Efficient, repeatable and reliable insertion of microneedles into skin is paramount to ensure efficacious drug and vaccine delivery, as well as effective microneedle-based biosensing. Through maintaining robust mechanical adhesion, this microneedle platform offers significant potential in therapeutic delivery and longitudinal wearable applications. Here, we have shown that an angled microneedle design, which is conducive to self-administration, has the potential to address key limitations in existing microneedle technology.