Abstract
Introduction: morcelized defatted bone-Bank graft (MOD-B) has been employed in 249 patients for different diseases in Rizzoli Institute from 1998 to 2002. 82 hip revisions, 51 spine fusions, 50 osteolitic bone cavities, 47 non-unions). Good results obtained with MOD-B have been the reason for different researches of his properties like an antibiotic carrier and, in the same time, a particular new bone graft.
Material and Methods:
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MOD-B with antibiotic powder and PMMA Cylinders (A-MB-C) have been placed in saline solution and plasma for 4 weeks, compared with cylinders made with PMMA and antibiotic.
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The mechanical resistance of A-MB-C to compressive test has been performed subsequently.
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About biocompatibility, A-MB-C were implanted in sheep’s Ilium. After 3 moths an histologic evaluation has been performed.
Results:
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The MOD-B + antibiotic + PMMA have released the higher quantity of antibiotic for all the 4 weeks.
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The A-MB-C resistance has been of 13.6 MPa, the same resistance of cancellous bone in the man’s femur.
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The histological result with a fluoroscopic microscope has been an osteogenesis in the full section of the cylinders.
Conclusions: morcelized defatted bone-Bank graft is an important opportunity to restore bone loss lesions but, with a septic situation, it is not so easy obtain good results. A very important goal would be to have a graft with good antibiotic deliver system, good mechanical compressive strength and the potential capacity to become new living bone.
The abstracts were prepared by editorial secretary, Mrs K. Papastefanou. Correspondence should be addressed to Professor K.N. Malizos, Department of Orthopaedic Surgery, School of Medicine, University of Thessalia, Larissa, 41222 GREECE
