Advertisement for orthosearch.org.uk
Results 1 - 18 of 18
Results per page:

Introduction. Achilles Tendon Rupture (ATR) is a prevalent injury in Western society. Much of the recent research has focused on measuring surgical methods and strength regained, rather than practical measures such as Return to Sport (RTS). A large systematic review was published in 2016 setting a benchmark RTS as 80%. The aim of this systematic review was to provide an up-to-date RTS following ATR. Methods. PubMed and SPORTdiscuss databases were used to search for eligible studies published since 2017 that focused on closed Achilles tendon ruptures with clear definitions of return to sport and a minimum length of follow-up. The Newcastle-Ottawa grading tool was used to assess risk of bias in all included studies. Results. Of 15 articles identified, 9 were ‘good’ and 6 were ‘fair’ after bias assessment, with none excluded for being poor. Return-to-sport (RTS) rate following Achilles tendon rupture was 76.76% (95% CI 74.19, 79.34 P= <0.001). Non-professional athletes had a higher RTS rate (78.29%; 95% CI 74.89, 81.68 P= <0.001) than professional athletes (74.91%; 95% CI 70.98, 78.85 P= <0.001). Surgical intervention resulted in a lower RTS rate (74.17%; 95% CI 70.74, 77.60 P= <0.001) than conservative management (70.00%; 95% CI 60.48, 79.52 P= <0.001). Conclusion. These findings highlight the need to identify factors affecting RTS rates, including the type of management, level of sport, and patient-specific factors. Clinicians can use these findings to guide informed shared decision-making with patients regarding the long-term implications of ATR and to develop more targeted rehabilitation strategies for this injury


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_11 | Pages 16 - 16
1 Nov 2022
Garg P Ray P
Full Access

Abstract. Introduction. FHL transfer for management of chronic Achilles' tendon ruptures is done both open and endoscopically. But there are no published studies comparing open and endoscopic results. Our study aims to compare them and determine the suitability of these methods. Materials and methods. Fourteen patients were treated endoscopically while 26 with an open technique. Of the 26, fourteen had an open Achilles tendon repair and FHL transfer while 12 has only open FHL transfer. All the endoscopic patients had only an FHL transfer. We compared demographics, complications of the procedure, recovery times, return to work and strength after 1 year. We noted ATRS at 6 months and 1 year for all three groups. We also conducted an MRI scan of three patients each of the three groups to determine the state of Achilles tendon and FHL tendon after 1 year of surgery. Results. There were similar complication rates for both the only FHL groups but the open FHL + Achilles' repair had more complications both for wound complications and saphenous neuropraxia. The recovery time, return to work and ATRS at 6 months was better for the endoscopic group as compared to both open groups. The strength and ATRS at 1 year were similar for all three groups. Conclusion. Endoscopic FHL transfer is safe and provides earlier return to work and better 6 months patient satisfaction then the open method. It also has less post op complications than open FHL + Achilles tendon repair, while maintains the same strength after 1 year


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 8 - 8
1 Jan 2013
Khan Y Stables G Iqbal H Barnes S
Full Access

Background. A large number of Tendo-Achilles (TA) injuries occur during sporting activity. Typically occurring in males aged 30–50, whom occasionally undertake sporting activities, the so called ‘weekend warriors’. Aims. To assess the impact of TA rupture on return to sporting activity in the non-elite athlete. Methods. Single unit 5 year retrospective analysis of TA rupture patients. Clinical notes were reviewed and a telephone interview was conducted using a designed questionnaire. Results. 68 patients were identified, 39 responded of which 25 were male and 14 were female. The mean age was 46 years with an age range of 17–77 years. Sporting activity was the major cause of rupture, causative in 27/39 patients, 84% of males and 43% of females. A third of patients had only just returned to the causative sport. In males, football contributed the most injuries, 48%, however for females, badminton contributed the highest number, 67%. 23 patients did not return to their pre-injury sporting activity level. Of these patients, 87% stopped the causative sport completely, 22% stopped sporting activity altogether with 78% returning to sport at a lower level, reducing both the intensity and variety. 20/23 of these patients were treated operatively. Reasons given for a reduction in sporting activity were a “real worry” of re-rupture, 83%, and a “loss of confidence” caused by the injury, 74%. Other reasons were related to pain in the Achilles, 65%, and “previous plans” to reduce level of activity anyway, 35%. Conclusion. Many patients cite the ability to return to sport as a reason for operative intervention. Our study highlights that many patients do not return to sports at all, with those that do, a significant number return at a lower level of intensity, irrespective of treatment. This information could be useful when assessing treatment options in the non-elite athlete


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_II | Pages 101 - 101
1 Feb 2012
David S Kotnis R Ostlere S Willett K
Full Access

If the lower re-rupture in operative treated patients was an effect of tendon-end apposition, then patients in whom that could be demonstrated in equinus by ultrasound could be equally well treated non-operatively without the attendant surgical risk. All patients undergoing ultrasound for a suspected Achilles tendon repair between January 2000-2005 were included. Patients with a residual gap, 5mm or more in equinus; were treated by surgical repair. Those with a gap of less than 5mm were treated non-operatively. We excluded patients with no rupture, partial rupture and musculo-tendinuous junction (MTJ) tears. We recorded the following: clinical findings, ultrasound measurements of tendon gap in neutral and equinus, distance of rupture from distal insertion, the treatment and complications. All patients were followed up to a minimum of 6 months. 156 patients were treated for a clinical Achilles tendon rupture during the study period. We excluded 5 patients with no rupture on ultrasound, 15 with a MTJ tear, 7 with a muscle tear and 4 patients did not follow the protocol. 125 patients comprising 88 males and 37 females were entered into the study. 67 patients were treated operatively (37 open, 30 percutaneous) and 58 non-operatively. There was no significant difference between the 2 groups with respect to age, sex and injury mechanism. Two patients in the non-operative group had a re-rupture (3.4%) compared with 1 (1.5%) in the non-operative group. There were 2 incidences of superficial wound infection and 2 of temporary dorsal foot numbness in the operative. One patient in the non-operative group had a DVT. There was no significant difference for any of the complications between the two groups. It may be possible to reduce the risk of re-rupture and surgery using dynamic ultrasound to determine which treatment the patient receives


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_12 | Pages 61 - 61
1 Dec 2022
Zhu S Ogborn D MacDonald PB McRae S Longstaffe R Garofalo J
Full Access

While controversy remains as to the relative benefit of operative (OM) versus non-operative management (NOM) of Achilles tendon ruptures (ATR), few studies have examined the effect on high impact maneuvers such as jumping and hopping. The purpose of this study is to compare functional performance and musculotendinous morphology in patients following OM or NOM for acute ATR. Eligible patients were aged 18-65 years old with an ATR who underwent OM or NOM within three weeks of injury and were at least one-year post injury. Gastrocnemius muscle thickness and Achilles tendon length and thickness were assessed with ultrasound. Functional performance was examined with single-leg hop tests and isokinetic plantar strength at 60o/s and 120o/s. 24 participants completed testing (12/ group). Medial (OM: 2.2 ± 0.4 cm vs 1.9 ± 0.3 cm, NOM 2.15 ± 0.5 cm vs 1.7 ± 0.5 cm; p = 0.002) and lateral (OM 1.8 ± 0.3 cm vs 1.5 ± 0.4 cm, NOM 1.6 ± 0.4 cm vs 1.3 ± 0.5 cm; p = 0.008) gastrocnemius thickness were reduced on the affected limb. The Achilles tendon was longer (OM: 19.9 ± 2.2 cm vs 21.9 ± 1.6 cm; NOM: 19.0 ± 3.7 cm vs 21.4 ± 2.9 cm; p = 0.009) and thicker (OM: 0.48 ± 0.16 cm vs 1.24 ± 0.20 cm; NOM: 0.54 ± 0.08 cm vs 1.13 ± 0.23 cm; p < 0.001) on the affected limb with no differences between groups. Affected limb plantar flexion torque at 20o plantar flexion was reduced at 60o/s (OM: 55.6 ± 20.2 nm vs 47.8 ± 18.3 nm; NOM: 59.5 ± 27.5 nm vs 44.7 ± 21.0 nm; p = 0.06) and 120o/s (OM: 44.6 ± 17.9 nm vs 36.6 ± 15.0 nm; NOM: 48.6 ± 16.9 nm vs 35.8 ± 10.7 nm; p = 0.028) with no group effect. There was no difference in single leg hop performance. Achilles tendon length explained 31.6% (p = 0.003) and 18.0% (p = 0.025) of the variance in plantar flexion peak torque limb symmetry index (LSI) at 60o/s and 120o/s respectively. Tendon length explained 28.6% (p=0.006) and 9.5% (p = 0.087) of LSI when torque was measured at 20o plantar flexion at 60o/s and 120o/s respectively. Conversely, tendon length did not predict affected limb plantar flexion peak torque (nm), angle-specific torque at 20o plantar flexion (nm) and affected limb single leg hop distance (cm) or LSI (%). There was no difference in tendon length between treatment groups and deficits in gastrocnemius thickness and strength are persistent. Deficits in the plantar flexion strength LSI are partially explained by increased tendon length following Achilles tendon rupture, regardless of treatment strategy. Hop test performance is maintained and may be the result of compensatory movements at other joints despite persistent plantarflexion weakness


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_32 | Pages 2 - 2
1 Sep 2013
Al-Mouazzen L Rajakulendran K Fry-Selwood D Ahad N
Full Access

The management of acute tendo-Achilles (TA) rupture still divides orthopaedic opinion. The advent of minimally invasive endoscopic or percutaneous techniques is thought to allow faster rehabilitation. We report the outcome of 30 patients with acute TA ruptures that have undergone percutaneous repair followed by an accelerated rehabilitation programme with early weight-bearing. A single centre, prospective cohort study was undertaken. 30 patients (21 men, 9 women; mean age: (40±9 years) with an acute TA rupture were enrolled and followed-up for an average of 12.5±2.9 months. All operations were performed under local anaesthesia, using a modified percutaneous technique, within 2 weeks of injury. Following surgery, patients were immobilised in an equinus cast for only 2 weeks then allowed to weight bear through a walker boot with 3 heel wedges, which were removed sequentially over a 6-week period. A standardised physiotherapy programme was started 2 weeks post-operatively and continued until 4 months. The primary outcome measure was the TA re-rupture rate and the Achilles tendon Total Rupture Score (ATRS) at 3 and 6 months. There were no re-ruptures in the study group. The mean 3- and 6-month ATRS was 57.75 and 86.95 respectively. This improvement was statistically significant (p<0.001). All patients were able to fully weight bear on the operated leg by the eighth week, without the walker boot. At the 6-month follow-up, the average satisfaction rate was 87±7.5%. Patients returned to their pre-rupture sports at an average of 10.4±3 months. The results of this study demonstrate that minimally invasive repair of acute TA ruptures, combined with an accelerated rehabilitation programme provides a safe and reproducible treatment option


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_II | Pages 100 - 100
1 Feb 2012
Costa M Chester R Shepstone L Robinson A Donell S
Full Access

The aim of this study was to compare immediate weight-bearing mobilisation with traditional plaster casting in the rehabilitation of non-operatively treated Achilles tendon ruptures. Forty-eight patients with Achilles tendon rupture were randomised into two groups. The treatment group was fitted with an off-the-shelf carbon-fibre orthotic and the patients were mobilised with immediate full weight-bearing. The control group was immobilised in traditional serial equinus plaster casts. The heel raise within the orthotic and the equinus position of the cast was reduced over a period of eight weeks and then the orthotic or cast was removed. Each patient followed the same rehabilitation protocol. The primary outcome measure was return to the patient's normal activity level as defined by the patient. There was no statistical difference between the groups in terms of return to normal work [p=0.37] and sporting activity [p=0.63]. Nor was there any difference in terms of return to normal walking and stair climbing. There was weak evidence for improved early function in the treatment group. There was 1 re-rupture of the tendon in each group and a further failure of healing in the control group. One patient in the control group died from a fatal pulmonary embolism secondary to a DVT in the ipsilateral leg. Immediate weight-bearing mobilisation provides practical and functional advantages to patients treated non-operatively after Achilles tendon rupture. However, this study provides only weak evidence of faster rehabilitation


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_17 | Pages 7 - 7
1 Nov 2017
Santhapuri S Foley R Jerrum C Tahmassebi R
Full Access

Treatment of Tendo Achilles (TA) ruptures can result in considerable morbidity and has significant socio-economic implications. The ideal management of these injuries has yet to be defined. Recent studies have demonstrated that non-surgical treatment with accelerated rehabilitation may have comparable outcomes to surgery. The aim of this study was to evaluate current management and outcomes of TA ruptures at a tertiary referral centre, with a view to developing contemporary treatment guidelines. A retrospective review of TA ruptures over a 12-month period was undertaken. Patients were managed on an individual based approach with no strict management algorithm followed. Data collection included pre-injury activity level, ultrasound findings and treatment methodology. Outcome data collected included return to activity, incidence of DVT and re-rupture. Patients were followed up for an average of 2 years. Data was collected in 49 patients. 31 (63%) of these were managed non-surgically. Ruptures were most common in men (65%) at an average age of 44 yrs. Ultrasound scan at initial diagnosis was performed in 28 patients. There was an average gap in equinus of 34mm in the surgical group, while the average gap within the non-surgical group was 24mm (p=0.23). There was no association between the gap observed on ultrasound and re-rupture rate. At a median of 2 year follow up, there was no significant reduction in average time spent immobilised in a below knee splint in the surgically treated group (10.2 weeks) compared to non-surgical group (10.9 weeks, p=0.35). 86.3% of patients returned to pre-injury level of activity in the non-surgical group and 86.7% in the surgery group (p=1.0). Complications within this patient cohort consisted of one superficial wound infection and one re-rupture, both occurring within the surgical group. Within the surgical group patients were treated with direct primary repair or primary reconstruction using FHL augmentation in cases of delayed presentation. DVT was not observed in either group. Only 22.6% received thromboprophylaxis in non-surgical group compared to 61.1% in surgical group. We observed that patients within the non-surgical group demonstrated the same return to pre-injury activity as the surgically treated group and had fewer complications. The time spent immobilised was also comparable. Based on these findings, we modified guidelines and now recommend that surgery should be limited to patients with gap of greater than 20 mm in full equinus on ultrasound and in those with delayed diagnosis. We also recommend thromboprophylaxis for 2 weeks in non-surgical group


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIV | Pages 15 - 15
1 Jul 2012
Wright J Gardner K Osarumwense D James L
Full Access

Treatment of acute Achilles tendon rupture is based on obtaining and maintaining apposition of the ruptured tendon ends. Surgical treatment utilises direct suture repair to produce this objective, while conservative or non-surgical management achieves the same effect of closing the tendon gap by immobilisation of the ankle joint in a plantar flexed position within a plaster cast or POP. There is still variability in the conservative treatment practices and protocols of acute Achilles tendon ruptures. The purpose of this study is to examine the current practice trends in the treatment of Achilles tendon ruptures amongst orthopaedic surgeons in the UK. A postal questionnaire was sent to 221 orthopaedic consultants in 25 NHS hospitals in the Greater London area in June 2010. Type and duration of immobilisation were considered along with the specifics of the regime used. Ninety questionnaires were returned giving a 41% response rate. Conservative treatment methods were used by 72% of respondents. A below knee plaster was the top choice of immobilisation (83%) within this group. The mean period of immobilisation was 9.2 weeks (Range 4-36). Weight bearing was allowed at a mean of 5.3 weeks (range 0-12). The specific regime used by consultants was quite heterogeneous across the group, however the most used immobilisation regimen was a below knee plaster in equinus with 3 weekly serial plaster changes to a neutral position, for a total of nine weeks. A heel raise after plaster removal was favoured by 73% of respondents used for a mean period of 6.4 weeks (Range 2-36). In response to ultrasound use as a diagnostic tool, 42.4% of respondents would never use it, 7.6% would use it routinely, while 50% would use it only according to the clinical situation. Comparison of foot and ankle specialists with non-specialists did not reveal a significant difference in practice in duration of immobilisation or time to bearing weight. Conservative management remains a widely practice option in the treatment of Achilles tendon ruptures. Although there are available a number of modern walking aids, the concept of functional brace immobilisation is not as widely used as below knee plaster cast immobilisation, which remains a popular choice amongst orthopaedic surgeons today. There is still no consensus on the ideal immobilisation regimen although a below knee plaster in equinus with serial changes for a total of nine weeks is the most frequently used choice. Further randomised controlled trials are required to establish the optimal treatment strategy for conservative management of Achilles tendon rupture


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_18 | Pages 16 - 16
1 Apr 2013
Dunkerley S Goubran A Clark L Talbot N Sharpe I
Full Access

There are longstanding debates regarding surgical versus conservative management of Achilles tendon ruptures, however there is limited focus on rehabilitation. A specific rehabilitation programme was initiated in 2008 to unify management and improve patient outcomes. We present the results at three and a half years. In October 2008 management was streamlined under the foot and ankle surgeons and a dedicated physiotherapy service. Operative management used mainly the Achillon device (Integra) and VACOped boot with a specific rehabilitation protocol. We prospectively collected data on all patients with Achilles tendon ruptures from October 2008 to March 2012. There were 246 patients in total with four lost to follow up. 80 were treated with the Achillon system, 18 had an open repair and 144 were treated conservatively (of which 56 were partial or musculocutaneous junction tears). Three patients sustained re-rupture (1.2%), all initially treated conservatively. There were two operative complications (2%), both wound breakdowns. Two patients suffered PE's (0.8%), confirmed on VQ scan or CTPA (one operative, one conservative). One non-compliant patient healed functionally long and required a shortening procedure. The authors experience has been that using the VACOped boot with our custom rehabilitation programme in dedicated physiotherapy clinics has produced excellent results


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 221 - 221
1 Jan 2013
Heaver C Pradhan A Carmont M
Full Access

Background. Recent meta-analyses have shown reduced re-rupture rates for the surgical management of Achilles ruptures. However percutaneous repair has been demonstrated to lead to improved function, patient satisfaction but greater complications than open repair. In the current economic climate, we believe it is reasonable to consider the financial cost of rupture management for both the patient and the provider. We aimed to determine the cost effectiveness of operative treatment of ruptures of the Achilles tendon based upon theatre occupancy, clinic attendance and cast changes, operative complications and functional assessment score. Methods. We audited the cost effectiveness of the surgical management of Achilles tendon ruptures between 2005–2011 in our unit by comparing 49 patients receiving percutaneous repair to 35 patients whom had open repairs (Retrospective cohort study level 3). Results. There was no significant difference in complications between the two surgical techniques: (Open vs. Pc) overall rates 14.3% vs. 10.4%: infection; 2.7% vs. 2.0%, transient sural nerve damage: 5.6% vs. 8.1%, wound breakdown: 2.8% vs. 0.0%, re-rupture: 2.8% vs. 2.0%. Achilles Total Rupture Scores (ATRS) were comparable (Open 89 (65–100) at 49 months vs. Pc 88.8 (33–100) at 12 months (P=0.9). Theatre occupancy (P< 0.00) and hospital stay (P< 0.00) were significantly longer with open repair (43 mins (26–70) and 2.9 days (0–4)) compared to Pc repair (15 mins (12–43) and 1.2 days (0–2)). Excluding the costs of running the operating theatre we have estimated the costs of surgery for open repair to be £935.36 and percutaneous repair to be £574.04. Conclusions. This study suggests that percutaneous repair of the Achilles tendon resulted in reduced costs and yet had comparable outcome and complications rates to open repair in surgical management of the Achilles tendon. We recommend that percutaneous repair should be considered as the primary method of cost effective surgical management of Achilles tendon rupture


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_18 | Pages 15 - 15
1 Apr 2013
Daoud M Jabil E Ball T Kincaid R
Full Access

Since NICE issued guidance on preventing venous thromboembolism (VTE), the use of chemoprophylaxis has increased dramatically in trauma and orthopaedics. However, enthusiasm is tempered by a lack of data regarding the true incidence of VTE in everyday practice. We investigated the epidemiology of VTE among ambulatory patients with lower limb injuries within our Trust. We identified all patients who suffered pulmonary embolism (PE) or deep vein thrombosis (DVT) over an 18 month period, and cross-referenced them with our trauma database. All lower limb injuries were included, whether operated or not. Hip fractures routinely receive dalteparin and were excluded. There were 11,594 new attendances or post-operative attendances in all fracture clinics over 18 months. Of these, 4530 had lower limb injuries and were immobilised. There were 21 DVTs and 7 PEs in these patients, an incidence of 0.43% and 0.14% respectively. Of note, three DVTs were in patients with Achilles tendon rupture. The incidence of symptomatic VTE is low in a population of ambulant patients with lower limb injuries in casts, without chemical thromboprophylaxis. Prophylaxis for VTE would thus have a large number needed to treat. The costs and complications of chemoprophylaxis should also be considered before it is introduced universally


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_19 | Pages 31 - 31
1 Apr 2013
Basu I Gulati A Aziz S Flyn J
Full Access

Introduction. Achilles tendinosis results from a chronic degenerative process within the tendon. Topaz micro-debridement aims to restore the degenerate micro-architecture within the tendon reducing painful symptoms experienced by patients. Topaz micro-debridement has been used to successfully treat upper limb tendinopathies but its application to tendinopathies of the foot and ankle is relatively new. This study aims to assess the functional outcomes following topaz radiofrequency micro-debridement for Achilles tendinosis. Materials/Methods. All cases of topaz micro-debridement for Achilles tendinosis were identified from hospital records spanning a five year period. VISA-A assessment questionnaires were sent to these patients to assess the patients functional status pre and post-surgery. Patients were asked to comment on their overall satisfaction and to report any complications they had experienced. Eight responses were received and included in analysis. Hospital records and imaging results were investigated for those that responded. Results. Average VISA-A scores improved from 18/100 to 63/100. The difference between the pre and post-surgery group was significant at the 0.02% level. All cases demonstrated objective improvement in functional outcome. Seven cases reported overall satisfaction but one was complicated by Achilles tendon rupture seven weeks following the procedure. This is the second reported case of rupture noted in current literature. Conclusion. This study confirms topaz micro-debridement is an excellent treatment for Achilles tendinosis, but that rupture is a real risk which persists for at least two months following the procedure. We would therefore recommend the procedure with a suitable period of rehabilitation to ensure full recovery


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIX | Pages 58 - 58
1 Sep 2012
Young A Evans S
Full Access

This study was undertaken to assess for equivalence or superiority in tendon reconstruction techniques. This is an in vitro analysis of several, different, reconstruction techniques for chronic Achilles tendon ruptures. The surgical techniques have been borne out of surgical preference rather than biomechanical principles with little published research into their comparability. Surgical preferences are a result of the supposed benefits of reduced operative time, single operative incision and decreased morbidity. An animal model, after human cadaveric tissue dissection to guide the specimen construction, was used to compare the different techniques using bovine bone and tendon and tested using a material testing machine. Ultimate load to failure was recorded for all specimens and statistical analysis of the results was undertaken. A statistically significant difference was shown between all the techniques by analysis of variance. This will guide clinical application of these techniques. The use of bone tunnels, through which the flexor hallucis longus tendon can be passed, were found to be biomechanically superior, with regard to ultimate load to failure, to either bone anchors or end-to-end tendon suture techniques. Interference screws were found to have a large range in their ultimate load suggesting a lack of consistency in the results. The mean of the bone tunnel group (482.8N, SD 83.6N) is significantly (p < 0.01) higher than the mean of the bone anchor group (180.2N, SD 19.3N), which is, in turn, significantly (p < 0.01) higher than the mean of the Bunnell group (73.7N, SD 20.9N). This study is larger than any previous study found in the literature with regard to number of study groups and allows the techniques to be compared side by side


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 178 - 178
1 Jan 2013
Alsousou J Franklin S Thompson M Harrison P Willett K
Full Access

Purpose. Platelet-Rich Plasma (PRP), an autologous derivative of whole blood that contains a supraphysiological concentration of platelets and growth factors. Most published studies have investigated the effect of PRP-conditioned media on cell cultures. We are not aware of any study that has investigated whole PRP with its cellular components on human tissue cultures. This study aims to investigate the effect of PRP on cell migration from human Achilles tendon explants, and the subsequent cellular proliferative effects in culture. Methods. This is an in-vitro study on tendon explants obtained from Achilles tendon rupture patients. The samples were collected in sterile DMEM F12 solution then carefully cut into approximately 1–3mm. 3. sections. Tendon explants were cultured in three media types: 1. 100% PRP; 2. 50% PRP; and 3. 50% fetal calf serum (FCS). 1 and 2 were made up using DMEM F12 media (standard culture medium). Explants and cells were incubated at 37°c in 5% CO. 2. for 48 hours. Results. Images of the explanted tissue were taken using a Nikon TE300 microscope with Retiga CCD camera and cells around each explant were counted. Kruskal-Wallis statistical test showed that 100%PRP and 50%PRP cultured explants have significantly higher number of cells (p ≤0.002 and 0.028 respectively) when compared with 50%FCS cultured explants. Ziva ultrasensitive proliferation assay revealed that 100%PRP significantly increased cell proliferation. In addition, PicoGreen assay showed that DNA content of 100% PRP cultured cells were significantly higher than the control. The concentration of TGF-b1, VEGF, PDGF-AB and IGF-1 growth factors were significantly higher in PRP comparing to 50% FCS medium. Conclusion. Our findings show that whole PRP strongly affect the behaviour of human tenocytes, indicating that PRP may have potential role as an orthobiological agent in ruptured tendon treatments


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 89 - 89
1 May 2012
J. A J. L E. M M. T A. N K. W
Full Access

Functional Ultrasound Elastography (FUSE) of Tendo Achilles is an ultrasound technique utilising controlled, measurable movement of the foot to non-invasively evaluate TA elastic and load-deformation properties. The study purpose is to assess Achilles tendons, paratenon and bursa mechanical properties in healthy volunteers and establish a clinical outcome tool for TA treatment. We studied 40 Achilles tendons in healthy volunteers using our novel Elastography method, which we developed in the University of Oxford. US scan device (Z.one, Zonare Medical System Inc., USA, 8.5 MHz) with and without the Oxford isometric dynamic foot and ankle mover were used. Tendon insertion, midportion and musculotendinous junction were examined during lateral movement and axial compression/decompression modes. B mode and elasticity images were derived from the raw ultrasound radio frequency data. The anatomical structures mechanical properties were evaluated by a semi-quantitative score of different colours representing stiff tissue (blue) to more soft tissue (green, yellow, red). The Achilles tendons showed mainly a hard structured pattern on sonoelastography. Compression/decompression modes are best used to demonstrate axial softening, while longitudinal displacement is best used to assess load transfer. The average strain along the tendon was 2% (range 0-6%). The overall correlation (?) between real-time sonoelastography and ultrasound findings was < 0.3. However, the correlation (?) between FUSE UEI and US findings was 1.0. Our findings show that FUSE seems to be a sensitive method for assessment of TA mechanical properties. The B mode and elasticity images must be viewed simultaneously. Elasticity and stiffness measurement may offer an invaluable tool to guide TA rupture and tendonopathy treatment and rehabilitation protocol


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XLI | Pages 96 - 96
1 Sep 2012
van Dijck S Young S Patel A Zhu M Bevan W Tomlinson M
Full Access

Acute achilles tendon ruptures are increasing in incidence and occur in 18 per 100 000 people per year, however there remains a lack of consensus on the best treatment of acute ruptures. Randomised studies comparing operative versus non-operative treatment show operative treatment to have a significantly lower re-rupture rate, but these studies have generally used non-weight bearing casts in the non-operative group. Recent series utilizing more aggressive non-operative protocols with early weight-bearing have noted a far lower incidence of re-rupture, with rates approaching those of operative management. Weight bearing casts may also have the advantages of convenience and an earlier return to work, and the purpose of this study was to compare outcomes of traditional casts versus Bohler-iron equipped weight-bearing casts in the treatment of acute Achilles tendon ruptures. 83 patients with acute Achilles tendon ruptures were recruited from three Auckland centres over a 2 year period. Patients were randomised within one week of injury to receive either a weight-bearing cast with a Bohler iron or a traditional non weight-bearing cast. A set treatment protocol was used, with a total cast time of eight weeks. Patients underwent detailed muscle dynamometry testing at 6 months, with further follow up at 1 year and at study completion. Primary outcomes assessed were patient satisfaction, time to return to work, and overall re-rupture rates. Secondary outcomes included return to sports, ankle pain and stiffness, footwear restrictions, and patient satisfaction. There were no significant differences in patient demographics or activity levels prior to treatment. At follow up, 1 patient (2%) in the Bohler iron group and 2 patients (5%) in the non weight bearing group sustained re-ruptures (p=0.62). There was a trend toward an earlier return to work in the weight-bearing group, with 58% versus 43% returning to work within 4 weeks, but the difference was not significant. 63% of patients in the weight bearing group reported freedom from pain at 12 months compared to 51 % in the non weight bearing group. There were no statistically significant differences in Leppilahti scores, patient satisfaction, or return to sports between groups. Weight-bearing casts in the non-operative treatment of Achilles tendon ruptures appear to offer outcomes that are at least equivalent to outcomes of non-weight bearing casts. The overall rerupture rate in this study is low, supporting the continued use of initial non-operative management in the treatment of acute ruptures


Bone & Joint Research
Vol. 3, Issue 6 | Pages 193 - 202
1 Jun 2014
Hast MW Zuskov A Soslowsky LJ

Tendinopathy is a debilitating musculoskeletal condition which can cause significant pain and lead to complete rupture of the tendon, which often requires surgical repair. Due in part to the large spectrum of tendon pathologies, these disorders continue to be a clinical challenge. Animal models are often used in this field of research as they offer an attractive framework to examine the cascade of processes that occur throughout both tendon pathology and repair. This review discusses the structural, mechanical, and biological changes that occur throughout tendon pathology in animal models, as well as strategies for the improvement of tendon healing.

Cite this article: Bone Joint Res 2014;3:193–202.