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Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_1 | Pages 37 - 37
1 Feb 2020
Veettil M Tsuda Y Abudu A Tillman R
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Aim. We present the long-term surgical outcomes, complications, implant survival and causes of implant failure in patients treated with the modified Harrington procedure using antegrade large diameter pins. Patients and Methods. A cohort of 50 consecutive patients who underwent the modified Harrington procedure along with cemented THA for peri-acetabular metastasis or haematological malignancy between 1990 and April 2018 were studied. The median follow-up time for all patients was 14 years (interquartile range, 9 – 16 years). Results. The 5-year overall survival rate was 33% for all the patients. However, implant survival rates were 100% and 46% at 5 and 10 years respectively. Eight patients survived beyond 5 years. There was no immediate peri-operative mortality or complications. Fifteen late complications occurred in 11 patients (22%). Five (10%) patients required additional surgeries to treat complications. The most frequent complication was pin breakage without evidence of acetabular loosening (6%). Two patients (4%) underwent revision for aseptic loosening at 6.5 and 8.9 years after surgery. Ambulatory status improved in 83%. Conclusions. The modified Harrington procedure for acetabular destruction showed low complication rates, good functional outcome and improved pain relief in selected patients. Long-term results are acceptable in this high risk group of patients. The described procedure using antegrade fully threaded large diameter pins combined with standard arthroplasty showed low rates of complications in this high risk cohort of patients with significant improvement in mobility and pain. This method of reconstruction remains robust for at least 5 years in appropriately selected group of patients


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 195 - 196
1 Mar 2003
Pollock R Lehovsky J Morley T Sebaie HE
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Introduction: The aim of this study is to compare the efficacy of the AO Universal Spine System (AO USS) with Harrington-Luque instrumentation for the treatment of King type II idiopathic scoliosis. Methods/Results: A retrospective analysis was performed on two groups of patients with King II adolescent idiopathic scoliosis. The first group consisted of 40 consecutive patients treated with Harrington-Luque instrumentation between 1990 and 1993. The second group consisted of 25 consecutive patients treated with AO USS instrumentation between 1994 and 1996. The groups were well matched with respect to age, sex and curve severity. Inclusion criteria were patients over the age of 12 years with a King II curve pattern and a Cobb angle of greater than 40°. Half of the patients in each group underwent anterior release prior to posterior fusion. All patients were followed up six monthly for 18 months. The thoracic curve, lumbar curve, kyphosis and lordosis were measured using the Cobb method. The mean pre-operative thoracic and lumbar curves were 62° and 43.9° respectively in the Harrington group and 57.5° and 35.9° in the AO USS group. On average 11.4 levels were fused in the Harrington group compared to 10.9 levels in the AO USS group. The mean post-operative correction of the thoracic curve in the AO USS group of 64% was significantly greater than the 51% achieved in the Harrington group (p< 0.005). At 18 months there was a 7% loss of correction in the Harrington group and 9% in the AO USS group. The correction of lumbar curve of 41% in the Harrington group and 46% in the AO USS group at 18 months was not significantly different. In the sagittal plane the AO USS group had significantly better preservation of the lumbar lordosis but there was no difference in kyphosis correction. Blood loss was similar in both groups. Mean operative time of 132 minutes in the AO USS group was shorter than the mean time of 153 minutes in the Harrington group (p< 0.05). Two hooks in the Harrington group became dislodged and two in the AO group. There were no neurological complications in either group. All the patients in both groups achieved a solid fusion. Conclusion: AO USS is a safe and effective instrumentation system for the treatment of King type II adolescent idiopathic scoliosis. Correction of the thoracic curve is superior to that achieved with Harrington-Luque instrumentation and operative time is shorter. AO USS enables better preservation of the lumbar lordosis than Harrington-Luque. There is no difference in blood loss, complication rate and fusion rates between the two techniques. It has become our instrumentation system of choice for this group of patients


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 196 - 196
1 Mar 2003
Salanova B Moreno P Boulot J
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Study design: To analyse the long term effect of Harrington Instrumentation and fusion to the lumbar spine in the treatment of idiopathic scoliosis. Objectives: To demonstrate there is a relationship between the strategy used (determination of fusion area) and pain or degenerative changes. Summary of background data: The literature has been fairly controversial in terms of pain and degenerative changes beyond a fusion for idiopathic scoliosis according as the lower level of fusion. This is the first study in which the results are analysed according as the “strategy used” and not the sole level of fusion. Methods: 250 patients operated on by Harrington instrumentation were clinically and radiographically reviewed. Pain was classified (as Moskowitz and Moe). To be included they should have an idiopathic scoliosis, a minimum follow up of 20 years (mean 26, max 36), 37% over 30 years, had to have been under 20 years at the time of surgery, and should have a full set of radiographs. Curves were classified according to our own classification (Salanova et al) 1973–2000 in single structural. Thoracic 114, thoraco-lumbar 21 and double structural thoracic and lumbar, true double major (52), false D.M. (45). The double thoracic was identified with permanent T1 tilt (18). On P.OP standing the lower level of fusion was identified: E.V. (Salanova et al 1973–2000) SV (King) other vertebra. On follow up radiographs standing coronal and sagittal, lumbar coronal and sagittal degenerative changes were evaluated, slipping lateral and sagittal, discopathy over 50% and classified as none, moderate, complete. Results: Mean age at surgery 15 years + 6. Mean age at follow up 49 years. Ten patients were reoperated on for various reasons. Overall results: Pain none 70, episodic 82, frequent 42, permanent 46. Degenerative changes none 155, moderate 62, complete 23. These data were evaluated according to the strategy used; there is a strong statistical relationship between strategy and final results. Our study proves that King’s classification for so-called King II curves is misleading. Conclusion: This study is the most important ever published in terms of patients, methodology, and follow up. It shows that if a clear analysis of curve(s) before surgery is effectuated for determination of fusion area, if for single curves the lower level of fusion is the good one and for double structural the choice between selective thoracic fusion and double fusion is correctly determinated the long term results are not so bad


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 600 - 600
1 Oct 2010
Ziegler S Ivanic G Loipur M Pink T
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Introduction: In 1962 Harrington published his method of spinal instrumentation in scoliosis treatment. 256 patients have been treated with this instrumentation at the Hospital for Orthopaedic Surgery Stolzalpe in the years of 1968 –1992. Material & Methods: A retrospective study was performed on 74 patients (48 female, 26 male) with a mean follow up time of 22,5 years. A clinical examination, x-ray, spirometry was performed as well as the Oswestry Score and the Visual Analogue Scale test (VAS) to determine the patients confidence and possibilities in activities of daily living (ADL), profession and sports. Also the ROM of the spine, degeneration of the adjacent levels and loss of correction were a subject of interest. Results: All patients were satisfied or very satisfied and there were no severe restrictions in their ADL. 92 % are busy in the normal working process, 61 % do sports without complaints. The mean Oswestry Score was 9 pts (1–12,5) and the average VAS was 1,1 of 10 (0–4), with major problems in sitting and standing. Spirometry was restricted in 33%, movement was limited in side bending in nearly all patients. Conclusion: Although with Harrington’s method no segmental correction was possible and long time casting and orthetic aids were necessary, we found very confident patients without major restrictions in daily life. Similar long term results with modern methods and instruments have to be proven


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_II | Pages 120 - 120
1 Feb 2004
Behensky H Giesinger K Krismer M
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Objective: To evaluate the long term radiological and clinical outcome after posterior correction of adolescent right thoracic idiopathic scoliosis with Cotrel-Dubousset instrumentation (CDI) and Harrington rod instrumentation (HRI). Design: Retrospective comparative analysis. Subjects: Out of preoperative standing radiographs of 229 patients 30 pairs of female patients, one patient with Harrington rod instrumentation (HRI) and the other with Cotrel-Dubousset instrumentation (CDI), could be identified. Curves within pairs were comparable with regard to curve magnitude (thoracic and lumbar) and level of stable and neutral vertebrae. Follow up examination included a clinical review, long cassette upright PA and lateral radiographs of the spine and two patient outcome questionnaires. Mean follow up time for CDI patients was 128 months and for HRI patients 198 months respectively. Outcome measures: The pain questionnaire according to Moskowitz [. 1. ] was used to assess back pain. A customized questionnaire was used to assess whether patients were satisfied with their postoperative cosmetic appearance. Results: In 92 per cent of the patients L2 was the lowest instrumented vertebra. The thoracic Cobb angle in the HRI group was corrected from 64° to 42° (34%) and in the CDI group from 66° to 24° (58%). Group differences were significant (p=0.004). The lumbar Cobb angle in the HRI group was corrected from 41° to 24° (41%) and in the CDI group from 44° to 21° (52%) respectively. Group differences were significant (p=0.03). The lumbar lordosis below the fusion could be improved postoperatively in CDI patients (L2–L5: 31° to 37°), whereas it remained unchanged in HRI patients (L2–L5: 32°). Group differences were significant (p=0.005). The overall cosmetic appearance was better in the CDI group (CDI 76% excellent and good, HRI 71%, p=0.04). 15% of the CDI patients and 24% of the HRI patients reported frequent low back pain episodes. Group differences were significant (p=0.008). A high correlation between incidence of low back pain and low degrees of lumbar lordosis below the fusion was revealed in HRI patients (p=0.02). Conclusion: With Cotrel-Dubousset instrumentation better correction of the thoracic and lumbar curves in the frontal plane and better restoration of the lumbar lordosis distal the fusion is achievable. The lack of restoration of lumbar lordosis below the fusion in HRI patients may have some impact on the higher incidence of low back pain episodes found in this group. The postoperative cosmetic result was better in patients with Cotrel-Dubousset instrumentation


Bone & Joint Research
Vol. 2, Issue 6 | Pages 96 - 101
1 Jun 2013
Harvie P Whitwell D

Objectives

Guidelines for the management of patients with metastatic bone disease (MBD) have been available to the orthopaedic community for more than a decade, with little improvement in service provision to this increasingly large patient group. Improvements in adjuvant and neo-adjuvant treatments have increased both the number and overall survival of patients living with MBD. As a consequence the incidence of complications of MBD presenting to surgeons has increased and is set to increase further. The British Orthopaedic Oncology Society (BOOS) are to publish more revised detailed guidelines on what represents ‘best practice’ in managing patients with MBD. This article is designed to coincide with and publicise new BOOS guidelines and once again champion the cause of patients with MBD.

Methods

A series of short cases highlight common errors frequently being made in managing patients with MBD despite the availability of guidelines.


Bone & Joint Research
Vol. 8, Issue 3 | Pages 146 - 155
1 Mar 2019
Langton DJ Natu S Harrington CF Bowsher JG Nargol AVF

Objectives. We investigated the reliability of the cobalt-chromium (CoCr) synovial joint fluid ratio (JFR) in identifying the presence of a severe aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL) response and/or suboptimal taper performance (SOTP) following metal-on-metal (MoM) hip arthroplasty. We then examined the possibility that the CoCr JFR may influence the serum partitioning of Co and Cr. Methods. For part A, we included all revision surgeries carried out at our unit with the relevant data, including volumetric wear analysis, joint fluid (JF) Co and Cr concentrations, and ALVAL grade (n = 315). Receiver operating characteristic curves were constructed to assess the reliability of the CoCr JFR in identifying severe ALVAL and/or SOTP. For part B, we included only patients with unilateral prostheses who had given matched serum and whole blood samples for Co and Cr analysis (n = 155). Multiple regression was used to examine the influence of JF concentrations on the serum partitioning of Co and Cr in the blood. Results. A CoCr JFR > 1 showed a specificity of 83% (77% to 88%) and sensitivity of 63% (55% to 70%) for the detection of severe ALVAL and/or SOTP. In patients with CoCr JFRs > 1, the median blood Cr to serum Cr ratio was 0.99, compared with 0.71 in patients with CoCr JFRs < 1 (p < 0.001). Regression analysis demonstrated that the blood Cr to serum Cr value was positively associated with the JF Co concentration (p = 0.011) and inversely related to the JF Cr concentration (p < 0.001). Conclusion. Elevations in CoCr JFRs are associated with adverse biological (severe ALVAL) or tribocorrosive processes (SOTP). Comparison of serum Cr with blood Cr concentrations may be a useful additional clinical tool to help to identify these conditions. Cite this article: D. J. Langton, S. Natu, C. F. Harrington, J. G. Bowsher, A. V. F. Nargol. Is the synovial fluid cobalt-to-chromium ratio related to the serum partitioning of metal debris following metal-on-metal hip arthroplasty? Bone Joint Res 2019;8:146–155. DOI: 10.1302/2046-3758.83.BJR-2018-0049.R1


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 66 - 67
1 Mar 2010
Smith G Machado B Whitwell D
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The treatment of acetabular metastases with total hip arthroplasty is technically challenging often with significant loss of structural continuity in the medial wall and roof of the acetabulum, as described by Harrington in 1981 as class III defects. Traditionally the acetabular component is stabilised with Harrington rods but the risk of post-operative complications, especially bleeding is significant. We performed 10 consecutive total hip arthroplasties in patients with metastases involving the acetabulum with Harrington class III defects. The first three patients had acetabular reconstruction with a Kerboull cage, (Stryker Howmedica.) The cage was secured using a combination of screw fixation to the ileum and PMMA cement filling voids behind the cage. A polyethylene acetabular cup is then cemented into the cage. There was concern about the superior fixation using this implant and so the remaining 7 patients were treated using the Graft Augmentation Prosthesis (GAP II), (Stryker How-medica.) This is a titanium reconstruction cage with two superior flanges allowing extensive screw fixation onto the ileum. Two patients had very large defects where there was not sufficient support to use this cage alone, so the technique was augmented with Harrington rods. No implants have failed to date. One patient, an 83 year old female, died 23 days post-operatively after suffering a stroke. Two patients died of their disease 95 and 115 days after surgery. The remaining patients continue to have good pain and mobility following surgery as demonstrated by the Oxford hip score. We conclude that in suitable patients with extensive metastatic involvement of the acetabulum, a flanged acetabular reconstruction cage prosthesis is much improved way of providing support for a total hip replacement. This procedure can greatly improve quality of life, and to date we have had no mechanical failures of fixation using this technique


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_15 | Pages 67 - 67
1 Nov 2018
Juhdi A Abdulkarim A Harrington P
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The treatment of massive chronic tears is problematic. The re-tear rate following surgery for extensive cuff tears remains high, and there is little consensus regarding optimum treatment. To investigate the outcome of a cohort of patients who had open repair of an extensive cuff tear using the Leeds Kuff patch as an augment. A retrospective cohort study of consecutive patients with a massive cuff tear who had surgery in our regional elective orthopaedic centre over a two year period from January 2015 to Dec 2016. All patients followed identical rehabilitation protocols, supervised by physiotherapists with an interest in the shoulder. Outcomes assessment was undertaken at a minimum of 12 months by a registrar or physiotherapist who was not part of the treating team. Pre-op data collection included; range of motion, pain score, Oxford shoulder score (OSS), assessment of muscle atrophy on MRI. Data collection was completed in 15 patients. The mean age was 62 yrs (56 – 75). The mean pre-op OSS was 22, improving to a mean of 43. The range of motion and pain score improved. There were no intra-operative complications. One patient required a second surgery for evacuation of a haematoma at 10 days post op. One patient had an obvious re-tear at 4 months. Open rotator cuff repair with synthetic Kuff patch augmentation for chronic degenerative tears appears worthwhile when assessed at 12 months and they continuous to improve even at 18 months. This treatment method may be a useful option for patients > 70 years old.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 403 - 403
1 Jul 2008
Ali M Harrington P
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We report the case of an 80-year-old woman treated by palliative knee arthrodesis for metastases of the proximal left tibia secondary to bladder carcinoma, using percutaneous femortibial intramedullary arthrodesis nailing.

The technique provided a simple alternative to massive allografting, total joint prosthesis or amputation, with advantages of low morbidity, short operating time, minimal blood loss, immediate ambulation and weight bearing, relief of pain, restoration of independence, and ease of nursing care.

We are satisfied with the procedure of percutaneous femorotibial intramedullary nailing as a palliative treatment of proximal tibial metastases in an elderly patient.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 55 - 55
1 Mar 2008
Pressman A Wunder J Bell R
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The outcome of complex acetabular reconstruction was evaluated in twenty-one patients who were confined to a wheelchair or bed because of pain from acetabular metastases. Reconstruction rings were used where bone loss exceeded 50% of the acetabulum. Six roof reinforcement-rings, eight ilioischial-rings and eight Harrington reconstructions were performed. All but two patients(90%) became ambulatory without pain. Median survival was nine months. Two patients underwent acetabular revision for recurrence. These results support the role of acetabular reconstruction for palliation of pain in appropriate patients with acetabular metastases. Metastatic disease of the acetabulum is painful and disabling. Operative intervention is indicated in certain patients with pathologic fractures, and non-responders to adjuvant treatment. The functional outcome of hip arthroplasty with reconstruction rings was evaluated in twenty-one patients with acetabular metastases between 1989 and 2001. Preoperatively all patients were confined to a wheelchair or bed and used significant narcotic medications. Preoperative radiotherapy was employed in eighteen cases (90%) and 30% had undergone chemotherapy. AAOS classification of the acetabular lesion revealed: six-type II, seven-type III and eight-type IV deficiencies. All cases required a reconstruction ring due to bone loss exceeding 50% of the acetabular dome. Six roof reinforcement rings, eight ilioischial rings and eight Harrington reconstructions with rings were performed in this group. Determination of the reconstructive technique was based on preoperative computerized tomography and intraoperative examination of the acetabular deficiency. All but two patients (90%) became ambulatory without significant pain. Eleven patients used a walker or two canes and nine walked with one or no canes. Median survival was nine months and patients with visceral involvement had a shorter duration. Eight early post-operative complications developed in six patients (29%). In two patients the acetabular construct failed with cup migration due to locally recurrent disease; both were successfully revised. The results of complex acetabular reconstruction for metastatic disease validate its role for palliation of pain and to improve ambulatory status. Preoperative planning with computerized tomography can assist in classifying acetabular bone loss and determining optimal reconstruction technique


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_1 | Pages 101 - 101
1 Feb 2020
Abbruzzese K Byrd Z Smith R Valentino A Yanoso-Scholl L Harrington MA Parsley B
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Introduction

Total hip arthroplasty (THA) is a physically demanding procedure where the surgeon is subject to fatigue with increased energy expenditure comparable to exercise[1]. Robotic technologies have been introduced into operating rooms to assist surgeons with ergonomically challenging tasks and to reduce overall physical stress and fatigue[2]. Greater exposure to robotic assisted training may create efficiencies that may reduce energy expenditure[3]. The purpose of this study was to assess surgeon energy expenditure during THA and perceived mental and physical demand.

Methods

12 THAs (6 cadavers) randomized by BMI were performed by two surgeons with different robotic assisted experience. Surgeon 1 (S1) had performed over 20 robotic assisted THAs on live patients and Surgeon 2 (S2) had training on 1 cadaver with no patient experience. For each cadaver, laterality was randomized and manual total hip arthroplasty (MTHA) was performed first on one hip and robotic assisted total hip arthroplasty (RATHA) on the contralateral hip. A biometric shirt collected surgeon data on caloric energy expenditure (CEE) throughout acetabular reaming (AR) and acetabular implantation (AI) for each THA procedure. Surgeon mental and physical demand was assessed after each surgery. Scores were reported from 1–10, with 10 indicating high demand. A paired sample t-test was performed between MTHA and RATHA within each surgeon group with a confidence interval of (α =0.05).


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_10 | Pages 18 - 18
1 Jun 2018
Taunton M
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Pathologic fractures about the hip are an uncommon, but increasingly prevalent, clinical scenario encountered by orthopaedic surgeons. These fractures about the hip usually necessitate operative management. Life expectancy must be taken into account in management, but if survivorship is greater than 1 month, operative intervention is indicated. Determination must be made prior to operative management if the lesion is a solitary or metastatic lesion. Imaging of the entire femur is necessary to determine if there are other lesions present. Bone lesions that have a large size, permeative appearance, soft tissue mass, and rapid growth are all characteristics that suggest an aggressive lesion. Biopsy of the lesion in coordination with the operative surgeon should be conducted if the primary tumor is unknown. Metastatic disease is much more common than primary tumors in the adult population. Many metastatic fractures in the intertrochanteric region, and all fractures in the femoral neck and head are an indication for hemiarthroplasty or total hip arthroplasty. Cemented femoral implants are generally indicated. This allows immediate weight bearing in a bone with compromised bone stock, thus reducing the risk of peri-operative fractures. Additionally, patients are often treated with radiation and/or chemotherapy, which may prevent proper osseointegration of an ingrowth femoral component. Highly porous ingrowth shells have been shown to provide reliable and durable fixation even in these situations. Management of a periacetabular pathologic fracture, particularly resulting in a pelvic discontinuity is a particularly challenging situation. Use of a highly porous acetabular component combined with an acetabular cage, a custom acetabular component, a cemented Harrington technique, or a primary acetabular reconstruction cage may be utilised. Patients with neoplastic disease are often at risk for infection and thromboembolic disease both from the disease and treatment. Pre-operative evaluation of nutrition status by measuring albumin and pre-albumin will give the surgeon insight. Additionally, dehydration is commonly seen in cancer patients, and adequate pre-operative optimization of fluids and electrolytes may reduce peri-operative complications from other organ systems


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XVII | Pages 33 - 33
1 May 2012
Nadeem S Al-Ajami A Harrington P
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The management of scapho-lunate (SL) instability remains controversial. Since 2001, the senior author has used a modified Brunelli tenodesis to achieve soft tissue stabilization in patients presenting with dynamic or static SL instability.

From 2001 to 2009, 13 patients were prospectively studied. All patients complained of painful clicking in the wrist, inability to use the wrist for loading activities, and all had a positive scaphoid shift test (Kirk Watson). Wrist arthroscopy was performed to confirm the diagnosis and to confirm the absence of degenerative change in all cases. Data collection pre-operatively included, range of motion, grip strength, DASH score and pain score.

All patients had wrist immobilisation in a forearm cast for six weeks post operatively. Physiotherapy commenced at that stage and clinical assessment was performed at 3 months, six months and 12 months post surgery. Patients were discharged from follow-up after 12 months.

A significant improvement in grip strength and DASH score was documented at the 12 month post operative assessment. The range of wrist flexion was decreased in all patients. The majority returned to their original employment. All patients reported that their wrist instability symptoms were improved.

Conclusion

Scapho-lunate ligament reconstruction using a split flexor carpi radialis tendon graft to achieve soft tissue stabilization, provided satisfactory results in patients with chronic SL instability. Improvement in DASH score and grip strength were documented at one year follow-up.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 140 - 140
1 Dec 2013
Moga I Harrington MA Ismaily S Noble P
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Introduction

The failure rate of Total Hip Replacement (THR) has been shown to be strongly influenced by the nature of the articulating interfaces, with Metal-on-Metal (MoM) articulations having three times the failure rate of Metal-on-Polyethylene (MoP) components. It has been postulated that this observation is related to edge wear and increased bearing torque of large MoM heads, which would lead to increased loading and wear at the head taper junction and, subsequently, to the release of metal ions and corrosion products. This suggests that taper wear and corrosion should not be as prevalent in large head MoP implants as in large head MoM implants. This study was undertaken to test the hypotheses that: (i) MoM implants exhibit higher rates of corrosion and fretting at the head taper junction than MoP implants, and that (ii) the severity of corrosion and fretting is greater in components of larger head diameter.

Materials and Methods

Our study included 90 modular implants (41 MoM; 49 MoP) retrieved during revision hip arthroplasties performed between 1992 and 2012. Only retrievals with head diameters greater than 32 mm were included, and trunnion sizes ranged from 10/12 mm to 14/16 mm with 12/14 mm being the most common size. The stem trunnion and head taper surfaces were examined under stereomicroscope by a single observer. Each surface was scored for both corrosion (using a modified Goldberg scoring system) and fretting (using the standard Goldberg scoring system). For both the trunnion and head tapers, the student's t-test was used to determine if differences exist in the severity of corrosion or fretting between the MoM and MoP groups and between different head sizes of the same articulation type.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_5 | Pages 137 - 137
1 Apr 2019
Oladokun A Vangolu Y Aslam Z Harrington J Brown A Hall R Neville A Bryant M
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Introduction

Titanium and its alloys are attractive biomaterials attributable to their desirable corrosion, mechanical, biocompatibility and osseointegration properties. In particular, β – titanium alloys like the TMZF possess other advantages such as its lower modulus compared to Ti6Al4V alloy. This reduces stress shielding effect in Total Hip Arthroplasty (THA) and the replacement of V in the Ti6Al4V alloy, eliminates in-vivo V-induced toxicity. Unfortunately, implants made of TMZF were later recalled by the FDA due to higher than acceptable revision rates. The purpose of this study was to compare the fretting corrosion characteristics of Ti6Al4V and TMZF titanium alloys. It is hoped the findings will inform better design of β – titanium alloys for future applications in THA.

Method

A ball-on-flat configuration was utilised in this study to achieve a Hertzian point contact for CoCrMo – Ti6Al4V and CoCrMo – TMZF material combinations. These were assessed at a fretting displacement of ±50 µm at an initial contact pressure of 1 GPa. Each fretting test lasted 6000 cycles at a frequency of 1 Hz. A two-electrode cell set-up was used to monitor in-situ open circuit potential (OCP). The simulated physiological solution consisted of Foetal Bovine Serum (FBS) diluted to 25% with Phosphate Buffered Saline (PBS) and 0.03% Sodium Azide (SA) balance. The temperature was kept at ∼37°C. Corrosion products on the worn surfaces and subsurface transformations in both alloys were characterised using the Scanning and Transmission Electron Microscopy (SEM/TEM) to obtain high resolution micrographs. The samples were prepared using a FIB-SEM. Bright-field, dark-field and selected area electron diffraction (SAED) patterns were all captured using a scanning TEM (STEM) and Energy Dispersed X-Ray spectroscopy (EDX) mapping was carried out.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_22 | Pages 17 - 17
1 Dec 2016
Haidukewych G
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The orthopaedic surgeon is often consulted to manage pathologic fractures due to metastatic disease, even though he or she may not be an orthopaedic oncologist. A good understanding of the principles of management of metastatic disease is therefore important. The skeleton remains a common site for metastasis, and certain cancers have a predilection for bone, namely, tumors of the breast, prostate, lung, thyroid, and kidney. Myeloma and lymphoma also often involve bone. The proximal femur and pelvis are most commonly affected, so we will focus on those anatomic sites. The patient may present with pain and impending fracture, or with actual fracture. Careful preoperative medical optimization is recommended. If the lesion is solitary, or the primary is unknown, the diagnosis must be made by a full workup and biopsy before definitive treatment is planned. For patients with known metastasis (the most common situation), the options for treatment of pathologic lesions of the proximal femur generally center on internal fixation versus prosthetic replacement. Patients with breast or prostate metastasis can live for several years after pathologic fracture, so constructs must be relatively durable. If fixation is chosen, it must be stable enough to allow full weight bearing, since the overwhelming majority of pathologic fractures will never heal. In general, long constructs are chosen to protect the entire length of the bone. Nails should protect the femoral neck as well, so cephalomedullary devices are typically chosen. Megaprostheses can be useful in situations where bony destruction precludes stable internal fixation. Postoperative radiation is recommended after wound healing. Acetabular involvement typically requires reinforcement rings or cement augmentation with the Harrington technique. Careful multi-disciplinary medical management is recommended to minimise complications


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 573 - 573
1 Oct 2010
Khan Y Halaby R Harrington P McGill P
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Blood transfusion requirement in shoulder surgery has been reported from 8.1% to up to 15%. Our observation was that blood transfusion rarely required after open shoulder surgery. We therefore decided to conduct a retrospective case notes study to look at the crossmatch-transfusion ratio for shoulder surgery.

A total of 211 patients were included in the study. Results were analysed using paired T-test from SPSS (15.0). There were 63 elective procedures and 148 trauma procedures during that period. Ten patients (4.8%) required intra-operative or post operative transfusion. Crossmatch-transfuison ratio was 21.

There should be a clear equation between crossmatch and its use, intra-operatively and post operatively. This study highlighted unnecessary cross-matching for shoulder operations which puts extra pressure on the laboratory staff, the blood bank and also has financial implications.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 49 - 49
1 Mar 2010
Khan Y McGill P Elhalaby R Harrington P
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At present patients who require shoulder hemiarthroplasty in our unit routinely have two units of blood cross matched pre-operatively. Our observation was that blood transfusion rarely required after open shoulder surgery. We therefore decided to look at the crossmatch-transfusion ratio for the following procedures in our department; elective shoulder hemiarthroplasty, reverse total shoulder replacement, open rotator cuff repair, shoulder hemi-arthroplasty for trauma, open reduction and internal fixation of proximal humeral fractures.

We undertook a retrospective review of all such patients during the period of 2002 to 2005. All trauma and elective surgery included. Hospital notes were analysed to include age, sex, pre operative haemoglobin level, blood transfusion intra-operatively and post-operatively.

A total of 211 patients were included in the study. There were 63 elective procedures and 148 trauma procedures during that period. No patient required intra-operative or post operative transfusion. Three patients who required transfusions post operatively, due to other associated injury (liver laceration x1, spleen injuries x 2) were excluded from the study. Crossmatch-transfuison ratio was > 2.

There should be a clear equation between cross-match and its use, intra-operatively and post operatively. This study highlighted unnecessary cross-matching for shoulder operations in our unit which puts extra pressure on the laboratory staff, the blood bank and also has financial implications. We recommend, Standardised approach for pre-operative cross match practise, pre-operative group and screen to detect atypical antibodies and efficient hospital pathology services, to provide blood for transfusion within specified time, for atypical antibody negative blood, should it require.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 395 - 395
1 Sep 2005
Thompson N Seniorou M Harrington M Theologis T
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Introduction: The purpose of this study was to quantify changes in lower limb muscle strength in children with spastic diplegic cerebral palsy 6 months after multi-level orthopaedic surgery.

Method: A consecutive sample of 20 children ( 10 girls and 10 boys, mean age 10.6) with spastic diplegia was studied prospectively. All participants had soft-tissue and bony surgical procedures performed as part of their clinical management. Physiotherapy treatment commenced following surgery. Lower limb muscle strength, pre and 6 months post-surgery, was measured, in addition to routine gait and function assessment. Maximum voluntary isometric strength of 5 muscle groups was measured bilaterally using a digital dynamometer. Paired-samples t-tests were performed.

Results: There was a marked deterioration of muscle strength (p < 0.05) in all muscle groups. Medial hamstrings and hip flexors showed the greatest decline with an average decrease of 54% and 41% respectively. Analysis of gait parameters showed a significant improvement in kinematics (p< 0.05) but a decrease in walking velocity and cadence. Motor function decreased significantly (p< 0.05). There was reduced motor power in 18 of the 20 at 6 months.

Discussion: Our results quantified objectively the magnitude of strength changes after multi-level surgery and show that weakness may be greater and persist longer than expected. This information will be useful for planning treatment after multi-level surgery and is part of a randomised trial investigating strength training. In general there is a decrease in power but an improvement in gait.