Aims: Foot and leg infections and osteomyelitis are common findings in diabetic patients. The primary goal at present is limb salvage. This study reviews our experience with this pathology. Methods: This is a study of 2–6 years of 458 consecutive diabetic patients with foot or leg infections. 29% of them had IDDM (Type I) and 71% had NIDDM (Type II). Initial treatment consisted of a meticulous surgical eradication of the infection combined with antibiotic treatment (26%-plantar incision, 14%-amputation of a single or more toes, 32%-amputation of a single or more metatarsals, 19%-below knee amputation and 9%-an above knee amputation. Follow-up consists of 410 Pts. The remaining 48 Pts died prior to the end of the study. Results: 357 patients (87%) had a complete healing of the infection following a single surgical intervention. 17 Pts had also reconstructive vascular procedures. 53 Pts (13%) had 2 or more surgical interventions, during one or more hospitalizations, mainly of “a proximal amputation” The percentage of successful foot salvage following initial foot surgery was 90% (267/296). The remaining 10% patients with initial foot infection, had a secondary below knee or above knee amputations. Conclusions: Based on this study it is suggested that meticulous debridement of the source of infection by “minor” amputations, combined with I.V antibiotics, have yielded a relatively high percentage of success of limb salvage and reduced the necessity for initial above or below knee amputation. It is further suggested that the NIDDM patients are more prone to leg and foot infections than the IDDM patients; hence, they should be observed regularly.