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Bone & Joint Research
Vol. 6, Issue 5 | Pages 307 - 314
1 May 2017
Rendon JS Swinton M Bernthal N Boffano M Damron T Evaniew N Ferguson P Galli Serra M Hettwer W McKay P Miller B Nystrom L Parizzia W Schneider P Spiguel A Vélez R Weiss K Zumárraga JP Ghert M

Objectives

As tumours of bone and soft tissue are rare, multicentre prospective collaboration is essential for meaningful research and evidence-based advances in patient care. The aim of this study was to identify barriers and facilitators encountered in large-scale collaborative research by orthopaedic oncological surgeons involved or interested in prospective multicentre collaboration.

Methods

All surgeons who were involved, or had expressed an interest, in the ongoing Prophylactic Antibiotic Regimens in Tumour Surgery (PARITY) trial were invited to participate in a focus group to discuss their experiences with collaborative research in this area. The discussion was digitally recorded, transcribed and anonymised. The transcript was analysed qualitatively, using an analytic approach which aims to organise the data in the language of the participants with little theoretical interpretation.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 161 - 161
1 Mar 2009
Galli M Pitocco D Ruotolo V Mancini L Collina M Chinni C Visci F Caputo S Ghirlanda G
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Background: The pathogenesis of CN is still unknown. An increase of the bone blood supply seems to be one of the mechanisms involved. A feature of CN is a bone reabsorption. IGF-1 can influence the bone tissue by various mechanisms but its vasodilatory effects in others tissues are well-known. Alendronate have an inhibitory effect on bone reabsorption. Aim of this study is to evaluate the effect of alendronate on foot bone density in CN and above all if this effect can be mediated by a modification in IGF-1 levels.

Methods: Twenty patients with a diagnosis of acute CN of the foot were enrolled. According to the randomization, 11 patients were treated with 70 mg of alendronate per os once a week (TG) and 9 patients were followed as control group (CG). Markers of bone turnover [urinary hydroxyprolin, serum collagen carboxyl-terminal telopeptide of type 1 collagen (ICTP), serum bone alkaline phosphatase (B-ALP)], IGF-1 and BMD by dual energy X-ray absorptiometry (DEXA).

Results: ICTP didn’t show significant difference between the two groups (0,54±0,05 ng/ml vs 0,56±0,06 ng/ml p< 0,6) at the outset, after six months the treated group had a significant decrease of this parameter (0,54±0,05 ng/ml vs 0,30±0,03 ng/ml p< 0,05).

In TG hydroxyprolin followed the same trend showing a significant decrease after the six month treatment (18±3,2 mg/l vs 13±3,6 mg/l p< 0,05).

At the same time B-ALP reduction was almost significant (36±4,8% vs 23±3,9% p=0,06)

DEXA demonstrated an improvement in total foot mineralization in the TG(0,18±0,06 g/cm2 vs 0,24±0,08 g/cm2 p< 0,05) and in the distal phalanxes (0,194 g/cm2 vs 0,242 g/cm2 p< 0,01) (fig. 3). Only the TG showed a significant decrease of IGF-1 throughout the trial (142,8±24 vs 123,5±41 ng/ml p< 0,05).

Conclusions: The increase in bone blood flow could be linked to the vascular effects of IGF-1. Alendronate in acute phase helps to stop bone reabsorption and this effect could be mediated by the decrease of IGF-1 levels.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_III | Pages 419 - 419
1 Oct 2006
Maccauro G Galli M Cerciello S Vasso M Nizegorodcew T
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Lateral unstable fractures of the femoral neck represent a controversial problem for the surgical treatment, due to the difficulty in achieving an adequate mechanically stable bone-devices system. Compression hip screw alone has proven to be inadequate, while in association with the trochanteric stabilizing plate (TSP) it offers better results. The authors analyse functional results and complications of a series of 87 lateral unstable fractures of the femoral neck (type A2 and A3 of the AO classification). Weight bearing was allowed 48 hours after surgery. The most important complications reported were: persistent trochanteric pain (12 cases) shaft medialization and device mobilization (2 cases) shortening of more than 2cm (3 cases). All complications were reported in A3 type fractures. Our data confirm the efficacy of the TSP the treatment of lateral unstable fractures of the femoral neck (type A2) because it stabilizes the lateral cortex. In A3 type fractures, intramedullary devices offers better results than compression hip screw and TSP in terms of complications rate and stability.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 23 - 23
1 Mar 2006
Galli M Mancini L Pitocco D Ruotolo V Vasso M Ghirlanda G
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Aim: Evaluation of multifactorial treatment of Charcot foot disease in diabetic patients

Materials and Method: We followed 25 diabetic patients with Charcot foot in acute phase (Eichenholtz Stage I) from 2001 to 2003 (mean follow-up 22 months) admitted to the Day Hospital of Diabetology of the Catholic University of Rome. All patients presented a good vascularization (ABI > 0.9) and osteomielytis was excluded by means of 111Indium labelled leukocyte scintigraphy.

Six patients presented a structural derangement localized to the forefoot (Pattern I according to Sanders and Frykberg Classification), one to the ankle (Pattern IV) and 18 to the mid-foot region (Pattern II and III). At first clinical evaluation, 13 patients presented a plantar monolateral ulcer. Their treatment was multifactorial. An offloading regimen was adopted, with the use of a total contact cast and crutches, in order to avoid weight-bearing on the affected foot for the first two months. Patients responsive to the treatment were successively treated with a pneumatic cast (Air cast) and partial weight-bearing for another four months. Four unresponsive patients underwent surgical treatment. 10 patients were also treated with alendronate (70 mg per os once a week). Three patients died during treatment and one during the follow-up, three of them for cardiovascular disease, one for bronchopneumopathy.

Results: All patients reached the quiescent or chronic phase (Eichenholtz Stage III) at an average of six months from the onset of the treatment (range 3 to 9 months). No major or minor amputation was performed. Multifactorial treatment prevented the development ulcers in all patients that started the treatment without this complication (12 patients). 7 out of 13 ulcerated patients developed a recalcitrant ulcer (unresponsive to medical and orthotic treatment). 4 patients underwent surgical treatment: midfoot arthrodesis with Ilizarov external fixation (2 patients), rockerbottom deformity resection (one patient), Lelievre realignment (one patient). 3 patients healed after surgical treatment. Thus an overall amount of 9 out of 13 ulcerated patients healed after multifactorial treatment.

Conclusions: Multifactorial treatment demonstrated effective in the management of Charcot foot in diabetic patients. Medical and orthotic treatment alone is effective in preventing complication throughout the natural history of the disease. Medical and orthotic treatment alone is frequently unsuccessful in treating plantar ulcers when major deformities has already developed. Medical and orthotic treatment combined with surgical treatment demonstrated an increased percentage of success.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 338 - 339
1 Mar 2004
Rosa M Galli M Gambino G De Santis V Caruso A
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Aim: This study evaluated the complication rate and surgical outcome following medial femoral neck fractures, in elderly patients over 75 y, treated by biarticu-lar endoprosthesis. Methods: We followed prospectively 100 patients over 75 years old consecutively operated in our department of clinical orthopaedics at Catholic University of Rome for subcapital femoral fractures graded as Garden 3 or 4. In the study were also included patients affected by senile dementia and Parkinson disease. Patients were operated on by several surgeon of different experience in the þeld, we evaluated the time needed for the intervention, blood loss, survival rate at 1 months. Outcome was evaluated on the basis of walking recovery rate and pain. Bed ridden patients were evaluated only for residual pain after surgery. Results: Mean time interval between trauma and surgery has been 3,96 days. The intervention lasted 45 minutes in average (range 35 Ð 70 minutes). Blood loss has been limited. Return to walking with assistance has been achieved in fourth postoperative day. Pain disappeared in almost every patient. Dislocation of prosthesis was observed in 2 patients. Survival rate at one month was 89%.,Conclusions: Biarticular endoprosthesis in our experience demonstrated to be an effective mean for treatment in the elderly patients and above all in the neurological patients.