Bone defects require implantable graft substitutes, especially porous and biodegradable biomaterial for tissue regeneration. The aim of this study was to fabricate and assess a 3D-printed biodegradable
Introduction. To evaluate the effect of
Targeted delivery of drugs is a major challenge in diseases such as infections and tumors. The aim of this study was to demonstrate that
Abstract. INTRODUCTION. Polyetheretherketone (PEEK) is a high-performance thermoplastic polymer which has found increasing application in orthopaedic implant devices and has a lot of promise for ‘made-to-measure’ implants produced through additive manufacturing [1]. However, a key limitation of PEEK is that it is bioinert and there is a requirement to functionalise its surface to make the material osteoconductive to ensure a more rapid, improved and stable fixation, in vivo. One approach to solving this issue is to modify PEEK with bioactive materials, such as
Abstract. Objectives. The objective of this study is to investigate the effect of solvents and rheological properties of PCL/
Osseointegration has been shown to be directly affected by surface roughness and bioactive coatings. This report compares bone response to
The aseptic loss of bone after hip replacement is a serious problem leading to implant instability.
Two calcium phosphate cements, brushite and
Introduction: Polyethylene wear debris is the main contributing factor that leads to aseptic loosening and osteolysis. The main objective of this study was to evaluate the role of
Aim. Treatment principles of chronic osteomyelitis include debridement, clean sampling, excision of dead bone, stabilization, dead space management, soft tissue closure and systemic antibiotic therapy. Dead space management becomes very complicated, if the bone infection is caused by multi-resistant bacteria. The aim of this investigation was to evaluate the effect of a new vancomycin-loaded
Introduction: The aetiology of dystrophic disc calcification in adult humans is unknown but a well-described clinical disorder with
A longitudinal study was done assessing the latest radiographs available in a series of collarless Corail uncemented stems which have reported survival rates of 95% at 20 years. Parameters scored included the degree of “Ghosting” or delamination, the Gruen, the stem fit in the femoral canal and the degree of calcar resorption. Patient and implant demographics were noted. At 3 years the loosening rate was 23% reaching 64% at 6 years after the index procedure. It was present in all age groups, with a peak in the 24 to 49 year age group. Males and females had the same occurrence. When it was present this was always in zone 1. It was present in 6% of patients in zone 7, but then always associated with zone 1 changes. High and standard off-set stems had the same loosening rates. The looser fit of the stem the higher the incidence of loosening. There was no correlation to the type of bearing surface or the degree of calcar resorption. Those patients with a BMI of 25 – 35 had lower loosening rates compared to those with higher or lower BMI's. We postulate that cancellous bone on-growth onto the
In revision THA, the solid acetabular reconstruction in the true acetabulum is often challenging. We are using the Kerboull acetabular reinforcement devices after packing
Sixty-two consecutive primary total hip arthroplasties were prospectively randomized to receive either
Introduction: Polyethylene wear debris is the main contributing factor that leads to aseptic loosening and osteolysis. The main objective of this study was to evaluate the role of
Aims: To investigate if coralline
Surgical failure, mainly caused by loosening implants, causes great mental and physical trauma to patients. Improving the physicochemical properties of implants to achieve favourable osseointegration will continue to be the focus of future research. Strontium (Sr), a trace element, is often incorporated into
The aim of this study was to evaluate the trochlear bone and cartilaginous regeneration of rabbits using a composite based on platelet rich plasma (PRP), chitosan and
Objective: To determine if a porous, coralline-derived