Introduction: The introduction of Oxford UKA byminimally invasive techniques has signiþcantly changed the treatment of anteromedial osteoarthritis of the knee joint. It is therefore necessary to evaluate this treatment option both clinically and radiologically. Aims: To study the radiographic and clinical results of the Oxford medial UKA in patients with a minimum follow up of 2 years in a single centre. Methods: A prospective independent study in which 67 consecutive UKAs were implanted by a single surgeon, using a minimally invasive technique. All patients with a minimum follow up of 2 years were pre- and postoperatively clinically evaluated by the AKSS and radiologically according to the Oxford Centre criteria, including ßuoroscopy. Results: Clinical: 28 patients with 30 prostheses (mean FU: 2.54 yr; mean age: 71.4 yrs) were included. The Knee Score improved signiþcantly from 58.7 (pre-op) to 95.0 (FU). The Function Score improved from 54.5 to 88.8. Mean ROM was 125û preoperatively and 121û at FU.Radiological: preop: varus deformity (n=18; mean 3.4û; range 2–10û), and valgus (n=12; 5.4, 2–12û). Postop: valgus alignment in all (n=30; 6.3û, 4–12û). Fifteen cases (50%) showed signs of patellofemoral arthritis (PFA); 11 cases with grade 2–3 PFA had a maximum pain score of 50. Full congruency of the tibial and femoral components was obtained in 18 cases, 10 cases were within and 2 out of margin according to the Oxford Centre criteria. Radiolucency below the tibial component was seen in 2 cases. Conclusions: This independent study has conþrmed preliminary þndings that using a minimally invasive approach good radiological and clinical results can be obtained. Presence of PFA had no inßuence on good clinical outcome.