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DILUTE ADRENALINE (EPINEPHRINE) SALINE IRRIGATION IN KNEE ARTHROSCOPY WITHOUT TOURNIQUET: A PROSPECTIVE, RANDOMISED, DOUBLE BLIND, CONTROL TRIAL



Abstract

Introduction and Aims: Achieving bloodless surgical field is vital for any arthroscopy surgery. Olszewski et al showed that dilute adrenaline saline irrigation (1mg/l) improves the clarity of operative field by reducing the bleeding. Jensen et al also showed that dilute adrenaline saline irrigation (0.33mg/l) is beneficial in achieving bloodless field in shoulder arthroscopy.

Method: A prospective, randomised, double blind, control trial was carried out to determine the effect of adrenaline (epinephrine) in knee arthroscopy without tourniquet. Ethics Committee approval was obtained for this study. A Doctors/Dentists Exemption Certificate (DDX) was obtained from Medicines Control Agency (UK govt) for use of adrenaline (epinephrine) in this trial. All patients undergoing knee arthroscopy were randomised into two groups: 1) to have dilute adrenaline (1 mg of adrenaline into three-litre bags of normal saline (0.33mg/l) for irrigation); and 2) not to have dilute adrenaline in normal saline irrigation.

Results: A total of 40 patients (24 male and 16 female) were included in the trial. All operations were performed using pressure-controlled pump system (75 mm Hg). No tourniquets were used. A visual analogue score (VAS) of zero to 10 (worst to best) was used by the surgeon to determine the clarity of surgical field at the end of operation. Mean age was 46.5 years (IQR 27–63 years). Twenty patients had dilute adrenaline saline irrigation and 20 had normal saline irrigation. Mean VAS was 8.5 (IQR 6 – 10). Mean VAS for group 1 was 8.4 and for group 2 was 8.7 (p= 0.59). There were no intra-operative or immediate post-operative complications noted in either group.

Conclusion: The study failed to identify any benefit of using adrenaline (epinephrine) in normal saline irrigation fluid in terms of achieving bloodless surgical field in knee arthroscopy. The study also conclude that pressure controlled pump system provides excellent bloodless surgical field in knee arthroscopy without tourniquet.

These abstracts were prepared by Editorial Secretary, George Sikorski. Correspondence should be addressed to Australian Orthopaedic Association, Ground Floor, The William Bland Centre, 229 Macquarie Street, Sydney, NSW 2000, Australia.

At least one of the authors is receiving or has received material benefits or support from a commercial source.