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Oncology

Stage-IIB osteosarcomas around the knee

A STUDY OF MMP-9 IN SURVIVING TUMOUR CELLS



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Abstract

We studied 55 patients with stage-IIB osteosarcoma around the knee with respect to the expression of matrix metalloproteinase (MMP)-9 in the surviving tumour cells in surgical resection specimens. They were followed up for a minimum of 2.5 years.

Factors significantly associated with poor overall survival were a high serum level of alkaline phosphatase at diagnosis and tumour cells expressing MMP-9 in the resection specimens. The only factor strongly associated with disease-free survival was the immunohistochemical status of tumour cells for MMP-9 in the resection specimens. The percentage of necrosis after chemotherapy failed marginally to reach statistical significance. On Cox regression analysis only MMP-9 remained significant for overall and disease-free survival.


Correspondence should be sent to Mr A. F. Foukas at 260 South Ferry Quay, Liverpool L3 4EJ, UK.

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