Aims. An algorithm to determine the constitutional alignment of the lower limb once arthritic deformity has occurred would be of value when undertaking kinematically aligned total knee arthroplasty (TKA). The purpose of this study was to determine if the arithmetic hip-knee-ankle angle (aHKA) algorithm could estimate the constitutional alignment of the lower limb following development of significant arthritis. Methods. A matched-pairs radiological study was undertaken comparing the aHKA of an osteoarthritic knee (aHKA-OA) with the mechanical HKA of the contralateral normal knee (mHKA-N). Patients with Grade 3 or 4 Kellgren-Lawrence tibiofemoral osteoarthritis in an arthritic knee undergoing TKA and Grade 0 or 1 osteoarthritis in the contralateral normal knee were included. The aHKA algorithm subtracts the lateral distal femoral angle (LDFA) from the medial proximal tibial angle (MPTA) measured on standing long leg radiographs. The primary outcome was the mean of the paired differences in the aHKA-OA and mHKA-N. Secondary outcomes included comparison of sex-based differences and capacity of the aHKA to determine the constitutional alignment based on degree of deformity. Results. A total of 51 radiographs met the inclusion criteria. There was no significant difference between aHKA-OA and mHKA-N, with a mean angular difference of −0.4° (95% SE −0.8° to 0.1°; p = 0.16). There was no significant sex-based difference when comparing aHKA-OA and mHKA-N (mean difference 0.8°; p = 0.11). Knees with deformities of more than 8° had a greater mean difference between aHKA-OA and mHKA-N (1.3°) than those with lesser deformities (-0.1°; p = 0.009). Conclusion. This study supports the arithmetic HKA algorithm for prediction of the constitutional alignment once arthritis has developed. The algorithm has similar accuracy between sexes and greater accuracy with lesser degrees of deformity. Cite this article: Bone Joint Open 2020;1-7:339–345

Background:. The literature is unclear about the optimal rotation of the femoral component during TKR. Measured resection techniques rely on the use of bony landmarks, while the balanced gap technique relies on soft tissue tensioning to guide the surgeon in rotating the femoral component. All these techniques still result in a wide range of component rotation. We compared the functional flexion axis (FFA) of 20 replaced knees to that of the contralateral normal knee to determine whether a balanced gap technique allowed us to recreate this normal anatomy. Methods:. We reviewed the records of our TKR's from Jan 2008 to Dec 2010 and included all patients who had a normally functioning contralateral knee, tibial cut <3° from perpendicular to the mechanical axis performed by/under supervision of a single surgeon. These patients were contacted for follow up and axial flexed knee x-rays to measure femoral rotation and FFA (angle between clinical transepicondylar line and mechanical axis of tibia). These values were compared between replaced and normal knees using Students T-test. Results:. 20 patients were eligible for the study. Femoral component rotation ranged from 4° internal to 5° external rotation (mean of 0.6° external). Mean difference in functional flexion axis was 3.7°, ranging from 0 to 6° (p<0.05). Conclusion:. The balanced gap technique is effective to restore the functional flexion axis of the replaced knee to that of the normal contralateral side

Aims. Electromagnetic induction heating has demonstrated in vitro antibacterial efficacy over biofilms on metallic biomaterials, although no in vivo studies have been published. Assessment of side effects, including thermal necrosis of adjacent tissue, would determine transferability into clinical practice. Our goal was to assess bone necrosis and antibacterial efficacy of induction heating on biofilm-infected implants in an in vivo setting. Methods. Titanium-aluminium-vanadium (Ti6Al4V) screws were implanted in medial condyle of New Zealand giant rabbit knee. Study intervention consisted of induction heating of the screw head up to 70°C for 3.5 minutes after implantation using a portable device. Both knees were implanted, and induction heating was applied unilaterally keeping contralateral knee as paired control. Sterile screws were implanted in six rabbits, while the other six received screws coated with Staphylococcus aureus biofilm. Sacrifice and sample collection were performed 24, 48, or 96 hours postoperatively. Retrieved screws were sonicated, and adhered bacteria were estimated via drop-plate. Width of bone necrosis in retrieved femora was assessed through microscopic examination. Analysis was performed using non-parametric tests with significance fixed at p ≤ 0.05. Results. The width of necrosis margin in induction heating-treated knees ranged from 0 to 650 μm in the sterile-screw group, and 0 to 517 μm in the biofilm-infected group. No significant differences were found between paired knees. In rabbits implanted with sterile screws, no bacteria were detected. In rabbits implanted with infected screws, a significant bacterial load reduction with median 0.75 Log10 colony-forming units/ml was observed (p = 0.016). Conclusion. Induction heating was not associated with any demonstrable thermal bone necrosis in our rabbit knee model, and might reduce bacterial load in S. aureus biofilms on Ti6Al4V implants. Cite this article: Bone Joint Res 2024;13(12):695–702

Introduction

Previous fluoroscopic studies compared total knee arthroplasty (TKA) kinematics to normal knees. It was our hypothesis that comparing TKA directly to its non-replaced controlateral knee may provide more realistic kinematics information. Using fluoroscopic analysis, we aimed to compare knee flexion angles, femoral roll-back, patellar tracking and internal and external rotation of the tibia.

Aims. Distal femoral osteotomies (DFOs) are commonly used for the correction of valgus deformities and lateral compartment osteoarthritis. However, the impact of a DFO on subsequent total knee arthroplasty (TKA) function remains a subject of debate. Therefore, the purpose of this study was to determine the effect of a unilateral DFO on subsequent TKA function in patients with bilateral TKAs, using the contralateral knee as a self-matched control group. Methods. The inclusion criteria consisted of patients who underwent simultaneous or staged bilateral TKA after prior unilateral DFO between 1972 and 2023. The type of osteotomy performed, osteotomy hardware fixation, implanted TKA components, and revision rates were recorded. Postoperative outcomes including the Forgotten Joint Score-12 (FJS-12), Tegner Activity Scale score, and subjective knee preference were also obtained at final follow-up. Results. A total of 21 patients underwent bilateral TKA following unilateral DFO and were followed for a mean of 31.5 years (SD 11.1; 20.2 to 74.2) after DFO. The mean time from DFO to TKA conversion was 13.1 years (SD 9.7) with 13 (61.9%) of DFO knees converting to TKA more than ten years after DFO. There was no difference in arthroplasty implant systems employed in both the DFO-TKA and TKA-only knees (p > 0.999). At final follow-up, the mean FJS-12 of the DFO-TKA knee was 62.7 (SD 36.6), while for the TKA-only knee it was 65.6 (SD 34.7) (p = 0.328). In all, 80% of patients had no subjective knee preference or preferred their DFO-TKA knee. Three DFO-TKA knees and two TKA-only knees underwent subsequent revision following index arthroplasty at a mean of 12.8 years (SD 6.9) and 8.5 years (SD 3.8), respectively (p > 0.999). Conclusion. In this self-matched study, DFOs did not affect subsequent TKA function as clinical outcomes, subjective knee preference, and revision rates were similar in both the DFO-TKA and TKA-only knees at mean 32-year follow-up. Cite this article: Bone Jt Open 2024;5(11):1013–1019

Reconstruction of the anterior cruciate ligament (ACL) allows to restore stability of the knee, in order to facilitate the return to activity (RTA). Although it is understood that the tendon autograft undergoes a ligamentous transformation postoperatively, knowledge about longitudinal microstructural differences in tissue integrity between types of tendon autografts (ie, hamstring vs. patella) remains limited. Diffusion tensor imaging (DTI) has emerged as an objective biomarker to characterize the ligamentization process of the tendon autograft following surgical reconstruction. One major limitation to its use is the need for a pre-injury baseline MRI to compare recovery of the graft, and inform RTA. Here, we explore the relationship for DTI biomarkers (fractional anisotropy, FA) between knees bilaterally, in healthy participants, with the hypothesis that agreement within a patient's knees may support the use of the contralateral knee as a reference to monitor recovery of the tendon autograft, and inform RTA. Fifteen participants with no previous history of knee injuries were enrolled in this study (age, 26.7 +/− 4.4 years; M/F, 7/8). All images were acquired on a 3T Prisma Siemens scanner using a secured flexible 18-channel coil wrapped around the knee. Both knees were scanned. A 3D anatomical Double Echo Steady State (DESS) sequence was acquired on which regions of interest (ROI) were placed consistent with the footprints of the ACL (femur, posteromedial corner on medial aspect of lateral condyle; tibia, anteromedial to intercondylar eminence). Diffusion images were acquired using fat saturation based on optimized parameters in-house. All diffusion images were pre-processed using the FMRIB FSL toolbox. The footprint ROIs of the ACL were then used to reconstruct the ligament in each patient with fiber-based probabilistic tractography (FBPT), providing a semi-automated approach for segmentation. Average FA was computed for each subject, in both knees, and then correlated against one another using a Pearson correlation to assess the degree of similarity between the ACLs. A total of 30 datasets were collected for this study (1/knee/participant; N=15). The group averaged FA (+/− standard deviation) for the FBPT segmented ACLs were found to equal 0.1683 +/− 0.0235 (dominant leg) and 0.1666 +/− 0.0225 (non-dominant leg). When comparing both knees within subjects, reliable agreement was found for the FBPT-derived ACL with a linear correlation coefficient (rho) equal to 0.87 (P < 0 .001). We sought to assess the degree of concordance in FA between the knees of healthy participants with hopes to provide a method for using the contralateral “healthy” knee in the comparison of autograft-dependent longitudinal changes in microstructural integrity, following ACL reconstruction. Our results suggest that good agreement in anisotropy can be achieved between the non-dominant and dominant knees using DTI and the FBPT segmentation method. Contralateral anisotropy of the ACL, assuming no previous injuries, may be used as a quantitative reference biomarker for monitoring the recovery of the tendon autograft following surgical reconstruction, and gather further insight as to potential differences between chosen autografts. Clinically, this may also serve as an index to supplement decision-making with respect to RTA, and reduce rates of re-injuries

Abstract. Objectives. Little is known about the impact of cartilage defects on knee joint biomechanics. This investigation aimed to determine the gait characteristics of patients with symptomatic articular cartilage lesions of the knee. Methods. Gait analyses were performed at the Regional North-West Joint Preservation Centre. Anthropometric measurements were obtained, then 16 retroreflective markers representing the Plug-in-Gait biomechanical model were placed on pre-defined anatomical landmarks. Participants walked for two minutes at a self-selected speed on a treadmill on a level surface, then for 2 minutes downhill. A 15-camera motion-capture system recorded the data. Knee kinematics were exported into Matlab to calculate the average kinematics and spatiotemporal parameters per patient across 20 gait cycles. Depending on the normality of the data, paired t-tests or Wilcoxon ranked tests were performed to compare both knees (α = 0.05). Results. 20 patients participated; one of whom has bilateral cartilage defects. All 20 data sets were analysed for level walking; 18 were analysed for downhill walking. On a level surface, patients walked at an average speed of 3.1±0.8km/h with a cadence of 65.5±15.3 steps/minute. Patients also exhibited equal step lengths (0.470±0.072m vs 0.471±0.070m: p=0.806). Downhill, the average walking speed was 2.85±0.5km/h with a cadence of 78.8±23.1 steps/minute and step lengths were comparable (0.416±0.09m vs 0.420±0.079m: p=0.498). During level walking, maximum flexion achieved during swing did not differ between knees (54.3±8.6° vs 55.5±11.0°:p=0.549). Neither did maximal extension achieved at heel strike (3.1±5.7° vs 5.4±4.7°:p=0.135). On average, both knees remained in adduction throughout the gait cycle, with the degree of adduction greater in flexion in the operative knee. However, differences in maximal adduction were not significant (22.4±12.4° vs 18.7±11.0°:p=0.307). Maximal internal-external rotation patterns were comparable in stance (0.9±7.7° vs 3.5±9.8°: p=0.322) and swing (7.7±10.9° vs 9.8±8.3°:p=0.384). During downhill walking, maximum flexion also did not differ between operative and contralateral knees (55.38±10.6° vs 55.12±11.5°:p=0.862), nor did maximum extension at heel strike (1.32±6.5° vs 2.73±4.5°:p=0.292). No significant difference was found between maximum adduction of both knees (15.87±11.0° vs 16.78±12.0°:p=0.767). In stance, differences in maximum internal-external rotation between knees were not significant (5.39±10.7° vs 6.10±11.8°:p=0.836), nor were they significant in swing (7.69±13.3° vs 7.54±8.81°:p=0.963). Conclusions. Knee kinematics during level and downhill walking were symmetrical in patients with a cartilage defect of the knee, but an increased adduction during flexion in the operative knee may lead to pathological loading across the medial compartment of the knee during high flexion activities. Future work will investigate this further and compare the data to a healthy young population. We will also objectively assess the functional outcome of this joint preservation surgery to monitor its success. Declaration of Interest. (b) declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported:I declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project

With the rising rates, and associated costs, of total knee arthroplasty (TKA), enhanced clarity regarding patient appropriateness for TKA is warranted. Towards addressing this gap, we elucidated in qualitative research that surgeons and osteoarthritis (OA) patients considered TKA need, readiness/willingness, health status, and expectations of TKA most important in determining patient appropriateness for TKA. The current study evaluated the predictive validity of pre-TKA measures of these appropriateness domains for attainment of a good TKA outcome. This prospective cohort study recruited knee OA patients aged 30+ years referred for TKA at two hip/knee surgery centers in Alberta, Canada. Those receiving primary, unilateral TKA completed questionnaires pre-TKA assessing TKA need (WOMAC-pain, ICOAP-pain, NRS-pain, KOOS-physical function, Perceived Arthritis Coping Efficacy, prior OA treatment), TKA readiness/willingness (Patient Acceptable Symptom State (PASS), willingness to undergo TKA), health status (PHQ-8, BMI, MSK and non-MSK comorbidities), TKA expectations (HSS KR Expectations survey items) and contextual factors (e.g., age, gender, employment status). One-year post-TKA, we assessed for a ‘good outcome’ (yes/no), defined as improved knee symptoms (OARSI-OMERACT responder criteria) AND overall satisfaction with TKA results. Multiple logistic regression, stepwise variable selection, and best possible subsets regression was used to identify the model with the smallest number of independent variables and greatest discriminant validity for our outcome. Receiver Operating Characteristic (ROC) curves were generated to compare the discriminative ability of each appropriateness domain based on the ‘area under the ROC curve’ (AUC). Multivariable robust Poisson regression was used to assess the relationship of the variables to achievement of a good outcome. f 1,275 TKA recipients, 1,053 (82.6%) had complete data for analyses (mean age 66.9 years [SD 8.8]; 58.6% female). Mean WOMAC pain and KOOS-PS scores were 11.5/20 (SD 3.5) and 52.8/100 (SD 17.1), respectively. 78.1% (95% CI 75.4–80.5%) achieved a good outcome. Stepwise variable selection identified optimal discrimination was achieved with 13 variables. The three best 13-variable models included measures of TKA need (WOMAC pain, KOOS-PS), readiness/willingness (PASS, TKA willingness), health status (PHQ-8, troublesome hips, contralateral knee, low back), TKA expectations (the importance of improved psychological well-being, ability to go up stairs, kneel, and participate in recreational activities as TKA outcomes), and patient age. Model discrimination was fair for TKA need (AUC 0.68, 95% CI 0.63-0.72), TKA readiness/willingness (AUC 0.61, 95% CI 0.57-0.65), health status (AUC 0.59, 95% CI 0.54-0.63) and TKA expectations (AUC 0.58, 95% CI 0.54-0.62), but the model with all appropriateness variables had good discrimination (AUC 0.72, 95% CI 0.685-0.76). The likelihood of achieving a good outcome was significantly higher for those with greater knee pain, disability, unacceptable knee symptoms, definite willingness to undergo TKA, less depression who considered improved ability to perform recreational activities or climb stairs ‘very important’ TKA outcomes, and lower in those who considered it important that TKA improve psychological wellbeing or ability to kneel. Beyond surgical need (OA symptoms) and health status, assessment of patients’ readiness and willingness to undergo, and their expectations for, TKA, should be incorporated into assessment of patient appropriateness for surgery

INTRODUCTION. Controversy exists regarding the ability of unicompartmental knee arthroplasty (UKA) to restore native knee kinematics, with some studies suggesting native kinematics are restored in most or all patients after UKA. 1–3. , while others indicate UKA fails to restore native knee kinematics. 4,5. Previous analysis of UKA articular contact kinematics focused on the replaced compartment. 2,5. , neglecting to assess the effects of the arthroplasty on the contralateral compartment which may provide insight to future pathology such as accelerated degeneration due to overload. 6. or a change in the location of cartilage contact. 7. The purpose of this study was to assess the ability of medial UKA to restore native knee kinematics, contact patterns, and lateral compartment dynamic joint space. We hypothesized that medial UKA restores knee kinematics, compartmental contact patterns, and lateral compartment dynamic joint space. METHODS. Six patients who received fixed-bearing medial UKA consented to participate in this IRB-approved study. All patients (4 M, 2 F; average age 62 ± 6 years) completed pre-surgical (3 weeks before) and post-surgical (7±2 months) testing. Synchronized biplane radiographs were collected at 100 images per second during three repetitions of a chair rise movement (Figure 1). Motion of the femur, tibia, and implants were tracked using an automated volumetric model-based tracking process that matches subject-specific 3D models of the bones and prostheses to the biplane radiographs with sub-millimeter accuracy. 8. Anatomic coordinate systems were created within the femur and tibia. 9. and used to calculate tibiofemoral kinematics. 10. Additional outcome measures included the center of contact in the medial and lateral compartments, and the lateral compartment dynamic joint space (i.e. the distance between subchondral bone surfaces). 11. The results of the three movement trials were averaged for each knee in each test session. All outcome measures were interpolated at 5° increments of knee extension (Figure 2). The average differences between knees at corresponding flexion angles were analyzed using paired t-tests with significance set at p < 0.05. RESULTS. The UKA knee was in 5.3° more varus than the contralateral knee prior to surgery (p=0.005). After surgery, the UKA knee was in 4.9° more valgus than before surgery (p=0.005). The UKA knee was 4.3° more externally rotated than the contralateral knee post-surgery (p=0.05) (Table 1). No significant differences were observed between knees or pre- to post-surgery in lateral compartment dynamic joint space or the center of contact in the medial and lateral tibia compartments (Table 1). DISCUSSION. These results suggest that medial UKA can restore native knee varus without significantly altering lateral compartment joint space or contact location during the chair rise movement. For any figures or tables, please contact the authors directly

Knee warmth is a common clinical observation following total knee arthroplasty (TKA). This can cause concern that infection is present. The purpose of our study was to establish the pattern of knee skin temperature following uncomplicated TKA. It was a prospective study carried out between 2001 and 2004. A pocket digital surface thermometer was used. A preliminary study established that the best site to measure knee skin temperature was superomedial to the patella and the best time was 12 noon. Patients with an increased risk of infection and those with a contralateral knee pathology or a previous surgery were excluded. Forty-eight patients fulfilled the inclusion criteria and consented to participate; the skin temperature of operated and contralateral knees was measured pre-operatively and daily during the first six weeks post-operatively. Measurements were also taken at 3, 6, 12 and 24 months following surgery. During the course of the study, patients developing complications of the operated knee or any pathology of the contralateral knee were excluded. Thirty-two patients completed the main study. Following surgery, systemic and both knees temperatures increased. Whereas systemic and contralateral knee temperatures settled within one week, the operated knee temperature took a longer time. The difference in temperature between the two knees had a mean value of +2.9°C at 7 days. This mean value decreased to +1.6°C at 6 weeks, +1.3°C at 3 months, +0.9°C at 6 months +0.3°C at 12 months and +0.04°C at 24 months. Following uncomplicated TKA, the operated knee skin temperature increases compared to the contralateral knee. This increase peaks at day 3 and diminishes slowly over several months; however, it remains statistically significant up to 6 months. These results correlate with the findings of previous studies that showed a prolonged elevation of inflammatory markers

Bilateral simultaneous total knee replacement surgery remains controversial with arguments for and against its use. Doing sequentially staged TKR's is a safer procedure and may have additional benefits as set out below. If both knees need to be replaced we have often seen that the symptoms of the contralateral knee improve after the one knee is replaced and that patients wait some time before having the opposite knee replaced. Materials:. 333 of 2084 patients having primary total knee replacements needing bilateral replacements were reviewed retrospectively. Results. 245 patients were seen initially with bilateral arthritis of the knee and needed bilateral TKR, while 88 patients developed arthritis in the contralateral knee following TKR. No patients had simultaneous bilateral TKR's; operations were done sequentially and the average time between the TKRs was 20.77 months with a range between 1.5–111 months. Most patients had the contralateral knee replaced within two years of the first knee replacement but 81 patients actually waited between 2 and 10 years before coming in for the second TKR. Conclusion:. It is possible to wait some time before it becomes necessary to replace the contralateral knee in patients who need bilateral TKRs and avoid the increased risk of bilateral simultaneous surgery. The delay not only reduces the cost for the first operation but also gives the second knee a longer time to failure. This is especially important in the typical patients who qualify for bilateral simultaneous TKR's i.e. the younger fitter patients

Introduction and Objective. Malunion after trauma can lead to coronal plane malalignment in the lower limb. The mechanical hypothesis suggests that this alters the load distribution in the knee joint and that that this increased load may predispose to compartmental arthritis. This is generally accepted in the orthopaedic community and serves as the basis guiding deformity correction after malunion as well as congenital or insidious onset malalignment. Much of the literature surrounding the contribution of lower limb alignment to arthritis comes from cohort studies of incident osteoarthritis. There has been a causation dilemma perpetuated in a number of studies - suggesting malalignment does not contribute to, but is instead a consequence of, compartmental arthritis. In this investigation the relationship between compartmental (medial or lateral) arthritis and coronal plane malalignment (varus or valgus) in patients with post traumatic unilateral limb deformity was examined. This represents a specific niche cohort of patients in which worsened compartmental knee arthritis after extra-articular injury must rationally be attributed to malalignment. Materials and Methods. The picture archiving system was searched to identify all 1160 long leg x ray films available at a major metropolitan trauma center over a 12-year period. Images were screened for inclusion and exclusion criteria, namely patients >10 years after traumatic long bone fracture without contralateral injury or arthroplasty to give 39 cases. Alignment was measured according to established surgical standards on long leg films by 3 independent reviewers, and arthritis scores Osteoarthritis Research Society International (OARSI) and Kellegren-Lawrence (KL) were recorded independently for each compartment of both knees. Malalignment was defined conservatively as mechanical axis deviation outside of 0–20 mm medial from centre of the knee, to give 27 patients. Comparison of mean compartmental arthritis score was performed for patients with varus and valgus malalignment, using Analysis of Variance and linear regression. Results. In knees with varus malalignment there was a greater mean arthritis score in the medial compartment compared to the contralateral knee, with OARSI scores 5.69 vs 3.86 (0.32, 3.35 95% CI; p<0.05) and KL 2.92 vs 1.92 (0.38, 1.62; p<0.005). There was a similar trend in valgus knees for the lateral compartment OARSI 2.98 vs 1.84 (CI −0.16, 2.42; p=0.1) and KL 1.76 vs 1.31 (CI −0.12, 1.01; p=0.17), but the evidence was not conclusive. OARSI arthritis score was significantly associated with absolute MAD (0.7/10mm MAD, p<0.0005) and Time (0.6/decade, p=0.01) in a linear regression model. Conclusions. Malalignment in the coronal plane is correlated with worsened arthritis scores in the medial compartment for varus deformity and may similarly result in worsened lateral compartment arthritis in valgus knees. These findings support the mechanical hypothesis that arthritis may be related to altered stress distribution at the knee, larger studies may provide further conclusive evidence

Aims. The present study investigates the effectiveness of platelet-rich plasma (PRP) gel without adjunct to induce cartilage regeneration in large osteochondral defects in a rabbit model. Methods. A bilateral osteochondral defect was created in the femoral trochlear groove of 14 New Zealand white rabbits. The right knees were filled with PRP gel and the contralateral knees remained untreated and served as control sides. Some animals were killed at week 3 and others at week 12 postoperatively. The joints were harvested and assessed by Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) MRI scoring system, and examined using the International Cartilage Repair Society (ICRS) macroscopic and ICRS histological scoring systems. Additionally, the collagen type II content was evaluated by the immunohistochemical staining. Results. After 12 weeks post-surgery, the defects of the PRP group were repaired by hyaline cartilage-like tissue. However, incomplete cartilage regeneration was observed in the PRP group for three weeks. The control groups showed fibrocartilaginous or fibrous tissue, respectively, at each timepoint. Conclusion. Our study proved that the use of PRP gel without any adjuncts could successfully produce a good healing response and resurface the osteochondral defect with a better quality of cartilage in a rabbit model. Cite this article: Bone Joint Res 2021;10(3):192–202

Purpose: The aim of our study was to establish the pattern of knee skin temperature following uncomplicated TKA. Methods and Materials: It was a prospective study that was carried out between 2001 and 2004. A pocket digital surface thermometer was used. A preliminary study established the site and time of temperature measurement.. Patients with an increased risk of infection and those with a contralateral knee pathology or a previous surgery were excluded. Forty-eight patients fulfilled the inclusion criteria and consented to participate; the skin temperature of operated and contralateral knees was measured preoperatively and daily during the first six weeks postoperatively. Measurements were also taken at 3, 6, 12 and 24 months following surgery. During the course of the study, patients developing complications of the operated knee or any pathology of the contralateral knee were excluded. Results: Thirty-two patients completed the main study. Following surgery, systemic and both knees temperatures increased. Whereas systemic and contralateral knee temperature settled within one week, the operated knee temperature took a longer time. The difference in temperature between the two knees had a mean value of +2.9. o. C at 7 days. This mean value decreased to +1.6. o. C at 6 weeks, +1.3. o. C at 3 months, +0.9. o. C at 6 months +0.3°C at 12 months and +0.04°C at 24 months. Conclusion: Following uncomplicated TKA, the operated knee skin temperature increases compared to the contra-lateral knee. This increase diminishes slowly over several months; however, it remains statistically significant up to 6 months

Previosuly, Komistek et al. have shown that the kinematics of the patellofemoral joint is altered after a TKA surgery. Specifically the implanted patella experiences significantly less rotation than the natural patella. Also, in early flexion, the patellofemoral contact positions differed significantly between implanted and non-implanted patellae. It was also found that some of TKA subjects experience patellofemoral separation. These kinematical differences may lead to adverse mechanical conditions and increase fatigue or cause loosening of the implant components. This study’s objective was to determine the three-dimensional patellofemoral kinematics and correlate it with the in vivo sound (vibrations) detected using accelerometers for subjects having a TKA and a non-implanted knee under in vivo, weight bearing conditions. The correlation of the knee mechanical conditions with the vibration data may indicate new parameters that may be used to diagnose the condition of the articular cartilage or implant components. Fifteen subjects (average age 71.8 ±7.4years) having one implanted knee (mobile bearing Hi-Flex PS) and the healthy contralateral knee, performed. deep knee bend to maximum flexion,. chair rise and. stair climb activities under fluoroscopic surveillance. Three miniature, piezoelectric, three-axial accelerometers were attached to the patella and femoral epicondyle. The study was approved by the Institutional Review Board and informed consent was obtained from all subjects. The sensors detected the vibration magnitudes and frequencies of the articulating patellofemoral joint surfaces. The signals were amplified and low-pass filtered at 5 kHz by a signal conditioner. The 3D tibiofemoral and patellofemoral kinematics were derived for both knees using a previously published 3D-to-2D registration technique. The 3D bone models were recovered from CT scans, while implant models were obtained from the manufacturer. The patellofemoral rotations were described using the Grood and Suntay convention. The kinematics and sound data were synchronized and recorded under fluoroscopic surveillance, for 10 patients. Then a subset of seven subjects having a TKA was re-analyzed for their contralateral (non-implanted) knee. The vibration signal was then converted to audible sound and correlated with the 3D kinematics. On average, the subjects achieved more flexion with their TKA (103.4°±15.9°) than with their contralateral knee (96.3°±18.3°). The patellofemoral kinematics varied between the TKA and nonimplanted patella groups; the resurfaced patella experienced less flexion, less medial rotation and less tilt than the contralateral patella. The patellar flexion results were consistent with previously reported literature for both TKA and non-implanted patellae. Also, the resurfaced patellae contacted the femur more proximally than healthy patellae. Audible signals were found for both groups of subjects. The frequency analysis demonstrated that specific frequencies were in similar range for both groups, but the magnitudes and variations were different for the TKA and contralateral knees. This study correlated 3D patellofemoral kinematics with sound under in vivo conditions for three different activities. Variable audible signals were detected for TKA and non-implanted knees. Vibration magnitude and frequency identification, under in vivo conditions, for TKA may lead to a better understanding of wear and failure modes with respect to the patellofemoral mechanics, more specifically, the patellar insert. Currently this initial study is being expanded to degenerated knee joints and failed TKAs for possible applications of the vibration analysis to the early diagnosis of knee arthritis, detection of implant loosening or wear and monitoring of implant osteointegration progress

Background: The purpose of the study was to evaluate whether anteroposterior translation (APT) after ACL reconstruction with intraoperative balancing of the transplant tension to that of the contralateral ACL could be obtained at follow up. Additionally, differences of APT’s following ACL reconstruction using either autologous patella bonetendon–bone (BTB) or autologous quadriceps-tendon-bone (QTB) were assessed. Methods: In a consecutive series of 44 patients (44 knees), ACL deficiency was treated in 30 patients (median age: 33, 16–58, 20 male, 22 right knee) with BTB–and in 14 patients (median age: 31, 17–50, 8 male, 10 right knee) with QTB-reconstruction. APT was evaluated in 20° knee flexion in the affected and healthy contralateral knee using the Rolimeter. ®. Measurements were performed in both knees preoperative, during, and immediately after ACL-reconstrucion, as well as 3, 6 and 12 months postoperatively in triplates. For statistical analysis the non-parametrical Kruskal-Wallis Test (post test: Dunn’s Test) was used. Results: Statistically significant decreases of APT were observed between pre–and intraoperative measurements in the BTB–and the QTB-group due to ACL reconstruction (11.1±2.0 to 6.3±0.7mm; p< 0.001 in the BTB and 11.1±2.3 to 6.8±1.2mm; p< 0.001 in QTB group). At the intraoperative measurements, there were no differences in APT between the contralateral healthy knee and the reconstructed knee in both groups. During the follow up, significant loss of APT in the balanced reconstructed knees were only observed in the BTB group after 12 months (6.3±0.7 to 7.5±1.2mm; p< 0.05). Conclusion: After reconstruction of the ACL, BTB–and QTB-ACL reconstruction groups, yielded the same anteroposterior translation (APT) as contralateral healthy knees. This new intraoperative technique provides ACL reconstruction with balancing of the anteroposterior knee translation of the healthy contralateral knee. An increase in APT could be observed 12 months after ACL reconstruction only in the BTB group. Further research is necessary to assess whether QTB-ACL-reconstruction should be preferred regarding preservation of the initial ligament tension at follow up

Introduction and aims: Osteoarthritis (OA) of the knee is a widespread problem, yet there is little known about the kinematics of the osteoarthritic knee, and nothing about the tibio-femoral contact pattern. This study aimed to describe the role of tibio-femoral interface events in articular surface wear and degenerative change. Method: Fourteen subjects with symptomatic OA in one knee, and no pain or injury in the contralateral knee were recruited. The tibio-femoral contact pattern was recorded for both knees, while performing a supine leg-press from 0 to 90 degrees flexion against a 150N load. Severity of osteoarthritis was measured by Kellgren Lawrence grade, bone mineral density (BMD) using Dual Energy X-ray Absorptiometry close to the subchondral bone, diagnostic MRI, and joint damage recorded at knee arthroplasty. Pain and disability was recorded using a WOMAC questionnaire. Results: Severity of OA in the knees ranged from grade two to four (mode=4) in the symptomatic knee, and from zero to three (mode=0) in the contralateral knee. Contact in the lateral compartment of the knee was more anterior on the tibial plateau than healthy knees (p≤ 0.01), and this was associated with severity of OA (p≤ 0.01). Contact in the medial compartment was also more anterior on the tibial plateau, and this was associated with severity of OA. Abnormality in tibio-femoral contact patterns was associated with disability reported by the WOMAC score (r= 0.54). There was no significant difference in BMD between the OA and contralateral knees. However, the BMD was correlated with pain and physical function of the WOMAC score, that is, as function decreased, bone density increased in the arthritic compartment (r = 0.49 to 0.63; p≤ 0.01). Conclusion: Severity of osteoarthritis was associated with loss of rollback normally coupled with flexion, especially in the lateral compartment. Consequently longitudinal rotation was lost. In severe osteoarthritis, ACL integrity did not affect the contact pattern. Kinematic abnormalities may explain loss of range of motion, and patterns of wear in osteoarthritic knees

Aim. Patellofemoral Arthroplasty (PFA) prosthesis with asymmetric trochlear component was introduced as an improvement from existing designs for surgical treatment of symptomatic isolated patellofemoral arthritis. The purpose of this study was to evaluate midterm results in patients who underwent PFA procedure using such prosthesis. Methods. Our study involved a continuous retrospective cohort of patients who underwent PFA using Journey PFJ with asymmetric trochlear component, performed between June 2007 and October 2018 at a non-designer centre. The Patient Reported Outcome Measures and patient satisfaction questionnaires were collected for final evaluation. Results. A total of 128 PFA performed on 96 patients were evaluated. All patients were under regular follow up, and no patient was lost to follow up. Eighteen patients underwent simultaneous bilateral procedures, and 14 patients underwent PFA of the contralateral knee later. Median age at the time of surgery was 59 years (interquartile range 53 – 66 years); the median follow up period was 6 years (interquartile range 2.5 – 7 years). The Oxford Knee Score showed improvement from a median of 18 to 37. There were statistically significant improvements in functional outcome scores. Beverland satisfaction questionnaire revealed that 22.1 % (19/86) were ‘Very happy’ and 39.5% (34/86) were ‘Happy’ following the procedure. Four knees were revised to Total Knee Arthroplasty for reasons not related to the implant. The cumulative survival estimated by the Kaplan-Meier method was 95.2% (95% confidence interval: 90.4%– 99.9%). Conclusion. This series of patients who underwent PFA with the asymmetric trochlear component has shown promising mid-term results with no implant related complications

The June 2012 Knee Roundup. 360. looks at: ACI and mosaicplasty; ACI after microfracture; exercise therapy and the degenerate medial meniscal tear; intra-articular bupivacaine or ropivacaine at knee arthroscopy; lateral trochlear inclination and patellofemoral osteoarthritis; bone loss and ACL reconstruction; assessing stability using the contralateral knee; tranexamic acid and a useful review of knee replacement

Aim. The aim of this study is to outline the steps and techniques required to create a patient specific 3D printed guide for the accurate placement of the origin of the femoral tunnel for single bundle ACL reconstruction. Introduction. Placements of the femoral tunnels for ACL reconstruction have changed over the years. Most recently there has been a trend towards placing the tunnels in a more anatomic position. There has been subsequent debate as to where this anatomic position should be. The problem with any attempt at consensus over the placement of an anatomic landmark is that each patient has some variation in their positioning and therefore a fixed point for all has compromise for all as it is an average. Our aim was to attempt to make a cost effective and quick custom guide that could allow placement of the center of the patients’ newly created femoral tunnel in the mid position of their contralateral native ACL femoral footprint. Materials & Methods. We took a standard protocol MRI scan of a patient's knee without ACL injury transferred the DICOM files to a personal computer running OsiriX (Pixmeo, Geneva, Switzerland.) and analysed it for a series of specific anatomical landmarks. OsiriX is an image processing software dedicated to DICOM images. We marked the most posterior edge of the articular cartilage on the lateral wall of the notch (1), the most anterior edge of the articular cartilage of the lateral wall of the notch (2), the most inferior edge of the articular cartilage of the lateral wall of the notch (3) and the center of the femoral footprint of the native ACL. Distances were then calculated to determine the position relative to the three articular cartilage points of the center of the ACL footprint. These measurements and points were then utilised to create a 3D computer aided design (CAD) model of a custom guide. This was done using the 3D CAD program 123Design (Autodesk Ltd., Farnbourgh, Hampshire). This 3D model was then exported as an STL file suitable for 3D printing. The STL file was then uploaded to an online 3D printing service and the physical guide was created in transparent acrylic based photopolymer, PA220 plastic and 316L stainless steel. The models created were then measured using vernier calipers to confirm the accuracy of the final guides. Results. The MRI data showed point 1 (AP), point 2 (distal-ACL), point 3 (Ant-ACL) and point 4 (Post-ACL) at a distance of 59.83, 15, 45.8 and 13.9 respectively. For the 3D CAD model, points 1, 2, 3 and 4 were at a distance of 59.83, 15, 45.8 and 13.9 respectively. For the PA220 plastic model, points 1, 2, 3 and 4 were at a distance of 59.86, 14.48, 45.85 and 13.79 respectively. For the 316L stainless steel model, points 1, 2, 3 and 4 were at a distance of 59.79, 14.67, 45.64 and 13.48 respectively. Lastly, for the photopolymer model, points 1, 2, 3 and 4 were at a distance of 59.86, 14.2, 45.4 and 13.69 respectively. The p-value comparing MRI/CAD vs. PA220 was p=0.3753; for the comparison between MRI/CAD vs. 316L, p=0.0683; lastly for the comparison between MRI/CAD Vs. Photopolymer, p=0.3450. The models produced were accurate with no statistical difference in size and positioning of the center of the ACL footprint from the original computer model and to the position of the ACL from the MRI scans. The costs for the models 3D printed were £3.50 for the PA220 plastic, £15 for the transparent photopolymer and £25 for the 316L stainless steel. The time taken from MRI to delivery for the physical models was 7 days. Discussion. Articles regarding the creation of 3D printed custom ACL guides from the patients contralateral knee do not feature in current literature. There has been much research on custom guides for other orthopaedic procedures such as in total knee arthroplasty for the accurate placement of implants. There has also been research published on the creation of custom cutting jigs from CT for complex corrective osteotomy surgery. This study serves as the first step and a proof of concept for the accurate creation of patient specific 3D printed guides for the anatomical placement of the femoral tunnel for ACL reconstruction. The guides were easy to create and produce taking only a week and with a cost of between £3.50 and £25. The design of the guides was to allow the tip of a standard Chondro Pick (Arthrex inc., Naples, Florida.) (3mm) used to mark the starting point of the femoral tunnel to enter through the guide. The next step for this research is to create guides from cadaveric matched knees and utilise the guides to carry out the creation of the femoral tunnels and to analyse of the placement of the tunnel in relation to the contralateral knee