Background

Evidence concerning the management of dorsal fracture dislocation (DFD) of the proximal interphalangeal joint (PIPJ) in the hand has been limited by small sample size and case heterogeneity within studies. This retrospective case control study examined clinical outcome of this specific subgroup managed by three different methods.

Purpose

To analyse the early results of unconstrained pyrocarbon joint replacements in patients with osteo-arthritis of the metacarpo-phalangeal joints.

Background and Objectives

Triangular fibrocartilaginous complex (TFCC) tears are common sources of ulna sided wrist pain and resultant functional disability. Diagnosis is based on history, clinical examination and radiological evidence of a TFCC central perforation or radial/ulna tear. The purpose of this study is therefore to evaluate the diagnostic accuracy of Magnetic Resonance Imaging (MRI) and Magnetic Resonance Arthrography (MRA) in the detection of TFCC injury in the adult population.

The purpose of this study was to profile the mRNA expression for the 23 known matrix metalloproteinases (MMPs), 4 tissue inhibitor of metalloproteinases (TIMPs) and 19 ADAMTSs (a disintegrin and metalloproteinase with thrombospontin motif) in Dupuytren's Disease and normal palmar fascia.

Dupuytren's Disease (DD) is a fibroproliferative disorder affecting the palmar fascia, leading to contractures. The MMPs and ADAMTSs are related enzymes collectively responsible for turnover of the extracellular matrix. The balance between the proteolytic action of the MMPs and ADAMTSs and their inhibition by the TIMPs underpins many pathological processes. Deviation in favour of proteolysis is seen in e.g. invasive carcinomata, whereas an imbalance towards inhibition causes e.g. fibrosis. A group of patients with end-stage gastric carcinoma was treated with a broad spectrum MMP inhibitor in an attempt to reduce the rate of carcinoma advancement; a proportion developed a ‘musculoskeletal syndrome’ resembling DD.

Tissue samples were obtained from patients undergoing surgery to correct contractures caused by DD and from healthy controls undergoing carpal tunnel decompression. The DD tissue was separated macroscopically into cord and nodule. Total RNA was extracted and mRNA expression analysed by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR), normalised to 18S rRNA. Comparing across all genes, the DD nodule, DD cord and normal palmar fascia samples each had a distinct mRNA expression profile. Statistically significant (p<0.05) differences in mRNA expression included: higher MMP-2, -7 and ADAMTS-3 levels in both cord and nodule; higher MMP-1, -14, TIMP-1 and ADAMTS-4 and -5 in nodule alone, lower MMP-3 in nodule and cord and lower TIMP-2, -3 and -4 and ADAMTS-1 and -8 levels in nodule alone.

The distinct mRNA profile of each group suggests differences in extracellular proteolytic activity which may underlie the process of fascial remodelling in DD.

Long-term follow up after replacement arthroplasty has become established as a “Gold Standard”, providing information that can aid optimisation in future prosthetic design and use. In less mainstream joint replacements however, the evidence for use of prostheses, and in particular long-term outcome, is scarce.

A cohort of 71 patients (93 implants) was reviewed in 1997 having had a De la Caffinière prosthesis implanted between 1980 and 1989. The conclusions of the study included the findings that the replacement was generally well regarded by recipients, pain was improved and survivorship was comparable with data from the best hip replacements.

Ethical permission was obtained to review the same cohort ten years on (16 – 26 years post-op). Similar outcome measures were employed as in the original study but in addition formal grip strength measurements were taken, along with newer outcome scores including the DASH (Disability of arm, shoulder and hand) and EQ-5D (a European quality of life measure). Radiographs allowed assessment of radiological failure using the criteria from the original study.

We found a significant mortality rate in the interim period since the original review (27 patients, 36 implants). A further 8 implants in 8 patients had been removed and were not clinically reviewed as per patients’ wishes. However, 39 implants in 26 patients were available for follow up at a mean 19 years (SD 6.3) leaving a “lost to follow up” rate of 10 patients (10 implants). Survivorship at 26 years was 73.9% (95% CI 61.2, 86.6) with the end-point as revision. Our data also demonstrated continued patient satisfaction without pain, satisfactory power and thumb mobility.

Such information may be used to counsel future patients requiring surgery that there is a functional alternative to excision arthroplasty (trapeziectomy).

Introduction: We present our results from a series of patients with symptomatic distal radial malunions. Between January 2005 and October 2008, 15 patients (11 female: 4 male) underwent corrective osteotomy using fixed-angle plates and either structural iliac crest or inlay hydroxyapa-tite (HA) graft. 2 patients had correction for palmar, and the remainder for dorsal, angulation. The mean age was 48 years. The mean time from injury to corrective osteotomy was 12 months (range 3–40 months).

Methods: Radiological parameters included ulna variance, radial inclination, palmar angulation and time to union following osteotomy. Clinical outcomes included wrist RoM, grip strength, VAS for pain and DASH score (Disability of the Arm, Shoulder and Hand) preoperatively and 3 months post-operatively.

Results: The mean change in radiographic parameters were 2mm increase in ulnar variance, 9° increase in radial inclination (14° – 23°) and 23° increase in palmar angulation (−26° – 3°). The only statistically significant change in RoM was an increase in supination from 55° preoperatively to 73° postoperatively. DASH scores improved from a mean 51 pre-op to 15 post-op, statistically and clinically significant. The mean improvement in grip strength was 8kg, and the VAS for pain improved from 5 preoperatively to 1 postoperatively.

We found a positive correlation between age and time to union/graft incorporation (R2 = 0.47). The mean time to graft incorporation was 16 weeks. All of the patients treated with iliac crest structural graft progressed to union. Only 2 of the 4 patients treated with HA graft achieved incorporation, while the other 2 have required revision surgery.

Conclusion: Our results therefore show a significant improvement in both radiological and clinical outcome measures following corrective surgery. We had inferior results with the HA graft, and have subsequently abandoned its use. These results support the use of corrective osteotomy following distal radial malunion.

The matrix metalloproteinases (MMPs) and ADAMTSs (a disintegrin and metalloproteinase with thrombos-pontin motif) are related enzymes collectively responsible for turnover of the extracellular matrix. The balance between the proteolytic action of the MMPs and ADAMTSs, and their inhibition by the tissue inhibitors of metalloproteinases (TIMPs), underpins many pathological processes. Deviation in favour of proteolysis is seen in e.g. invasive carcinoma, whereas an imbalance towards inhibition causes e.g. fibrosis.

Dupuytren’s Disease (DD) is a fibroproliferative disorder affecting the palmar fascia, leading to contractures. A group of patients with end-stage gastric carcinoma were treated with a broad spectrum MMP inhibitor in an attempt to reduce the rate of tumour advancement: a proportion developed a ‘musculoskeletal syndrome’ resembling DD. Several groups have looked at subsets of the metalloproteinase family in relation to DD, but to date, a study of the gene expression of all of the members has not been published. We therefore set out to profile the mRNA expression for the 23 known MMPs, 4 TIMPs & 19 ADAMTSs in DD and normal palmar fascia.

Tissue samples were obtained from patients undergoing surgery to correct contractures caused by DD and from healthy controls undergoing carpal tunnel decompression. The DD tissue was separated macroscopically into cord and nodule. Total RNA was extracted and mRNA expression analysed by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR), normalised to 18S rRNA. Comparing across all genes, the DD nodule, DD cord and normal palmar fascia samples each had a distinct mRNA expression profile. Statistically significant (p< 0.05) differences in mRNA expression included: higher MMP-2, -7 and ADAMTS-3 levels in both cord and nodule; higher MMP-1, -14, TIMP-1 and ADAMTS-4 and -5 in nodule alone, lower MMP-3 in nodule and cord and lower TIMP-2, -3 and -4 and ADAMTS-1 and -8 levels in nodule alone.

The distinct mRNA profile of each group suggests differences in extracellular proteolytic activity which may underlie the process of fascial remodelling in DD. Further in vitro experiments are planned based on these observed differences in gene expression.

Aim: Intracapsular hip fractures in young adults have a significant risk of fracture healing complications. Consequently, some authors advocate urgent and/or open fracture reduction. Our aim was to analyse outcomes following such fractures with reference to influence of fracture displacement, timing of surgery and method of reduction (open/closed) on the incidence of non-union (NU) and avascular necrosis (AVN).

Methods: Specific search terms were used to retrieve relevant published studies from 1966 to May 2003.

Results: Eighteen studies involving 564 fractures were analysed. The overall incidence of NU was 50/564 (8.9%) and AVN was 130/564 (23.0%). There was a higher incidence of NU and AVN following displaced than undisplaced fractures. NU occurred more frequently after open reduction than closed reduction (10/89 [11.2%] versus 13/275 [4.7%])

There was an increased incidence of AVN after closed than open reduction but this became not statistically significant when one study with a markedly higher reported incidence of AVN was excluded.

The difference in the incidence of NU and AVN following early (< 12 hours) or late (> 12 hours) surgery was not significant for either NU or AVN.

Conclusion: Early or open reduction of these fractures may not reduce the risk of NU or AVN. There is a suggestion of a higher incidence of NU following open reduction than closed reduction. Randomised studies with two year follow-up are required to report on a larger number of patients before definite conclusions on treatment can be made.

Background: Intracapsular hip fractures in young adults under 50 years of age have a significant risk of fracture healing complications which has led some authors to advocate urgent fracture reduction and/or open reduction. As these fractures are infrequent, limited information is available from published studies to advocate a particular method of treatment to reduce the risk of complications. The purpose of this study is to analyze outcomes following such fractures with particular reference to the influence of the degree of fracture displacement, timing of surgery, method of reduction (open/closed) on the incidence of non-union and avascular necrosis.

Methods: Specific search terms were used to retrieve relevant studies from MEDLINE, EMBASE, and CINAHL extending from 1966 to May 2003. Guidelines for reporting of meta-analysis, adapted from QUOROM statement were followed.

Results: Eighteen studies with 564 fractures were identified for analysis. The overall incidence of non-union was 50/564 (8.9%) and avascular necrosis (AVN) was 130/564 (23.0%). There was a higher incidence of non-union and AVN following displaced than undisplaced fractures. Non-union occurred more frequently after open reduction than closed reduction (10/89 [11.2%] versus 13/275 [4.7%], P=0.04, RR=0.42, 95% CI: 0.19 to 0.93).

There was an increased incidence of AVN after closed than open reduction (P= 0.0005, RR = 2.77, 95% CI: 1.45 to 5.29) but this became not statistically significant when one study with a markedly higher reported incidence of AVN was excluded (P = 0.07, RR= 1.85, 95% CI: 0.93 to 3.68).

The difference in the incidence of non-union and AVN following early (< 12 hours) or late (> 12 hours) surgery was not significant for either non-union or AVN (13/110 [11.8%] versus 3/60 [5.0%], p=0.18, RR2.36, CI 0.70 to 7.97 for non-union, 15/110 [13.6%] versus 9/60 [15.0%], p=0.82, RR=0.91, CI 0.42 to 1.95 for AVN).

Conclusion: Early (< 12 hours) or open reduction of these fractures may not reduce the risk of non-union or avascular necrosis. There is a suggestion of a higher incidence of non-union following open reduction than closed reduction. Randomized studies or prospective observational studies with a minimum follow-up of two years are required to report on a larger number of patients in this age group before definite conclusions on treatment can be made.

Temporary immobilisation of joints can lead to permanent ankylosis or fusion. The aim of this study is to demonstrate that treatment of vertebral fractures by single level fusion and 2 level fixation preserves movement in the unfused lower motion segment after removal of metalwork.

12 consecutive thoracolumbar fractures were treated by posterior fixation over two motion segments with fusion of the upper injured segment. Average age 39 years (27–50yrs.) and 6 were male. L2 was most frequently affected (6) then T12 (3), L1(2) and L3(1). Using the Denis classification 9 were Burst type B, 1 was Burst type A and 2 were Compression type B. No patients had abnormal neurology or any other vertebral injury. All operations were performed by one surgeon (RC) within 7 days of injury. Metalwork bridging the injured vertebra was removed at mean 11 months (8–13 * one patient 27 months) and average follow up in this study was 12 months (2–40) after removal of metalwork. A simple pain questionnaire and flexion-extension radiographs were obtained. The average movement in the motion segment previously bridged by metalwork was 5 degrees (0–12). For comparison, the level below moved an average of 7 degrees (2–17). Kyphus angle was 11 degrees (1–18) on presentation corrected to 0 degrees at operation (−6 - +12) returning 1 year after removal of metalwork to 5 degrees (1–16). Pain scores (0–10) were measured retrospectively, prior to the accident mean 0(0–1) and at review 2.6 (0–6).

Only one patient failed to return to previous employment. She had the highest pain score at 6, showed no movement at the bridged motion segment where removal of metalwork was delayed to 27 months.