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Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 474 - 474
1 Jul 2010
Casanova J Freitas J Carvalhais P Lucas M Real JC Marques A Rebelo E Serrano P Furtado E Laranjo A Garcia H Alves MJEP
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Introduction: Soft tissue sarcomas (STS) are rare tumors. A multidisciplinary approach including surgery, chemotherapy and radiation therapy is recommended.

Materials and Methods: In the last 12 years, 249 patients with STS were teated in our Institution. All of them were treted with a multidisciplinary approach using all or some of the previous refered treatments.

Results: The overall local recurrence rate in the group of patients submited to surgery was 25% and this factor was related mostly with contaminated margins. Surgical resections were associted with soft tissue reconstructions when needed.

Radiation therapy was used in both regimens pre and post operativly, chemotherapy was also used in 85% of the patients, and was not dependent of tumor histotype.

23 patients were submited to surgery of lung metastasis.

Survival rates were determined and compared with stage (AJCC), tumor histotype and surgical margins.

Conclusions: Multidisciplinary approach is the recommended treatment for STS.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 189 - 189
1 Mar 2006
Balaco I Casanova J Matos P Teixeira C Tavares P Garcia H Laranjo A Portela J
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In the last ten years, 172 bone sarcomas and 126 soft tissue sarcomas, were treated by our Orthopaedic Oncology Unit. From those patients 49 (16.5%) meet criteria for pulmonary metastasis resection. Patient group were 27 males (55%) and 22 females (45%); median age 28.8 years (range 12–71); histology of the primary tumours were in 33 cases bone lesions (67%): 17 osteosarcomas, 8 Ewing sarcomas, 3 Malignant Fibrous Histiocytoma (MFH) and 1 Giant Cell Tumor and 16 cases (23%) for soft tissue tumours: 5 synovial sarcoma, 3 schwannoma and MFH, 2 leiomiosarcoma and liposarcoma and 1 rhabdomyosarcoma. From those sarcomas 8 (17.8%) were metastatic at presentation. Treatment included surgical resections of the secondary lesions and chemotherapy. The lung metastasis were bilateral in 20 cases (41%) and unilateral in 29 cases (59%). The number of metastasis range from one to 24 and the surgical sessions for each patient were from one to eight. The median disease free survival in the patients with no metastatic lesions at presentation was 17.8m (range 2–88). From this group of patients 25 (51%) were dead of disease (DOD), and 24 (49%) were survivors (median follow-up 42 month: range 12–120 month), being 14 with no evidence of disease (NED) and 10 alive with disease (AWD).

The authors perform a statistical analysis relating survival with local recurrence and the amount of necrosis in the surgical specimen.