Strain is a robust indicator of bone failure initiation. Previous work has demonstrated the measurement of vertebral trabecular
Initial stability of cementless components in bone is essential for longevity of Total Hip Replacements. Fixation is provided by press-fit: seating an implant in an under-reamed bone cavity with mallet strikes (impaction). Excessive impaction energy has been shown to increase the risk of periprosthetic fracture of bone. However, if implants are not adequately seated they may lack the stability required for bone ingrowth. Ideal fixation would maximise implant stability but would minimise peak
Background. Cementless acetabular cups rely on press-fit fixation for initial stability; an essential pre-requisite to implant longevity. Impaction is used to seat an oversized implant in a pre-prepared bone cavity, generating
INTRODUCTION:. Clinical densitometry studies indicate that following TKR implantation there is loss of bone mineral density in regions around the implant. Bone density below the tibial tray has been reported to decrease 36% at eight years after TKR. This bone loss (∼5%/year) is substantially greater than osteoporosis patients in the same age group (∼1–2%/year) and could contribute the loss of mechanical support provided by the peri-implant leading to loosening of components in the long term. High patient mass and body mass index have also been implicated in increased loosening rates, and was thought to be due to high stress or strain on the tibial constructs. These findings suggest that peri-implant
INTRODUCTION. Hip resurfacing offers a more bone conserving solution than total hip replacement (THR) but currently has limited clinical indications related to some poor design concepts and metal ion related issues. Other materials are currently being investigated based on their successful clinical history in THR such as Zirconia Toughened Alumina (ZTA, Biolox Delta, CeramTec, Germany) which has shown low wear rates and good biocompatibility but has previously only been used as a bearing surface in THR. A newly developed direct cementless fixation all-ceramic (ZTA) resurfacing cup offers a new solution for resurfacing however ZTA has a Young's modulus approximately 1.6 times greater than CoCr - such may affect the acetabular bone remodelling. This modelling study investigates whether increased stress shielding may occur when compared to a CoCr resurfacing implant with successful known clinical survivorship. METHODS. A finite element model of a hemipelvis constructed from CT scans was used and virtually reamed to a diameter of 58mm. Simulations were conducted and comparisons made of the ‘intact’ acetabulum and ‘as implanted’ with monobloc cups made from CoCr (Adept®, MatOrtho Ltd, UK) and ZTA (ReCerf ™, MatOrtho Ltd. UK) orientated at 35° inclination and 20° anteversion. The cups were loaded with 3.97kN representing a walking load of 280% for an upper bound height patient with a BMI of 35. The cup-bone interface was assigned a coulomb slip-stick function with a coefficient of friction of 0.5. The percentage change in strain energy density between the intact and implanted states was used to indicate hypertrophy (increase in density) or stress shielding (decrease in density). RESULTS. Implanting both cups changed the strain distribution observed in the hemipelvis, Figure 1. The change in strain distribution was similar between materials and indicated a similar response from the bone, Figure 2. In both implanted cases, the inferior peri-acetabular bone around the implant indicated a reduction in
INTRODUCTION. Mechanical overloading of the knee can occur during activities of daily living such as stair climbing, jogging, etc. In this finite element study we aim to investigate which parameters could detrimentally influence peri-implant bone in the tibial reconstructed knee. Bone quality and patient variables are potential factors influencing knee overloading (Zimmerman 2016). METHODS. Finite element (FE) models of post-mortem retrieved tibial specimens (n=7) from a previous study (Zimmerman 2016) were created using image segmentation (Mimics Materialise v14) of CT scan data (0.6 mm voxel resolution). Tibial tray and polyethylene inserts were recreated from CT data and measurements of the specimens (Solidworks 2015). Specimens with varying implant geometry (keel/pegged) were chosen for this study. A cohesive layer between bone and cement was included to simulate the behavior of the bone–cement interface using experimentally obtained values. The FE models predict plasticity of bone according to Keyak (2005). Models were loaded to 10 body weight (BW) and then reduced to 1 BW to mimic experimental measurements. Axial FE
Introduction. Periprosthetic bone remodelling after Total Knee Arthroplasty (TKA) may be attributed to local changes in the mechanical strain field of the bone as a result of the stiffness mismatch between high modulus metallic implant materials and the supporting bone. This can lead to significant loss of periprosthetic bone density, which may promote implant loosening, and complicate revision surgery. A novel polyetheretherketone (PEEK) implant with a modulus similar to bone has the potential to reduce stress shielding whilst eliminating metal ion release. Numerical modelling can estimate the remodelling stimulus but rigorous validation is required for use as a predictive tool. In this study, a finite element (FE) model investigating the local biomechanical changes with different TKA materials was verified experimentally using Digital Image Correlation (DIC). DIC is increasingly used in biomechanics for strain measurement on complex, heterogeneous anisotropic material structures. Methodology. DIC was used following a previously validated technique [1] to compare
Proximal humeral fractures occur frequently, with fixed angle locking plates often being used for their treatment. However, the failure rate of this fixation is high, ranging between 10 and 35%. Numerous variables are thought to affect the performance of the fixation used, including the length and configuration of screws used and the plate position. However, there is currently limited quantitative evidence to support concepts for optimal fixation. The variations in surgical techniques and human anatomy make biomechanical testing prohibitive for such investigations. Therefore, a finite element osteosynthesis test kit has been developed and validated - SystemFix. The aim of this study was to quantify the effect of variations in screw length, configuration and plate position on predicted failure risk of PHILOS plate fixation for unstable proximal humerus fractures using the test kit. Twenty-six low-density humerus models were selected and osteotomized to create a malreduced unstable three-part fracture AO/OTA 11-B3.2 with medial comminution which was virtually fixed with the PHILOS plate. In turn, four different screw lengths, twelve different screw configurations and five plate positions were simulated. Each time, three physiological loading cases were modelled, with an established finite element analysis methodology utilized to evaluate average peri-screw
Introduction. Polyetheretherketone (PEEK) has been proposed as an implant material for femoral total knee arthroplasty (TKA) components. Potential clinical advantages of PEEK over standard cobalt chrome alloys include modulus of elasticity and subsequently reduced stress shielding potentially eliminating osteolysis, thermal conduction properties allowing for a more natural soft tissue environment, and reduced weight enabling quicker quadriceps recovery. Manufacturing advantages include reduced manufacturing and sterilization time, lower cost, and improved quality control. Currently, no PEEK TKA implants exist on the market. Therefore, evaluation of mechanical properties in a pre-clinical phase is required to minimize patient risk. The objectives of this study include evaluation of implant fixation and determination of the potential for reduced stress shielding using the PEEK femoral TKA component. Methods and Materials. Experimental and computational analysis was performed to evaluate the biomechanical response of the femoral component (Freedom Knee, Maxx Orthopedics Inc., Plymouth Meeting, PA; Figure 1). Fixation strength of CoCr and PEEK components was evaluated in pull-off tests of cemented femoral components on cellular polyurethane foam blocks (Sawbones, Vashon Island, WA). Subsequent testing investigated the cemented fixation using cadaveric distal femurs. The reconstructions were subjected to 500,000 cycles of the peak load occurring during a standardized gait cycle (ISO 14243-1). The change from CoCr to PEEK on implant fixation was studied through computational analysis of stress distributions in the cement, implant, and the cement-implant interface. Reconstructions were analyzed when subjected to standardized gait and demanding squat loads. To investigate potentially reduced stress shielding when using a PEEK component, paired cadaveric femurs were used to measure local
Introduction. Survival rates of recent total ankle replacement (TAR) designs are lower than those of other arthroplasty prostheses. Loosening is the primary indication for TAR revisions [NJR, 2014], leading to a complex arthrodesis often involving both the talocrural and subtalar joints. Loosening is often attributed to early implant micromotion, which impedes osseointegration at the bone-implant interface, thereby hampering fixation [Soballe, 1993]. Micromotion of TAR prostheses has been assessed to evaluate the stability of the bone-implant interface by means of biomechanical testing [McInnes et al., 2014]. The aim of this study was to utilise computational modelling to complement the existing data by providing a detailed model of micromotion at the bone-implant interface for a range of popular implant designs, and investigate the effects of implant misalignment during surgery. Methods. The geometry of the tibial and talar components of three TAR designs widely used in Europe (BOX®, Mobility® and SALTO®; NJR, 2014) was reverse-engineered, and models of the tibia and talus were generated from CT data. Virtual implantations were performed and verified by a surgeon specialised in ankle surgery. In addition to the aligned case, misalignment was simulated by positioning the talar components in 5° of dorsi- or plantar-flexion, and the tibial components in ± 5° and 10° varus/valgus and 5° and 10° dorsiflexion; tibial dorsiflexed misalignement was combined with 5° posterior gap to simulate this misalignment case. Finite element models were then developed to explore bone-implant micromotion and loads occurring in the bone in the implant vicinity. Results. Micromotion and bone loads peaked at the end of the stance phase for both the tibial and talar components. The aligned BOX and SALTO demonstrated lower tibial micromotion (with under 30% of bone-implant interface area subjected to micromotion larger than 100µm, as opposed to > 55% for Mobility; Figure 1). Talar micromotion was considerably lower for all designs, and no aligned talar component demonstrated micromotion larger than 100µm. The aligned SALTO showed the largest talar micromotion (Figure 2). Dorsiflexed implantation of all tibial components increased micromotion and
As an alternative to total hip arthroplasty (THA), hip resurfacing arthroplasty (HRA) provides the advantage of retaining bone stock. However, femoral component loosening and femoral neck fracture continue to be leading causes of revision in HRA. Surgical technique including cementation method and bone preparation, and patient selection are known to be important for fixation. This study was designed to understand if and to what extent compromise in bone quality and the presence of cysts in the proximal femur contribute to resurfacing component loosening. A finite element (FE) model of a proximal femur was used to calculate the stress in the cement layer. Bone density to Young's modulus relationship was used to calibrate the bone stiffness in the model using computed tomography. A contemporary resurfacing implant (BHR, Smith & Nephew) was used in the FE model. The effect of reduced bone quality (35% reduction relative to normal baseline; osteoporosis threshold) and presence of cysts on stress in the bone cement layer was then assessed using the same FE model. The center of the cyst (a localized spherical cavity 1 cm in diameter) was located directly under the contact patch. Simulations were run with two locations of the center of the cyst, on the surface of the resected bone and 1 cm below it. The surface cyst was filled with bone cement, but the inner cyst was empty. The contact force and location for the model were obtained from instrumented implant studies. Simulations were run representing the peak loads during two activities, jogging and stand-up from seated position. While density reduction of the bone reduced the stress in the CoCr femoral head, the Von-Mises stress in the cement layer was amplified. The peak Von-Mises stress in the cement layer under the contact patch increased more than six times for the jogging activity, and more than ten times for the stand-up activity, relative to values for normal bone density. The impact of cysts on the cement layer stress or the strain distributions in the bone were minimal. The results show a greater risk of failure of the cement layer under conditions of reduced bone density. In contrast cement stresses and
To achieve desirable outcomes in cementless total knee replacement (TKR), sufficient primary stability is essential. The primary stability inhibits excessive motions at the bone-implant interface, hence providing the necessary condition for osseointegration [1]. Primary stability for cementless TKR is provided by press-fit forces between the bone and implant. The press-fit forces depend on several factors including interference fit, friction between bone and implant surface, and the bone material properties. It is expected that bone mineral density (BMD) will affect the stability of cementless TKR [2]. However, the effect of BMD on the primary stability of cementless femoral knee component has not been investigated in vitro. Phantom calibrated CT-scans of 9 distal femora were obtained after the surgical cuts were made by an experienced surgeon. Since the press-fit forces of the femoral component mainly occur in the Anteroposterior (AP) direction, the BMD was measured in the anterior and posterior faces for a depth of 5 mm; this depth was based on stress distributions from a Finite Element Analysis of the same implant design. In addition, four strain gauges were connected to different locations on the implant's outer surface and implant strain measured throughout as an indication of underlying
Incidence of intraoperative fracture during cementless Total Hip Arthroplasty (THA) is increasing. This is attributed to factors such as an increase in revision procedures and the favour of cementless fixation. Intraoperative fractures often occur during the seating of cementless components. A surgical mallet and introducer are used to generate the large impaction forces necessary to seat the component, sometimes leading to excessive hoop strain in the bone. The mechanisms of
Revision knee prostheses are often augmented with intramedullary stems to provide stability following bone loss. However, there are concerns with the use of such stems, including loosening caused by strain-shielding, end-of-stem pain, and removal of healthy bone surrounding the medullary canal. Extracortical fixation plates may present an alternative. The aim of the study was to quantitatively evaluate and compare strain-shielding in the tibia following implantation of a knee replacement component augmented with either a conventional intramedullary stem (design1), or extracortical plates (design2) on the medial and lateral surfaces. Eight composite synthetic tibiae were implanted with one of the two designs, painted with a speckle pattern, loaded in axial compression (peak 2.5 kN) using a materials test machine, and imaged with a 5-megapixel digital image correlation (DIC) system throughout loading. Bone loss was simulated in all models by removing a volume of metaphyseal bone. For four tibiae, the tibial tray was augmented with a cemented stem (∼150 mm). The others were augmented by extracortical plates (maximum 90 mm long) along the medial and lateral surfaces (Fig. 1). Strains were computed using an ARAMIS 5M software system between loaded and unloaded states in the longitudinal direction, for the medial, posterior and lateral surfaces of the tibiae. Strains were checked locally by use of strain gauge rosettes at three levels on medial, lateral and posterior aspects. The
Introduction. Varying degrees of posterior glenoid bone loss occurs in patients with end stage osteoarthritis and can result in increased glenoid retroversion. Ultimately, the goal is to correct retroversion to restore normal biomechanics of the glenohumeral joint. The goal of this study was to identify the optimal augmented glenoid design based on finite element model analysis which will provide key insights into implant loosening mechanisms and stability. Materials and Methods. Two different augmented glenoid designs, posterior wedge and posterior step- were created as a computer model by a computer aided design software (CAD). These implants were virtually implanted to correct 20° glenoid retroversion and the different mechanical parameters were calculated including: the glenohumeral contact pressure, the cement stress, the shear stress, and relative micromotions at the bone cement interface. Results. During abduction, high strain was concentrated around the peg and posterior glenoid
Introduction:. The mechanical stresses and strains surrounding orthopaedic implants can influence bone resorption and formation, micro-fracture, and consequently implant fixation or loosening. Experimental measurement of these internal parameters is generally not feasible. Computational predictions by finite element modeling are promising, but until recently have been limited to assuming the surrounding cancellous bone as a continuous volume, without modeling individual trabeculae. A recent study demonstrated errors in bone-implant stiffness exceeding 100% when using this continuum assumption [1]. Conversely, recently micro-finite element computer models have been built from high resolution imaging of trabecular bone. In the present study we developed such models of central pegs cemented into cadaveric glenoids. We hypothesized that additional applied cement would lead to stronger implant fixation, but less physiologic strains in the trabeculae. Methods:. Two cadaveric specimens were implanted, with the applied cement volume in the Specimen 2 approximately double that of Specimen 1. The specimens were imaged by micro-computed tomography (vivaCT 40, Scanco, Switzerland) with a resolution of 12 microns. Images were filtered and resampled, then imported in Mimics (Materialise, Belgium) for semi-automated segmentation and 3D reconstruction based on our laboratory's published methods. Finite element models containing 1.7 to 1.8 million elements having sides of 0.1 mm were generated by a direct image voxel-to-element approach [2] (Fig. 1). The material properties of cement and bone were assumed linear elastic (bone: E = 3.5 GPa, cement: E = 3.0 GPa, and implant (UHMWPE): E = 1.3 GPa), and interfaces were assumed fully bonded. All outer walls of the bone were fixed, and a downward force of 250 N was applied to the implant peg. Simulations were run using Abaqus (Simulia, Pawtucket RI) on a 32-core, 1 TB-memory server at PSU's High Performance Computing Systems. Results:. Specimen 1 had 254 mm. 3. cement measured in the model, whereas Specimen 2 had 535 mm. 3. Strain energy density was less for Specimen 2 for bone underneath the implant, but similar between specimens for bone around the implant sides (Figs 2 and 3), providing initial indication of complex effects of cement volume on peri-implant strains. In Specimen 2 a slightly larger volume of cement (8.6 vs. 6.8 mm. 3. ) was exposed to von Mises stresses exceeding 10 MPa. Discussion:. This study is novel in its prediction of stresses and strains down to the level of individual glenoid trabeculae surrounding a cemented implant. In this pilot investigation we found that bone embedded in the cement mantle is subject to low strains, whereas the bone immediately surrounding the cement mantle is subject to abnormally high strains, with both cement technique and trabecular architecture likely influencing results. The study is limited by the lack of application of more complex loads and boundary conditions. Future work includes modeling of additional specimens and statistical analyses, and investigation of the roles of cement stiffness and peg design in dictating peri-implant
Introduction. The number of total knee joint replacements has increased dramatically, from 28,000 in 2004 to over 73,000 in 2008 in the UK. This increase in procedures means that there is a need to assess the performance of an implant design in the general population. For younger, more active patients, cementless tibial fixation is an attractive alternative means of fixation and has been used for over 30 years. However, the clinical results with cementless fixation have been variable, with reports of extensive radiolucent lines, rapid early migration and aseptic loosening [1]. This study investigates the inter-patient variability of