Guidelines for the use of preoperative blood tests for elective surgery were established. However, there is less evidence and no guidelines regarding using these tests when a young, healthy patient undergoes minor orthopaedic trauma surgery. Bloodwork is often ordered routinely, regardless of medical history or the nature of the injury. We hypothesized that unnecessary blood work is requested for younger pre-operative patients, and their results will not change peri-operative management. This practice is not a judicious use of healthcare resources. This study aimed to evaluate the frequency, type, cost, and impact on clinical decisions if standard preoperative bloodwork was completed in healthy patients requiring surgical management of a minor fracture or dislocation.

After the approval of our institutional ethics board, a retrospective chart review was conducted. Inclusion criteria were patients aged 18-60 years, who had an isolated minor orthopaedic trauma requiring outpatient surgery, who were American Society of Anesthesiologists (ASA) class 1. ASA class 1 is defined as “a normal healthy patient, without any clinically important comorbidity and without a clinically significant past/present medical history.” Data records from January 1, 2016, to December 31, 2018, were extracted from a provincial database (the Analytics Data Integration, Measurement and Reporting) for five hospitals. Data including demographics, surgical treatment, type and number of blood tests ordered, and ordering physician were collected. Any abnormal test results were checked to see whether they led to a change in patient management or related to a postoperative adverse event. Independent samples t-tests and Chi-square tests were used to compare the characteristics of patients who had preoperative bloodwork versus those who did not. The cost of preoperative blood work was estimated.

During these two years, 627 patients met inclusion criteria, and 27% (n=168) of these patients had bloodwork completed pre-operatively, while only 34% (n=57) of these had one or more abnormal laboratory parameters. These abnormalities were minor and did not alter clinical management or result in repeated bloodwork peri-operatively. Patients who had bloodwork were significantly older (40.2 years) compared with patients without preoperative blood work (37.8 years; p=0.03), but there was no difference in sex between those who had bloodwork (53.4% male) and those who did not (51.4% male; p=0.63). The most common blood test ordered was a complete blood count, and the most commonly abnormal result was a mildly elevated white blood cell count (19%; n= 29). The most common patients to receive bloodwork were those with ankle (34%) and distal radius (34%) fractures. The bloodwork was primarily ordered by clinical associates (26%; n=46) and emergency department physicians (22%; n=38). Without considering lab personnel, consumables, and analysis time, the cost of this bloodwork was approximately $7685, an average of $45 per patient.

Pre-operative bloodwork in young, healthy, asymptomatic patients requiring outpatient surgery for minor orthopaedic trauma had no clinical significance and did not change patient management. Rigorous prospective research is warranted to establish national guidelines for appropriate pre-operative bloodwork ordering to minimize unnecessary and costly investigations.

Introduction

The role of soft tissue balancing in optimizing functional outcome and patient satisfaction after total knee arthroplasty surgery is gaining interest. This is due in part to the inability of pure alignment to demonstrate excellent functional outcomes 6. Consistent soft tissue balancing has been aided by novel technologies that can quantify loads across the joint at the time of surgery 4. In theory, compressive load equilibrium should be correlated with ligamentous equilibrium between the medial and lateral collateral ligaments. The authors propose to use the Collateral Ligaments Strain Ratio (CLSR) as a functional tool to quantify and track surgical changes in laxity of the collateral ligaments and correlate this ratio to validated functional scores and patient reported outcomes. The relationship with intra-operative balancing of compartmental loads can then be scrutinized. The benefits of varus-valgus balancing within 2o include increased range of motion 7, whereas pressure imbalance between the medial and lateral joint compartments has been linked to condylar liftoff and abnormal kinematics post-TKA 8.

Introduction

The mechanical classical method of knee surgical instrumentation by alignment is based on built-in compromises and is considered insufficient to ensure consistent success. Soft tissue balancing is thus now seen as necessary for optimal functional outcomes and patient satisfaction. (Matsuda 2005, Winemaker 2002). The authors have previously demonstrated that balancing can be achieved through specific strategic moves. In this study, the goal was to determine the efficacy of a given surgical algorithm and to define predictors of improved outcome. The surgical target is equilibrium of contact loads. The mechanical axis remains in neutral, however subtle variation in the joint line obliquity and posterior slope are tolerated within the literature established boundaries of +/− 3 degrees and less than 10 degrees respectively.

Introduction

The role of soft tissue balancing in optimising functional outcome and patient satisfaction after total knee arthroplasty surgery is gaining interest. Consistent soft tissue balancing has been aided by novel technologies that can quantify loads across the joint at the time of surgery. Based on free body diagram theory, compressive load equilibrium should be correlated with ligamentous equilibrium between the medial and lateral collateral ligaments. The authors propose to use the Collateral Ligaments Strain Ratio (CLSR) as a functional tool to quantify and track the effectuated surgical change in laxity of the medial and lateral collateral ligaments and correlate this ratio to validated functional scores and patient reported outcomes. The relationship with intra-operative balancing of compartmental loads can then be scrutinised.

Introduction

Balancing at surgery is important for clinical outcome in terms of pain relief, flexion range, and function. The methodology usually involves making bone cuts to achieve correct leg alignment, and then obtaining equal gaps in extension and flexion using spacer blocks or tensor devices. In this study, we describe a method for quantifying balancing throughout the flexion range and show the effect of different surgical corrections from an unbalanced to a balanced state. In this way, we quantified how accurately balancing could be achieved within the practical time frame of a surgical procedure.

The objective of this study was to evaluate the suitability of autologous periosteal cells for spinal fusion in humans. Lumbar spondylodesis has a slow consolidation rate with a consecutive lengthy period of inability to work and the risk of non-union. This study evaluates the applicability of a cell-matrix construct for spinal fusion using clinical and radiological parameters.

All experiments were approved by the university ethics committee. Lumbar spondylodesis of the segments L4/5 or L5/S1 was performed in 20 healthy patients (mean age 45 years). Indication for surgery was DDD resistant to conservative treatment. 10 weeks before fusion operation, a piece of periosteum was harvested from the proximal tibia of the patient. The material was chopped and digested. In the washed cell suspension cell number and viability were determined. The viability was greater 90% before seeding. After four passages, the cells were mixed with human fibrinogen, and soaked into polymer fleeces. Polymerization was achieved by adding thrombin. The 3D constructs were cultured for 3 weeks. The final application form were chips of 2mm thickness and 8mm diameter. Spondylodesis was performed using a ventral approach for implantation of 2 titanium cages and a dorsal approach for application of a transpedicular screw-rod system (Medtronic, Sofamor Danek). In 10 patients the chips were implanted ventrally within the cage. The other 10 patients obtained a dorsal intertransverse transplantation of the chips. Pre-operative, 3, 6, 9, and 12 months after surgery a clinical examination was performed, radiographs, and functional scores were obtained.

No implant associated side effects were noted. Especially, signs of infection or allergic reaction have not been observed. The harvest sites of all patients presented symptom-free after 3 months. The rate of consolidation was 60% after 6 months, 90% after 9 months, and 100% after 12 months. No clinical or radiological signs for implant failure or malpositioning were observed. 90% of the patients were satisfied with the outcome of the surgery.

Cultured autologous periosteal cells are a suitable material for anterior as well as posterior spinal fusion in humans. They may accelerate the rate of fusion and reduce the risk of non-union. Rate and velocity of osseous consolidation need to be compared to that of patients treated with iliac crest autograft. A major advantage might be the lower rate of graft site morbidity.