Ultra-high molecular weight polyethylene (UHMWPE) can provide local sustained delivery of therapeutics1,2. For example, it can deliver analgesics to address post-arthroplasty pain2. Given that several analgesics, such as bupivacaine (anesthetic) and tolfenamic acid (NSAID), were shown to possess antibacterial activity against Bupivacaine and tolfenamic acid were incorporated into UHMWPE via phase-separated compression molding. Drug release from the prepared samples was measured using high-performance liquid chromatography. Antibacterial studies of the obtained materials were conducted against methicillin-sensitive, and methicillin-resistant Introduction
Methods