with normal WBC, CRP and their ultrasound showed effusion from 0 – 6 mm. 1/5 patient had URTI. All the remaining 115 patients in group A and 17 patients in group B had normal WBC and CRP values. No associated medical problems were found in 102 patients in group A and 12 patients in group B. Upper respiratory tract infection was noted in 40 patients in group A and 9 patients in group B. Gastroenteritis was noted in 4 patients in group A and 1 patient in group B. Conclusion: Questions are raised with regards to the role of ultrasound in management of Irritable hips. Ultrasound for irritable hips in weight bearing patients with normal WBC and CRP is of no help. Ultrasound may be considered for non-weight bearing patients despite normal parameters. Significance: Ultrasound is not of much help in management of irritable hip with normal WBC and CRP. Ultrasound is of definite value to surgeon before any operative procedure for the hip joint

We describe a technique of ‘cross-hip distraction’ to reduce a dislocated hip with subsequent reconstruction of the joint for septic arthritis with extensive femoral osteomyelitis. A 27-year-old woman presented with a dislocated, collapsed femoral head and chronic osteomyelitis of the femur. Examination revealed a leg-length discrepancy of 7 cm and an irritable hip. A staged technique was used with primary clearance of osteomyelitis and secondary reconstruction of the hip. A cross-hip monolateral external fixator was used to establish normal anatomy followed by an arthroplasty. A good functional outcome was achieved. The use of cross-hip distraction avoids soft-tissue and nerve damage and achieved improved abductor function before arthroplasty

The limping or non-weight bearing child can present a difficult diagnostic dilemma. It may be possible to avoid admission of a large proportion of these patients if septic arthritis or other serious pathology can be exclude d. We have established a continuing, prospective study of all patients admitted for hip pain (with normal radiographs) to Starship Children’s’ Hospital between two and 13 years of age. Forty-two patients had a final diagnosis of transient synovitis. Only two patients during an eight month period had septic arthritis. Due to small numbers of patients with serious pathology we compared the transient synovitis group with a retrospective review of those with septic arthritis treated at Starship Hospital in the previous four years. Following comparisons of these two groups, we found that there was a greater incidence of septic arthritis in Maori and Pacific Islanders and septic arthritis tended to occur in younger children. The patients’ initial history, temperature, white cell count and ESR were sensitive in discriminating between septic arthritis and irritable hip. Once the diagnosis of “irritable hip” was made it was unlikely to be altered. We therefore would recommend that it is possible to avoid admission in a large number of these patients. We would however continue to recommend admission for those with a clear history of current illness, Maori or Pacific Islanders, children under the age of four, those with an elevated temperature, and any patient with an elevated white cell count especially neutrophil count or ESR

Between 1989 and 1992 we admitted 426 children with an irritable hip, 363 (85.2%) once and 63 (14.8%) on 143 occasions. We assessed the records retrospectively to determine whether the groups differed and in particular whether recurrence was followed by pathological sequelae. We identified no feature which distinguished between them at either presentation. The use of bone isotope scans was greatly increased in recurrent cases, without clinical benefit. No relationship between recurrence and subsequent abnormality was identified, with 22 (42%) of the recurrences taking place in the opposite hip. The only difference was a higher incidence of 'psychosocial factors' recorded in the notes of children who presented on more than two occasions. The incidence of recurrent irritable hip is larger than previously indicated and in the presence of normal radiographs and low-grade clinical signs, more detailed investigation on subsequent admission is unlikely to be helpful

We made a prospective study of 111 children with acute hip pain to assess whether ultrasound can replace traditional radiography. An effusion was diagnosed in 71% by ultrasound but in only 15% by radiography. This effusion persisted for a mean of nine days; symptoms lasted for five days. Two patients found to have Perthes' disease had longer-lasting effusion and symptoms. Patients without an effusion had no obvious cause for their pain, so the pressure of an effusion from a transient synovitis does not account for all patients with irritable hips. Patients with an effusion persisting for over 24 days (the mean + 2 s.d. of our series) had more symptoms, a significantly larger effusion and greater limitation of movement. They may be more at risk for avascular necrosis. We found that radiographic examination influenced the immediate management of only two patients, those with Perthes' disease. We therefore propose a protocol of management for irritable hip, using ultrasonography at the first presentation of certain categories of patients. This would reduce the number of early radiographs by 75%

Three cases are reported which presented as "irritable" or "observation" hips and failed to respond to rest at home and in hospital. In each case a campylobacter organism was grown from the faeces; none were found in a group of 20 patients in the paediatric ward for other reasons. The patients responded to a course of erythromycin. It is postulated that they may have had a reactive arthropathy of the hip and suggested that cultures for Campylobacter be made as part of the investigation of irritable hip

A prospective survey was carried out on all cases of irritable hip presenting at the Royal Liverpool Children's Hospital over a period of one year. All children had a radioisotope scan of the hips and were then followed for one year by serial radiography. Five of the 50 children seen during the one year had areas of ischaemia in the capital femoral epiphysis demonstrated on the scan. all five developed radiological signs of Perthes' disease within sic months. The remaining 45 had radiographically normal hips at one year