Introduction: Although THR can provide excellent pain relief and restore functional ability for most patients, there is a proportion of patients who experience a poor functional outcome after THR. One factor that could contribute to a poor outcome after THR is leg length discrepancy (LLD). Restoration of leg length is important in optimising hip biomechanics and LLD has several consequences for the patient, including back pain and a limp. Assessment of LLD using radiographs is time consuming and labour intensive, and therefore limits large scale studies of LLD. However, patients self-report of perceived LLD may be a useful tool to study LLD on a large scale. Therefore, the aim of this postal audit survey was to determine the prevalence of patient-perceived LLD after primary THR and its impact on mid-term functional outcomes. Methods: A cross-sectional postal audit survey of all consecutive patients who had a primary, unilateral THR at the Avon Orthopaedic Centre 5–8 years previously was conducted. Several questions about LLD were included on the questionnaire. Firstly, patients were asked if they thought that their legs were the same length. For those who thought their legs were different lengths, they were asked if the difference bothered them, whether the difference in length leg was enough to comment upon, and whether they used a shoe raise. Participants also completed an Oxford hip score (OHS), which is a self-report measure that assesses functional ability and pain after THR, including limping. Results: 1,114 THR patients returned a completed questionnaire, giving a response rate of 73%. 329 patients (30%) reported that they thought their legs were different lengths. The median OHS for patients with a perceived LLD was 22, which was significantly worse than the OHS of 18 for patients who thought their legs were the same length (p< 0.001). Of the 329 patients with a perceived LLD, 161 patients (51%) were bothered by the difference, 65 patients (20%) thought the discrepancy was sufficient to comment upon and 101 patients (31%) used a shoe raise. 31% of patients with LLD limped most or all of the time compared to only 9% of patients without LLD. Conclusion: In conclusion, this study found that the prevalence of perceived LLD at 5–8 years after THR was 30%. Of the patients with LLD, over 50% were bothered by the LLD and over a third used a shoe raise to equalise leg lengths. Patients with perceived LLD have a significantly poorer self-report functional outcome than those patients without LLD. It is therefore important that patients are informed pre-operatively of the high risk of LLD after THR and the associated negative impact this may have on their outcome

Introduction. Corrosion products from modular taper junctions of hip prostheses have been implicated in adverse local tissue reactions after THR. Numerous factors have been proposed as the root causes of this phenomenon, including implant design and materials, manufacturing variables, intraoperative assembly, and patient lifestyle. As significant taper damage only occurs in a few percent of cases of THR, we have addressed this complication using a “forensic” examination of retrieval specimens to gain insight into the factors initiating the cascade leading to irreversible damage of the modular interface. In this study we report the categorization of over 380 retrievals into groups having shared damage patterns, metallic composition, and interface surface geometries to isolate the genesis of mechanically-assisted corrosion and its relation to intraoperative assembly, manufacturing, and postoperative loading. Methods. A total of 384 femoral components were examined after retrieval at revision THR. The implants were produced by a diverse range of manufacturers, 271 in CoCr, and 113 in TiAlV, with both smooth (253) and machined (131) tapers. Initially, the implants were sorted into groups based on composition and taper roughness. Each trunnion was then cleaned to remove organic deposits and examined by stereomicroscopy at X6-X31. After an initial pilot study, we developed a classification system consisting of 8 basic patterns of damage (Table 1). We then classified all 384 trunnions according to this 8-group system. The prevalence of each pattern was calculated on the basis of both composition and surface texture of the trunnion. Results. Overall, 81% of the trunnions had visible areas of surface damage, which varied as a function of composition (CoCr: 77%; TiAlV: 90%; p=0.002) and finish (smooth: 88%; machined: 67%; p<0.001). The most common pattern of damage was a circumferential ring at the base of the taper (24%) followed by a group with slight fretting or assembly damage distributed over the entire taper (19%). Damage to one quadrant at the bottom third was seen in approximately 18%. When combining material types, 41% of smooth tapers had circumferential patterns of damage corresponding to groups 2, 3, and 5. Conversely, 77% of the machined tapers had damage limited to one side or on two opposite sides (Patterns 4, 6, 7, 8, and 9). Discussion. Our results show that the pattern and location of damage is influenced not only by composition and surface texture, but can also be an indicator of component fit. The damage patterns observed on almost half (45%) of the trunnions were not circumferential (Chart 2), suggesting that misalignment of the head during assembly may be responsible for initiating the corrosion cascade in stems with machined taper surfaces. Summary. We categorized over 380 implant retrievals into groups having shared damage patterns, metallic composition, and interface surface geometries to isolate the genesis of corrosion

Background. As the number of ceramic THR bearings used worldwide is increasing, the number of implants that experience off-normal working conditions, e.g. edge loading, third bodies in the joint, soft tissues laxity, dislocation/subluxation of the joint, increases too. Under all such conditions the bearing surfaces can be damaged, leading eventually to a limitation of the expected performances of the implant. Methods. We characterised the damage resistance of different bearing surfaces (alumina matrix composite BIOLOXdelta, alpha-alumina BIOLOXforte, zirconia 3Y-TZP, oxidized zirconium alloy Zr-2.5Nb, CoCr-alloy) by scratch tests performed following the European standard EN 1071–3:2005. Also the scratch hardness of same materials has been assessed. Results. The Lc1 value (i.e., the load for the onset of a scratch) measured for BIOLOXdelta is about fivefold the one measured for the oxidized zirconium alloy (OXZr) surface and about tenfold the Lc1 measured for the CoCr alloy. The height of ridges along the scratch edges due to plastic flow in the composite ceramic BIOLOXdelta are only 21% in height than in CoCr, and only a small fraction (0.04%) of the height of ridges measured on OXZr surfaces. The scratch hardness of the metal samples tested (CoCr, OXZr) results one order of magnitude lower than the ones of ceramics. This behavior is not influenced by of the presence of the coating on OXZr surface. Conclusions. The transformation toughened ceramics tested (BIOLOXdelta, 3Y-TZP) are the materials that exhibit the higher resistance to scratching. Ridges at scratch edges are lower in ceramics than in coated or uncoated metals. The result show the superior scratch resistance behavior of toughened ceramics for THR wear couples with respect to coated or bare alloys. Level of Evidence. Level 1

Introduction: Total hip replacement (THR) and total knee replacement (TKR) are widely accepted as effective surgical procedures to alleviate chronic joint pain and improve functional ability. Clinical evidence suggests that joint replacement results in excellent outcomes. Traditionally, reporting of outcomes has been focused on implant survivorship and surgeon based assessment of objective outcomes, such as range of motion, knee stability and radiographic results. However, because there is a discrepancy between patient and clinician ratings of health, patient-reported outcome measures have been validated to allow patients to rate their own health, thereby placing them at the centre of outcome assessment. The aim of this study was to compare the mid-term functional outcomes of TKR and THR using validated patient-reported outcome measures. Methods: A cross-sectional postal audit survey of all consecutive patients who had a primary, unilateral THR or TKR at the Avon Orthopaedic Centre 5–8 years previously was conducted. Participants completed an Oxford hip score (OHS) or Oxford knee score (OKS). The Oxford questionnaires are self-report joint-specific measures that assess functional ability and pain from the patient’s perspective. They consist of 12 questions about pain and physical limitations experienced over the past four weeks because of the hip or knee. Results: 1112 THR patients and 613 TKR patients returned a completed questionnaire, giving a response rate of 72%. The median OKS of 26 was significantly worse than the median OHS of 19 (p< 0.001). TKR patients experienced a poorer functional outcome than THR patients on all domains assessed by the Oxford questionnaire, independent of age. The percentage of patients reporting moderate-severe pain was two-fold greater for TKR than THR patients (26% vs 13%, respectively). Conclusion: This survey found that TKR patients report more pain and functional limitations than THR patients at 5–8 years post-operatively, independent of age. The finding that over a quarter of TKR patients reported moderate-severe pain at 5–8 years post-operative indicates that a large proportion of people are undergoing major knee surgery that is failing to achieve its primary aim of pain relief. This raises questions about whether patient selection for TKR is appropriate. To improve patient selection, it may be necessary to have a preoperative screening protocol to identify patient factors predictive of a poor outcome after TKR. Currently, no such protocol exists and this is an area of orthopaedics requiring further research

The current, most popular recommendation for cup orientation, namely the Lewinnek box, dates back to the 70's, that is to say at the stone age of hip arthroplasty. Although Lewinnek's recommendations have been associated with a reduction of dislocation, some complications, either impingement or edge loading related, have not been eliminated. Early dislocations are becoming very rare and most of them probably occur in “outlier” patients with atypical pelvic/hip kinematics. Because singular problems usually need singular treatments, those patients need a more specific personalised planning of the treatment rather than a basic systematic application of Lewinnek recommendations. We aim in this review to define the potential impacts that the spine-hip relations (SHRs) have on hip arthroplasty. We highlight how recent improvements in hip implants technology and knowledge about SHRs can substantially modify the planning of a THR, and make the «Lewinnek recommendations» not relevant anymore. We propose a new classification of the SHRs with specific treatment recommendations for hip arthroplasty whose goal is to help at establishing a personalized planning of a THR. This new classification (figures 1 and 2) gives a rationale to optimize the short and long-term patient's outcomes by improving stability and reducing edge loading. We believe this new concept could be beneficial for clinical and research purposes

Aims: Elevated serum cobalt and chromium ion levels associated with carcinogenesis and chromosomal damage in animals has raised concerns that metal-on-metal (MOM) total hip replacement (THR) in humans may produce the same effects over time. Considering that the risks may be related to the level of these ions in the body, this study compared the serum cobalt and chromium ion levels in patients with unilateral versus bilateral 28 mm diameter MOM THR. Methods: All patients having THR at our institution were prospectively registered on a computerised database. From our database, we identified 108 patients with Ultima (Johnson and Johnson, Leeds) MOM THR with 28 mm bearing made of cobalt-chromium alloy. After patient review in clinic and before blood results were known, patient matching was performed by date after surgery at blood sampling, activity level and body mass. Using these stringent criteria, 11 unilateral THR could be adequately matched with 11 bilateral THR. Blood serum was taken with full anti-contamination protocols and serum analysed via inductively coupled plasma mass spectrometry. Statistical analysis used the Mann-Whitney U test. Results: The serum cobalt ion level after unilateral MOM THR was 4.4 times normal (median 22 nmol/L, range 15 to 37 nmol/L) compared to 8.4 times normal (median 42 nmol/L, range 19 to 221 nmol/L) for bilateral MOM THR (p=0.001). The serum chromium ion level after unilateral MOM THR was 3.8 times normal (median 19 nmol/L, range 2 to 35 nmol/L) compared to 10.4 times normal (median 52 nmol/L, range 19 to 287 nmol/L) for bilateral MOM THR (p=0.04). Conclusions: This study has shown that the serum cobalt and chromium ion levels in patients with bilateral MOM THR are significantly higher than those in patients with unilateral MOM THR. With levels of up to 50 times the upper limit of normal, this finding may be of relevance for the potential development of long-term side effects

The current, most popular recommendation for cup orientation, namely the Lewinnek box, dates back to the 70's, that is to say at the stone age of hip arthroplasty. Although Lewinnek's recommendations have been associated with a reduction of dislocation, some complications, either impingement or edge loading related, have not been eliminated. Early dislocations are becoming very rare and most of them probably occur in “outlier” patients with atypical pelvic/hip kinematics. Because singular problems usually need singular treatments, those patients need a more specific personalised planning of the treatment rather than a basic systematic application of Lewinnek recommendations. We aim in this review to define the potential impacts that the spine-hip relations (SHRs) have on hip arthroplasty. We highlight how recent improvements in hip implants technology and knowledge about SHRs can substantially modify the planning of a THR, and make the « Lewinnek recommendations » not relevant anymore. We propose a new classification of the SHRs with specific treatment recommendations for hip arthroplasty whose goal is to help at establishing a personalized planning of a THR. This new classification gives a rationale to optimize the short and long-term patient's outcomes by improving stability and reducing edge loading. We believe this new concept could be beneficial for clinical and research purposes

Introduction:. Ankle arthritis is a leading cause of pain and disability. The effect of this condition on physical and mental health is similar to end stage hip arthritis. There is paucity of literature on PROMS following total ankle replacements (TAR) in comparison to total hip replacement (THR) or knee replacement (TKR). We aimed to study 5 year outcomes of TAR in comparison with TKR and THR. Methods:. PROMS data from patients who underwent a primary THR, TKR or TAR from March 2003 to 2013 were collected from our hospital patient registry. They were divided into 3 groups based on the type of primary joint replacement. Patient demographics and patient reported outcomes (WOMAC, SF-36 scores and patient satisfaction scores at follow up) were compared at pre-op and 5 year follow up. Results:. There was data available on 1920 THR, 2582 TKR and 248 TAR patients. Pre-operatively, TAR patients reported higher function scores when compared to THR and TKR (40.2 vs. 34.2 and 35.8; p<0.05). For SF-36 scores, there was no difference between groups for general health, role emotional components (P>0.05); TAR patients reported similar scores to TKRs for physical domains; to THRs for the mental domains (P>0.05). At 5 years post-op, TARs reported lower scores than THRs and TKRs for function and stiffness. For SF-36 scores, TARs reported similar outcomes to THR and TKR for mental health components (p>0.05), similar scores to TKR for 3/4 physical domains (p<0.05), but lower satisfaction rates for ADL and recreation when compared to THR (P<0.05). Conclusion:. TAR patients had similar outcomes to THR or TKR patients for disease specific and mental health domains, and lower patient satisfaction rates in terms of pain relief, ADL and recreation. Further research is warranted including clinical outcomes along with PROMS with a long term follow up

Introduction: Outcome reporting following THR constitute a significant proportion of orthopaedic publications. Publication bias in the form of underreporting of studies showing non satisfactory or negative results is a well recognised problem in other specialities. We tried to find out the magnitude of this problem in orthopaedics publications dealing with THR. Method and materials: We reviewed all publications on THR in the year 2004 in three general orthopaedic journals namely JBJS (BR), JBJS (Am), CORR. Of the 1034 original articles published in these three journals more than 400 articles were concerned with total hip replacement. Results and Discussion: In this study we found only 6% of the published articles were showing non significant or negative results. This raises concerns about evidence based approach in THR and the need for preventive measures like registering all clinical trials and change in the attitude of editorial board

In order to enhance the acceptance of computer assisted surgery in joint replacement, a development-cooperation with BrainLAB, Germany was set up to develop a user-friendly handheld navigation device. A sterile draped Apple® IPod-Touch which is placed into a hardcover cradle, is used as navigation monitor and touchscreen control. Different instruments, such as navigation-pointer are attached to the cradle. In addition the workflows for TKR and THR procedures have been optimised. Therefore the main focus for TKR is navigation of femoral and tibial resection as well as leg alignment control. For the THR the system enables an intraoperative control of leg-length and femoral-offset measurement in comparison with the preoperative situation. Each step of the procedure is supported by video animations of the specific navigation workflow. Between September and December 2010 the first clinical study on the usability in TKR and THR was performed for 20 cases using a prototype system. The study was approved by the local ethic committee and the “German Federal Institute for Drugs and Medical Devices (BfArM)”. Special interest was taken to the aspects of usability and the necessary time periods for specific steps of the procedure. Usability was measured for specific time periods of the procedure assessment of the usability of the surgical team. In addition postoperative x-rays were evaluated for implant position, leg alignment for TKR and hip joint geometry for THR cases. Throughout the study for each assigned patient the procedure could be performed as planned. Several design inputs were identified for further improvement of the final system. Therefore time measurements of the first five cases were excluded. For the TKR cases the registration process of the last 5 cases was less than 3 minutes. The interval for the tibial resection was between 3 and 7 minutes (aligning tibial cutting block – end of tibial verification). The interval for the distal femur resection was between 7 and 11 minutes (aligning femoral cutting block – end of femoral verification). All 10 Patients showed a final leg alignment on the postoperative standing x-ray within the save-zone of +/− 3° from neutral alignment. For the THR cases the preoperative registration period including the femoral head resection and acetabular registration was between 7 and 12 Minutes. Each final measurement of the hip geometry was done in less than 2 minutes. The evaluation of the pelvic ap-x-ray pre- and postoperative showed equivalent measurements of the new hip geometry compared with the intraoperative measured values. No specific complications occurred throughout the study. In conclusion the BrainLAB–DASH-System has shown a high grade of usability and very short learning curve within this first clinical study. The use of a standard Apple® IPod-touch as a user interface seems to enhance the acceptance of the navigation technique. Equivalent precision compared to standard navigation systems have been demonstrated

The choice to use alumina in the manufacture of a low-wear THR bearing made by Boutin and its co-workers has proven its effectiveness in almost 35 years of clinical use. A continuous development process aimed to improve mechanical properties led to today’s materials that exhibit extreme high reliability. The recent introduction in clinical use of alumina matrix composites represents the latest evolution of alumina that thanks to high hardness, toughness, and bending strength allow to manufacture new design of ceramic components. Composites obtained introducing zirconia in the alumina matrix, known as Zirconia Toughened Alumina (ZTA) are candidate for use in THA bearings from a long time. A real breakthrough was represented by alumina ceramics toughened both by zirconia both by platelets nucleated in-situ during sintering (Zirconia-Platelet Toughened Alumina - ZPTA). The chemical composition and the microstructure of ZPTA were optimised to achieve a ceramic material joining strength of more than 1200MPa, Vickers hardness 1975, fracture toughness of 6,5 MPa m-1/2, andextremely low wear also in the most severe simulator tests performed in microseparation mode The paper reviews the improvements introduced in the technology of ceramic for arthoplasty, and their effects on the microstructural properties and on the performances of the past and actual generation of ceramic for THR bearings, and summarise the results obtained in the development of alumina matrix composites

Introduction: Hip resurfacing has been promoted as a procedure that results in a better outcome in sporting and work activity after surgery compared to total hip replacement (THR). Recently more standard THRs have offered the same large metal on metal joint articulation but using a standard stem. Method: Questionnaires were analysed from 125 metal on metal total hip replacement (THR) and 108 hip resurfacing (HR) patients regarding participation in sport and returning to work at a minimum of a year after surgery. Results: The two groups had similar mean age (61 vs 60) and pre-operative Oxford hip scores (41 vs 38). Seventy-one of 125 THR (57%) patients compared to 76 of 108 (70%) HR patients participated in sporting activity in the year after their surgery (fishers exact test, p value=0.04). When including only patients that played sport before their surgery 54 of 75 (72%) THR and 66 of 83 (80%) HR patients returned to same sporting activity level after their surgery (fishers exact test, p value=0.35). Of the patients that worked before surgery 35 of 44 (80%) THR patients compared to 70 of 74 (95%) HR patients returned work to after their surgery (fishers exact test, p value= 0.02). Conclusion: There was no difference in the proportion of patients who played sport prior to their surgery returning to sport. After hip resurfacing however more people took up a sporting activity and at a year post surgery a greater number of patients were taking part in sport after a hip resurfacing. Patients with a hip resurfacing were more likely to return to work after surgery

Introduction. A recent report based on the NARA database (Nordic Arthroplasty Register Association) found that the 10-year survivorship of patients under 50 with traditional total hip arthroplasty was only 83% in 14,600 cases. The purpose of this study was to compare our experience using metal-on-metal hip resurfacing arthroplasty (HRA) to treat these patients. Methods. from May 2001 to Feb 2012, a single surgeon performed 1029 metal-on-metal HRA in 855 patients younger than 50 years old. Three different implants were used in consecutive groups of patients, first the Corin hybrid HRA (182); then the Biomet hybrid HRA (306); and finally the Biomet uncemented HRA (541). The primary diagnoses were OA (707); dysplasia (125); osteonecrosis (98); post-trauma (28); Legg-Calve-Perthes (27) and others (44). The average age was 43±6 years; 74% were men; the average BMI was 27±4; mean femoral component size was 50±4 (range 40–62); the average T-score was 0±1. 37% of our patients reported a UCLA Activity level of 9 or 10 (impact sports). Six died with causes unrelated to their HRAs. The rate of follow-up was 94%. Our patients were not selected by any criteria except the surgeon's technical ability to perform an HRA. Results. There were a total 42 failures: acetabular component loosening in 15 cases (8 before two years) femoral component loosening in 9 cases; femoral neck fracture in 5 cases; adverse wear related failure (AWRF) in 4 cases; deep infection in 3 cases; recurrent dislocation in 1 case; other causes in 5 cases. With revision of any component as the end point, the Kaplan-Meier survivorship rate was 94.9% at 8 years and 92.5% at 10 years for the entire group. We compared survivorship between groups at shorter follow-up intervals to determine if results were improving. The survivorship rate at 8 years for Biomet Hybrid group was 95.8%, which was significantly better than 89.1% for the earlier Corin Hybrid group; the survivorship rate at 5 years for the latest Biomet Uncemented HRA group was 98.7%, also better than 96.5% for the prior Biomet Hybrid group. (P=0.0001). Conclusion. Metal-on-metal hip resurfacing has less than half the 10-year failure rate of THR in young patients. As HRA technology and experience improve, our data suggests that the results further improve. HRA currently meets the NICE criteria for 10-year survivorship of implants while THR doesn't in young patients. Our HRA patients are allowed unrestricted activity, while THR patients are typically restricted. AWRF (0.4%) is a minor problem that has been blown far out of proportion to its significance. Patient selection against HRA in certain subgroups (women, small bearings, history of metal allergy) may not be advisable based on our results

Background: Resurfacing is becoming increasingly popular as an option for primary hip arthroplasty. However, there is minimal documentation of objective post-operative outcomes which support the perceived benefits of resurfacing over traditional stemmed THR. Most comparative studies have reported differences in X-ray findings, such as component alignment and femoral offset, which only allow speculation of their relative effects on patient function. Studies have also reported general clinical outcomes following resurfacing, and although resurfacing shows promising medium term results, these studies have been largely subjective and have lacked a direct same study comparison with standard THR. Potential benefits of resurfacing include improved abductor muscle function, resulting from preservation of the femoral neck offset, and greater range of hip motion, resulting from the larger diameter bearings. Mont et al (2007) compared biomechanical outcomes during gait for individuals with unilateral resurfacing and standard arthroplasty and concluded that hip resurfacing yielded superior function, as defined by faster walking speeds. However, comprehensive data of 3-dimensional moments and hip kinematics was not presented and functional assessment was limited to gait analysis only. Methods: Kinematic and kinetic outcomes were evaluated for 28 individuals (age 40–60) with unilateral resurfacing (Durom, Zimmer) or standard stemmed THR (ceramic-on-ceramic Trident, Stryker) at 3 and 12 months following surgery. Data was collected using an 8 camera Vicon 612 motion analysis system and two Kistler force plates while subjects completed level walking and stair ascent and descent activities using a 4-step stair case, instrumented with a force plate on the second step. A lower limb marker set was used with pointer trial calibration of anatomical landmarks. 3-dimensional hip moments, angles and temporospatial parameters were compared and preferred motion patterns analysed. Results: Peak hip moments showed no statistically significant group difference during the ambulatory activities although slightly greater peak hip angles were achieved by those with standard THR. Stair negotiation highlighted greater differences in biomechanical outcomes between the groups than level gait analysis. Those with hip resurfacing exhibited less protective motion patterns and performed walking and stair negotiation at a faster pace. Conclusions: The greater diameter bearings of the resurfacing prosthesis do not appear to yield a greater functional range of motion post-operatively. Preserving the femoral offset with a hip resurfacing does not appear to benefit abductor muscle function. Statistically, both arthroplasty types demonstrate equivalent functional outcomes

Introduction: The hip resurfacing in younger patients is being performed more frequently in the UK. At the same time conventional Total Hip Replacement (THR) is also being performed.. We carried out a study to compare the patient satisfaction and outcome following Birmingham Hip Resurfacing (BHR) and Total Hip Replacement (THR) in patients below the age of 55 years. Methods: There were 93 BHR in 73 patients and 74 THR in 64 patients performed between February 1997 to June 2005.. Retrospective evaluation of notes and complications were identified. We carried out our study using Oxford Hip score and Modified WOMAC questionnaire by postal and telephonic survey. Results: We found that mean length of stay was 4.5 days for BHR and 6.4 days for THR patients. (P< 0.0001) The dislocation rate was 0% for BHR as oppose to 4% for THR. (P< 0.05) The mean Oxford Hip score improved from pre-operative 43 to 14 for BHR as oppose to 48 to 22 for THR patients. The mean modified WOMAC score improved from 21 to 8.4 for BHR as oppose to 25 pre-operative score to 12 for THR. We also found early and sustained improvement in these scores for BHR as compare to THR during their follow-up within 6 months to 8 years. The improvement in pain score was 100% following BHR as opposed to 84% for THR. Following BHR 70% patients were very active or active as oppose to only 30% of THR patients. Return to the work and sporting activities following BHR was at a mean of 9 weeks as oppose to 14 weeks following THR. (P < 0.05) The level of satisfaction was 98% following BHR as oppose to 84% following THR. (P=0.356)

There is a critical need for safe innovation in total joint replacements to address the demands of an ageing yet increasingly active population. The development of robust implant designs requires consideration of uncertainties including patient related factors such as bone morphology but also activity related loads and the variability in the surgical procedure itself. Here we present an integrated framework considering these sources of variability and its application to assess the performance of the femoral component of a total hip replacement (THR). The framework offers four key features. To consider variability in bone properties, an automated workflow for establishing statistical shape and intensity models (SSIM) was developed. Here, the inherent relationship between shape and bone density is captured and new meshes of the target bone structures are generated with specific morphology and density distributions. The second key feature is a virtual implantation capability including implant positioning, and bone resection. Implant positioning is performed using automatically identified bone features and flexibly defined rules reflecting surgical variability. Bone resection is performed according to manufacturer guidelines. Virtual implantation then occurs through Boolean operations to remove bone elements contained within the implant's volume. The third feature is the automatic application of loads at muscle attachment points or on the joint contact surfaces defined on the SSIM. The magnitude and orientation of the forces are derived from models of similar morphology for a range of activities from a database of musculoskeletal (MS) loads. The connection to this MS loading model allows the intricate link between morphology and muscle forces to be captured. Importantly, this model of the internal forces provides access to the spectrum of loading conditions across a patient population rather than just typical or average values. The final feature is an environment that allows finite element simulations to be run to assess the mechanics of the bone-implant construct and extract results for e.g. bone strains, interface mechanics and implant stresses. Results are automatically processed and mapped in an anatomically consistent manner and can be further exploited to establish surrogate models for efficient subsequent design optimization. To demonstrate the capability of the framework, it has been applied to the femoral component of a THR. An SSIM was created from 102 segmented femurs capturing the heterogeneous bone density distributions. Cementless femoral stems were positioned such that for the optimal implantation the proximal shaft axis of the femurs coincided with the distal stem axis and the position of the native femoral head centre was restored. Here, the resection did not affect the greater trochanter and the implantations were clinically acceptable for 10000 virtual implantations performed to simulate variability in patient morphology and surgical variation. The MS database was established from musculoskeletal analyses run for a cohort of 17 THR subjects obtaining over 100,000 individual samples of 3D muscle and joint forces. An initial analysis of the mechanical performance in 7 bone-implant constructs showed levels of bone strains and implant stresses in general agreement with the literature

Introduction: Metal on metal Hip Resurfacing Arthroplasty (MoMHRA) has gained popularity due to its perceived advantages of bone conservation and relative ease of revision to a conventional THR if it fails. This retrospective study is aimed at assessing the functional outcome of failed MoMHRA revised to THR and comparing it with a matched cohort of primary THRs. Method: Since 1999 we have revised 53 MoMHRA to THR. The reasons for revision were femoral neck fracture (Group A, n=21), pseudotumour (Group B, n=16) and other causes (Group C, n=16: loosening, avascular necrosis and infection). Average follow-up was 3 years months (1.2–7.3). These revisions were compared with 106 primary THRs which were age, gender and follow-up matched with the revision group in a ratio of 2:1. Results: The mean Oxford Hip Score (OHS) was 20.1 (12–51) for group A, 39.1 (14– 56) for group B, 22.8 (12–39) for group C and 17.8 (12–45) for primary THR group. In group A, there were three infections requiring further revisions. In group B, there were three recurrent dislocations, three patients with femoral nerve palsy and one femoral artery stenosis. In group C, there were no complications. The differences in clinical and functional outcome between group B and the remaining groups as well as the difference in the outcome between group B and control group were statistically significant (p < 0.05). Conclusions: THR for failed MoMHRA was associated with significantly more complications, operation time and need for blood transfusion for the pseudotumour group. In addition, the revisions secondary to pseudotumour also had significantly worse functional outcome when compared to other MoMHRA revisions or primary THR

Summary Statement. This data may help explain the variability in physical function after primary TKR as compared to primary THR. Introduction. Total knee replacement (TKR) and total hip replacement (THR) reliably relieve pain, restore function, and ensure mobility in patients with advanced joint arthritis; however these results are not uniform across all patient populations. We compared baseline demographic and symptom profiles in patients from a US national cohort undergoing primary TKR and THR. Methods. Patients undergoing primary TKR and THR between 7/1/2011 and 3/30/2012 were identified from the national research consortium which collects comprehensive data on enrolled patients from 120 surgeons across 23 states. Gathered data includes patient demographics, comorbidity (Charlson Comorbidity Index), operative joint pain severity, physical function (SF-36; Physical Component Score (PCS)), emotional health (SF-36 Mental Component Score (MCS)), and musculoskeletal burden of illness (Hip and Knee Disability and Osteoarthritis Outcome Scores; Oswestry Disability Index). Descriptive statistics compared baseline demographic and symptom profiles. Results. Our analysis compared 1362 primary TKR patients and 1013 primary THR patients. US TKR patients were significantly older (66.5 vs. 64.3 years), more obese (BMI 31.7 vs. 29.3), and less educated (p<0.005). TKR patients had higher rates of comorbidities, specifically diabetes, gastrointestinal ulcers, and cerebrovascular disease (p≤0.006). THR patients had significantly worse physical function (PCS 31.6 vs. 33.3), lower back pain (35.6% vs. 30.5% moderate-severe), and operative joint pain, stiffness, and function (p<0.005). Conclusion. US patients undergoing primary TKR are older with more comorbidities, however THR patient baseline functional and musculoskeletal limitations are significantly greater than primary TKR patients

Introduction:. Total knee replacement (TKR) and total hip replacement (THR) reliably relieve pain, restore function, and ensure mobility in patients with advanced joint arthritis; however these results are not uniform across all patient populations. Moreover, it is well established that knee replacement patients have outcomes inferior to those undergoing hip replacement procedures with lower rates of dissatisfaction with post-operative function and pain relief. We compared baseline demographic and symptom profiles in patients from a US national cohort undergoing primary TKR and THR to determine whether differences in demographic make-up, pre-operative symptoms, or pre-existing co-morbidities might contribute to these differences observed post-operatively. Methods:. A cohort of 2375 patients undergoing primary TKR and THR was identified from the FORCE national research consortium from all surgeries performed between July 1. st. 2011 and March 30. th. 2012. This set of patients was derived from 120 contributing surgeons in 23 US states. Gathered data included patient demographics, comorbidity (Charlson Comorbidity Index), operative joint pain severity (Western Ontario and McMaster Universities Arthritis Index (WOMAC)), physical function (SF-36; Physical Component Score (PCS)), emotional health (SF-36; Mental Component Score (MCS)), and musculoskeletal burden of illness (Hip and Knee Disability and Osteoarthritis Outcome Scores; Oswestry Disability Index). Using descriptive statistics, we compared the baseline demographic characteristics and symptom profiles of patients undergoing TKR (n = 1362) and those undergoing THR (n = 1013). Results:. In this large national sample, patients receiving knee replacements were found to be significantly older (66.5 vs. 64.3 years), more obese (BMI 31.7 vs. 29.3), and less educated (p < 0.005) than those undergoing THR. TKR patients had higher rates of medical comorbidities, specifically diabetes, gastrointestinal ulcers, and cerebrovascular disease (p ≤ 0.006). Conversely, THR patients had significantly worse physical function (PCS 31.6 vs. 33.3), lower back pain (35.6% vs. 30.5% moderate-severe), and operative joint pain, stiffness, and function (p < 0.005) when compared to those undergoing TKR. Conclusions:. US patients undergoing primary TKR are older with more comorbidities, however THR patient baseline functional and musculoskeletal limitations are significantly greater than primary TKR patients. These data may help explain the variability in physical function after primary TKR as compared to primary THR

Introduction: The goal of the study was to compare the squeaking frequencies of Ceramic-on-Ceramic THR in-vitro and in-vivo among patients who underwent THR. Method: Four patients, who underwent THR with a Ceramic-on-Ceramic THR (Trident. ®. , Stryker. ®. ) presented a squeaking noise. The noise was recorded and analysed with acoustic software (FMaster. ®. ). In-vitro 2 alumina ceramic (Biolox Forte Ceramtec. ®. ) 32 mm diameter (Ceramconcept. ®. ) components were tested using a PROSIM. ®. hip friction simulator. The cup was positioned with a 70° abduction angle in order to achieve edge loading conditions and the head was articulated ± 10° at 1 Hz with a load of 2.5kN for a duration of 300 cycles. Tests were conducted under lubricated conditions with 25% bovine serum and with the addition of a 3rd body alumina ceramic particle (200 μm thickness and 2 mm length). Results: In-vivo, recordings had a dominant frequency ranging between 2.2 and 2.4 kHz. In-vitro no squeaking occurred under edge loading conditions. However, with the addition of an alumina ceramic 3rd body particle in the contact region squeaking was obtained at the beginning of the tests and stopped after ~20 seconds (dominant frequency 2.6 kHz). Discussion and Conclusion: Squeaking noises of a similar frequency were recorded in-vitro and in-vivo. In-vitro noises followed edge loading and 3rd body particles and despite, the severe conditions, squeaking was intermittent and difficult to reproduce. The lower frequency of squeaking recorded in-vivo, demonstrates a potential damping effect of the soft tissues. No damage was observed on the components, however, the test duration was very short. Squeaking may be related to third body particles that could be generated by wear or impingement between the femoral neck and the metal back. Cup design seems to be of particular importance in noisy hip, leading to a high variability of squeaking rate according to the implants