Introduction: There has been a substantial increase of Clostidium Difficile (C.difficile) in Europe over the last decade. This increased incidence of C.difficile has been attributed in part to the prophylactic use of antibiotics during orthopaedic and trauma surgery. The consequences of a C.difficile infection can be an increase in mortality, length of stay and cost of medical care. The mortality associated with C.difficile has been quoted to be up to 25% in frail elderly people and the cost of treating a single case of C. difficile infection has been estimated at 4500 Euros (£4000).

The antibiotic prophylaxis for orthopaedic and trauma patients undergoing metal work implantation was changed in our unit to specifically reduce the incidence of C.difficile. The aim of this study was to determine whether this change did reduce the incidence of post-operative C.difficile infections presenting on the orthopaedic ward. The secondary aim was to ensure that the change in prophylaxis did not increase the incidence of deep wound infections.

Method: The old prophylactic protocol involved a dose of Cefuroxime at induction, followed by two further doses post-operatively. The new protocol was a single dose of Gentamicin and Flucloxacillin or a single dose of Gentamicin and Teicoplanin (if MRSA positive or penicillin allergy) at induction. The incidence of C.difficile infection and deep wound infection were recorded for a six month period prior to the protocol change and for a six month period once the new antibiotic protocol had been established. Patients included into the study were those undergoing a primary arthroplasty of the knee or hip and patients undergoing metalwork implantation for a proximal femoral fracture.

Results: 1566 patients were included in the study. The overall rate of C.difficle infection reduced form 3.7% to 1.3% (p less than 0.005) after the prophylactic antibiotic protocol was changed. This was most marked in the trauma patients from 8% to 3% (p less than 0.05). There was no significant difference in the incidence of deep wound infections for the trauma patients (p equals 0.5) or the elective patients (p equals 0.7).

Conclusion: The change in antibiotic prophylaxis did significantly reduce the incidence of C.difficile in patients undergoing metalwork implantation and did not change the rate of deep wound infections.