Objective. In total knee arthroplasty, three-dimensional “criss-cross” line locate femoral osteotomy and conventional osteotomy were used. By comparing the two methods osteotomy in patients before and after surgery and imaging-related information data, to evaluate the recent post operative efficacy, at the same time to find out if there has clinical evidence that three-dimensional “criss-cross” line locate femoral osteotomy can be used in total knee arthroplasty. Methods. From July 2012 to July 2014, 64 patients who undertook the artificial total knee arthroplasty were divided into 2 groups: conventional osteotomy group(group A)and three-dimensional “criss-cross” line locate femoral osteotomy group(group B). In the X-ray of the two groups, it was measured that the hip-knee-ankle angle and the joint gap symmetry of 90°flexion degree. It was also measured that the two group joints range of motion. Those data were statistically analyzed. The KSS score of the two groups were compared. Results. In Group B the excellent and good rate was 93.8%, and Group A was 81.3%. The postoperative results of Group A were relatively better than Group B in limb alignment and joint mobility. There were significant differences between the prosthesis placement of the two group patients. Conclusion. The Short-term results of the three-dimensional “criss-cross” line locate femoral osteotomy group was better than the conventional osteotomy group. The reference osteotomy method of three-dimensional “criss-cross” line is very helpful to have a good result in TKA

Purpose. Proximal femoral osteotomy is an attractive joint preservation procedure for osteonecrosis of the femoral head. The purpose of this study was to investigate the cause of failure of proximal femoral osteotomy in patients with osteonecrosis of the femoral head. Patients and Methods. Between 2008 and 2014, proximal femoral osteotomy was performed by one surgeon in 13 symptomatic hips. Ten trans-trochanteric rotational osteotomies (anterior: 7, posterior: 3) and 3 intertrochanteric curved varus osteotomy were performed. Of the patients, 9 were male and 1 was female, with a mean age at surgery of 36.9 years (range, 25–55 years). The mean postoperative follow-up period was 38 months (range, 12–72 months). Three patients (4 hips) had steroid-induced osteonecrosis, and 7 (9 hips) had alcohol-associated osteonecrosis. At 6 postoperative weeks, partial weight bearing was permitted with the assistance of 2 crutches. At more than 6 postoperative months, full weight bearing was permitted. Patients who had the potential to achieve acetabular coverage of more than one-third of the intact articular surface on preoperative hip radiography, computed tomography, and magnetic resonance imaging were considered suitable for this operation. A clinical evaluation using the Japanese Orthopaedic Association (JOA) scoring system and a radiologic evaluation were performed. Clinical failure was defined as conversion to total hip arthroplasty (THA) or progression to head collapse and osteoarthritis. The 13 hips were divided into two groups, namely the failure and success groups. Results. The mean preoperative JOA score was 59 points. The score in the success group (7 hips) improved to 89 points at the time of final follow-up. In the failure group (6 hips), 5 hips were converted to THA because of progression to secondary collapse or osteoarthritis in a mean postoperative period of 35 months (range, 24–51 months). After converting to THA, good clinical and radiographic results were achieved, except in 1 patient who had incomprehensible severe pain around the affected hip. Advanced osteoarthritis was observed in 1 hip awaiting THA. Various factors cause failure of proximal femoral osteotomy, such as difficulty in controlling the underlying disease with less than 10 mg of steroid (Fig. 1), overuse of the affected hip within 6 postoperative months without the physician's consent, vascular occlusion after total necrosis of the femoral head as a result of damage to the nutritional vessel during or after the operation, and incorrect judgement of the indication of the operation and the extent of the intact load-bearing area. Conclusion. We think that full weight bearing should be permitted postoperatively only after more than 6 months, and heavy work and sport, only after more than 1 year. Efforts should be made to improve surgeons' skill in proximal femoral osteotomy and accurate judgement of imaging data. For steroid-induced osteonecrosis of the femoral head, proximal femoral osteotomy is an acceptable procedure for relieving pain if the underlying disease can be controlled with not more than 5 mg of steroid

We developed a custom-made template for corrective femoral osteotomy during THA in a patient with a previous Schanz osteotomy. A seventy-year-old woman presented to our clinic with a chief complaint of right hip, left knee and left ankle pain with marked limp. She had undergone Schanz osteotomy of the left femur because of high dislocation of the left hip when she was 20 years old. After right THA was performed, we decided to perform left THA with corrective femoral osteotomy. A custom-made osteotomy template was designed and manufactured with use of CT data. During surgery, we placed the template on the bone surface, cut the bone through a slit on the template, and corrected the deformity as preoperatively simulated. Two years after surgery, she had no pain in any joints, could walk more than one hour without limp. Japanese Orthopedic Association hip score were 100 points for both hips. THA in patients with previous Schanz osteotomy was reported to be technically demanding and the rate of complications was high. In 2008, Murase T et al. developed a system, including a 3D computer simulation program and a custom-made template to corrective osteotomy of malunited fractures of the upper extremity. We applied the system to corrective femoral osteotomy during THA in a patient with a previous Schanz osteotomy. The surgical procedure was technically easy and accurate osteotomy brought the patient to acquire good alignment of lower extremities with good clinical results

Revision arthroplasty poses many challenges including extensile exposure and difficulty in safe removal of cemented/uncemented femoral component and/or distal cement particularly from a poor bone stock. Extended trochanteric osteotomies are associated with complications including non-union, proximal migration of the trochanter or osteotomised segment, wire breakage and difficulties associated with reattachment of the fragment. We present a technique of trochanter sparing extended anterior femoral osteotomy (AFO) through a modified Hardinge approach in reducing the difficulties associated in conventional and ETO. We assessed the performance of this technique in 23 patients with a maximum follow-up of 10 years. No trochanteric escape or fractures seen in any cases. No proximal migration, subsidence or failure of femoral component seen. Union was seen in all cases. Mean time for union was 3 months. 1 patient developed recurrent dislocations that required constrained liner. Improvement in Harris Hip scores was noted from 13 (pain) and 9 (function) pre-operatively to 39 (pain) and 22 (function) (p<0.05). Extended trochanter sparing AFO allows extensive exposure similar to traditional ETO. It heals reliably without the use of vertical wires, trochanteric plates or grips. The avoidance of abductor mechanism and osteotomy through weakest anterior non weight bearing area of the proximal femur may be a significant advantage

Introduction. Perthes disease is associated with coxa breva, plana and magna, and a high riding prominent greater trochanter causing abductor shortening and weakness, leg shortening and extra-articular impingement. A trochanteric advancement with an infero-lateralizing sliding osteotomy of the proximal femur would lengthen femoral neck, improve abductor length and strength, relieve impingement and improve leg length. We assessed the mid-term outcomes for this procedure. Method. We included patients who underwent the operation by the senior author (JNOH) with more than 2 years follow-up. The osteotomies were performed under image intensifier guidance and fixed with blade plate or locking plates. We assessed functional scores, radiological changes in neck length, Tonnis grading for arthritis and evidence of progression in femoral head avascular necrosis, time interval for conversion to hip arthroplasty and associated complications. Results. Twenty four patients (25 hips) underwent the procedure at mean age of 18.7 years (range:9.3–38.8) with a mean follow-up of 5 years (range:2–13.8). At the last assessment, the mean Oxford Hip Score was 41.6 (range:58–27), Non-Arthritic Hip Score was 53.4 (range:25–77) and UCLA activity score was 4.2 (range:2–6). For changes in neck length, the mean “Head-centre-to-Greater-trochanteric-tip-distance” was 60 mm (range:43–78) compared to 39 mm (range:30–48) pre-operatively and the mean “Head-center-to-Lesser-trochanteric-tip-distance” was 54 mm (range:47–64) compared to 37 mm (range:31–41) pre-operatively. The mean Tonnis grade was 1.5 (range:1–3) compared to 1.3 (range:1–2) pre-operatively. Two patients underwent arthroplasty conversion at 2 and 13.8 years later. One patient needed head-neck debridement for impingement and 2 patients underwent trochanteric refixation for non-union. There was no progression in avascular necrosis of femoral head. Discussion. Symptomatic Perthes hip deformity in adolescents and young adults is difficult to treat with joint preserving surgery. The mid-term clinical, functional and radiological results for double proximal femur osteotomy are encouraging

Hypothesis. Successful total hip arthroplasty (THA) in the presence of developmental dysplasia of the hip (DDH) depends on restoration of the anatomic centre of hip rotation and may require simultaneous femoral osteotomy. Techniques using uncemented components are widely reported. In osteopenic bone an all-cemented technique may be more appropriate; however, the outcome following this procedure is not known. We present the results of a series of thirty-five cemented THA with simultaneous subtrochanteric osteotomy. Methods and analysis. 28 patients with DDH (35 hips) who underwent this procedure at a mean age of 47.3 years were retrospectively reviewed. Two patients (two hips) died within 12 months of surgery. The clinical notes and radiographs of the remaining patients were reviewed with a minimum follow-up of 2 years (mean, 5.6 years; range, 2-14 years). Complications were noted. SF-12 and Oxford hip scores (OHS) were recorded for 18 patients pre-operatively and after 6 and 12 months. Results. Union occurred in 32 of 33 femora (97%); one patient had an infected nonunion. The overall revision rate was 19% at 5.6 years (8% femoral revision rate). There were three dislocations, two of which required further surgery. Two patients had a transient neuropraxia. The mean SF-12 physical component score increased from 32 to 52 and mean SF-12 mental component score increased from 48 to 51. The mean OHS decreased from 40 to 27. Conclusion. Combined subtrochanteric osteotomy and cemented THA is technically demanding with a higher complication rate than routine THA. The rate of union, complications, implant survivorship, and early OHS were comparable to those for similar techniques using cementless components

Purpose. To evaluate the clinical and radiologic midterm results of rotational acetabular osteotomy (RAO) in incongruent hip joints. Material and Methods. A consecutive series of 15 hips in 14 patients who underwent RAO in incongruent hip joint were evaluated at an average follow-up of 52.3 months (range from 36 to 101 months). The average age at operation was 27 years (range from 12 to 38 years) old. The preoperative diagnoses were developmental dysplasia in 4 hips, sequelae of Legg-Calvé-Perthes disease in 8 hips, and multiple epiphyseal dysplasia in 3 hips. The RAO procedures were combined with a femoral valgus oseotomy in 10 hips, advance osteotomy of greater trochanter in 4 hips, derotational osteotomy in 2 hips. Clinically, Harris hip score, range of motion, leg length discrepancy(LLD) and hip joint pain were evaluated. Radiological changes of anterior and lateral center-edge(CE) angle, acetabular roof angle, acetabular head index(AHI), ratio of body weight moment arm to abductor moment arm, and a progression of osteoarthritis were analyzed. Results. The Harris hip score ha been improved from average from 67.5 points preoperatively to 97.6 points postoperatively. There have been no significant changes in the range of motion. The anterior CE angle increased from an average of 9.0°(-19.7□18.6°) to 32.5°(22.6□39.1°), the lateral CE angle from 7.6°(-12.1□14.1)° to 31.7°(26.5□37.8°) and the AHI from 61%(33□73%) to 86%(65□100%). The average ratio of body weight moment arm to abductor moment arm was changed 1.88 to 1.49. There was no case showing progression of osteoarthritis. None of the patients experienced revision surgery. Conclusion. The conventional salvage operation, such as Chiari osteotomy, has been recommended in incongruent hip. However, if we can expect to have a congruency after RAO with/without any femoral osteotomies, it would be a hopeful procedure for the incongruent joints by enhancing acetabular coverage, taking joint surface with normal articular cartilage, increasing abductor moment arm with additional improvement in LLD

Because of post traumatic mal union or constitutionnal intraosseous femoral or tibial deviation, an extra articular deformity may be present in patients requiring TKR. In those cases, recreation of the mechanical axis will affect the orientation of femoral or tibial bone cuts and soft tissue balance. In those important deformities, an extra articular correction may be necessary. Between 1998 and 2013 we performed 31 TKR associated with femoral (6 cases) or tibial (25 cases) osteotomy in one time surgery. This study was prospective and the patients were examinated at 1, 2, 5, 10 and 15 years for the first patients. There were 17 males (one bilateral case) and 13 females with a 63 years average age (from 29 to 79). The deformity was constitutionnal in 14 cases, post trauma in 9 cases, post osteotomy in 8 cases. The extra articular deformity was between 10° and 35°: 15 in varus, 11 in valgus, 2 multidirectionnal, 1 intraosseous flessum, 1 important translation and 1 rotational deformity. In all the cases we used a long stem implant in the osteotomized bone: an osteosynthesis was performed in 26 cases (7 plates, 19 stapples). A posterostabilised prosthesis was used in 28 patients, a CCK implant in 3. We studied pre and post operatively with a 3 to 17 years follow up, IKS scoring, knee motion, knee stability and radiologicaly, HKA, tibial and femoral mechanical angle. In the knees with a varus deformity the average HKA was 158° before surgery and 181 after osteotomy combinated with TKR. In the valgus cases, the average HKA was 198° pre and 179° post operatively. Complications consisted in 1 peroperative fracture, 1 extension lag of 15° and 1 hematoma.

TKR associated with osteotomy seems to be a possible alternative in patients with severe constitutional or post traumatic extra articular deformities after discussion of the other solutions: osteotomy and TKR in two times surgery (particulaly in young patients) or constraint TKR (rotating hinged implants) in patients over 80 years of age.

Introduction. Derotation osteotomies are commonly performed in paediatric orthopaedic and limb reconstruction practice. The purpose of this study was to determine whether the use of a digital inclinometer significantly improves the accuracy in attaining the desired correction. Materials & Methods. We designed an electronic survey regarding derotation femoral osteotomy (DFO) including methods of intra-operative angular correction assessment and acceptable margins of error for correction. This was distributed to 28 paediatric orthopaedic surgeons in our region. A DFO model was created, using an anatomic sawbone with foam covering. 8 orthopaedic surgeons each performed two 30-degree DFOs, one using K-wires and visual estimation (VE), and the other using a Digital Inclinometer (DI). Two radiologists reported pre and post procedure rotational profile CT scans to assess the achieved rotational correction. Results. There was a 68% response rate to the survey. The most popular methods of estimating intra-operative correction were reported to be K-wires and rotation marks on bone. The majority of respondents reported that a 6–10 degree margin of error was acceptable for a 30-degree derotation. This was therefore set as the upper limit for acceptable error margin in the simulation study. The mean error in rotation in the VE group of simulated DFO was 19.7 degrees, with error>5 degrees and error>10 degrees in 7 (88%) and 6 (75%) cases respectively. Mean error in DI group was 3.1 degrees, with error>5 degrees in 1 case (13%). Conclusions. Our results show that the compared to conventional techniques, the use of an inclinometer significantly improves the accuracy of femoral de-rotation and significantly reduces the incidence of unacceptable errors in correction. We would suggest that digital inclinometers be used to assess intra-operative correction during derotation osteotomies

Introduction. Limb deformity is usually assessed clinically assisted by long leg alignment radiographs and further imaging modalities (MRI and CT). Often decisions are made based on static imaging and simple gait interpretation in clinic. We have assessed the value of gait lab analysis in surgical decision making comparing surgical planning pre and post gait lab assessment. Materials & Methods. Patients were identified from the local limb reconstruction database. Patients were reviewed in the outpatient clinic and long leg alignment radiographs and a CT rotational limb profile were performed. A surgical plan was formulated and documented. All patients then underwent a formal gait lab analysis. The gait lab recommendations were then compared to the initial plan. Results. Twelve patients (8 female) with mean age of 14 (range 12–16) were identified. Nine were developmental torsional malalignments, one arthrogryposis, one hemiparesis secondary to spinal tumour resection and one syndromic limb deficiency. The gait lab recommended conservative management in four patients and agreed with eight surgical plans with one osteotomy level changing. Five patients are post-operative: two bilateral distal tibial osteotomies, two de-rotational femoral osteotomy with de-rotational tibial osteotomies and one bilateral femoral de-rotational osteotomies. Conclusions. Limb deformity correction is major surgery with long rehabilitation and recovery period. Gait lab analysis can identify who would benefit from conservative management rather than surgery with our study showing changes to surgical planning in one third of patients. The gait lab analysis helps to identify patients with functional and neuromuscular imbalances where correcting the bony anatomy may not actually benefit the patient

Introduction. Torsional deformities of the femur have been recognized as a cause of femoroacetabular impingement (FAI) and hip pain. High femoral antetorsion can result in decreased external rotation and a posterior FAI, which is typically located extraarticular between the ischium and trochanter minor. Femoral osteotomies allow to correct torsional deformities to eliminate FAI. So far the mid-term clinical and radiographic results in patients undergoing femoral osteotomies for correction of torsional deformities have not been investigated. Objectives. Therefore, we asked if patients undergoing femoral osteotomies for torsional deformities of the femur have (1) decreased hip pain and improved function and (2) subsequent surgeries and complications?. Methods. We retrospectively evaluated 21 hips (18 patients) who underwent femoral osteotomies for correction of torsional deformities between April 2005 and October 2014. Twenty hips with excessive femoral antetorsion (47.7° ± 8.6°, range 32° – 65°) had a derotational femoral osteotomy. One hip with decreased femoral antetorsion of 11° underwent rotational femoral osteotomy. Previous surgery were performed in 43% of the hips including hip arthroscopy (5 hips), acetabular osteotomy (2 hips), open reduction for high dislocation (2 hips), surgical hip dislocation (2 hips) and varus intertrochanteric osteotomy (1 hip). In 10 hips a concomitant offset correction and in 5 hips a concomitant periacetabular osteotomy were performed. The mean followup was 3.6 ± 2.3 (1 – 10) years. One patient (one hip) died from a cause unrelated to surgery at the 2 year follow-up. We used the anterior and posterior impingement test to evaluate pain. Function was assessed using the Merle d'Aubigné Postel score, WOMAC, UCLA activity score and Harris hip score. Results. The incidence of a positive anterior impingement test decreased from preoperatively 85% to 29% at latest follow-up (p<0.001). The incidence of a positive posterior impingement test decreased from preoperatively 90% to 5% at latest follow-up (p<0.001). The mean Merle d'Aubigné Postel score increased from 13 ± 2 (11 – 16) to 16 ± 1 (13 – 17) at latest followup (p<0.0001). For the WOMAC, UCLA and Harris hip score no preoperative values existed but at latest followup they all showed fair to good values with a mean WOMAC score of 14 ± 15 (1 – 50), UCLA score of 6 ± 1 (3 – 8) and Harris hip score of 77 ± 13 (47 – 96). Subsequent surgeries included hardware removal in 14 hips (66%) and hip arthroscopy with offset creation in 1 hip. Complications occurred in 5 hips (24%) all graded Grade III according to Sink and included conversion to total hip arthroplasty in 1 hip, reosteosynthesis due to pseudarthrosis in 3 hips and hip arthroscopy for adhesiolysis in 3 hips. Conclusion. Femoral osteotomies for the treatment of torsional deformities of the femur result in decreased pain and improved function in patients with FAI. However, these procedures are associated with a complication rate of 24% which is mainly due to pseudarthrosis and intraarticular adhesions in patients with concomitant offset correction

Purpose. The tibia first technique in unicompartmental knee arthroplasty (UKA) may have the advantage that surgeons can obtain a balanced flexion-extension gap. However, changes of the soft tissue tension during UKA has not been elucidated yet. The purpose of this study was to examine the correlation between the soft tissue tension before the femoral osteotomy and after the femoral component in place using the tensor in UKA. Methods. Thirty UKAs for isolated medial compartmental osteoarthritis or idiopathic osteonecrosis were assessed. The mean age was 71.8±8.5 years old (range: 58–85), and the average coronal plane femorotibial angle (FTA) was 181.2±3.2 degree preoperatively. All the patients received a conventional medial Zimmer Unicompartmental High Flex Knee System (Zimmer Inc, Warsaw, Ind). The actual values of the proximal and posterior femoral osteotomy were calculated by adding the thickness of the bone saw blades to the thickness of the bony cut. Using a UKA tensor which designed to facilitate intra-operative soft tissue tension throughout the range of motion (ROM), the original gap before the femoral osteotomy, the component gap after the femoral osteotomy, and component placement were assessed under 20 lb distraction forces. (Figure 1). Results. The mean actual thickness of the distal femoral osteotomy 6.5 ± 1.3 mm and the posterior femoral osteotomy was 7.4 ± 1.3 mm. The distal thickness of the Zimmer UKA was set to 6.5 mm and the mean posterior thickness of the prosthesis used in this study was 5.8 ± 0.3 mm. There is a positive correlation between the original and component gap throughout the ROM (R > 0.5). The original and component gap showed the same kinematic pattern from full extension to 90 degrees of knee flexion. However, the component gap showed significantly higher compared to the original gap after 120 degrees of knee flexion (p < 0.001). (Figure 2). Conclusions. Despite the fact that the component gap showed significantly higher compared to the original gap in deep flexion, there is a positive correlation between the original and component gap throughout the ROM. The discrepancy during deep flexion was due to the posterior design of the prosthesis that is designed to be thinner than the actual thickness of the posterior osteotomy in order to prevent flexion gap tightness. These results suggest that the tibia first technique with the tensor have the advantage that surgeons can predict final soft tissue tension before femoral osteotomies with the comprehension of the prosthetic design and help restore natural knee kinematics, potentially improving implant survival and functional outcomes

The extended proximal femoral osteotomy has been used primarily in conjunction with cementless fixation, but has been described for use with cemented stems as well. The extended proximal femoral osteotomy is indicated for the removal of well-fixed cemented and cementless implants, as well as removal of cement in patients with a loose femoral component in a well-fixed cement mantle. Although the osteotomy is not required for many femoral revisions, it is an absolute indication in patients with femoral component loosening and subsequent varus remodeling of the proximal femur. The osteotomy diminishes the risk of an inadvertent fracture of the often compromised greater trochanter especially upon removal of a failed femoral component from its subsided or migrated position. The osteotomy enhances the exposure of the acetabulum which may be difficult in the revision setting due to multiple surgeries, severe migration of the acetabular component or the heterotopic ossification. The extended proximal femoral osteotomy can also be used in the primary setting when a proximal femoral deformity interferes with straight reaming of the femoral canal, such as in patients with various dysplasias, previous corrective osteotomies or malunions

Important issues related to total hip replacement for dysplasia are: placement of the cup and bone stock, the role of femoral osteotomy, and the choice of acetabular and femoral components. The cup can be placed at the correct or near correct anatomical level with or without a bone graft, in a high position (high hip center) or at the right level in a protruded position. All three techniques can provide adequate coverage of the cup. In the high hip position bone graft is not usually necessary to obtain cup coverage. There is, however, a higher rate of component loosening, a higher dislocation rate, and lengthening is limited to the femoral side. Placing the cup in a protruded position to obtain coverage does not restore bone stock for future surgery, but it does place the hip at the correct level. Placing the cup in the correct anatomical position (i.e. at the right level and not protruded) may require a structural autograft which adds to the complexity of the case. However, bone stock is restored for future surgery. Revision of acetabular components that have had a shelf graft have a survivorship of 96.5% at 10 years and only 5 of 34 required structural support (2 augments, 3 structural allografts). Femoral osteotomy may be used as part of the exposure for diaphyseal shortening or for derotation of excessive anteversion. The osteotomy is carried out in the sub-trochanteric region and may be oblique, step-cut or transverse. Fixation of the osteotomy is achieved via the stem, a plate, or a cortical strut. Cementless components are usually used because of the relatively young age of this patient population. Small components may be necessary. On the femoral side, the stem should be straight or modular so excessive anteversion can be neutralised

The extended proximal femoral osteotomy has been used primarily in conjunction with cementless fixation, but has been described for use with cemented stems as well. The extended proximal femoral osteotomy is indicated for the removal of well-fixed cemented and cementless implants, as well as removal of cement in patients with a loose femoral component in a well-fixed cement mantle. Although the osteotomy is not required for many femoral revisions, it is an absolute indication in patients with femoral component loosening and subsequent varus remodeling of the proximal femur. The osteotomy diminishes the risk of an inadvertent fracture of the often compromised greater trochanter especially upon removal of a failed femoral component from its subsided or migrated position. The osteotomy enhances the exposure of the acetabulum which may be difficult in the revision setting due to multiple surgeries, severe migration of the acetabular component or heterotopic ossification. The extended proximal femoral osteotomy can also be used in the primary setting when a proximal femoral deformity interferes with straight reaming of the femoral canal, such as in patients with various dysplasias, previous corrective osteotomies or malunions

Aim. Staphylococcus aureus is the leading pathogen in fracture-related infection (FRI). Virulence factors vary between different strains, which may have a decisive influence on the course of infection. Previous in vitro experiments, in vivo testing in wax moth larvae, and genomic analysis of S. aureus isolates from FRI identified a low- and high-virulent strain. These findings correlated with the acute course of FRI induced by the high-virulent pathogen, whereas the low-virulent strain caused a chronic FRI in its human host. However, the role of bacterial virulence in FRI is not completely understood. Therefore, the present study aimed to compare the identified high- and low-virulent S. aureus isolates in a murine FRI model. Method. Skeletally mature C57Bl/6N mice received a femoral osteotomy stabilized by titanium locking plates. FRI was established by inoculation of either high-virulent S. aureus EDCC 5458 or low-virulent S. aureus EDCC 5464 in the fracture gap. Mice were euthanized 4 and 14 days after surgery, respectively. Severity and progression of infection were assessed in terms of clinical presentation, quantitative bacteriology, semiquantitative histopathologic evaluation, and serum cytokine profile. Results. Quantitative bacteriological results 4 days after surgery revealed a higher bacterial load in soft tissue samples in high-virulent infected animals (p =0.026). Mice infected with the high-virulent strain also displayed higher rates of organ dissemination (24/36 organs in high-virulent, versus 5/36 organs in low-virulent infected animals; p <0.0001). In the histopathological assessment, bacterial agglomerations at the fracture ends were present to a greater extent in the high-virulent cohort and barely detectable in low-virulent infected mice. In both cohorts, no bone healing was observed after 4 days. On day 14, bone healing at the fracture site was visible in low-virulent infected animals, whereas callus formation was observed in only one animal from the high-virulent infected cohort. Furthermore, osteonecrosis and osteolysis were increased in high-virulent infected animals. Regarding serum cytokines, innate immune markers were elevated in both groups at day 4. By day 14, a more pronounced proinflammatory response indicated by increased serum cytokine levels of IFN-γ, IL-1β, and IL-6 was observed in high-virulent infected animals. Conclusions. The present study demonstrated distinct bacteriological and histopathological differences between two different virulent S. aureus strains previously shown to have different courses in human patients. While host physiology is often considered to have a major impact on the course of FRI, this study highlights the critical influence of the invading pathogen and its virulence characteristics

Important issues related to total hip replacement for dysplasia are: placement of the cup and bone stock; the role of femoral osteotomy, and the choice of acetabular and femoral components. The cup can be placed at the correct or near correct anatomical level with or without a bone graft, in a high position (high hip center) or at the right level in a protruded position. All three techniques can provide adequate coverage of the cup. In the high hip position bone graft is not usually necessary to obtain cup coverage. There is, however, a higher rate of component loosening, a higher dislocation rate, and lengthening is limited to the femoral side. Placing the cup in a protruded position to obtain coverage does not restore bone stock for future surgery, but it does place the hip at the correct level. Placing the cup in the correct anatomical position (i.e., at the right level and not protruded) may require a structural autograft which adds to the complexity of the case. However, bone stock is restored for future surgery. Femoral osteotomy may be used as part of the exposure for diaphyseal shortening or for derotation of excessive anteversion. The osteotomy is carried out in the sub-trochanteric region and may be oblique, step-cut or transverse. Fixation of the osteotomy is achieved via the stem, a plate, or a cortical strut. Cementless components are usually used because of the relatively young age of this patient population. Small components may be necessary. On the femoral side, the stem should be straight or modular so excessive anteversion can be neutralised

Introduction. Through the paediatric LCP Hip plating system, the highly successful technique of the locking compression plate used in adult surgery, has been incorporated in a system dedicated to paediatrics. The purpose of this study was to review the outcome of the paediatric LCP Hip plate use in children, both with and without neuromuscular disease, for fixation of proximal femoral osteotomy for a variety of indications. Materials and methods. We retrospectively reviewed the notes and radiographs of all those children who have had Paediatric LCP Hip Plate for the fixation of proximal femoral osteotomy and proximal femur fractures in our institution, between October 2007 and July 2010, for their clinical progress, mobilization status, radiological healing and any complications. Results. Forty-three Paediatric LCP hip plates were used in forty patients for the fixation of proximal femoral osteotomies (n=40) and proximal femur fractures (n=3). The osteotomies were performed for a variety of indications including Perthes disease, DDH, Cerebral Palsy, Down's syndrome, coxa vara, Leg length discrepancy and previous failed treatment of SUFE. Twenty-five children were allowed touch to full weight bearing post operatively. Two were kept non-weight bearing for 6 weeks. The remaining 13 children were treated in hip spica due to simultaneous pelvic osteotomy or multilevel surgery for cerebral palsy. All osteotomies and fractures radiologically healed within 6 months (majority [n=40] within 3 months). There was no statistically significant difference (p = 0.45) in the neck shaft angle between the immediately postoperative and final x-rays after completion of bone healing. There were no implant related complications. Conclusion. The Paediatric LCP Hip Plate provides a stable and reliable fixation of the proximal femoral osteotomy performed for a variety of paediatric hip conditions in children with and without neuromuscular disease

Introduction. The primary purpose of Total Hip Arthroplasty (THA), aside from pain relief, is to restore hip biomechanics such that the patient experiences no discernible functional deficit, while also providing an environment conducive to implant longevity. Key factors in determining a successful THA include achieving the desired pre-operative femoral offset and leg length, as well as the restoration of range of motion (ROM). Minor leg length discrepancies (LLDs), less than a centimetre, are common after THA and usually well tolerated. However, in some patients, even these small discrepancies are a source of dissatisfaction. More significant discrepancies can be a risk factor for more serious concerns such as nerve injury, abnormal gait and chronic pain. The level of the femoral neck osteotomy is a critical step in reproducing a planned femoral stem position. Frequently the femoral osteotomy is too high and can lead to an increase in leg length and varus stem positioning. If the desired implant positions are identified from preoperative 3D templating, a planned femoral osteotomy can be used as a reference to recreate the correct leg length and offset. The aim of this study was assess the accuracy of a 3D printed patient-specific guide for delivering a pre-planned femoral neck osteotomy. Methodology. A consecutive series of 33 patients, from two surgeons at a single institution, were sent for Trinity OPS pre-operative planning (Optimized Ortho, Australia). Trinity OPS is a pre-operative, dynamic, patient-specific modelling system for acetabular and femoral implant positioning. The system requires a pre-operative CT scan which allows patient specific implant sizing as well as positioning. Once the preoperative implant positioning plan was confirmed by the surgeon, a patient-specific guide was designed and printed to enable the planned level of femoral neck osteotomy to be achieved, Fig 1. All patients received a Trinity cementless acetabular component (Corin, UK) and a cementless TriFit TS femoral component (Corin, UK) through a posterior approach. The achieved level of osteotomy was confirmed postoperatively by doing a 3D/2D registration, in the Mimics X-ray Module (Materialise, Belgium), of the planned 3D resected femur to the postoperative AP radiograph, Fig 2. The image was then scaled and the difference between the planned and achieved level of osteotomy was measured (imatri Medical, South Africa), Fig 2. Results. The mean absolute difference between the planned and achieved osteotomy level was 0.7mm (range 0.1mm − 6.6mm). Only 1 patient had a difference of more than 3mm, Fig 3. Of the 33 patients, 28 had a difference of less than 1mm. Conclusions. The results from this initial series of 33 patients suggest that a 3D printed patient-specific guide can be a simple and accurate way of intraoperatively reproducing a planned femoral neck osteotomy, though there was one significant outlier. Whether the 3D planning, patient-specific guide and accurate femoral osteotomy can then be used to achieve precise leg length and offset recreation is the subject of an on-going evaluation

Introduction. Many patients who had previous proximal femoral osteotomies develop deformities that may not be amenable to total hip replacement (THR) with standard off-the-shelf femoral stems. Previous studies have shown high revision rates (18% at 5–10 years follow-up). Computer-assisted-design computer-assisted-manufacture (CAD-CAM) femoral stems are indicated but the results are not known. We assessed the clinical results of THR using CAD-CAM femoral stems specifically for this group of patients. Methods. We included patients with previous proximal femoral osteotomy and significant deformity who underwent THR with CAD-CAM femoral stem operated by the senior author (AHN) from 1997 with a minimum of 5 years follow-up. We noted revision rates, associated complications and functional outcome. Radiological outcomes include assessment for loosening defined as development of progressive radiolucent lines around implant or implant migration. Results. We included 54 patients (57 THRs) at a mean age of 32 years (range 19 to 49) with a mean follow-up of 9.1 years (range 5.9–12.8). There was 2 (3.5%) stem revision for loosening. Seven polyethylene liners were revised because of eccentric wear/osteolysis after a mean of 10 years (range 7–11.5) but there was no associated radiological stem loosening. Other associated complications include 2 (3.5%) intraoperative femur fractures, 1 (1.8%) infection treated with antibiotics and 1 (1.8%) greater trochanteric fracture non-union. At the last follow-up review, the mean Oxford hip score was 35 (11–48) and the mean UCLA activity score was 5.1 (3–10). Conclusion. In contrast to previous studies that have shown high revision rates for THR in patients with previous proximal femoral osteotomy and osteotomy, the use of CAD-CAM hip stems has shown good mid- to long-term clinical outcomes with a considerably lower revision rate