Introduction: The incidence of Legg-Calvé-Perthes Disease (LCPD) has varied considerably both between countries and between population groups. The incidence of LCPD has not been reported in Korea. The purpose of this study was to determine the annual incidence of LCPD in Korea and to compare this to other population groups. Materials and Methods: Firstly, only LCPD children who were living in Chonnam Province, Korea, and were aged 14 years and under during the years 1999, 2000, and 2001, were reviewed to measure the annual incidence. Secondly, for a further study regarding the variables related to the epidemiological interest, 816 hips, which were treated at our hospital during the last 32 years from 1972 to 2003, were reviewed. Results: The population aged 14 years and under was 734,645 in 1999, 728,721 in 2000, and 719,504 in 2001. Among them, the number of LCPD children was 29 in 1999, 28 in 2000, and 24 in 2001. The annual incidence was 3.9 per 100, 000 in 1999, 3.8 in 2000, and 3.3 in 2001, with a mean incidence of 3.7 per 100, 000. Discussion: The annual incidence of LCPD in Korean children aged 14 years and under was 3.7 per 100,000. This Korean incidence was lower than the 5.1 to 21.1 per 100,000 incidence reported in Caucasians and higher than the 0.45/100,000 reported in blacks or mixed decent. The incidence of gender, bilaterally, age of disease onset, extent of head involvement, and other related epidemiological parameters was similar to those reported in other studies

Alternative bearing surfaces has been introduced to reduce wear debris-induced osteolysis after total hip arthroplasty (THA) and offered favorable results. Large population-based data for total joint surgery permit timely recognition of adverse results and prediction of events in the future. The purpose of this study was to present the epidemiology and national trends of bearing surface usage in primary total hip arthroplasty (THA) in Korea using nationwide database. A total of 30,881 THAs were analyzed using the Korean Health Insurance Review and Assessment Service database for 2007 through 2011. Bearing surfaces were sub-grouped according to device code for national health insurance claims and consisted of ceramic-on-ceramic (CoC), metal-on-polyethylene (MoP), ceramic-on-polyethylene (CoP), and metal-on-metal (MoM). The prevalence of each type of bearing surface was calculated and stratified by age, gender, hospital type, primary payer, and procedure volume of each hospital. The number of primary THAs increased by 25.2% from 5,484 in 2007 to 6,866 in 2011. The average age of the entire study population was 58.1 years, and 53.5% were male [Table 1]. CoC was the most commonly used bearing surface (76.7%), followed by MoP (11.9%), CoP (7.3%), and MoM (4.1%). The distribution of bearing surfaces was identical to that in the general population regardless of age, gender, hospital type, and primary payer [Table 2]. The mean age of patients that received hard-on-hard bearing surfaces (CoC and MoM) was significantly younger than that of patients receiving hard-on-soft bearing surfaces (CoP and MoP) (56.9 years vs. 62.6 years). During the study period, 55.1% of THAs that used a hard-on-hard bearing surface were performed in males, while 53.0% of THAs that used a hard-on-soft bearing surface were performed in females. The order of prevalence of bearing surfaces was identical in low- and medium-volume hospitals (CoC was first, MoP was second, CoP was third, and MoM was fourth). The mean hospital charges did not differ according to the bearing surface used, with the exception of CoP, which was associated with a lower mean hospital charge. There were no changes in the distribution of bearing surfaces in each year between 2007 and 2011. Overall, the percentage of THAs that used CoC bearing surfaces increased substantially from 71.6% in 2007 to 81.4% in 2011, while the percentage that used CoP, MoP, and MoM decreased significantly [Fig. 1]. One of the reasons for the dominant usage of hard-on-hard bearing surfaces may be that the principal diagnosis of primary THAs and the patient age group distribution in Korea differ from those in other countries. The most common indication for primary THA is osteonecrosis of the femoral head in Korea. In contrast, the majority of primary THAs are performed for osteoarthritis in Western countries. The choice of bearing surface may be affected by many factors, including the nation's medical delivery system, payment type, disease pattern, and age distribution of patients that undergo THA. In future, the results of a large-scale nationwide study on primary THAs using CoC bearing surfaces in Korea will be reported. For any figures or tables, please contact authors directly (see Info & Metrics tab above).

Although the clinical manifestation of ONFH is well summarized as forms of various stages, its etiology, natural history or epidemiology has not been clearly elucidated yet. With this study, we wanted to find out the estimated annual incidence, epidemiologic characteristics and the effect of known risk factors of ONFH. Therefore we can understand the disease better to provide optimal management to the patients. Among 133 189 patients who diagnosed as osteonecrosis of femoral head (ONFH) in database of national health insurance system in Korea from 2002 to 2006, three hundreds an eighty-two samples were randomly extracted with 5% error range in 95% confidence interval. With a structured worksheet, medical records and radiographs of each sample were reviewed at corresponding clinic or hospital by authors and trained orthopedic surgeons. With these data, we calculated the prevalence and associated risk factors. The mean number of annual requests was 23 466. Among 382 samples, two hundreds and seventy-four were confirmed to have ONFH. Diagnostic accuracy was 71.7 %. Diagnosis was more accurate when the patient was male or hospitalized. After the logistic regression analysis, calculated diagnostic accuracy during 2002 and 2006 was 60.3% (51 823/85 987). The annual predicted number of cases of ONFH during this period was 14 103. It corresponds to 28.91 patients per 100 000 populations. Alcohol abuse was noted in 45% and 22% was related to use of steroid. 37% showed bilateral involvement. Bone graft procedures in any kind was the most frequently performed joint preserving procedure. With this, the first epidemiologic study for ONFH in Korea, we estimated nationwide annual prevalence of ONFH as 28.91 per 100,000 populations during 2002 and 2006. There is an absolute male predominance. Alcohol abuse is the most frequent risk factors. We believe that this result can serve as a baseline data for understanding the epidemiology, clinical characteristics and treatment of ONFH

Introduction. Total knee arthroplasty (TKA) is a proven treatment method for advanced knee arthritis in terms of pain relief, function restoration, and quality-of-life improvement. The TKA use has increased significantly over the past decade and the growing rate is more prominent in Asian countries. Thus, the revision TKA may also increase in recent days, which represents a burden to the national health care system. To the best of our knowledge, little information is currently available regarding the incidence and related factors of revision TKA in Asian countries on the basis of nationwide database. This study sought to find the incidence of revision TKA and related factors in South Korea using national database from 2007 to 2012. Material and Method. Data collected by the Health Insurance Review Agency of Korea, from 260,068 TKA patients between 2007 and 2012, were used to estimate the incidence of revision TKA according to age group, gender and hospital TKA and manufacturer prosthesis volume (i.e., the number of TKA procedures carried out at a given hospital, and the number of procedures performed using a given manufacturer's prosthesis, respectively). Age group and hospital and manufacturer volumes were categorized into three groups and TKA incidence rates were computed for groups stratified according to age, gender and hospital and manufacturer volumes. Result. Incidence rates per 100,000 person-years were as follows: 1) by age: < 65 years, 447.2; 65–74 years, 363.7; ≥ 75 years, 270.9, 2) by gender: male, 537.8; female, 346.1; 3) by hospital volume (procedures/year): < 20, 536.9; 20–199, 432.3; ≥ 200, 300.1; and 4) by manufacturer volume (prostheses/year): < 1500, 772.3; 1500–3999, 453.9; ≥ 4000, 345.6. TKA incidence rate in young males was significantly higher compared to that in elderly females. The difference in cumulative incidence, between hospitals with an annual volume of < 20 procedures and those with a volume of 20–199 procedures, was reduced for manufacturers with an annual volume of ≥ 4000. Similarly, the difference in cumulative incidence between manufacturers with an annual volume of < 1500 and those with a volume of 1500–3999 was reduced in hospitals with an annual volume of ≥ 200. Conclusions. Revision TKA incidence varied according to age, gender and hospital and manufacturer volumes. This data could inform clinical decisions and healthcare strategies

Purpose:. To investigate treatment patterns and efficacy of postoperative strong opioids in patients who underwent total knee arthroplasty (TKA) in Korea. Methods:. A prospective, non-interventional study of 301 patients who underwent TKA and received strong opioids following patient controlled analgesia (PCA) was conducted by reviewing patient charts and diaries from 19 teaching hospitals. Clinical characteristics, strong opioid treatment patterns, efficacy of strong opioid on a scale of 0–10, and opioid-related adverse events (AEs) were investigated during hospitalization and at first outpatient visit. Safety analysis was conducted on 301 patients, and efficacy analysis was conducted on full analysis set (FAS) which consisted of all the patients who had at least 1 efficacy result among 301 patients. Results:. Among the FAS population of 298 patients, 86.9% were female, and mean age was 68.7 ± 7.5 years. Average duration of PCA was 4.3 ± 1.7 days, and average length of hospital stay including surgery was 16.3 ± 7.6 days. The mean duration of strong opioid prescription on a regular basis between PCA discontinuation and discharge was 10.3 ± 6.7 days. At the initial treatment with strong opioid following PCA, mean pain intensity score was 6.1 ± 2.1 upon movement and 4.2 ± 2.4 at rest. At discharge, mean pain intensity score was 4.1 ± 1.9 upon movement and 2.3 ± 1.8 at rest. Meanwhile, pain intensity score at the first outpatient visit was assessed only in 146 patients (49.0%) treated with opioid, and mean pain intensity scores upon movement and at rest were 3.5 ± 2.1 and 1.7 ± 1.8, respectively. Most frequently prescribed opioid was oral oxycodone (47.4%), followed by pethidine injection (17.2%), oral oxycodone/naloxone (12.6%), and transdermal fentanyl (12.0%). Additionally, the most frequently prescribed opioid on a regular basis was oral oxycodone (53.3%), and that on a PRN (pro re nata) basis was pethidine injection (48.4%). Among treatments, mean duration and mean daily dose of oral oxycodone during hospitalization were 6.1 ± 5.6 days and 13.9 ± 8.2 mg, 1.6 ± 1.2 days and 45.5 ± 24.5 mg for pethidine injection, 7.3 ± 5.3 days and 16.2 ± 7.3 mcg/hr for transdermal fentanyl, and 9.4 ± 8.0 days and 23.2 ± 16.8 mg/11.6 ± 8.34 mg for oral oxycodone/naloxone. At discharge, 150 patients (50.3%) were prescribed opioids. The most frequently prescribed strong opioid as discharge medications and their mean daily dose were 17.9 ± 10.5 mg of oxycodone (56.6%), 26.8 ± 17.0 mg/13.4 ± 8.5 mg of oxycodone/naloxone (17.1%), and 15.9 ± 6.1 mcg/hr of fentanyl (11.4%). Of 301 patients, 36 opioid-related AEs were reported in 26 patients (8.6%); the most frequently reported opioid-related AEs were nausea/vomiting in 13 patients (4.3%) experiencing 17 events, constipation in 10 patients (3.3%) experiencing 10 events, and sedation in 3 patients (1.0%) experiencing 3 events. Conclusion:. The first nationwide non-interventional study was conducted to investigate treatment patterns and efficacy of strong opioids in patients who underwent TKA. Among these patients, strong opioids provided favorable pain relief and were well tolerated at relatively low dose following PCA till the first outpatient visit

Aims

Joint arthroplasties may be associated with a blood loss, which necessitates transfusion. Especially, hip arthroplasties are highly associate with transfusion to compensate perioperative bleeding. Orthopaedic surgeons and patients have increasing concerns regarding complications of blood transfusions. Although various methods to reduce transfusions have been attempted in TJA, a high percentage of patients require a transfusion during and after the procedures. The purposes of this study were to evaluate the trends of the transfusion(transfusion rates, transfusion amounts, economic burden) in hip arthroplasties, using nationwide data from the National Health Insurance Service (NHIS).

It is still difficult to determine an appropriate hinge position to prevent fracture in the lateral cortex of tibia in the process of making an open wedge during biplane open wedge high tibial osteotomy. The objective of this study was to present a biomechanical basis for determining the hinge position as varus deformity. T Three-dimensional lower extremity models were constructed using Mimics. The tibial wedge started at 40 mm distal to the medial tibial plateau, and osteotomy for three hinge positions was performed toward the head of the fibula, 5 mm proximal from the head of the fibula, and 5 mm distal from the head of the fibula. The three tibial models were made with varus deformity of 5, 10, 15 degrees with heterogeneous material properties. These properties were set to heterogeneous material properties which converted from Hounsfield's unit to Young's modulus by applying empirical equation in existing studies. For a loading condition, displacement at the posterior cut plane was applied referring to Hernigou's table considering varus deformity angle. All computational analyses were performed to calculate von-mises stresses on the tibial wedges. The maximum stress increased to an average of 213±9% when the varus angle was 10 degrees compared to 5 degrees and increased to an average of 154±8.9% when the varus angle was 15 degrees compared to 10 degrees. In addition, the maximum stress of the distal position was 19 times higher than that of the mid position and 5 times higher than that of the proximal position on average. Conclusion:. For varus deformity angles, the maximum stress of the tibial wedge tended to increase as the varus deformity angle increased. For hinge position of tibial wedge, maximum stress was the lowest in the mid position, while the highest in the distal position. *This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (NRF-2022R1A2C1009995)

Aims. National hip fracture registries audit similar aspects of care but there is variation in the actual data collected; these differences restrict international comparison, benchmarking, and research. The Fragility Fracture Network (FFN) published a revised minimum common dataset (MCD) in 2022 to improve consistency and interoperability. Our aim was to assess compatibility of existing registries with the MCD. Methods. We compared 17 hip fracture registries covering 20 countries (Argentina; Australia and New Zealand; China; Denmark; England, Wales, and Northern Ireland; Germany; Holland; Ireland; Japan; Mexico; Norway; Pakistan; the Philippines; Scotland; South Korea; Spain; and Sweden), setting each of these against the 20 core and 12 optional fields of the MCD. Results. The highest MCD adherence was demonstrated by the most recently established registries. The first-generation registries in Scandinavia collect data for 60% of MCD fields, second-generation registries (UK, other European, and Australia and New Zealand) collect for 75%, and third-generation registries collect data for 85% of MCD fields. Five of the 20 core fields were collected by all 17 registries (age; sex; surgery date/time of operation; surgery type; and death during acute admission). Two fields were collected by most (16/17; 94%) registries (date/time of presentation and American Society of Anesthesiologists grade), and five more by the majority (15/17; 88%) registries (type, side, and pathological nature of fracture; anaesthetic modality; and discharge destination). Three core fields were each collected by only 11/17 (65%) registries: prefracture mobility/activities of daily living; cognition on admission; and bone protection medication prescription. Conclusion. There is moderate but improving compatibility between existing registries and the FFN MCD, and its introduction in 2022 was associated with an improved level of adherence among the most recently established programmes. Greater interoperability could be facilitated by improving consistency of data collection relating to prefracture function, cognition, bone protection, and follow-up duration, and this could improve international collaborative benchmarking, research, and quality improvement. Cite this article: Bone Joint J 2023;105-B(9):1013–1019

Glutamate regulates the expression of apoptosis-related genes and triggers the apoptosis of fibroblasts in rotator cuff tendons. Subacromial bursitis is always accompanied by symptomatic rotator cuff tear (RCT). However, no study has been reported on the presence of glutamate in subacromial bursa and on its involvement of shoulder pain in patients who had RCT. The purposes of this study were to determine whether the glutamate expression in subacromial bursa is associated with the presence of RCT and with the severity of shoulder pain accompanying RCT. Subacromial bursal tissues were harvested from patients who underwent arthroscopic rotator cuff tendon repair or glenoid labral repair with intact rotator cuff tendon. Glutamate tissue concentrations were measured, using a glutamate assay kit. Expressions of glutamate and its receptors in subacromial bursae were histologically determined. The sizes of RCT were determined by arthroscopic findings, using the DeOrio and Cofield classification. The severity of shoulder pain was determined, using visual analog scale (VAS). Any associations between glutamate concentrations and the size of RCT were evaluated, using logistic regression analysis. The correlation between glutamate concentrations and the severity of pain was determined, using the Pearson correlation coefficient. Differences with a probability <0.05 were considered statistically significant. Glutamate concentrations showed significant differences between the torn tendon group and the intact tendon group (P = 0.009). Concentrations of glutamate significantly increased according to increases in tear size (P < 0.001). In histological studies, the expressions of glutamate and of its ionotropic and metabotropic receptors have been confirmed in subacromial bursa. Glutamate concentrations were significantly correlated with pain on VAS (Rho=0.56 and P =0.01). The expression of glutamate in subacromial bursa is significantly associated with the presence of RCT and significantly correlated with its accompanying shoulder pain. Acknowledgements: This research was supported by the Basic Science Research Program, through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2015R1D1A3A01018955 and 2017R1D1A1B03035232)

It is known that the gait dynamics of elderly substantially differs from that of young people. However, it has not been well studied how this age-related gait dynamics affects the knee biomechanics, e.g., cartilage mechanical response. In this study, we investigated how aging affects knee biomechanics in a female population using subject-specific computational models. Two female subjects (ages of 23 and 69) with no musculoskeletal disorders were recruited. Korea National Institute for Bioethics Policy Review Board approved the study. Participants walked at a self-selected speed (SWS), 110% of SWS, and 120% of SWS on 10 m flat ground. Three-dimensional marker trajectories and ground reaction forces (Motion Analysis, USA), and lower limbs’ muscle activities were measured (EMG, Noraxon USA). Knee cartilage and menisci geometries were obtained from subjects’ magnetic resonance images (3T, GE Health Care). An EMG-assisted musculoskeletal finite element modeling workflow was used to estimate knee cartilage tissue mechanics in walking trials. Knee cartilage and menisci were modeled using a transversely isotropic poroviscoelastic material model. Walking speed in SWS, 110%, and 120% of SWS were 1.38 m/s, 1.51 m/s, and 1.65 m/s for the young, and 1.21 m/s, 1.34 m/s and 1.46 m/s for the elderly, respectively. The maximum tensile stress in the elderly tibial cartilage was ~25%, ~33%, and ~32% lower than the young at SWS, 110%, and 120% of SWS, respectively. These preliminary results suggest that the cartilage in the elderly may not have enough stimulation even at 20% increases in walking speed, which may be one reason for tissue degeneration. To enhance these findings, further study with more subjects and different genders will investigate how age-related gait dynamics affects knee biomechanics. Acknowledgments: Australian NHMRC Ideas Grant (APP2001734), KITECH (JE220006)

Purpose. The purpose of this study is to report the results of the first 1000 cases hip arthroplasty using the Bencox. ®. hip stem, the first hip prosthesis developed and manufactured in Korea. Material & Method. This study reviewed 1000 cases retrospectively who underwent arthroplasty using Bencox. ®. hip system. The Bencox. ®. hip stem is the first hip prosthesis developed and manufactured in Korea. This stem have a double-tapered, wedge shape figure with a rectangular-shaped cross-section and specially designed neck shape, which is design to achieve normal stress pattern of the proximal femur and to increase initial stability and to increase range of motion. Surface is treated with MAO (Micro Arc Oxidation) coating. From the first arthroplasty with this system in September 2006, sequentially 1000 arthroplasties were performed by single surgeon until the July 2014. This material included 439 men and 561 female. Average age of patients was 65 year old. Follow up period was average 72.1 month (minimum 34 months to maximum 120 months). 1000 cases consisted of 569 hips in patients with femoral neck or intertrochanteric fracture or subtrochanteric fracture (fracture group), 155 hips in osteoarthritis, 192 hips in patients with osteonecrosis of the femoral head (arthritis group), 84 hips in revision surgery (revision group). Revision cases consisted of 58 hips with aseptic loosening and 26 hips with loosening due to infection sequelae. They were underwent hip arthroplasty using a Bencox. ®. hip stem in combination with Bencox. ®. bipolar cup and Bencox. ®. acetabular cup. Patients in the fracture group usually underwent bipolar hip arthroplasty, and those in the arthritis group and revision group underwent total hip arthroplasty. They were reviewed by medical records, clinically and radiologically. Results. During the follow-up period, there were no cases of revision of the femoral stem. Radiographically, there were no cases of radiolucent line except very proximal part of the stem endosteal bone ongrowth was found in most cases. Postoperative complications such as stem loosening, infection, dislocation, and ceramic breakage were not noted. But periprosthetic fracture was encountered in 7 hips due to slip down. They were treated by open reduction and internal fixation with plate and cables. There were no cases of failure of these treatments. Conclusion. Clinical and radiographic evaluations of hip arthroplasty using the Bencox. ®. hip system showed excellent outcomes with average 72.1 month follow-up in 1000 case

Total Hip Arthroplasty (THA) has been more frequently performed for relatively young patients with osteonecrosis of the femoral head in Korea. Moreover, squatting and sitting with crossed legs are more common in Asian cultures than in Western cultures. Wear debris generated by conventional metal-on-PE articulations has been giving rise to extensive osteolysis. Due to these characteristics, higher incidence of pelvic osteolysis was observed after THA in Korea. As a result, interest in alternative bearings such as ceramic-on-ceramic bearing has been increased. Furthermore, the patients who require revision THA are still young in Korea. With this point of view, an application of ceramic-on-ceramic bearing throughout revision THA seems to be reasonable. The clinical and radiographical outcomes after revision THA with use of third generation ceramic-on-ceramic bearing in Korean patients were evaluated. Materials and Methods: We have analyzed 42 hips (37 patients; 17 men and 20 women), in whom revision THAs were performed using cementless cups with ceramic-on-ceramic bearing (Biolox Forte; CeramTec, Plochingen, Germany). They underwent THA at a single institution between February 2000 and December 2004, and were consecutively enrolled in this study. Their mean age was 48.8 years (32 – 59 years), and their mean weight was 61.5 ± 5.8 kg (50 – 72 kg) and BMI was 23.8. The mean interval from primary to revision THA was 9.5 ± 3.2 years (3.3 – 16.1 years). The preoperative diagnoses for primary THA were osteonecrosis of the femoral head in 31 hips, neglected femoral neck fracture in 3, rheumatoid arthritis in 2, degenerative osteoarthritis in 2, pyogenic arthritis in 2, tuberculosis arthritis in 1, and fused hip in 1. Dissociation of PE liner was observed in 21 hips (50%). For acetabular cup revision, Trilogy ceramic acetabular cups (Zimmer, Warsaw, IN) were used in 22 hips, EP-FIT plus cups (Plus Orthopedics, Rotkreuz, Switzerland) in 14 hips, and Duraloc Option Ceramic cups (DePuy, Warsaw, IN) in 6 hips. Stems were revised in all hips. The follow-up protocol included radiographic and clinical evaluations, and the mean duration of follow-up monitoring after revision THA was 5.4 ± 1.7 years (3.2 – 8.0 years). At final follow-up examination, clinical outcomes including Harris Hip Score and complications were assessed. All changes in inclination were documented radiographically. The presence of radiolucent lines, vertical or horizontal migration of acetabular cup (> 2 mm), and osteolysis were also evaluated. Results: At final follow-up evaluation after revision, the average Harris Hip Score was 91.3. There were no revised hips during follow-up period. In 6 hips (14.3%), minor complications were observed: 3 heterotopic ossifications, 2 dislocations, 1 infection. No revision was necessary for the treatment of these complications. There were no hips with radiolucent lines, vertical or horizontal acetabular cup migration or osteolysis during the follow-up period. In 21 hips with bone graft, incorporation of bone graft was observed radiographically at final follow-up examination. Conclusions: Our data showed that clinical and radiographical outcomes after revision THA using third generation ceramic-on-ceramic bearing were favorable. Revision THA with the use of ceramic-on-ceramic bearing surfaces can be preferentially considered especially in young patients. Further studies with long-term follow-up data are warranted

The purpose of this study was to obtain anatomical measurements of the distal tibia and talus of Korean ankles and to evaluate, based on those measurements, the compatibility of the HINTEGRA prostheses in the context of total ankle replacement (TAR). We measured the length, width, height, and angles of the distal tibia and talus of 51 cadavers and compared these measurements with the corresponding dimensions of the HINTEGRA prostheses. The male ankles were larger than the female ones as was expected, but their overall shapes did not differ, which fact validates use of the prostheses irrespective of patients' sex. The dimensions of the talus itself did not differ significantly from those previously reported for American whites and blacks and South African whites. This might suggest a possibility that the HINTEGRA prostheses, being used in these countries, would be compatible to Korean ankles, too. In fact, the length range of the talar components was generally compatible with those derived from cadaveric measurements of the trochlea. However, the widths of the tibial and talar components were not completely compatible to Korean ankles. Above all, the length of the large-sized tibial components was much longer than the largest ankles, which would confine the choice of prosthesis mainly to small-sized ones for arthroplasty in Korea. Even though these prostheses are currently used, some modifications are needed to extend their usability in Korea, such as shortening and width/length ratio adjustment of the tibial component, and of the talar component accordingly

Introduction. Bone morphogenetic proteins (BMPs) are members of the TGF-beta superfamily of growth factors and are known to regulate proliferation and expression of the differentiated phenotype of chondrocytes, osteoblasts, and osteoclasts. To investigate the osteoblastic differentiation gene expressions that contribute to BMP-7 dependent ostogenesis, we performed gene expression profiling of BMP-7-treated mouse bone marrow stromal cells. Methods. D1 cells (mouse bone marrow stromal cells) were cultured in osteogenic differentiation medium (ODM) for 3 days, and then treated with BMP-7 for 24 hr. Total RNA was extracted using Trizol, purified using RNeasy columns. Total RNA was amplified and purified using the Ambion Illumina RNA amplification kit to yield biotinylated cRNA. The data analysis up- and down-regulation developmental processes (anterior/posterior patterning, ectoderm development, embryogenesis, gametogenesis, mesoderm development, other development process, and segment specification) genes expression fold. Results. We detected 18 mRNAs (Id2, Igf2, Pparg, S100a10, Foxn3, Tulp3, Mycbp2, Notch3, Ptk7, Lrp4, Tnfrsf11b, Ogn, Cyr61, Mglap, Akp2, Ltbp4, Ibsp, and Thbs1) that were differentially up-regulated after BMP-7 stimulation. 3 mRNAs (Wars, Adss and Trim35) were differentially down-regulated after BMP-7 stimulation. Conclusion. The data indicate that BMP-7 regulate various developmental processes genes expression during osteoblastic differentiation. Though further studies are needed in relation to each expression gene profiles and osteoblastic differentiation, this information may serve as a point of comparison for osteoblastic differentiation of BMP-7. Furthermore, the data should facilitate the informed use of BMP-7 as a therapeutic agent and tissue engineering tool. Acknowledgement. This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MEST) (No. R01-2008-000-10089-0)

Aims

Achilles tendon re-rupture (ATRR) poses a significant risk of postoperative complication, even after a successful initial surgical repair. This study aimed to identify risk factors associated with Achilles tendon re-rupture following operative fixation.

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Orthopaedic surgery requires grafts with sufficient mechanical strength. For this purpose, decellularized tissue is an available option that lacks the complications of autologous tissue. However, it is not widely used in orthopaedic surgeries. This study investigated clinical trials of the use of decellularized tissue grafts in orthopaedic surgery.

Introduction. The mid- or long-term results of acetabular revision total hip arthroplasty (THA) in Korea are rare. The purpose of this study is to report the mid-term radiographic results (> 5 years) of acetabular revision THA with porous-coated cementless Trilogy. ®. cup (Zimmer, Warsaw, IN, USA). Materials and Methods. Between 1999 and 2010, 77 patients (79 hips) had underwent acetabular revision THA with Trilogy. ®. cup. Eight patients (8 hips) were excluded due to death before 5-year follow-up, and 22 patients (23 hips) were excluded due to less than 5-year follow-up or follow-up loss. Forty-seven patients (48 hips) were included in our study. The mean age was 57.9 years (range, 36 to 76 years) and the mean follow-up was 9.8 years (range 5.0 to 16.2 years). The causes of revision were aseptic loosening in 40 hips, and septic loosening in 8 hips, respectively. Both acetabular and femoral revisions were performed in 14 hips and isolated acetabular revision was done in 34 hips. Preoperetive acetabular bone defect according to Paprosky classification was; 1 in type I, 6 in IIA, 11 in IIB, 9 in IIC, 15 in IIIA, and 6 in IIIB. Results. Radiolucent lines less than 2mm were found in 2 hips; one in zone I, another in zone I, II, III. Four hips (1 in type IIC, 1 in IIIA and 2 in IIIB) showed cup migration greater than 5 mm accompanying change of position greater than 5 degrees. However, these patients did not complain pain and showed fixation by secondary stabilization. The Kaplan-Meier survivorship with aseptic loosening as the end point at 10 years was 92.6% (95% confidence interval [CI], 82.6 – 100) and at 15 years was 83.8 % (95% CI, 69.1 – 98.6), respectively. Non-recurrent dislocations occurred in 4 hips. There were no other complication such as sciatic nerve palsy, infection and deep vein thrombosis. Conclusion. Mid-term radiographic results (>5 years) of acetabular revision THA with porous-coated cementless Trilogy. ®. cup showed durable longevity. However, other options such as anti-protrusio cage or cup-cage construct should be considered in severe acetabular bone defect

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The presence of facet tropism has been correlated with an elevated susceptibility to lumbar disc pathology. Our objective was to evaluate the impact of facet tropism on chronic lumbosacral discogenic pain through the analysis of clinical data and finite element modelling (FEM).

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The aim of this meta-analysis was to determine the pooled incidence of postoperative urinary retention (POUR) following total hip and knee arthroplasty (total joint replacement (TJR)) and to evaluate the risk factors and complications associated with POUR.

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Systematic reviews of randomized controlled trials (RCTs) are the highest level of evidence used to inform patient care. However, it has been suggested that the quality of randomization in RCTs in orthopaedic surgery may be low. This study aims to describe the quality of randomization in trials included in systematic reviews in orthopaedic surgery.