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The Bone & Joint Journal
Vol. 105-B, Issue 5 | Pages 474 - 480
1 May 2023
Inclan PM Brophy RH

Anterior cruciate ligament (ACL) graft failure from rupture, attenuation, or malposition may cause recurrent subjective instability and objective laxity, and occurs in 3% to 22% of ACL reconstruction (ACLr) procedures. Revision ACLr is often indicated to restore knee stability, improve knee function, and facilitate return to cutting and pivoting activities. Prior to reconstruction, a thorough clinical and diagnostic evaluation is required to identify factors that may have predisposed an individual to recurrent ACL injury, appreciate concurrent intra-articular pathology, and select the optimal graft for revision reconstruction. Single-stage revision can be successful, although a staged approach may be used when optimal tunnel placement is not possible due to the position and/or widening of previous tunnels. Revision ACLr often involves concomitant procedures such as meniscal/chondral treatment, lateral extra-articular augmentation, and/or osteotomy. Although revision ACLr reliably restores knee stability and function, clinical outcomes and reoperation rates are worse than for primary ACLr.

Cite this article: Bone Joint J 2023;105-B(5):474–480.


The Bone & Joint Journal
Vol. 105-B, Issue 3 | Pages 331 - 340
1 Mar 2023
Vogt B Toporowski G Gosheger G Laufer A Frommer A Kleine-Koenig M Roedl R Antfang C

Aims. Temporary hemiepiphysiodesis (HED) is applied to children and adolescents to correct angular deformities (ADs) in long bones through guided growth. Traditional Blount staples or two-hole plates are mainly used for this indication. Despite precise surgical techniques and attentive postoperative follow-up, implant-associated complications are frequently described. To address these pitfalls, a flexible staple was developed to combine the advantages of the established implants. This study provides the first results of guided growth using the new implant and compares these with the established two-hole plates and Blount staples. Methods. Between January 2013 and December 2016, 138 patients (22 children, 116 adolescents) with genu valgum or genu varum were treated with 285 flexible staples. The minimum follow-up was 24 months. These results were compared with 98 patients treated with 205 two-hole plates and 92 patients treated with 535 Blount staples. In long-standing anteroposterior radiographs, mechanical axis deviations (MADs) were measured before and during treatment to analyze treatment efficiency. The evaluation of the new flexible staple was performed according to the idea, development, evaluation, assessment, long-term (IDEAL) study framework (Stage 2a). Results. Overall, 79% (109/138) of patients treated with flexible staples achieved sufficient deformity correction. The median treatment duration was 16 months (interquartile range (IQR) 8 to 21). The flexible staples achieved a median MAD correction of 1.2 mm/month/HED site (IQR 0.6 to 2.0) in valgus deformities and 0.6 mm/month/HED site (IQR 0.2 to 1.5) in varus deformities. Wound infections occurred in 1%, haematomas and joint effusions in 4%, and implant-associated complications in 1% of patients treated with flexible staples. Valgus AD were corrected faster using flexible staples than two-hole plates and Blount staples. Furthermore, the median MAD after treatment was lower in varus and valgus AD, fewer implant-associated complications were detected, and reduced implantation times were recorded using flexible staples. Conclusion. The flexible staple seems to be a viable option for guided growth, showing comparable or possibly better results regarding correction speed and reducing implant-associated complications. Further comparative studies are required to substantiate these findings. Cite this article: Bone Joint J 2023;105-B(3):331–340


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_5 | Pages 19 - 19
1 Apr 2022
Tsang SJ Stirling P Simpson H
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Introduction. Distal femoral and proximal tibial osteotomies are effective procedures to treat degenerative disease of the knee joint. Previously described techniques advocate the use of bone graft to promote healing at the osteotomy site. In this present study a novel technique which utilises the osteogenic potential of the cambial periosteal layer to promote healing “from the outside in” is described. Materials and Methods. A retrospective analysis of a consecutive single-surgeon series of 23 open wedge osteotomies around the knee was performed. The median age of the patients was 37 years (range 17–51 years). The aetiology of the deformities included primary genu valgum (8/23), fracture malunion (4/23), multiple epiphyseal dysplasia (4/23), genu varum (2/23), hypophosphataemic rickets (1/23), primary osteoarthritis (1/23), inflammatory arthropathy (1/23), post-polio syndrome (1/23), and pseudoachondroplasia (1/23). Results. There were two cases lost to follow-up with a median follow-up period 17 months (range 1–32 months). Union was achieved in all cases, with 1/23 requiring revision for early fixation failure for technical reasons. The median time to radiographic union 3.2 months (95% Confidence Interval (CI) 2.5–3.8 95% CI). CT scans demonstrated early periosteal callus, beneath the osteoperiosteal flap, bridging the opening wedge cortex. Clinical union occurred at 4.1 months (95% CI 3.9–4.2 months). Complications included superficial surgical site infection (1/23), deep vein thrombosis (1/23), and symptomatic metalwork requiring removal (7/23). Conclusions. The osteoperiosteal flap technique was a safe and effective technique for opening wedge osteotomies around the knee with a reliable rate of union


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_5 | Pages 6 - 6
1 Apr 2022
Moore D Noonan M Kelly P Moore D
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Introduction. Angular deformity in the lower extremities can result in pain, gait disturbance, deformity and joint degeneration. Guided growth modulation uses the tension band principle with the goal of treatment being to normalise the mechanical axis. To assess the success of this procedure we reviewed our results in an attempt to identify patients who may not benefit from this simple and elegant procedure. Materials and Methods. We reviewed the surgical records and imaging in our tertiary children's hospital to identify all patients who had guided growth surgery since 2007. We noted the patient demographics, diagnosis, peri-operative experience and outcome. All patients were followed until skeletal maturity or until metalwork was removed. Results. 173 patients with 192 legs were assessed for eligibility. Six were excluded due to inadequate follow-up or loss of records. Of the 186 treated legs meeting criteria for final assessment 19.8% were unsuccessful, the other 80.2% were deemed successful at final follow up. Complications included infection and metal-work failure. Those with a pre-treatment diagnosis of idiopathic genu valgum/ varum had a success rate of 83.6%. Conclusions. In our hands, guided growth had an 80-percent success rate when all diagnosis were considered. Those procedures that were unlikely to be successful included growth disturbances due to mucopolysaccharide storage disease, Blounts disease and achondroplasia. Excluding those three diagnoses, success rate was 85.4%. We continue to advocate the use of guided growth as a successful treatment option for skeletally immature patients with limb deformity


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_13 | Pages 128 - 128
1 Nov 2021
Stallone S Trisolino G Zarantonello P Ferrari D Papaleo P Napolitano F Santi GM Frizziero L Liverani A Gennaro GLD
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Introduction and Objective. Virtual Surgical Planning (VSP) is becoming an increasingly important means of improving skills acquisition, optimizing clinical outcomes, and promoting patient safety in orthopedics and traumatology. Pediatric Orthopedics (PO) often deals with the surgical treatment of congenital or acquired limbs and spine deformities during infancy. The objective is to restore function, improve aesthetics, and ensure proper residual growth of limbs and spine, using osteotomies, bone grafts, age-specific or custom-made hardware and implants. Materials and Methods. Three-dimensional (3D) digital models were generated from Computed Tomography (CT) scans, using free open-source software, and the surgery was planned and simulated starting from the 3D digital model. 3D printed sterilizable models were fabricated using a low-cost 3D printer, and animations of the operation were generated with the aim to accurately explain the operation to parents. All procedures were successfully planned using our VSP method and the 3D printed models were used during the operation, improving the understanding of the severely abnormal bony anatomy. Results. The surgery was precisely reproduced according to VSP and the deformities were successfully corrected in eight cases (3 genu varum in Blount disease, 2 coxa vara in pseudo achondroplasia, 1 SCFE, 1 missed Monteggia lesion and 1 post-traumatic forearm malunion deformity). In one case, a focal fibrocartilaginous dysplasia, the intraoperative intentional undersizing of the bone osteotomy produced an incomplete correction of a congenital forearm deformity. Conclusions. Our study describes the application of a safe, effective, user-friendly, VSP process in PO surgery. We are convinced that our study will stimulate the widespread adoption of this technological innovation in routine clinical practice for the treatment of rare congenital and post-traumatic limb deformities during childhood


The Bone & Joint Journal
Vol. 102-B, Issue 10 | Pages 1412 - 1418
3 Oct 2020
Ballhause TM Stiel N Breyer S Stücker R Spiro AS

Aims

Eight-plates are used to correct varus-valgus deformity (VVD) or limb-length discrepancy (LLD) in children and adolescents. It was reported that these implants might create a bony deformity within the knee joint by change of the roof angle (RA) after epiphysiodesis of the proximal tibia following a radiological assessment limited to anteroposterior (AP) radiographs. The aim of this study was to analyze the RA, complemented with lateral knee radiographs, with focus on the tibial slope (TS) and the degree of deformity correction.

Methods

A retrospective, single-centre study was conducted. The treatment group (n = 64 knees in 44 patients) was subclassified according to the implant location in two groups: 1) medial hemiepiphysiodesis; and 2) lateral hemiepiphysiodesis. A third control group consisted of 25 untreated knees. The limb axes and RA were measured on long standing AP leg radiographs. Lateral radiographs of 40 knees were available for TS analysis. The mean age of the patients was 10.6 years (4 to 15) in the treatment group and 8.4 years (4 to 14) in the control group. Implants were removed after a mean 1.2 years (0.5 to 3).


Bone & Joint 360
Vol. 8, Issue 6 | Pages 36 - 39
1 Dec 2019


Bone & Joint 360
Vol. 8, Issue 2 | Pages 38 - 41
1 Apr 2019


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_8 | Pages 16 - 16
1 May 2018
Moore D Noonan M Kelly P Moore D
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Purpose. Angular deformity in the lower extremities can result in pain, gait disturbance, cosmetic deformity and joint degeneration. Up until the introduction of guided growth in 2007, which has since become the gold standard, treatment for correcting angular deformities in skeletally immature patients had been either an osteotomy, a hemiepiphysiodesis, or the use of staples. Methods. We reviewed the surgical records and diagnostic imaging in our childrens hospital to identify all patients who had guided growth surgery since 2007. All patients were followed until skeletal maturity or until their metalwork was removed. Results. 113 patients, with 147 legs were assessed for eligibility. Three were excluded for various reasons including inadequate follow-up or loss of records. Of the 144 treated legs which met the criteria for final assessment 32 (22.2%) were unsuccessful, the other 112 (77.8%) were deemed successful at final follow up. Complications were few, but included infection in one case and metal failure in another. Those with a pre-treatment diagnosis of idiopathic genu valgum/genu varum had a success rate of 83.6%. Conclusions. In our hands, guided growth had a seventy-eight percent success rate when all diagnosis were considered. Those procedures that were unlikely to be successful included growth disturbances due to mucopolysaccharide storage disease (28% failure rate), Blounts disease (66.6% failure rate) and achondroplasia (37.5% failure rate). If you exclude those three diagnoses, success rate for all other conditions was 81.4%. We continue to advocate the use of guided growth as a successful treatment option for skeletally immature patients with limb deformity


The Bone & Joint Journal
Vol. 99-B, Issue 2 | Pages 204 - 210
1 Feb 2017
Xu J Jia Y Kang Q Chai Y

Aims

To present our experience of using a combination of intra-articular osteotomy and external fixation to treat different deformities of the knee.

Patients and Methods

A total of six patients with a mean age of 26.5 years (15 to 50) with an abnormal hemi-joint line convergence angle (HJLCA) and mechanical axis deviation (MAD) were included. Elevation of a tibial hemiplateau or femoral condylar advancement was performed and limb lengthening with correction of residual deformity using a circular or monolateral Ilizarov frame.


The Bone & Joint Journal
Vol. 99-B, Issue 1 | Pages 5 - 11
1 Jan 2017
Vulcano E Myerson MS

The last decade has seen a considerable increase in the use of in total ankle arthroplasty (TAA) to treat patients with end-stage arthritis of the ankle. However, the longevity of the implants is still far from that of total knee and hip arthroplasties.

The aim of this review is to outline a diagnostic and treatment algorithm for the painful TAA to be used when considering revision surgery.

Cite this article: Bone Joint J 2017;99-B:5–11.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_1 | Pages 11 - 11
1 Jan 2017
Stefanou M Pasparakis D Darras N Papagelopoulos P
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Many studies describe the use of the Ilizarov ring fixator for lower limb lengthening and for the management of the 3-dimensional lower limb deformities in achondroplasia, and most confirm the efficacy of this technique. However, long term follow up of these achondroplastic patients is lacking. Most studies have focused on magnitude of lengthening, treatment time required and complications, but no study has analyzed the long term postoperative condition of these patients using an objective, functional method such as gait analysis. Nineteen (19) achondroplastic patients, 12 males and 7 females, aged 19–38 years (mean 27.3 y) who have undergone tibia and femur lengthening, using the Ilizarov method, at the age of 9–19 years (mean 12.6 y), were evaluated 5–19 years (mean 10.1 y) after their last surgery, using 3-dimensional gait analysis. Nineteen (19) normal, height-matched subjects were used as controls. The VICON Nexus 8 Camera System was used to accurately measure spatiotemporal characteristics (walking velocity, stride length, step length, cadence) and kinematics (range of motion) of lower limb joints. Statistical comparison of deformity parameters between achondroplastic patients and normal population was done using the student t- test. A level of p<0.05 was considered statistically significant. Walking velocity, step length and stride length were statistically significantly decreased (p<0.05) in achondroplastic patients compared to normal population values. The achondroplastic group presented with excessive anterior pelvic tilt (mean 21.9. o. ± 7.3), excessive pelvic rotation (range 28.7. o. ±7.8), decreased hip extension (mean 1.8. o. ±10.1) and decreased plantar flexion (mean 17.1. o. ±5.1) when compared to normal controls. There was no statistically significant difference in the knee kinematics between the operated achondroplastic patients and normal controls. The achondroplastic patients present decreased values in their spatiotemporal characteristics compared to the normal subjects because, despite the height gain, their lower limbs remain shorter. Their excessive anterior pelvic tilt is attributed to their lordosis. Their excessive forward pelvic rotation is an attempt to increase stride and step length. The decreased hip extension is due to their anterior pelvic tilt. The correction of these patients genu varum restored knee kinematics to normal. In order to address the hip and pelvis deformities a proximal femoral osteotomy should be considered. The Ilizarov method provides functional height gain and substantially corrects the three-dimensional lower limb deformities of achondroplastic patients especially around the knee joint but more planning needs to be implemented when the system is applied to correct the disease specific deformities of the hip and pelvis. Gait analysis is an objective tool that can be used to address these design issues


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_17 | Pages 65 - 65
1 Nov 2016
Lewallen D
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Instability currently represents one of the main causes of residual pain and symptoms following TKA and thus is a major cause of revision total knee replacement, second only to component loosening in some series. Instability related to ligamentous laxity can be categorised by the pattern of relative laxity of the soft tissue structures and this in turn helps in determination of the bony alignment issue, component sizing or positioning problem or ligamentous abnormality that may be contributory and require correction. Instability patterns associated with TKA can be symmetrical and global type instability where there is laxity in all planes, and can also more commonly be asymmetrical or isolated laxity problems where there is good stability in some planes or positions of the knee but excessive laxity in at least one direction. Isolated laxity problems can be subcategorised into one of 3 patterns: Extension instability, Flexion instability, and Recurvatum. Global laxity can occur due to inadequate tibial component thickness, or globally incompetent soft tissues, and can present initially after TKA or alternatively can present late from slow stretch of soft tissues over time as can be seen with some pathologic states. Asymmetrical or Isolated laxity occurs in the sagittal plane when medial vs. lateral “gaps” are unequal and may be due to contracture of tight structures either medially or laterally or can be due to insufficiency or injury of the ligamentous structures on one side vs. the normal structures on other side. Occasionally there is a combination of both contracture on one side and attenuation/stretch on the other side as seen in some patients with severe long standing genu varum or genu valgum. Asymmetrical laxity in the frontal plane generally results in unequal extension vs. flexion “gaps”. This can cause either anteroposterior laxity in flexion but full extension with good stability or alternatively, there may be AP stability in flexion but a lack of full extension in the presence of the exact same pattern of imbalance when a “too thick” polyethylene insert is used to correct what would otherwise be flexion instability. In both cases, the extension gap is tighter than the flexion gap. Isolated recurvatum occurs when the posterior capsular structures are relatively lax or deficient so that a knee that is otherwise stable in the medial-lateral plane in extension, and is stable in the AP plane when in flexion, hyperextends in the fully extended position. In any TKA procedure (but especially revision for instability) it is critical to understand the effect of selected bone resection (or build ups) on soft tissue balancing in order to avoid or treat ligamentous laxity: distal femur – effects extension gap only; posterior femur – effects flexion gap only; proximal tibia – both flexion and extension spaces. During revision for instability, careful evaluation of the cause of the laxity and failure is critically important, especially if there is associated axial deformity or malalignment which generally must be corrected for any reconstruction or revision components to work. Most knees revised for instability issues will require a posterior stabilised or constrained condylar design. Constrained condylar implants are used to compensate for residual medial-lateral imbalance still present after standard soft tissue releases medially (subperiosteal tibia) or laterally (vis selective pie-crust method). However, if the patient displays residual major medial-lateral or global instability that cannot be corrected, or when there is an excessive flexion gap that cannot be stabilised with maximal allowable component sizing, a rotating hinge constrained total knee replacement design may be required. Recent data has shown that rotating hinges can work reliably in restoring stability to the knee in such cases with satisfactory durability and clinical results over time


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_15 | Pages 15 - 15
1 Sep 2016
Saville S Atherton S Ayodele O Walton R Bruce C
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We present a review of our Specialist Physiotherapy clinic for normal physiological variations of the lower limb (SPNV) clinics, demonstrating them to be clinically effective and cost effective. Children with normal variation of rotational profile and limb angulation present much anxiety to parents and primary care. Providing consultation: to eliminate significant pathology and reassure families, is an important service that a Paediatric Orthopaedic department provides. In our tertiary referral department we have a Specialist Physiotherapy led clinics into which primary care practitioners refer children with whom there are concerns about lower limb development variation. The (SPNV) Clinic was first set up by a Consultant and Senior Physiotherapist in 1999. The aim of the clinic was to reduce the waiting times for incoming referrals but ensuring they are seen in an appropriate environment by an experienced health care professional. Clinics are run by Senior Specialist Physiotherapists, alongside Consultant clinics who are available for advice and direction. This provides security for the physios, the Trust and the patient. Over 15 years there have been more than 4000 patient visits to this clinic. Over 80% were new patient visits. 70% of these visits were discharged in one or two reviews. 97.4% of new referrals were discharged without subsequent review by an orthopaedic surgeon. The most common conditions reviewed were Genu valgum (25%), Genu Varum (16%), intoeing (17%) and flexible flat feet (11%). The clinic has proven to be cost effective as well in drawing in up to £500,000 revenue into the trust in a single year. The department has been approached by other trusts to assist in the implementation of similar clinics. We present this review of the patients, as a template for supporting the work of Paediatric Orthopaedic Departments. This service has facilitated the streamlining of our Consultant Paediatric Orthopaedic clinics


The Bone & Joint Journal
Vol. 98-B, Issue 4 | Pages 483 - 489
1 Apr 2016
Tigchelaar S Rooy JD Hannink G Koëter S van Kampen A Bongers E

Aim

Nail patella syndrome (NPS) is a skeletal dysplasia with patellofemoral dysfunction as a key symptom. We present the first in-depth radiological evaluation of the knee in a large series of NPS patients and describe the typical malformations.

Patients and Methods

Conventional radiological examination of 95 skeletally mature patients with NPS was performed. Patellar morphology was classified according to the Wiberg classification as modified by Baumgartl and Ficat criteria, and trochlear shape was classified according to the Dejour classification.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_4 | Pages 76 - 76
1 Jan 2016
Trabish M
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Hypothesis. The use of cartilage compensated virtual standing CT images for pre surgical planning improves the reliability of preoperative planning. Materials and Method. Sampling included in this study were > 62 years of age (mean age 58.17 yrs ±3.54 yrs, range 55–62) with symptomatic isolated medial osteoarthritis, genu varum (mean varus 5.6°±2.6 °, range 2.1°–8.6°), good range of motion (flexion > 90° and flexion contracture < 10°) and with minimal ligamentous instability. All subjects had obtained a pre-op CT scan, MRI scan and weight-bearing long bone x ray. Post-op CT and long standing x-rays were taken prior to hospital discharge. A virtual software suite (HTO-OP3D, Zapalign Inc, Seoul, Korea) was utilised to determine an optimal osteotomy site, hinge location and a gap necessary to achieve the targeted virtual passing point. Prerequisite to performing the necessary calculations a virtual standing pose for each patient specific bone models was created using the following steps. To transfer the pre surgical plan intra-operatively, a customised alignment jig was manufactured. Results. Analysing the data using three dimensional imagery the femorotibial angle was corrected from a mean varus 5.5° ±2.3 ° (range 2.1°–8.6°) to a mean valgus 4.1° ±1.1° (range 2.9°– 6.1°). There was no statistical difference [p = 0.514] between the virtual simulatedpre-op valgus vs actual post-op valgus results extrapolated from the post op CT data {−0.18° ±0.3° (range −0.7°–1.0°)}. Analysing the same parameters using two dimensional standard X-rays, the femorotibial angle was corrected from a mean varus 6.6° ±2.9 ° (range 3.4°–10.6°) to a mean valgus 3.9° ±1.2° (range 2.9°–6.1°) respectively showing no statistical difference in average change in alignment measured using both modalities [p = 0.13]. The mean opening gap calculated using the three dimensional imagery vs two dimensional were 8.2mm ±2.9mm (range 5mm – 12mm) and 13.3mm ±3.3mm (range 10.2mm – 17.6mm) respectively, the difference between these data sets being statistically different [p = 0.03059]. The post operative evaluation of the posterior slope showed no statistical difference [p = 0.371] between the native slope {11.6° ±3.7° (range 5.3°–15.0°)} vs the post operative tibial slope {11.6° ±3.6° (range 6.2°–16.1°)} respectively indicating that the patients slope was well preserved. Conclusion. The use of patient specific bone model images superimposed into a cartilage compensated full extension simulated weight bearing pose and used to calculate the femorotibial corrective alignment and opening gap produces predictable results that is not influenced by the condition of the patients soft tissue. Corrective angles and opening gap calculations using two dimensional weight bearing X-rays does not always relate to good surgical outcome, primarily due to the influence of laxity on the alignment in standing pose. Furthermore, a patient specific clamping type surgical guide is effective to implement the pre surgical and aid in maintaining the tibial slope


The Bone & Joint Journal
Vol. 96-B, Issue 9 | Pages 1269 - 1273
1 Sep 2014
Kitoh H Mishima K Matsushita M Nishida Y Ishiguro N

Two types of fracture, early and late, have been reported following limb lengthening in patients with achondroplasia (ACH) and hypochondroplasia (HCH).

We reviewed 25 patients with these conditions who underwent 72 segmental limb lengthening procedures involving the femur and/or tibia, between 2003 and 2011. Gender, age at surgery, lengthened segment, body mass index, the shape of the callus, the amount and percentage of lengthening and the healing index were evaluated to determine predictive factors for the occurrence of early (within three weeks after removal of the fixation pins) and late fracture (> three weeks after removal of the pins). The Mann‑Whitney U test and Pearson’s chi-squared test for univariate analysis and stepwise regression model for multivariate analysis were used to identify the predictive factor for each fracture. Only one patient (two tibiae) was excluded from the analysis due to excessively slow formation of the regenerate, which required supplementary measures. A total of 24 patients with 70 limbs were included in the study.

There were 11 early fractures in eight patients. The shape of the callus (lateral or central callus) was the only statistical variable related to the occurrence of early fracture in univariate and multivariate analyses. Late fracture was observed in six limbs and the mean time between removal of the fixation pins and fracture was 18.3 weeks (3.3 to 38.4). Lengthening of the tibia, larger healing index, and lateral or central callus were related to the occurrence of a late fracture in univariate analysis. A multivariate analysis demonstrated that the shape of the callus was the strongest predictor for late fracture (odds ratio: 19.3, 95% confidence interval: 2.91 to 128). Lateral or central callus had a significantly larger risk of fracture than fusiform, cylindrical, or concave callus.

Radiological monitoring of the shape of the callus during distraction is important to prevent early and late fracture of lengthened limbs in patients with ACH or HCH. In patients with thin callus formation, some measures to stimulate bone formation should be considered as early as possible.

Cite this article: Bone Joint J 2014;96-B:1269–73.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 197 - 197
1 Jul 2014
Marmotti A Castoldi F Rossi R Bruzzone M Dettoni F Marenco S Bonasia D Blonna D Assom M Tarella C
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Summary Statement. Preoperative bone-marrow-derived cell mobilization by G-CSF is a safe orthopaedic procedure and allows circulation in the blood of high numbers of CD34+ve cells, promoting osseointegration of a bone substitute. Introduction. Granulocyte-colony-stimulating-factor(G-CSF) has been used to improve repair processes in different clinical settings for its role in bone-marrow stem cell(CD34+ and CD34-) mobilization. Recent literature suggests that G-CSF may also play a role in skeletal-tissue repair processes. Aim of the study was to verify the feasibility and safety of preoperative bone-marrow cell (BMC) mobilization by G-CSF in orthopaedic patients and to evaluate G-CSF efficacy in accelerating bone regeneration following opening-wedge high tibial valgus osteotomy(HTVO) for genu varum. Patients/Methods. 24 patients were enrolled in a prospective phase II trial. The osteotomy gap was filled by a hydroxyapatite-tricalciumphosphate bone substitute(HATriC). Patients were randomised to receive (GROUP A) or not receive (GROUP B) preoperatively a daily dose of 10µg/kg of G-CSF for three consecutive days, with an additional dose 4 hours before surgery. BMC-mobilization was monitored by white blood cell (WBC)-count, flow-cytometry analysis of circulating CD34+cells and Colony-forming cell assays. Patients were evaluated by: Lysholm and SF-36 scores preoperatively and at 1, 2, 3, 6, and 12 months after surgery;. X-ray evaluation preoperatively and at 1, 2, 3, 6, and 12 months after surgery, in order to compare the percentage of osseointegration of the bone-graft junction using the semi-quantitative score of Dallari[1]. CT-scan of the host bone-substitute interface at 2 months, in order to estimate the quality of the newly formed bone at the bone-graft junction by a quantitative measure of bone density (by Hounsfield unit) at the proximal and distal bone-graft junctions. Results. All patients completed the treatment program without major side effects; G-CSF was well tolerated. BMC-mobilization occurred in all Group A patients, with median peak values of 110/µL (range 29–256) of circulating CD34+ve cells. Circulating clonogenic progenitors paralleled CD34+ve cell levels. A significant improvement in the SF-36-Role-Physical scale and in the Lysholm score was recorded at follow-up in Group A compared to Group B(p<0.05). At the X-ray-evaluation, there was a significant increase in osseointegration at the bone-graft junction in Group A at 1, 2, 3 and 6 months post-surgery compared to Group B(p<0.05). CT-scans of the grafted area at 2 months post-surgery showed no significant difference in the quality of the newly formed bone between the two Groups. Discussion/Conclusions. These results suggest that G-CSF can be safely administered preoperatively in subjects undergoing HTVO. In addition, the clinical, radiographic and CT monitoring indicate that preoperative G-CSF administration promotes bone graft substitute osseointegration. Enhanced osseointegration might be the result of the direct activity of G-CSF on the host bone or a cellular effect mediated by bone marrow-derived progenitors mobilised by G-CSF, or by a combination of all these factors. This study is a proof-of-principle that preoperative G-CSF might be an alternative treatment option to enhance bone regeneration in the field of bone marrow stem cell therapy and reconstructive orthopaedic surgery


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 368 - 368
1 Dec 2013
Kazemi SM Mehrabani MB Qoreishi SM Safdari F
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Background:. It has been suggested that double-level osteotomy can prevent the occurrence of joint line obliquity (JLO), as one of the complications following high tibial osteotomy (HTO). In this study, we aimed to compare the preoperative distal femoral and proximal tibial obliquity in patients with primary genu varum with a group of normal subjects (without genu varum). Materials and methods:. 75 patients with primary genu varum and 75 normal persons, contributed to a case-control study. The medial distal femoral mechanical angle (MDFMA), medial proximal tibial mechanical angle (MPTMA), joint diversion angle (JDA) and femoral and tibial JLO were measured and compared between the two groups. The percentage of patients' with > 4 degrees of JLO in both distal of femur and proximal of tibia, were then determined. Results:. The mean of MDFMA and MPTMA were significantly lower and JDA and femoral and tibial JLO were significantly higherin genu varum group (p < 0.05). Double-level osteotomy was required in 25.3% of patients with genu varum to prevent post-operative JLO. Conclusion:. JLO is a common finding in patients with genu varum and normal group; however, it is significantly higher in patients with genu varum


Bone & Joint Research
Vol. 2, Issue 8 | Pages 155 - 161
1 Aug 2013
Mathew SE Madhuri V

Objectives

The development of tibiofemoral angle in children has shown ethnic variations. However this data is unavailable for our population.

Methods

We measured the tibiofemoral angle (TFA) and intercondylar and intermalleolar distances in 360 children aged between two and 18 years, dividing them into six interrupted age group intervals: two to three years; five to six years; eight to nine years; 11 to 12 years; 14 to 15Â years; and 17 to 18 years. Each age group comprised 30 boys and 30 girls. Other variables recorded included standing height, sitting height, weight, thigh length, leg length and length of the lower limb.