Purpose: Approximately, 10% of two-stage TKA revisions for deep sepsis become re-infected. The purpose of this study was to determine the success in terms of sepsis eradication and factors associated with failure of repeat two-stage revision TKA. Method: Between 1991 and 2006, 129 two-stage revision TKRs for deep sepsis were performed. Ten cases which became re-infected were identified. These unfortunate patients, representing 8% of all the two-stage TKA revisions performed during this time period, are the focus of this study. Their progress and treatment interventions were followed for the purposes of this study. Results: Ten patients were identified with a two-stage revision TKA which became re-infected. Mean patient age was 72 with 40 % being female. Following recurrent sepsis all patients went on to require more than one further two-stage revision (mean 3.67 further revision surgeries). Infection was only successfully eradicated in 28.7% of cases, the remaining require chronic suppressive therapy or have ongoing active infection. Two patients went on to have an arthrodesis (both remain on suppressive anti-biotics) and one patient had trans-femoral amputation. Staph Aureus and Coagulase neg Staph accounted for 80% of primary infective organisms with only one primary infection with methicillin resistant staph aureus (MRSA). Cultures at subsequent revisions were the same organism in 67% cases. Additional organism cultured included Pseudomonas and Propionibacterium. These patients had an increased incidence of multiple medical co-morbidities including Type-2 Diabetes Mellitus and Rheumatoid Arthritis. Conclusion: Patients with recurrent sepsis after a two-stage revision for infection in TKR all required multiple further surgeries. Eradication of infection was only achieved in 28.7% cases. Risk factors for recurrent sepsis include Rheumatoid Arthritis and Type-2 Diabetes Mellitus

Introduction & Aim. The use of All-Poly Tibia has been in practice since the early 1970's. Recently due to the reports on wear and osteolysis in other articulations, this component has generated significant interest. In the current study we aim to report early medium-term results of All-poly Tibial components in elderly (>70 years) patients. Method. Study of 455 cases done between 2005-2020. All the cases were performed by a single surgeon. All-Poly Tibial component implantations were performed using Standard mechanical jigs and the same posterior-stabilized implant was used for all cases. Results. 20 cases were lost to follow-up. 25 patients died due to natural causes. Mean age at index surgery was 74 years (70 - 91 years). Preop KSS average was 47 (31- 62). Post operative at the last follow up was 87 (71- 93). Of the 410 cases there were 8 revisions, 6 for deep sepsis and 2 for periprosthetic fractures. There were no revisions for aseptic loosening or osteolysis. All cases are performing well functionally and clinically. 18 cases had a non-progressive radiolucent line beneath the Tibial component. The combination of perfect alignment and soft tissue balance creates an environment for a successful TKR. The choice of the All-Poly Tibial component for functionally low demand age group patients reduces the chances of premature wear and osteolysis. In elderly patients the implant should outlive the patient. Here it is observed that at 5-7 years aseptic loosening and subsequent revision chances are low. The all-poly Tibial component is significantly cheaper as compared to its metal back counterpart. Conclusion. An excellent clinical result in our hands for this group of patients supports the continued use of this implant strongly

Introduction. Uncontrolled deep sepsis in the diabetic foot often leads to below knee amputation (BKA). However, for deep sepsis in the forefoot, a transmetatarsal amputation can be curative while preserving the native ankle and hindfoot and allowing mobility without a prosthesis. We critically examined the outcome of transmetatarsal amputation in our diabetic patients with forefoot ulceration and proven osteomyelitis. Materials and Methods. Data were collected prospectively at the multidisciplinary diabetic foot clinic. We recorded demographic details, duration of diabetes, comorbidities, nature of ulceration, radiological findings, Texas wound score and details of surgery. Patients were followed up regularly in the diabetes clinic. Medical records were reviewed and complications recorded. Results. Between January 2005 and December 2008, eleven patients (nine male, two female) underwent transmetatarsal amputation for osteomyelitis resistant to antibiotic therapy. Mean age was 58.5 years. Of the ten followed up, six had an intact hindfoot stump in Feburary 2010 (mean 36 months, range 32-46). One patient died with the stump intact at 21 months. Five patients remained ambulatory, while two had already been using a wheelchair. Three patients required BKA for continued sepsis and ischaemia. Discussion. Given the high comorbidities of our patients, it is encouraging that 7 out of 10 patients had successful transmetatarsal amputations. Numbers are small, as the procedure has a relatively narrow indication (severe sepsis confined to the forefoot). In retrospect, pre-operative MRI might have helped to delineate the extent of necrosis, and might have led to better patient ion and a lower re-operation rate. Conclusions. BKA is not necessary for all diabetic feet with uncontrolled deep sepsis. Transmetatarsal amputation can preserve the hindfoot and maintain ambulatory function for three years or more, even in complex patients with comorbidities. Decision-making and perioperative care are challenging and require a dedicated multidisciplinary team

The purpose of the study was to identify factors that affect the incidence of deep wound infection after hip fracture surgery. Data from a hip fracture database of 7057 consecutively treated patients at a single centre was used to determine the relationship between deep wound sepsis and a number of factors. Fisher's exact test and the unpaired T test were used. All patients were initially followed up in a specialist clinic. In addition a phone call assessment was made at one year from injury to check that no later wound healing complications had occurred. There were 50 cases of deep infection (rate of 0.7%). There was no significant difference in the rate of deep sepsis with regards to the age, sex, pre-operative residential status, mobility or mental test score of the patient. Specialist hip surgeons and Consultants have a lower infection rate compared with surgeons below Consultant grade, p=0.01. The mean length of anaesthesia was longer in the sepsis group (76minutes) compared to the no sepsis group (65minutes), this was significant, p=0.01. The patient's ASA grade and fracture type were not significant factors. The rate of infection in intracapsular fractures treated by hemiarthroplasty was significantly greater than those that had internal fixation, p=0.001. The rate of infection in extracapsular fractures fixed with an extra-medullary device was significantly greater than those fixed with an intra-medullary device, p=0.021. The presence of an infected ulcer on the same leg as the fracture was not associated with a higher rate of deep infection. In conclusion we have found that the experience (seniority) of the surgeon, the length of anaesthesia and the type of fixation used are all significant factors in the development of deep sepsis. These are all potentially modifiable risk factors and should be considered in the treatment of hip fracture patients

Introduction: Some centres in the UK have recently seen a shift away from internal fixation and free tissue transfer (Fix and Flap), towards temporary monolateral external fixation, soft tissue coverage and definitive Ilizarov frame fixation (Flap and Frame). Methods: Patients sustaining open fractures were identified prospectively and followed up beyond frame removal. After open wound debridement a monolateral ex-fix was applied. Soft tissue coverage was then achieved by our plastic surgeons. As the soft tissues settled, the temporary ex-fix was exchanged to an Ilizarov frame for definitive fixation. Open fractures with bone loss were similarly treated, with either acute shortening or bone transport, depending on the extent of bone loss and state of soft tissues. Results: Between July 2002 and June 2004, 21 grade 3 open fractures in 18 patients were treated by Flap and Frame. There were 15 male and 3 female patients, with mean age 36. Segment involved was 19 tibias and 2 femurs. There was associated bone loss (mean 9cm) in 6 fractures. 8 had other associated injuries. Gustilo grade, 3A/3B/3C = 6/13/2. Both 3C fractures required early amputation. Wound closure, 5/6 fractures with bone loss required free tissue transfer (FTT); however only 3/15 fractures without bone loss required FTT to achieve soft tissue cover, most requiring fasciocutaneous flap or split skin graft only. Median time in Ilizarov frame was 160 days for patients without bone loss. For those fractures with bone loss frame time ranged from 180–540 days, with some patients still requiring ongoing Ilizarov treatment. All fractures without bone loss united. At mean 14 month follow up only one fracture of 21 had clinical evidence of deep sepsis. 1 tibial fracture showed a 12 degree malunion, while 7/18 patients had a superficial pinsite infection requiring a course of oral antibiotics. One free tissue transfer failed in a grade 3C fracture, leading to early amputation (in conjunction with the recognised vascular injury). Conclusions: Grade 3 open fractures remain a significant treatment challenge. This was particularly true of those with associated bone loss, where without exception the treatment time in an Ilizarov frame was prolonged. A deep sepsis rate of 1/21 fractures treated by Flap and Frame compares favourably with other published series. In the 15 fractures without bone loss, times to union also compared very favourably. Unlike in previous series, many fractures did not require free tissue transfer, as there was no internal fixation device present at the fracture site requiring coverage. Flap and Frame appears to be a very satisfactory method of treating grade 3 open fractures, with low deep sepsis rate, high union rate, satisfactory times to union, and reduced requirement for free tissue transfer to obtain soft tissue coverage

Purpose. To identify the incidence and reasons for revision of the Oxford prosthesis (OXF) in New Zealand. Methods. Review and compare UKA and TKA data including patient-generated Oxford scores after operation. Results. 105 surgeons performed 3,624 OXF (66.5% of all UKA). UKA made up 12.8% of all knee arthroplasties. There were 216 OXF revisions and revision rate (RR) of 1.39 per 100 component-years (p100cy); for UKA this was 1.42 p100cy, and for TKA 0.54 p100cy (OXF vs TKA p< 0.0001). The indications for OXF revisions were unexplained pain (38.0%); aseptic loosening (38.0%); bearing dislocation (9.3%) and deep sepsis (4.2%). For TKA, unexplained pain (28%) was significantly lower than from OXF (p=0.005). Revision for deep sepsis was significantly lower for OXF compared with TKA (4.2% vs 13.1%, p < 0.001). The Oxford scores 6 months post-op were excellent or good in 79% of OXF vs 72% TKA patients (p< 0.0001); at 5 years after operation these were 88% for OXF and 81% for TKA (p=0.001). Twenty high-use OXF surgeons (10 or more operations/year) performed 44% of the operations (RR of 1.3 p100cy), 62 medium-use surgeons (2-9/year) performed 54% (RR of 1.3 p100cy). 23 low-use surgeons (2 or less/year) performed 2% (RR of 3.9p100cy). The differences in RR high vs low users (p< 0.001) and medium vs low groups (p< 0.001) were significant. RR for OXF high or medium users was significantly higher than the overall rate for TKA (p< 0.001). Conclusion. RR for the OXF was 2.5 times greater than that for TKA. Deep infection rate was lower, and 6-month and 5-year function scores were significantly higher OXF vs TKA

The aim was to identify frequency and pattern of early UKR failure in New Zealand. We analysed data from the New Zealand National Joint Register in a 44 month period of 2000–2003. Thirty-five percent of the 1790 registered UKRs were performed in the last 8 months [ie. in 18% of the total time period]. The ratio of UKRs to TKRs performed was 1:6.25. Fifty two revisions meant a failure rate of 2.9% for UKR (n=1790) compared with 1.6% for TKR (n=11243). The most commonly used implants were the Oxford P3 (68% of total with 2.2% revision rate), MG uni (14.6% with 4.6% revision rate) and Preservation (7% with 5.6 revision rate). The most common reasons for revision (n=52) were aseptic loosening (28%), bearing dislocation or impingement (19%), and unexplained pain (13%). The deep sepsis rate for UKR was 0.33% compared to 0.43% for TKR. UKR usage is rapidly increasing in NZ. The revision rate for UKR was 1.8 x that for TKR. The revision rate for deep sepsis was 77% that for TKR. Unexplained pain in apparently technically normal UKR was the 3rd most common reason for revision. Bearing impingement was as common as bearing dislocation as a cause for failure in the Oxford P3 UKR. Early polythene wear was the reason for revision only in the 8mm MG prosthesis

Acute urinary retention (AUR) is a common complication following arthroplasty of the major joints and may lead to a delayed discharge with financial considerations not to mention the risks of sepsis – in the urinary tract and also rarely but very significantly in the joint itself. Our aim was to study the various factors associated with risk of AUR following arthroplasty. We conducted a retrospective review of all available casenotes of patients undergoing total hip (THR) and knee arthroplasty (TKR) in a consecutive three year period. Variables noted included rate of AUR, catheterisation, urinary tract infection (UTI), urinanalysis, joint sepsis, anaesthetic type, use of patient controlled analgesia, postoperative morphine requirement, alpha blockade, past medical and urological history. 100 patients underwent THR. AUR occurred in 22%. Deep joint sepsis occurred in 1% – this patient had not been catheterised. 3% had positive urine analysis but were asymptomatic. No patients had a symptomatic postoperative UTI. 117 patients underwent TKR. AUR occurred in 19%. The rate of deep joint sepsis was 0.85%. There was one case of superficial infection. Neither of these cases was catheterised. There were no cases of postoperative UTI. There was correlation between previous AUR and incidence of AUR (p=0.95). There was no significant correlation between past medical history and AUR contrary to reports by previous authors. The correlation between previous AUR with risk of AUR in the TKR group warrants further investigation. Catheterisation has been previously thought to be associated with infection. In our study with cefuroxime at induction and two doses postoperatively and gentamicin for catheter insertion and removal there were no cases of postoperative UTI and although deep sepsis was seen it was not associated with catheterisation either pre-operatively, perioperatively or postoperatively in AUR

In five teaching hospitals, seventy-two patients with seventy-three bicondylar tibial plateau fractures were prospectively randomized by envelope to treatment either by AO methods (group A) or ring fixator methods (group B). Outcome measures included clinical and radiographic parameters, & HSS knee scores. Results: Re-intervention was necessary within six months in ten group A & seven Group B patients. Forty-three procedures were performed (thirty-three Group A-ten Group B) I& D 12- 3: STSG 3-0: Quadricepsplasty 1-0; Manipulation 2–4; Muscle flap 2–0; Above knee amputation 1–0; Revision ORIF 5–1; Revision Rings 0–1; Bone graft 2–1; Bead pouch 3-0; Synovectomy 1-0; Sequestrectomy 1-0. More patients had more septic and wound complications resulting in more need for re-intervention following ORIF. Conclusion. For bi-condylar tibial plateau fractures (OTA 41.C) six-month HSS scores are significantly higher after treatment with Ring Fixator methods. Reintervention rates for deep sepsis/wound problems are higher with AO methods. Wound and infection complications occurring after AO treatment are more severe and require multiple procedures for control. We have conducted a prospective randomized trial to determine the outcomes of treatment by. Open reduction and internal fixation or. Closed reduction and ring fixation for the treatment of bi-condylar tibial plateau fractures (OTA 41.C). We report our early findings on re-intervention rates for complications. In five teaching hospitals, seventy-two patients with seventy-three bi-condylar tibial plateau fractures were prospectively randomized by envelope to treatment either by AO methods (group A) or ring fixator methods (group B). Outcome measures included clinical and radiographic parameters, & HSS knee scores. Randomization gave the following demographics. Re-intervention was necessary within six months in ten group A & seven Group B patients. Forty-three procedures were performed (thirty-three Group A-ten Group B) I& D 12- 3: STSG 3-0: Quadricepsplasty 1-0; Manipulation 2-4; Muscle flap 2-0; Above knee amputation 1-0; Revision ORIF 5-1; Revision Rings 0-1; Bone graft 2-1; Bead pouch 3-0; Synovectomy 1-0; Sequestrectomy 1-0. More patients had more septic and wound complications resulting in more need for re-intervention following ORIF. For bi-condylar tibial plateau fractures (OTA 41.C) six-month HSS scores are significantly higher after treatment with Ring Fixator methods. Reintervention rates for deep sepsis/wound problems are higher with AO methods. Wound and infection complications occurring after AO treatment are more severe and require multiple procedures for control. Please contact author for pictures and/or diagrams

Obtaining primary wound healing in total joint arthroplasty (TJA) is essential to a good result. Wound healing disturbances (WHD) can occur and the consequences can be devastating to the patient and to the surgeon. Determination of the host healing capacity can be useful in predicting complications. Cierney and Mader classified patients as Type A: no healing compromises and Type B: systemic or local healing compromise factors present. Local factors include traumatic arthritis with multiple previous incisions, extensive scarring, lymphodema, poor vascular perfusion, and excessive local adipose deposition. Systemic compromising factors include diabetes, rheumatic diseases, renal or liver disease, immunocompromise, steroids, smoking, and poor nutrition. Low serum albumin, total lymphocyte count, and low transferrin increase WHD. In high risk situations the surgeon should encourage positive patient choices such as smoking cessation and nutritional supplementation to modify healing responses. Use of tourniquet in obese patients also increases WHD. Careful planning of incisions, particularly in patients with scarring or multiple previous operations, is productive. Around the knee the vascular viability is better in the medial flap. Thusly, use the most lateral previous incision, do minimal undermining, and handle tissue meticulously. We do all potentially complicated TKA's without tourniquet to enhance blood flow and tissue viability. The use of perioperative anticoagulation will increase wound problems. If wound drainage or healing problems do occur, immediate action is required. Deep sepsis can be ruled out with a joint aspiration and cell count (less than 2500), differential (less than 60% polys), and negative culture and sensitivity. All hematomas should be evacuated and necrosis or dehiscence should be managed by debridement to obtain a live wound

Obtaining primary wound healing in Total Joint Arthroplasty (TJA) is essential to a good result. Wound healing problems can occur and the consequences can be devastating to the patient and to the surgeon. Determination of the host healing capacity can be useful in predicting complications. Cierney and Mader classified patients as Type A: no healing compromises and Type B: systemic or local healing compromises factors present. Local factors include traumatic arthritis with multiple previous incisions, extensive scarring, lymphedema, poor vascular perfusion, and excessive local adipose deposition. Systemic compromising factors include diabetes, rheumatic diseases, renal or liver disease, immunocompromise, steroids, smoking, and poor nutrition. In high risk situations the surgeon should encourage positive patient choices such as smoking cessation and nutritional supplementation to elevate the total lymphocyte count and total albumin. Careful planning of incisions, particularly in patients with scarring or multiple previous operations, is productive. Around the knee the vascular viability is better in the medial flap. Thusly, use the most lateral previous incision, do minimal undermining, and handle tissue meticulously. We do all potentially complicated TKAs without tourniquet to enhance blood flow and tissue viability. The use of peri-operative anticoagulation will increase wound problems. If wound drainage or healing problems do occur immediate action is required. Deep sepsis can be ruled out with a joint aspiration and cell count [less than 2500], differential [less than 60% polys], and negative culture and sensitivity. All hematomas should be evacuated and necrosis or dehiscence should be managed by debridement to obtain a live wound

Material and methods:. Fifteen patients sustaining high energy Gustilo 3B injuries of the tibia were treated from 2003 to 2009 with initial debridement followed by application of an external fixation device allowing immediate acute shortening of the bone gap. The bone defects ranged from 3 cm to 5 cm. Wound management was achieved with a vacuum assisted closure device (VAC) until granulation tissue covering the exposed bone made coverage with split skin grafting possible. A delayed progressive lengthening procedure was used to equalize the leg length discrepancy after wound cover was achieved. Results:. The mean age of the 15 patients was 30 years and treatment times varied from 4 to 12 months. All fractures united with acceptable alignment and equalization of the leg length discrepancy. One patient required repeat procedures for a pin site infection by changing a wire. There was no deep sepsis. Conclusion:. This method is a satisfactory and safe alternative for the acute management of the compound wound, when plastic surgery skills are either unavailable or flap cover is contraindicated in the presence of sepsis or as a salvage procedure following flap failure. Wire placement needs to be carefully planned in order to accommodate initial VAC placement, followed by final definitive fixation after wound cover has been achieved

This paper reports the clinical outcomes and survivorship of a prospective series of Advantim cementless TKR performed at the RAH between 1993 and 2005. There were 210 knees in 176 patients. All procedures were performed or supervised by a single surgeon. All patients were followed up at regular intervals, up to 15 years later, with Knee Society Cinical Rating System and X-Rays. No patients were lost to follow-up. The knee rating improved from a median of 47 to 90. The median range of motion was 0–100. At 11 years the survivorship of the tibial component was 95.5% and femur was 93.7%. There were two major revisions and three minor revisions for polyethelene exchange. There was no deep sepsis. There was no knee stiffness requiring arhrolysis or manipulation. No screw osteolysis observed. Advantim was the best perfoming TKR in the AOA registry in 2008 with 0.3 revisions per 100 observed component years. Conclusions. Advantim has excellent clinical outcomes and survivorship. Screws provide rigid initial and ongoing stability to tibial implant-bone construct. Screw osteolysis should not be a concern in a good implant design

Purpose of Study. We intended to determine our rates of deep infection and non-union in severe open tibial fractures treated at our institution with Ilizarov frames. Methods. We retrospectively reviewed the case notes and radiographs of sixty consecutive cases of severe (Gustillo-Anderson Grade III) open fractures of the tibia treated in our tertiary referral unit with the ‘Flap and Frame’ technique. This technique involves early aggressive soft tissue and bone debridement and temporary skeletal stabilisation, followed by soft tissue coverage and then, when the soft tissues have settled, definitive skeletal stabilisation with the Ilizarov frame. The primary outcome measures were the presence of deep infection, occurence of union with the index frame, and any requirement for secondary amputation. Results. Mean average age was 43.3 years (range 16–89). None had neurovascular injuries requiring repair, while three quaters required soft tissue coverage procedures. Half of the fractures had significant bone loss following debridement, with a mean average loss of 28.1 mm (range 5–125). Mean followup was 10.3 months. The deep sepsis rate was 1.7 percent, or 5 percent including cases with significant soft tissue infection but no confirmed bone infection, with a 5 percent non-union rate. Conclusion. In our centre management of severe open fractures of the tibia treated with the ‘Flap and Frame’ technique, with Ilizarov, fixation achieves rates of deep infection and union which compare favourably with previously reported results

Obtaining primary wound healing in Total Joint Arthroplasty (TJA) is essential to a good result. Wound healing problems can occur and the consequences can be devastating to the patient and to the surgeon. Determination of the host healing capacity can be useful in predicting complications. Cierney and Mader classified patients as Type A: no healing compromises and Type B: systemic or local healing compromises factors present. Local factors include traumatic arthritis with multiple previous incisions, extensive scarring, lymphedema, poor vascular perfusion, and excessive local adipose deposition. Systemic compromising factors include diabetes, rheumatic diseases, renal or liver disease, immune compromise, steroids, smoking, and poor nutrition. In high risk situations the surgeon should encourage positive patient choices such as smoking cessation and nutritional supplementation to elevate the total lymphocyte count and total albumin. Careful planning of incisions, particularly in patients with scarring or multiple previous operations, is productive. Around the knee the vascular viability is better in the medial flap. Thus, use the most lateral previous incision, do minimal undermining, and handle tissue meticulously. We do all potentially complicated TKAs without tourniquet to enhance blood flow and tissue viability. The use of perioperative anticoagulation will increase wound problems. If wound drainage or healing problems do occur immediate action is required. Deep sepsis can be ruled out with a joint aspiration and cell count, and negative culture and sensitivity. All hematomas should be evacuated and necrosis or dehiscence should be managed by debridement to obtain a live wound. Options available for coverage of complex wound problems include myocutaneous flaps, pedicled skin flaps, and skin grafts. Wet, occlusive dressings and wound VACs encourage epithelisation of chronic wounds

Introduction. Various implant designs and bearing surfaces are used in TKR. The use of All Poly Tibia and poly moulded on Tibial metal base plate has been in practice since long. Recently due to the reports on wear and osteolysis in modular articulations, these components have generated significant interest. Aim. To report early medium term results in elderly (>70 years) patients. Method. Study of 130 cases done between 2005–2009. All cases were performed by the author. Inclusion Criteria:. Patients with physiological age > 70 years. Patients with low functional demand. Good bone quality. Exclusion Criteria: Inflammatory arthropathy. Osteoporosis and poor bone quality. High functional demand. All Poly Tibial component/ Moulded Metal back Tibia implantations were performed. A PS design was used in all cases fixed with CMW 1 gentamicin cement. Results. 12 cases were lost to follow up. 11 patients deceased due to medical conditions. This left us with 107 cases at the time of the last follow up. Mean age at index surgery was 72.5 years.(70–91 years). Preop KSS average was 42 (25–62). Post operative at the latest Follow up was 89 (68–97). Of 107 cases there were 4 revisions - two for deep sepsis and two for periprosthetic fractures. There were no revisions for aseptic loosening or osteolysis. All 103 cases are performing well functionally and clinically. 19 cases have a nonprogressive radiolucent line beneath the Tibial component. Discussion. Use of Monobloc Tibia is somewhat controversial. The first Total condylar Knee was an all poly design in early 70s. 1. The monobloc tibia eliminates backside wear. The overall thickness of polyethylene in this implant is 2 to 4mm thicker in allpoly tibia design. The metal base plate with compression moulded polyethylene dissipates stresses evenly in osteopaenic bones. The polywear and osteolysis are two most important factors for aseptic loosening. If Symptomatic, loosening warrants a revision surgery. Metal back fixed bearing implant has a disadvantage that it wears from both the surfaces. The highly polished trays are supposed to reduce the wear but it is too early for a statistically significant conclusion. Functionally low demand patients have lesser stresses as compared to their counterparts. The surgical technique for insertion of these implants is slightly demanding as compared to modular implants. The combination of perfect alignment and soft tissue balance creates an environment for a successful TKR. The choice of Monobloc Tibial component for functionally low demand age group patients reduce the chances of premature wear and osteolysis. In elderly patients the implant should outlive the patient. Here it is observed that at early medium term (5 to 9 yr.s) aseptic loosening and subsequent revision chances are low. The Monobloc Tibial component is cheaper as compared to its metal back counterpart. Conclusion. An excellent clinical result in our hands for this group of patients supports the continued use of this implant strongly

Background. Hospital acquired MRSA is globally endemic and is a leading cause of surgical site infection (SSI). Of great concern is the emergence of community acquired MRSA (CA MRSA) with its unique virulence characteristics. Infected hip or knee prostheses due to MRSA are associated with multiple reoperations and prolonged hospital stay. Few studies have been done to assess for risk of SSI in MRSA carriers undergoing elective orthopaedic surgery following decolonisation. However in these studies, the eradication status was not confirmed prior to proceeding for surgical intervention. Aim. The purpose of the study was to evaluate the incidence of SSI in MRSA carriers undergoing elective hip and knee arthroplasty, who had confirmed eradication of MRSA carrier status and to compare it with incidence of SSI in non MRSA carriers. Material and Methods. This is a retrospective analysis of 6613 patients who underwent elective hip (3347) and knee arthroplasty (3266) at our institution between January 2008 and August 2012. A cohort of patients who were preoperatively colonised with MRSA was identified. These patients were offered decolonisation protocol and successful eradication was ensured prior to surgery. The MRSA negative patients served as the control group and we looked into the incidence of SSI in both groups up to one year after surgery. Categorical variables were investigated between groups using chi-squared tests and p value of < 0.05 was taken as significant. Results. Out of 6613 patients, MRSA colonisation was observed in 83 patients (a mean age of 76 years with a M:F ratio of 1:1.2) pre-operatively with a colonisation rate of 1.3%. A total of 79 patients had confirmed eradication of carrier status prior to surgical intervention. Of these 38 were THRs and 41 were TKRs. Total number of MRSA negative patients were 6530 with 3307 THRs and 3223 TKRs in control group. Teicoplanin was used for antibiotic prophylaxis in these patients. 5 of 79 patients had “deep SSI” within 1 year of surgery giving an infection rate of 6.32%. There were 2 MRSA infections in hip replacements with an infection rate of 5.26%. There were 2 MRSA and 1 MSSA infection in TKR resulting in an infection rate of 7.31%. These patients did not belong to the “high-risk” group for MRSA colonisation. A significant statistical difference in infection rates from MRSA negative control group was noted, which had a deep sepsis rate of 1.17% (p value − 0.03) in THRs and 0.87% in TKRs (p value − 0.0016). Conclusions and Clinical Implication. In spite of a selective treatment program for carriers and confirmed eradication in terms of achieving a reduction in the rate of SSI, there is still a significantly increased risk of SSI in MRSA colonised patients undergoing hip and knee replacements. Also, should infection develop, MRSA is the most likely causative organism. Patients should be made aware of this higher risk of infection and the serious consequences of developing MRSA SSI

We present our clinical experience in treating atrophic non-union of long bones by injecting, percutaneously, autologous bone marrow aspirate concentrated as a source of progenitors stem cells. Bone marrow aspirated from the iliac crest contains progenitor cells that can be used to obtain bone-healing of non-union. However, its efficacy appears to be related to the number and concentration of progenitors in the graft. The last three-year period, 11 patients (8 men-3 women) with established atrophic non-union were treated in our department. In all cases, the gap between the fragments was smaller than 5 mm. A constant volume of 60+60 ml of marrow were aspirated from both iliac crests and centrifuged for 15 minutes aiming at the increase of concentration of progenitor-mononucleotide cells. An average volume of 20 ml (+/− 2) concentrated bone marrow was injected percutaneously, under C-arm, at the site of non-union. The graft contained an average of 272.64 x 10(6)/ ml mononucleotide cells. The evaluation of treatment was based on the clinical and radiological findings after 3, 6, 9 and 12 months. However, prior to administration of bone marrow stem cells, there was no case with evidence of ongoing deep sepsis. Bone union was obtained in 10 out of 11 patients (full weight bearing, callus formation in 3 out of 4 cortices). In one case a second operation was needed due to impaired indications of treatment. However, in all cases, there were no signs of local or systematic complications. Percutaneous concentrated bone marrow grafting is an efficient and safe method, for treating atrophic non-unions, with a minimal invasion technique. Contraindications for the above technique are a gap larger than 5 mm and a preexisting angular and axial deformity

The Osteoprotegerin/RANK/RANKL system has been implicated in the biological cascade of events initiated by particulate wear debris and bacterial infection resulting in periprosthetic bone loss around loosened total hip arthroplasties (THA). Individual responses to such stimuli may be dictated by genetic variation and we have studied the effect of single nucleotide polymorphisms (SNPs) within these genes. We performed a case control study of the Osteoprotegerin, RANK and RANKL genes for possible association with deep sepsis or aseptic loosening. All patients included in the study were Caucasian and had had a cemented Charnley THA and polyethylene acetabular cup. Cases consisted of 91 patients with early aseptic loosening and 71 patients with microbiological evidence at surgery of deep infection. Controls consisted of 150 THAs that were clinically asymptomatic for over 10 years and demonstrated no radiographic features of aseptic loosening. DNA samples from all individuals were genotyped using Taqman allelic discrimination. The A allele (p<0.001) and homozygous genotype A/A (p<0.001) for the OPG-163 SNP were highly associated with aseptic failure. Additionally, the RANK-575 (C/T SNP) T allele (p=0.004) and T/T genotype (p=0.008) frequencies were associated with aseptic failure. No statistically significant relationship was found between aseptic loosening and the OPG- 245 or OPG-1181 SNPs. When the septic group was compared to controls, the frequency of the A allele (p<0.001) and homozygous genotype A/A (p<0.001) for the OPG-163 SNP were statistically significant. No statistically significant relationship was found between septic failure and the OPG- 245, OPG-1181 or RANK-575 SNPs. Aseptic loosening and possibly deep infection of THA may be under genetic influence to candidate susceptibility genes. SNP markers may serve as predictors of implant survival and aid pharmacogenomic prevention of THA failure