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Research

EMPLOYING CLINICALLY RELEVANT TRANSGENIC ANIMAL MODELS: MUSCULOSKELETAL REGENERATION IN THE POLGA MOUSE MODEL OF AGEING

The European Orthopaedic Research Society (EORS) 31st Annual Meeting, Porto, Portugal, 27–29 September 2023. Part 2 of 2.



Abstract

Aging impairs the regenerative capacity of musculoskeletal tissues and is associated with poor healing outcomes. PolgAD257A/D257A (PolgA) mice present a premature aging phenotype due to the accumulation of mitochondrial DNA (mtDNA) point mutations at rates 3 – 5 fold higher compared to wild type mice. Consequently, PolgA mice exhibit the premature onset of clinically-relevant musculoskeletal aging characteristics including frailty, osteo-sarcopenia, and kyphosis. I will present our recent findings on the use of PolgA mice to investigate the effects of aging on the regenerative capacity of bone. In particular, I will focus on the mechano-sensitivity of the regenerative process in aged bone environments and the opportunities it presents for clinical translation of mechanical intervention therapies.


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