The aim of the study is to determine the histological, biochemical, and biomechanical efficacy of fibrin clot and
Complex regional pain syndrome type 1 (CRPS-I) is a devastating complication that can occur after limb extremity injuries. The effectiveness of
Introduction and purpose:
Following ischaemia-reperfusion (I-R) tissues undergo a neutrophil mediated oxidant injury.
Purpose of the study: The pathophysiology of reflex dystrophy or type I complex regional pain syndrome remains poorly understood, but the cost is considerable in terms of public health expenditures both for programmed and emergency orthopedic surgery. We present a historical cohort assessed to evaluate the usefulness of
Rotator cuff repair is performed to treat shoulder pain and disability. Failure of the tendon repair site is common; one strategy to improve healing is to enforce a period of post-operative immobilisation. Immobilisation may have unintended effects on tendon healing. Tenocytes under uniaxial strain form more organised collagen and up regulate expression of proliferative genes.
Osteoarthritis of the trapeziometacarpal joint can be treated by different surgical procedures. These are known to lead to complications, complex regional pain syndrome (CRPS) type I being one of them. We investigated prospectively our clinical results after total joint arthroplasty under
Aim: There were no reports of epiphyseal separation in cerebral palsy/spastic conditions, though cases of displaced metaphyseal &
diaphyseal fractures have been reported. Materials and Methods: There were 9 cases of epiphyseal separation involving the distal femur and proximal humerus in 4 severely handicapped children with spastic cerebral palsy. In these 9 cases there was significant epiphyseal slip with periosteal stripping with extensive subperiosteal ossification obvious on the X-rays. The X-rays also showed the following radiological signs: Frankel’s line and a scurvy line. Clinically the area was swollen and painful. Results: The X-ray appearances confirmed the cause to be that of scurvy. Treatment was with
The December 2014 Trauma Roundup. 360 . looks at: infection and temporising external fixation;
Introduction and Aim: While displaced metaphyseal and diaphyseal fractures in children with severe spastic cerebral palsy have been reported in literature, there is no reference to epiphyseal separations in this group. Physeo-epiphyseal injuries have been reported in meningomyelocoele patients, but these injuries differ significantly in their etiology and natural history. Method and Results: We report nine epiphyseal separations involving the distal femur and proximal humerus in four severely handicapped children with spastic cerebral palsy, and find scurvy to be the major cause of such epiphyseal slips. These epiphyseal slips have a good prognosis unlike those reported in MMC children. Treatment with
Introduction. Recently, oxidative stress has been implicated in the development of osteonecrosis. Here we focused on vitamins with marked antioxidant potency to see whether their use might prevent the development of osteonecrosis associated with corticosteroid administration. Methods. Fifteen male Japanese white rabbits weighing about 3.5 kg were injected once into the right gluteal muscle with methylprednisolone (MPSL) 40 mg/kg (S Group). Ten other rabbits, in addition, received consecutive daily intravenous injections of vitamin E 50 mg/kg starting from the day of MPSL administration (E Group), and 10 other animals similarly received consecutive daily intravenous injections of
Accumulated evidence indicates that local cell origins may ingrain differences in the phenotypic activity of human osteoblasts. We hypothesized that these differences may also exist in osteoblasts harvested from the same bone type at periarticular sites, including those adjacent to the fixation sites for total joint implant components. Human osteoblasts were obtained from the acetabulum and femoral neck of seven patients undergoing total hip arthroplasty (THA) and from the femoral and tibial cuts of six patients undergoing total knee arthroplasty (TKA). Osteoblasts were extracted from the usually discarded bone via enzyme digestion, characterized by flow cytometry, and cultured to passage three before measurement of metabolic activity, collagen production, alkaline phosphatase (ALP) expression, and mineralization.Aims
Methods
Introduction: Oxidative stress occurs when reactive oxygen species (ROS) are produced faster than they can be removed by cellular defence mechanisms contributing to ageing, many chronic diseases, such as atherosclerosis, RA, Parkinson and Alzheimer’s disease and skeletal pathologies. Here we address the impact of ROS on the viability of early osteogenic precursors in the bone marrow and study the influence of estrogen on this interaction. Cells have a number of mechanisms to protect themselves from ROS, which are constantly being formed in the cell through normal metabolic pathways, such as
The October 2013 Research Roundup360 looks at: Orthopaedics: a dangerous profession?; Freezing and biomarkers for bone turnover; Herniation or degeneration first?; MARS MRI and metallosis; Programmed cell death in partial thickness cuff tears; Lead glasses for trauma surgery?; Smoking inhibits bone healing; Optimising polyethylene microstructure.