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COMPARISON OF OUTCOMES IN MONO SEGMENTAL LUMBAR TOTAL DISC REPLACEMENT REGARDING PREOPERATIVE NUCLEUS PULPOSUS STATUS, HERNIATED/NON HERNIATED AND SCIATICA – DATA ANALYSIS OF 358 PATIENTS FROM AN OBSERVATIONAL MULTI CENTER STUDY, SWISSSPINE



Abstract

Introduction: To date, herniated nucleus pulposus (NP) with radiculopathy and central or lateral recess stenosis are considered as contraindications for lumbar disc arthroplasty. In the present study we used data from a unique mandatory spine register, SWISSspine to investigate associations between preoperative status of NP herniated/non herniated with presence/absence of sciatica and clinical outcome

Methods: Between 3/2005 and 8/2008, 358 mono-segmental lumbar total disc arthroplasties were documented in a prospective observational multicenter mode. The data collection included peri-operative data and clinical outcomes based on NASS, EuroQol and VAS. The patients were divided into 4 groups: group I-128 patients with herniated NP with sciatica, group II-48 patients with herniated NP without sciatica, group III-74 patients without herniated NP but with sciatica and group IV-108 patients without herniated NP and no sciatica (classic indication). The groups were pair wise compared regarding 1-year postoperative VAS, EuroQol and NASS scores using ANOVA-test with Boferroni-Holm adjustment (α=0.05)

Results: The 4 groups had similar demographic characteristics. Statistical analyses showed no significant outcome differences between the classic and the other indications. For example a outcomes for group IV: NASS back pain pre-post: 72.0/31.7 EQ-5D pre-post: 0.32/0.69.

Discussion and Conclusion: Our analysis revealed no differences between patients with herniated NP combined with neural compression and patients with stenosis of recesses regarding pain alleviation and QoL improvement. The findings suggest that these diagnoses may not have to be considered as absolute contraindications for TDR anymore. The results of this multicenter observational study however, need to be verified in a controlled or experimental study design.

Correspondence should be addressed to: EFORT Central Office, Technoparkstrasse 1, CH – 8005 Zürich, Switzerland. Email: office@efort.org