Query: The means for treating Osteochondrosis dissecans (OD) of the knee joint in adolescents remains today a matter of controversial discussion. Not only the different treatments, whether purely conservative or one of the various surgical procedures, are rated differently with respect to their benefit, but also the question of the right time to operate is not easy to answer. The objective of this prospective study was to examine the long-term results of a bioabsorbable fixation system in the treatment of OD and to determine possible relationships between the baseline conditions, such as stage of disease, patient’s age, severity or localization and the results in each case. Method: Between 1995 and 2005, 312 patients aged 7 to 19 years with Osteochondrosis dissecans were treated by means of arthroscopic operation on the knee joint. In 257, fixation using ethipins could be performed, the dissecate had to be removed in 31 patients. An MRT was performed preoperative in all patients, the knee joint function, activity level and patient’s quality of life were evaluated postoperative using the modified Cincinnati Score, the Tegner Activity Index and the Lysholm Score. Results: 255 of the 312 patients were available to follow-up over a longer period (Ø 7.9 years). The Lysholm Score for all patients 5 years after surgery was 87.6 points, after 10 years 76.5. Classified by baseline stage, it was found that the postoperative course was clearly better in those patients in whom fixation was required. Moreover, an early stage of OD and younger patient age were prognostically favorable factors. The MRT follow-up examination showed re-integrated vital cartilage areas without signs of fixation residuals in patients in whom fixation was performed. Conclusion: Surgical treatment of Osteochondrosis dissecans brings different results depending on the stage of the disease. Moreover the results depend on patients age, location of the defect, duration of symptoms. If fixation of the dissecate using bioabsorbable pins is successful, the long-term results achieved are good to excellent. Overall, the data obtained justify an early decision for a surgical procedure in the treatment of Osteochondrosis dissecans of the knee joint in children and adolescents

Juvenile Osteochondritis dissecans (JOCD) in humans and subchondral cystic lesions (SCL) in horses (also termed radiolucencies) share similarities: they develop in skeletally immature individuals at the same location in the medial femoral condyle (MFC) and their etiology is only partially understood but trauma is suspected to be involved. JOCD is relatively uncommon in people whereas SCLs arise in 6% of young horses leading to lameness. Ischemic chondronecrosis is speculated to have a role in both osteochondrosis and SCL pathogenesis. We hypothesize that MFC radiolucencies develop very early in life following a focal internal trauma to the osteochondral junction. Our aims were to characterize early MFC radioluciencies in foals from 0 to 2 years old. Distal femurs (n=182) from Thoroughbred horses (n=91, 0–2 years old), presented for post-mortem examination for reasons unrelated to this study, were collected. Radiographs and clinical tomodensitometry were performed to identify lesions defined as a focal delay of ossification. Micro-tomodensitometry (m-CT) and histology was then performed on the MFCs (CT lesions and age-matched subset of controls). Images were constructed in 3D. The thawed condyles, following fixation, were sectioned within the region of interest, determined by CT lesion sites. Hematoxylin eosin phloxin and safran (HEPS) and Martius-Scarlet-Blue (MSB) stains were performed. Histological parameters assessed included presence of chondronecrosis, fibrin, fibroplasia and osteochondral fracture. An additional subset of CT control (lesion-free) MFCs (less 6 months old) were studied to identify early chondronecrosis lesions distant from the osteochondral junction. One MFC in clinical CT triages controls had a small lesion on m-CT and was placed in the lesion group. All m-CT and histologic lesions (n=23) had a focal delay of ossification located in the same site, a weight bearing area on craniomedial condyle. The youngest specimen with lesions was less than 2 months old. On m-CT 3D image analysis, the lesions seemed to progressively move in a craniolateral to caudomedial direction with advancing age and development. Seventy-four percent (n=17/23) of the lesions had bone-cartilage separation (considered to be osteochondral fractures) confirmed by the identification of fibrin/clot on MSB stains, representing an acute focal bleed. Fibroplasia, indicating chronicity, was also identified (74%, n=17/23). In four cases, the chondrocytes in the adjacent cartilage were healthy and no chondronecrosis was identified in any sections in the lesions. Nineteen cases had chondronecrosis and always on the surface adjacent to the bone, at the osteochondral junction. None of the subset of control specimens, less than 6 months old (n=44), had chondronecrosis within the growth cartilage. Early subchondral cystic lesions of the medial femoral condyle may arise secondary to focal internal trauma at the osteochondral junction. The presence of fibrin/clot is compatible with a recent focal bleed in the lesion. Medial femorotibial joint internal forces related to geometry could be the cause of repetitive trauma and lesion progression. In the juvenile horse, and potentially humans, the early diagnosis of MFC lesions and rest during the susceptible period may reduce progression and promote healing by prevention of repetitive trauma, but requires further study

The current study aims to ascertain the outcome of ACI with simultaneous transplantation of an autologous bone plug for the restoration of osteoarticular defects in the femoral condyle of the knee (‘Osplug’ technique). Seventeen patients (mean age of 27±7 years), twelve with Osteochondritis dissecans (OD) and five with an osteochondral defect (OCD) was treated with unicortical autologous bone graft combined with ACI (‘Osplug’ technique). Functional outcome was assessed with Lysholm scores obtained for 5 years post-operatively. The repair site was evaluated with the Oswestry Arthroscopy Score (OAS), MOCART MRI score and ICRS II histology score. The mean defect size was 4.5±2.6 SD cm² and mean depth was 11.3±5 SD mm. A significant improvement of Lysholm score from 45 (IQR 24, range 16–79) to 77 (IQR 28, range 41–100) at 1 year (p-value 0.001) and 70 (IQR 35, range 33–91) at 5 years (p-value 0.009). The mean OAS of the repair site was 6.2 (range 0–9) at a mean of 1.3 years. The mean MOCART score was 61 ± 22SD (range 20–85) at 2.6 ± 1.8SD years. Histology demonstrated generally good integration of the repair cartilage with the underlying bone. Poor lateral integration of the bone graft on MRI and low OAS were significantly associated with a poor outcome and failure. The Osplug technique shows significant improvement of functional outcome for up to 5 years. This is the first report describing the association of bone graft integration with functional outcome after such a procedure

Purpose: We present the rate of osteochondritis disse-cans in a specific group of patients and the results after treatment which was done arthroscopic. Material-Method: During a period from 1995 to 2001, in 39 patients with mean age 23.4 years suffering of knee pain, osteochondritis dissecans was diagnosed. The classification of the lesions was based on magnetic resonance and surgically treatment was decided. In 32 pts, a partially detached lesion was found and reattachment with biodegradable pins took place. In five pts the lesion was recently detached and treated similarly with pinning after debridement of the crater. In the last two patients the detachment was old, the osteochondral segment was removed and drilling took place. Results: All patients were followed up for two years and the evaluation was based on the Lyscholm score. Successful healing certified radiologically was achieved in 33 patients. Conclusion: Osteochondritis dissecans of the knee is seen between young adults who participate in sports activities. The arthroscopic treatment in our clinic was successful in the 84% of patients with good and excellent clinical results

Introduction. Osteochondritis dissecans (OCD) is a localised disorder of subchondral bone and the overlying articular cartilage. The most commonly used classification systems involve arthroscopy and MRI. Aim. To investigate the correlation between arthroscopic and MR findings in patients with OCD of the talus. Methods. 16 ankles in 14 patients with radiographically proven OCD were reviewed. Nine were male and five female. Mean age was 35yrs (range 18–64yrs). The lesions were staged independently using the Guhl. 1. arthroscopic and Dipaola. 2. MR classification systems. Results. Arthroscopically there were eight stable and eight unstable lesions. Of the eight stable lesions, MRI staged five as stable and three as unstable. Of the eight unstable lesions, MRI staged six as unstable and two as stable. This gives a sensitivity of diagnosing unstable lesions as 0.75, with a specificity of 0.63. Conclusions. This small study demonstrates that MR scans may have some limitations in classifying OCD lesions of the talus. Possible explanations are discussed. We propose that MRI findings, of OCD of the talus, should not be taken in isolation, but correlated with the patients symptoms and signs to avoid unnecessary arthroscopy

Purpose: Osteochondritis dissecans (OCD) of the capitellum most commonly affects adolescent pitchers and gymnasts, and presents with pain and mechanical symptoms. Fragment excision is the most commonly employed surgical treatment; however, patients with larger lesions have been reported to have poorer outcomes. It’s not clear whether this is due to increased contact pressures on the surrounding articular surface, or if fragment excision causes instability of the elbow. The purpose of this study was to determine if fragment excision of simulated OCD lesions of the capitellum alters kinematics and stability of the elbow. Method: Nine fresh-frozen cadaveric arms were mounted in an upper extremity joint motion simulator, with cables attaching the tendons of the major muscle tendons to motors and pneumatic actuators. Electromagnetic receivers attached to the radius and ulna enabled quantification of the kinematics of both bones with respect to the humerus. Three-dimensional CT scans were used to plan lesions of 12.5% (mean 0.8cm2), 25%, 37.5%, 50%, and 100% (mean 6.2cm2) of the capitellar surface, which were marked on the capitellum using navigation. Lesions were created by burring through cartilage and subchondral bone. The arms were subjected to active and passive flexion in both the vertical and valgus-loaded positions, and passive forearm rotation in the vertical position. Results: No significant differences in varus-valgus or rotational ulnohumeral kinematics were found between any of the simulated OCD lesions and the elbows with an intact articulation with active and passive flexion, regardless of forearm rotation and the orientation of the arm (p> 0.7). Radiocapitellar kinematics were not significantly affected during passive forearm rotation with the arm in the vertical position (p=0.07–0.6). Conclusion: In this in-vitro biomechanical study even large simulated OCD lesions of the capitellum did not alter the kinematics or laxity of the elbow at either the radiocapitellar or ulnohumeral joints. These data suggest that excision of capitellar fragments not amenable to fixation can be considered without altering elbow kinematics or decreasing stability. Further study is required to examine other factors, such as altered contact stresses on the remaining articulation, that are thought to contribute to poorer outcomes in patients with larger lesions