Objective

To determine what factors affect fracture healing with low-intensity pulsed ultrasound (LIPUS) for delayed unions and nonunions.

Background: Low-intensity pulsed ultrasound (LIPUS) was shown to accelerate fracture healing with delayed unions and non-unions as well as fresh fractures.

Objective: To know the factors which affected clinical results of LIPUS treatment for delayed unions and non-unions.

Design: Prospective Cohort Study

Setting: University Hospital

Intervention: 192 delayed or non-unions of long bone or clavicle were treated by LIPUS from May 1998 to April 2007. Background factors (age and gender of patient, history of smoking, personality of each fracture, intervals from injury to application of LIPUS treatment) were prospectively investigated. All patients were followed up at the outpatient clinic and AP and lateral view of radiographs were taken usually every 4 weeks. Main outcome of this study was set as “bone union” and it was defined as cortical continuity in a minimum of three cortices on two views on radiographs and without pain at the fracture site on palpation.

Main Outcome Measurement: The overall success rate was 75%, and the success rate of subcutaneous bones were higher (tibia: 81%, radius and ulna: 80%)than that of deeper bone (femur: 64%, humerus 58%). Logistic multi-variant regression showed that the greatest gap size between the main bone fragments (p< 0.0001), instability of a fracture site (p< 0.0001), and the intervals between injury to the application of LIPUS (p< 0.05) were independent predictors for the success of LIPUS treatment for delayed and non-unions.

Conclusion: We believe that the greatest gap size of main fragments, instability of a fracture site, and the age of non-union are the factors that affected LIPUS clinical results.

We assessed the Japanese specific bone age standard with Tanner-Whitehouse 2 (TW2) method for the evaluation of skeletal maturity in adolescent scoliosis.

TW2 bone age was investigated by the left hand-wrist X-rays of 120 girls with adolescent scoliosis. Their chronological age ranged from 10.2 to 19.0 years. Because Risser’s sign is uncertain between Risser IV and V, for comparison of TW2 bone age with Risser’s sign, we classified apophyses that with an apparent narrowing of cartilage and that with a partial fusion as the later of Risser IV. In addition, clinical courses of the skeletal matured cases (adult bones) in 6 months before investigation were reviewed retrospectively. Even or less than 5 degrees change of Cobb’s angle was evaluated as unchanged. Furthermore, bone age distribution of immature cases was also reviewed for comparision of the unchanged group with the progressive group.

None was evaluated as adult bone in the stage from Risser 0 to III. The rate of adult bone which was shown in Risser IV was 43.5%, but 88.9% was in the later of IV. 95.8% of Risser V was already adult bone. Moreover, 93.1% of adult bone was unchanged in their clinical courses. Remaining 4 cases (6.9%) was progressive, but had not progressed in the following 6 months. Bone ages of the progressive immature group distributed in the range from 11.7 to 13.9 years. Those of the unchanged immature group distributed mainly over 13.1 years.

Although it is necessary to follow the immature longitudinally, adult bone appeared almost in the later of Risser IV, and appeared earlier than Risser V. And Cobb’s angle may become unchanged before adult bone. At least adult bone would be an indicator between Risser IV and V.