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Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 244 - 244
1 Jul 2014
Parchi P Cecchini M Antonini S Piolanti N Andreani L Poggetti A Lisanti M Orazio V
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Summary

Aim of this study is to design, develop and preclinical test PET nanostructured scaffolds for the transplantation and differentiation of MSCs in the treatment of bone defects. The interaction of cells with nanotopographical features has proven to be an important signaling modality in controlling MSC differentiation.

Introduction

The wide bone defects, caused by trauma, tumor, infectious, periprosthetic osteolysis, need to be surgically treated because their low potential of repair. Nowadays the bone allograft and autograft represent 80% of all transplantation done in the world. However this technique shows many disadvantages, such as the risk of infections, the immunological rejection, the low bone availability and the high costs. These reasons have motivated extensive research to find alternative strategies. As shown in literature, the future strategies are based on the synergic combination of different methodologies: use of biomimetic scaffold in order to support bone regeneration, use of mesenchymal stromal cells (MSCs) and growth factors. Successful regeneration necessitates the development of tissue-inducing scaffolds that mimic the hierarchical architecture of native tissue extracellular matrix (ECM). Cells in nature recognise and interact with the surface topography they are exposed to via ECM proteins. Here we are going to show the guidelines recently published for the design and development of nanostructured scaffolds for the bone regeneration, and the morphofunctional changing of MSCs interacting with nanogratings.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 354 - 354
1 May 2010
Marchetti S Scaglione M Baccelli M Menconi A Bulgarelli C Latessa M Parchi P Togo R Piolanti N
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Introduction: Tibial plateau fractures are usually challanging although they are not really common. In fact this type of lesion represent about 1,5% of all fractures, and mostly they interest young patients.

The classification system commonly used the Muller and Schatzker ones those relate grade to treatment ad outcome.

Aim of study: It was to evaluated mid term results of tibial plateau fracture treated using hybrid external fixation performed (with k-wires and pins and transfixing pins) and minimally invasive osteosynthesis.

Material and Methods: In the last five years there were treated 39 patients in our hospital using external fixation and minimal invasive osteosynthesis, 35 of those were evaluated in radiographs and functional outcome. The mean follow-up was 2,5 years.

Results: Our study showed good results and a poor complication rate related to the applied technique. The clinical outcome overall was 86% good, while the evaluation of function was good in 77% of cases revised. The radiographs were satisfactory in 91% of cases.

Conclusions: It is authors’ opinion that the quality of results are related to early motion of the knee, while bad results are often due to scar and to mechanism of injury (high energy trauma, floating knee). External fixation has shown to give good results with low complications.