Abstract. Background. Conventional TKR aims for neutral mechanical alignment which may result in a smaller lateral distal femoral condyle resection than the implant thickness. We aim to explore the mismatch between implant thickness and bone resection using 3D planning software used for Patient Specific Instrumentation (PSI) TKR. Methods. This is a retrospective anatomical study from pre-operative MRI 3D models for PSI TKR. Cartilage mapping allowed us to recreate the native anatomy, enabling us to quantify the mismatch between the distal lateral femoral condyle resection and the implant thickness. Results. We modelled 292 knees from PSI TKR performed between 2012 and 2015. There were 225 varus knees and 67 valgus knees, with mean supine hip-knee-angle of 5.6±3.1 degrees and 3.6±4.6 degrees, respectively. In varus knees, the mean cartilage loss from medial and lateral femoral condyle was 2.3±0.7mm and 1.1±0.8mm respectively; the mean overstuffing of the lateral condyle 1.9±2.2mm. In valgus knees, the mean cartilage loss from medial and lateral condyle was 1.4±0.8mm and 1.5±0.9mm respectively; the mean overstuffing of the lateral condyle was 4.1±1.9mm. Conclusions. Neutral alignment TKR often results in overstuffing of the lateral condyle. This may increase the patello-femoral pressure at the lateral facet in flexion. Anterior knee pain may be persistent even after patellar resurfacing due to tight lateral retinacular structures. An alternative method of alignment such as anatomic alignment may minimise this problem

INTRODUCTION. In living normal knee the lateral femoral condyle rolls posteriorly more than the medial side to the extent that in deep flexion the lateral femoral condyle sublux from the tibial surface (Nakagawa et al). The purpose of this presentation is to study the tibiofemoral movement in patients who had full flexion after total knee replacements and to compare it with that of normal knee. MATERIALS AND METHODS. 23 knees were scanned using SIEMENS SIREMOBILE Iso-C with 3D Extension C-arm. The system is able reconstruct 3D images that can be viewed from deferent angle and precise measurements of distances between the deferent components of the implant can be made. The knee was scanned while the patient is sitting in kneeling position with the calf touching the thigh (flexion of over 150 degree). RESULTS. All the cases studied showed a variable roll back between the medial and lateral femoral condyle. In all cases the lateral roll back was much more than the medial. In 14 cases we confirmed lateral condyle subluxation similar to what is seen in normal knee. The position of the foot (internal or external rotation) during scanning did not affect the lateral femoral condyle role back. DISCUSSION. Although previous studies have shown paradoxical types of tibiofemoral movement in patients who have total knee replacements throughout the range of movement, the knees in patients who had full flexion after TKA tend to have the same tibiofemoral movement as the normal knee in deep flexion. The lateral femoral condyles spin off or subluxation could adversely affect the implant components especially if the design does not accommodate this movement. CONCLUSION. The lateral femoral condyle may sublux from the tibia during kneeling in patients who had full flexion after TKA. These findings should call for changes in the implant design to accommodate the lateral condyle roll back

Introduction. Oriental people habitually adopt formal sitting and squatting postures, the extreme flexion of the knees allowing of this. The influence exercised by pressure and posture are, therefore, found at the posterior side of knee joint. However, we don't have many report about articular cartilage of posterior femoral condyle. Objectives. The purpose of this study was to reveal the accurate prevalence and related factors to the presence of degenerative changing of the articular cartilage of posterior femoral condyle in cadaveric knee joints. Methods. One hundred and thirty two knees from 66 cadavers (42 male knees and 24 female knees, formalin fixed, Japanese anatomical specimens) were included in this study. The average age of the cadavers was 81.4 (56–101) years. Knees were macroscopically evaluated the depth of cartilage degeneration of the patellofemoral joint, medial and lateral femoral condyle, medial and lateral posterior femoral condyle following the Outerbridge's classification. Grading was as follows: Grade 1: normal cartilage or softening and swelling of the cartilage. Grade 2: partial-thickness defect which did not reach the subchondral bone and was less than 1.3 cm in diameter. Grade 3: partial-thickness defect which did not reach the subchondral bone and was more than 1.3 cm in diameter. Grade 4: exposed subchondral bone and visible reactive tissue formation. When there were multiple lesions of different Outerbridge's classification grades, the sizes of the lesions were added up. Lesions with degenerative changes more severe than Outerbridge's classification grade 3 were regarded as OA lesions. Statistical analysis was performed to reveal the correlation between the occurrences of cartilage degeneration of medial and lateral posterior femoral condyle and medial and lateral femoral condyle and gender. Results. The prevalence of OA-positive was 48.5% (64 knees). Analyzing in the prevalence in gender, male was 31% (26 knees) OA-positive, female was 79.2% (38knees) OA-positive. The frequency of OA-positive was significantly higher in females than in males (P < 0.001). The prevalence of OA-positive in posterior condyle was 53.1% (34 knees) in 64 knees of OA-positive. Analyzing in the prevalence in gender, male was 15.4% (4 knees) in 26 knees of OA-positive, female was 78.4% (30knees) in 38 knees of OA-positive. The frequency of OA-positive in posterior condyle was significantly higher in females than in males (P < 0.001). Conclusions. In this study, the prevalence of OA-positive in posterior condyle was evaluated in cadaveric knees. The prevalence of OA-positive in posterior condyle was 53.1% in OA-positive knees, and was significantly correlated with the gender

While double-bundle anterior cruciate ligament (ACL) reconstruction attempts to recreate the two-bundle anatomy of the native ACL, recent research also indicates that double-bundle reconstruction more closely reproduces the biomechanical properties of the ACL and restores the rotatory and sagittal stability to the level of the intact knee that was not attainable with anatomic single-bundle reconstruction. Though double-bundle reconstruction provides these potential biomechanical benefits, it poses a significant challenge to the surgeon who must attempt to accurately place twice as many tunnels while avoiding tunnel convergence compared to single-bundle reconstruction. In addition, previous work has shown that tunnel malpositioning may cause grafts that fail to reproduce the native biomechanics of the ACL, increase graft tension in deep knee flexion, increase anterior tibial translation, and produce lower IKDC (International Knee Documentation Committee) scores. We hypothesise that experienced surgeons without the use of computer-assisted navigation will place tunnels on the tibial plateau and lateral femoral condyle that more closely emulate the locations of the native anteromedial (AM) and posterolateral (PL) ACL bundles than inexperienced surgeons with the use of computer-assisted navigation. A novice surgeon group comprised of three medical students each performed double-bundle ACL reconstruction using passive computer-assisted navigation on a total of eleven cadaver knees. Their individual results were compared to three experienced orthopaedic surgeons each performing the identical procedure without the use of computer-assisted navigation on a total of nine cadaver knees. There were no significant differences in placement of either the AM or PL tunnels on the tibial plateau between novice surgeons using computer-assisted navigation and experienced surgeons without the use of computer navigation. On the lateral femoral condyle, novice surgeons placed the AM and PL tunnels significantly more anterior along Blumensaat's line on average compared to experienced surgeons. Both groups placed femoral AM and PL tunnels anterior to previously described AM and PL bundle positions. Novice surgeons utilizing computer-assisted navigation and experienced surgeons without computer assistance place the AM and PL tunnels on the tibial side with no significant difference. On the lateral femoral condyle, novice surgeons utilising computer-assisted navigation place tunnels significantly anterior along Blumensaat's line compared to experienced surgeons without the use of computer navigation

Introduction:. Contemporary Posterior Cruciate Ligament (PCL) retaining TKA implants (CR) are associated with well-known kinematic deficits, such as absence of medial pivot motion, paradoxical anterior femoral sliding, and posterior femoral subluxation at full extension. The hypothesis of this study was that a biomimetic implant, reverse engineered by using healthy knee kinematics to carve the tibial articular surface, could restore normal kinematic patterns of the knee. Methods:. Kinematics of the biomimetic CR and two contemporary CR implants (A, B) were evaluated during simulated deep knee bend and chair-sit in LifeModeler KneeSIM™ software. Anteroposterior motion of the medial and lateral femoral condyle centers was measured relative to a tibial origin. The implants were mounted on an average knee model created from magnetic resonance imaging (MRI) of 40 healthy knees. The medial and lateral collateral ligaments, posterior cruciate ligament, quadriceps mechanism, and the overall capsular tension were modeled. The soft-tissue insertions were obtained from the average knee model, and the mechanical properties were obtained from literature. In vivo knee kinematics of healthy subjects from published literature was used for reference. Results:. During the simulated deep knee bend, the biomimetic CR showed knee motion similar to that reported for healthy knees in vivo, with an overall medial pivot and greater rollback of the lateral femoral condyle than the medial condyle (7.2 mm medial vs. 13.2 mm lateral, Fig 1. and Fig. 3). In contrast, contemporary CR-A showed no medial pivot rotation, and the femur underwent paradoxical anterior sliding from 0 deg to 90 deg flexion. Contemporary CR-B did not show paradoxical anterior femoral sliding. However, contemporary CR-B also did not show medial pivot and the posterior rollback of the medial femoral condyle was slightly greater than that of the lateral condyle (9.7 mm medial vs. 7 mm lateral). Similar trends were seen for all implants during the simulated chair sit (Fig 2. and Fig. 3). Conclusion:. The results confirmed the hypothesis that, during the simulated activities, the biomimetic CR implant could provide kinematics similar to that reported for healthy knees, unlike contemporary CR implants. The biomimetic implant showed medial pivot motion with greater rollback of the lateral femoral condyle than the medial condyle. In contrast, the contemporary implants showed several abnormalities including absence of medial pivot, paradoxical anterior femoral sliding and reduced posterior rollback

“The shortest distance between two points is a straight line.” This explains many cases of patellar maltracking, when the patellar track is visualised in three dimensions. The three-dimensional view means that rotation of the tibia and femur during flexion and extension, as well as rotational positioning of the tibial and femoral components are extremely important. As the extensor is loaded, the patella tends to “center” itself between the patellar tendon and the quadriceps muscle. The patella is most likely to track in the trochlear groove IF THE GROOVE is situated where the patella is driven by the extensor mechanism: along the shortest track from origin to insertion. Attempts to constrain the patella in the trochlear groove, if it lies outside that track, are usually unsuccessful. Physiologic mechanisms for tibial-femoral rotation that benefit patellar tracking (“screw home” and “asymmetric femoral roll-back”) are not generally reproduced. Practical Point. A patellofemoral radiograph that shows the tibial tubercle, illustrates how the tubercle, and with it the patellar tendon and patella itself, are all in line with the femoral trochlea. To accomplish this with a TKA, the femoral component is best rotated to the transepicondylar axis (TEA) and the tibial component to the tubercle. In this way, when the femoral component sits in its designated location on the tibial polyethylene, the trochlear groove will be ideally situated to “receive” the patella. Knee Mechanics. Six “degrees of freedom” refers to translation and rotation on three axes (x,y,z). This also describes how arthroplasty components can be positioned at surgery. The significant positions of tibial, femoral and patellar components are: 1. Internal-external rotation (around y-axis) and 2. Varus-valgus rotation (around z axis). 3. Medial-lateral translation (on x-axis). The other positional variables are less important for patella tracking. Biomechanical analyses of knee function are often broken down into: i. Extensor power analysis (y-z or sagittal plane) and ii. Tracking (x-y or frontal plane). These must be integrated to include the effects of rotation and to better understand patellar tracking. Effect of Valgus. Frontal plane alignment is important but less likely to reach pathological significance for patellar tracking than rotational malposition clinically. For example if a typical tibia is cut in 5 degrees of unintended mechanical valgus, this will displace the foot about 5 cm laterally but the tibial tubercle only 8 mm laterally. An excessively valgus tibial cut will not displace the tubercle and the patella as far as mal-rotation of the tibial component. Effect of Internal Rotation of Tibial Component. By contrast, internal rotation of the tibial component by 22 degrees, which is only 4 degrees in excess of what has been described as tolerable by Berger and Rubash, displaces the tubercle 14 mm, a distance that would place the center of most patella over the center of the lateral femoral condyle, risking dislocation. Dynamically, as the knee flexes, if the tibia is able to rotate externally this forces the tubercle into an even more lateral position, guaranteeing that the patella will align lateral to the tip of the lateral femoral condyle, and dislocate. The design of femoral components, in particular the varus-valgus angle of the trochlear groove, has an effect on patellar tracking. This effect will be accentuated by the surgical alignment technique of the femoral and tibial components. Component positions that mimic the orientation of the normal anatomy usually include more valgus alignment of the femoral component. This rotates the proximal “entrance” of the femoral trochlear groove more medially, making it more difficult for the patella to descend in the trochlear groove

Introduction. The Bi-Cruciate Stabilized (BCS) total knee arthroplasty (TKA) incorporates two cam-post mechanisms to reproduce the functionality and stability provided by the anterior cruciate ligament and posterior cruciate ligament in the native knee. The anterior cam-post mechanism provides stability in full extension and early flexion (≤20°) while the posterior cam-post mechanism prevents anterior sliding of the femur during deeper flexion (≥60°). Recently (2012), a second generation BCS design introduced more normal shapes to the femur and tibial bearing geometries that provides delayed lateral femoral condyle rollback and encourages more stable positioning of the medial femoral condyle. The purpose of this study was to compare the in vivo kinematics exhibited by the two generations during weight bearing flexion. Methods. In vivo kinematics were derived for 126 patients. Eighty-six subjects were implanted with a first generation BCS (BCS 1) TKA and 40 with the second generation BCS (BCS 2) TKA. Fluoroscopic videos were captured for patients while they performed a deep knee bend (DKB) from full extension to maximum flexion. Anterior-posterior motion of the lateral femoral condyle (LAP) and the medial femoral condyle (MAP), as well as tibio-femoral axial rotation, were analyzed at 30° increments from full extension to maximum flexion using a 3D-to-2D image registration technique. Statistical analysis was conducted at the 95% confidence level. Results. From full extension to 120° of flexion the amount of posterior femoral rollback (PFR) for the lateral condyle was −25.8±5.87 mm and −14.4±4.75 mm for the BCS1 and BCS2 groups respectively (p=0.003). Over the same range of motion, the anterior-posterior motion of the medial condyle in the BCS1 and BCS2 groups was −15.8±3.03 mm and −8.46±2.35 mm respectively (p=0.001). Significant differences in LAP and/or MAP position existed at each flexion increment from 0–120° of flexion (Figure 1). The BCS1 group exhibited 12.1±6.57° of axial rotation from full extension to 120° of flexion, while the BCS2 rotated 7.36±4.31° (p=0.046). Significant differences in femoral rotation with respect to the tibia existed at full extension and 30°of flexion (Figure 2). Discussion and Conclusion. Compared to BCS2 subjects, those implanted with the BCS1 exhibited greater magnitudes of anterior-posterior motion and more tibio-femoral axial rotation during DKB. The guided motion of the BCS1 encouraged large translations and rotations that may have led to complications such as dislocations and anterolateral knee pain. In comparison, the BCS2 exhibits attenuated and more stable anterior-posterior motions, while still maintaining sufficient magnitudes of rollback and rotation as intended

Valgus deformity is less common than varus. There is an associated bone deformity in many cases – dysplasia of the lateral femoral condyle. There are also soft tissue deformities, including tightness of the lateral soft tissues, and stretching of those on the medial side. Unlike varus, where the bone deformity is primarily tibial, in valgus knees it is most often femoral. There is both a distal and a posterior hypoplasia of the lateral femoral condyle. This results in a sloping joint line, and failure to correct this results in valgus malalignment. Posterior lateral bone loss also results in accidental internal rotation of the femoral component, which affects patellar tracking. Using the trans-epicondylar axis and Whiteside's line helps to position the femoral component in the correct rotation. Soft tissue balancing is more complex in the valgus knee. Releases are performed sequentially, depending on the particular combination of deformities. It is important to note whether the knee is tight in flexion, in extension, or both. Tightness in extension is the most common, and is corrected by release of the iliotibial band. Tightness in flexion as well as extension requires that the lateral collateral ligament +/− the popliteus tendon be released. Cruciate substituting designs are helpful in many cases, and in extreme deformity with medial stretching, a constrained or “total stabilised” design is needed. Patellar maltracking is common, and a lateral retinacular release may be needed. Beware of over-releasing the posterolateral corner, as excessive release may cause marked instability. Use the pie-crust technique of Insall

Objectives. Articular cartilage damage is a primary outcome of pre-clinical and clinical studies evaluating meniscal and cartilage repair or replacement techniques. Recent studies have quantitatively characterized India Ink stained cartilage damage through light reflectance and the application of local or global thresholds. We develop a method for the quantitative characterisation of inked cartilage damage with improved generalisation capability, and compare its performance to the threshold-based baseline approach against gold standard labels. Methods. The Trainable WEKA Segmentation (TWS) tool (Arganda-Carreras et al., 2017) available in Fiji (Rueden et al., 2017) was used to train two separate Random Forest classifiers to automatically segment cartilage damage on ink stained cadaveric ovine stifle joints. Gold standard labels were manually annotated for the training, validation and test datasets for each of the femoral and tibial classifiers. Each dataset included a sample of medial and lateral femoral condyles and tibial plateaus from various stifle joints, selected to ensure no overlap across datasets according to ovine identifier. Training was performed on the training data with the TWS tool using edge, texture and noise reduction filters selected for their suitability and performance. The two trained classifiers were then applied to the validation data to output damage probability maps, on which a threshold value was calibrated. Model predictions on the unseen test set were evaluated against the gold standard labels using the Dice Similarity Coefficient (DSC) – an overlap-based metric, and compared with results for the baseline global threshold approach applied in Fiji as shown in Figures 1 and 2. Results. Test set results for the global threshold approach against gold standard labels were 45.0% DSC for the femoral condyle and 32.0% DSC for the tibial plateau. Results for the developed TWS classifiers on the same unseen test data were 79.0% and 72.7% DSC, showing absolute gains of 34.0% and 40.7% DSC over the global threshold baseline for the femoral and tibial classifiers. The trained TWS classifiers were then applied to an external set of unlabelled images of ink stained femoral condyles and tibial plateaus. Model results on sample images shown in Figure 3 further highlight the generalisation capability of the developed models. The most prominent classification features were Hessian filters (32.9%), Entropy (19.4%), Gaussian blur (10.1%), Gabor filters (6.3%) and Sobel filters (6.0%), with all other features contributing less than 6%. Conclusions. Our findings show that the developed segmentation method more accurately quantifies cartilage damage and provides improved generalisation capability over a range of input variations such as inconsistent orientation and lighting conditions. The developed model enables the use of articular cartilage damage as a reliable and quantitative outcome measure in studies involving large datasets, with reduced requirements for complex pre-processing and specialised equipment. For any figures or tables, please contact the authors directly

Over the last two decades, anatomic anterior cruciate ligament (ACL) reconstructions have gained popularity, while the use of extraarticular reconstructions has decreased. However, the biomechanical rationale behind the lateral extraarticular sling has not been adequately studied. By understanding its effect on knee stability, it may be possible to identify specific situations in which lateral extraarticular tenodesis may be advantageous. The primary objective of this study was to quantify the ability of a lateral extraarticular sling to restore native kinematics to the ACL deficient knee, with and without combined intraarticular anatomic ACL reconstruction. Additionally, we aimed to characterise the isometry of four possible femoral tunnel positions for the lateral extraarticular sling. Eight fresh frozen hip-to-toe cadavers were used in this study. Navigated Lachman and mechanised pivot shift examinations were performed on ACL itact and deficient knees. Three reconstruction strategies were evaluated: Single bundle anatomic intraarticular ACL reconstruction, Lateral extraarticular sling, Combined intraarticular ACL reconstruction and lateral extraarticular sling. After all stability tests were completed, we quantified the isometry of four possible femoral tunnel positions for the lateral extraarticular sling using the Surgetics navigation system. A single tibial tunnel position was identified and digitised over Gerdy's tubercle. Four possible graft positions were identified on the lateral femoral condyle: the top of the lateral collateral ligament (LCL); the top of the septum; the ideal tunnel position, as defined by the navigation system's own algorithm; and the actual tunnel position used during testing, described in the literature as the intersection of the linear projections of the LCL and the septum over the lateral femoral condyle. For each of the four tunnel positions, the knee was cycled from 0 to 90® of flexion and fiber length was recorded at 30® intervals, therefore quantiying the magnitude of anisometry for each tunnel position. Stability testing: Sectioning of the ACL resulted in an increase in Lachman (15mm, p = 0.01) and mechanised pivot shift examination (6.75mm, p = 0.04) in all specimens compared with the intact knee. Anatomic intraarticular ACL reconstruction restored the Lachman (6.7mm, p = 3.76) and pivot shift (−3.5mm, p = 0.85) to the intact state. With lateral extraarticular sling alone, there was a trend towards increased anterior translation with the Lachman test (9.2mm, p = 0.50). This reconstruction restored the pivot shift to the intact state. (1.25mm, p = 0.73). Combined intraarticular and extraarticular reconstruction restored the Lachman (6.2mm, p = 2.11) and pivot shift (−3.75mm, p = 0.41) to the intact state. There was no significant difference between intraarticular alone and combined intraarticular and extraarticular reconstruction. (p = 1.88). Isometry: The ideal tunnel position calculated by the navigation system was identified over the lateral femoral condyle, beneath the mid-portion of the LCL. The anisometry for the ideal tunnel position was significantly lower (5.9mm; SD = 1.8mm; P<0.05) than the anisometry of the actual graft position (14.9mm; SD = 4mm), the top of the LCL (13.9mm; SD = 4.3mm) and the top of the septum (12mm; SD = 2.4mm). In the isolated acute ACL deficient knee, the addition of a lateral extraarticular sling to anatomic intraarticular ACL reconstruction provides little biomechanical advantage and is not routinely recommended. Isolated lateral extraarticular sling does control the pivot shift, and may be an option in the revision setting or in the lower demand patient with functional instability. Additionally, the location of the femoral tunnel traditionally used results in a significantly more anisometric graft than the navigation's system mathematical ideal location. However, the location of this ideal tunnel placement lies beneath mid-portion of the fibers of the LCL, which would not be clinically feasible

Introduction. An equal knee joint height during flexion and extension is of critical importance in optimizing soft-tissue balancing following total knee arthroplasty (TKA). However, there is a paucity of data regarding the in-vivo knee joint height behavior. This study evaluated in-vivo heights and anterior-posterior (AP) translations of the medial and lateral femoral condyles before and after a cruciate-retaining (CR)-TKA using two flexion axes: surgical transepicondylar axis (sTEA) and geometric center axis (GCA). Methods. Eleven patient with advanced medial knee osteoarthritis (age: 51–73 years) who scheduled for a CR TKA and 9 knees from 8 healthy subjects (age: 23–49 years) were recruited. 3D models of the tibia and femur were created from their MR images. Dual fluoroscopic images of each knee were acquired during a weight-bearing single leg lunge. The OA knee was imaged again one year after surgery using the fluoroscopy during the same weight-bearing single leg lunge. The in vivo positions of the knee along the flexion path were determined using a 2D/3D matching technique. The GCA and sTEA were determined based on existing methods. Besides the anterior-posterior translation, the femoral condyle heights were determined using the distances from the medial and lateral epicondyle centers on the sTEA and GCA to the tibial plateau surface in coronal plane (Fig. 1). The paired t-test was applied to compare the medial and lateral condyle motion within each group (Healthy, OA, and CR-TKA). Two-way ANOVA followed post hoc Newman–Keuls test was adopted to detect significant differences among the groups. p<0.05 was considered significant. Results. The results demonstrated that following TKA, the medial and lateral femoral condyle heights were not equal at mid-flexion (15° to 45°, medial condyle lower then lateral by 2.4mm at least, p<0.01), although the knees were well-balanced at 0° and 90° (Fig. 2). While the femoral condyle heights increased from the pre-operative values (>2mm increase on average, p<0.05), they were similar to the intact knees except that the medial sTEA was lower than the intact medial condyle between 0 and 90°. At deep flexion (>90°), both condyles were significantly higher (>2mm, p <0.01) than the healthy knees. Anterior femoral translation of the TKA knee was more pronounce at mid-flexion (Fig. 3), whereas limited posterior translation was found at deep flexion. Conclusion. Femoral condyle heights and AP translations of the CR TKA knees were significantly different from the healthy knees during the weight bearing flexion activity when measured using both the sTEA and GCA, especially at mid-flexion (15° to 45°) and deep flexion (>90°). These results suggest that a well-balanced knee intra-operatively might not necessarily result in mid-flexion and deep flexion balance during functional weight-bearing motion, implying mid-flexion instability and deep flexion tightness of the knee. The data could be useful for improvement of future prostheses designs and surgical techniques in treatment of patients with end-stage medial knee OA

Background. The Bi-Cruciate Stabilized (BCS) total knee arthroplasty (TKA) incorporates two cam-post mechanisms in order to replicate the functionality and stability provided by the anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) in the native knee. Recently (2012), a second generation BCS design has introduced femur and tibial bearing modifications that are intended to delay lateral femoral condyle rollback and encourage more stable positioning of the medial femoral condyle to more closely replicate normal knee kinematics. The purpose of this study was to compare the kinematics of this TKA to the normal knee during a weight bearing flexion activity. Methods. In vivo kinematics were derived for 10 normal non-implanted knees and 40 second generation BCS TKAs all implanted by a single surgeon. Computed tomography (CT) scans were obtained for each normal patient, and 3D reconstruction of the femur, tibia/fibula, and patella was performed. Fluoroscopic images were captured at 60 Hz using a mobile fluoroscopic unit that tracked the knee while patients performed a deep knee bend (DKB) from full extension to maximum flexion. A 3D-to-2D image registration technique was used at 30° increments to determine the transformations of the segmented bones or TKA components. The anterior-posterior motion of the lateral femoral condyle contact point (LAP) and the medial femoral condyle contact point (MAP), as well as tibio-femoral axial rotation, were measured at 30° increments from full extension to maximum flexion. Statistical analysis was conducted at the 95% confidence level. Results. From full extension to 120° of knee flexion the lateral condyle contact point translated posteriorly by 14.55 mm ± 5.11 mm and 10.47 mm ± 3.14 mm in the Normal and BCS groups respectively (p=0.1984). Over the same range of motion, the anterior-posterior motion of the medial condyle contact point in the Normal and BCS groups was −5.05 mm ± 2.91 mm and −10.66 mm ± 4.46 mm respectively (p=0.0433). Significant differences in LAP and/or MAP position existed at each flexion increment from 0–120° of flexion (Figure 1). The Normal group exhibited 19.85° ± 6.92° of axial rotation from full extension to 120° of flexion, while the BCS rotated 7.36° ± 4.31° (p=0.0085). Significant differences in femoral rotation with respect to the tibia existed at full extension as well as at 30° and 60° of knee flexion (Figure 2). Conclusions. Like the normal knee, the BCS experiences larger amounts of posterior motion in the first 30 degrees of knee flexion, compared to its mid-flexion phases (30°–90°). After 90 degrees the posterior motion in the BCS continues to increase, likely in part due to posterior cam-post engagement as intended. In this sample of normal knee subjects, very little posterior motion of either femoral condyle happens between 90 and 120 degrees of knee flexion although significant amounts of rollback are expected thereafter as reported in the literature. The axial rotation experienced by the BCS group is quite less than that experienced by the Normal group, however it is quite comparable to other TKAs, if not greater

Introduction:. While kinematic abnormalities of contemporary TKA implants have been well established, a solution has not yet been achieved. We hypothesized that contemporary TKA implants are not compatible with normal soft-tissue function and normal knee motion. We propose a novel technique for reverse engineering advanced implant articular surfaces (biomimetic surface), by using accurate 3D kinematics of normal knees. This technique accounts for surgical placement of the implants, and allows design of tibial and femoral articular surfaces in conjunction. Methods:. Magnetic resonance imaging was used to create 3D knee models of 40 normal subjects (24 male, 16 female, age 29.9 ± 9.7 years), and bi-planar fluoroscopy was used to capture 3D knee motion during a deep knee bend. These data were combined to create a 3D virtual representation of an average normal knee and its motion pathway. A TKA femoral component was mounted on the average knee, and moved through its normal kinematic pathway to carve out an articular surface from a tibial template (Fig. 1 and 2). The geometry of the resulting biomimetic tibia was compared to that of the native tibia, and a contemporary TKA tibial insert that uses the same femoral component. Results:. The biomimetic tibia had a dished medial plateau and a convex lateral plateau similar to the native tibia, with anterior/posterior lips analogous to the native menisci (Fig. 3). The anterior/posterior lips were carved by the femoral component at its end points in extension and full flexion (Fig. 2). In contrast, while the medial geometry of the contemporary TKA tibia was similar to the biomimetic tibia, the lateral geometry was significantly different (Fig. 3). Anteriorly, the contemporary tibia was excessively proud. The resulting soft-tissue tightening would prevent anterior location of lateral femoral condyle in extension, and block screw home femoral rotation. Posteriorly, again the contemporary tibia was excessively proud. The resulting soft-tissue tightening would prevent posterior rollback of the lateral femoral condyle in flexion. Conclusion:. The non-anatomic geometry of the contemporary TKA tibia, especially on the lateral side, conflicted with normal knee motion. In contrast, a biomimetic tibia reverse engineered directly from normal knee motion, had an anatomic geometry, with anterior/posterior lips similar to the native menisci. Such a biomimetic surface would allow normal soft tissue function and normal knee motion. The reverse engineering technique described herein enables for the first time, the direct use of in vivo knee kinematics to generate advanced implant articular surfaces

Introduction. The SAIPH™ (MatOrtho, UK) total knee replacement is a new fixed-bearing prosthesis design having attributes of a mobile bearing and the posterior stabilised categories for knee arthroplasties. The implant design goal is an articulation that provides definitive anteroposterior stability to beneficially control tibiofemoral translation, the ability for the tibia to axially rotate to accommodate various lifestyle activities, and to maintain a relatively posterior femoral position on the tibia to facilitate range of motion. This study aims to analyze knee kinematics of the SAIPH™ total knee arthroplasty (TKA) by videofluroscopy during four different weightbearing activities. Method. Fourteen consecutive patients operated on by a single surgeon, with a minimum follow up of 24 months were included in this IRB-approved study. A medially conforming knee was implanted in all cases. Participants in the study were asked to perform weightbearing kneeling, lunging, step-up/down and pivoting activities while their knee motions were recorded by videofluoroscopy. Three-dimensional (3D) joint kinematics were determined using model-image registration. The 3D orientation of each TKA component was expressed using standard joint angle conventions, and the anterior/posterior location of each condyle was expressed relative to the deepest part of the tibial sulcus. Results. Maximum knee flexion during the kneeling activity averaged 127 ° (100°–155°). Condylar contact was posterior on the tibia during kneeling (Figure 1). The medial femoral condyle (MFC) translated an average of 4 mm (SD 3 mm) posteriorly at 127 ° of kneeling flexion. The lateral femoral condyle (LFC) translated posteriorly 8 mm (SD 3 mm). None of these knees demonstrated paradoxical forward slide of the femur during this activity. The tibia rotated internally an average of 5° during flexion. During the lunge activity mean knee flexion was 121°. There was a similar asymmetric posterior translation of the femoral condyles, 5 mm for the MFC, and 8 mm for the LFC, and an average internal rotation of the tibia of 3°. During the step-up/down activity the MFC translated posteriorly 2 mm, and the LFC 3 mm (Figure 2). The tibia internally rotated 4° from extension to 85° flexion during stepping. During the pivot activity, the MFC remain stable in the tibial sulcus and the LFC translated posteriorly while the tibia rotated externally to internally (Figure 3). Conclusion. The SAIPH™ knee shows a medial pivot motion with tibial internal rotation of the tibia during active weightbearing flexion and deep knee flexion, as seen in previous studies. The kinematics are similar in pattern to normal knees showing an asymmetric posterior translation of the lateral femoral condyle and tibial internal rotation with knee flexion. A medially conforming implant design provides intrinsic anteroposterior stability to control femoral translation across the entire range of flexion, allows tibial rotation, and provides functional flexion comparable to specialized posterior-stabilised implant designs

Aims. Recently, total knee arthroplasty (TKA) has been generalized as an operation that achieves excellent clinical results. However, younger and Asian patients require even greater implant longevity and functional performance. We hypothesized a novel posterior cruciate-retaining TKA design that restores the anatomical jointline in both sagittal and coronal planes, maintains the femoral posterior condylar offset, and provides low contact stress would provide enhanced patient function with the potential for greater implant longevity. Methods. The novel TKA design was created based on geometry determined from anatomic specimens, 3-degree step of femorotibial jointline was incorporated in the TKA design for Asian. The novel TKA has an asymmetrical design between the medial and lateral femoral condyle, the medial femoral condyle designed to be 3 degrees larger than the lateral femoral condyle. It refined using finite element analyses (FEA) to minimize peak contact stresses. The alignment evaluation after TKA was performed using using bidirectional CR and CT images. Femorotibial-angle (FTA), the position of the femoral component relative to the 3D mechanical axis, and the rotational alignment of the femoral component relative to the PC line were evaluated before and after TKA to identify changes in the femoral condylar shape. The kinematic evaluation after TKA was performed using a 3D-to-2D model registration technique. Single-plane fluoroscopic imaging was used to record and quantify the motions of knees during a stair-step activity. The contact points between the tibiofemoral motions and the tibial rotational angle were evaluated. Results. FEA showed peak von Mises stress of 10.5 MPa under 2000 N load, well below the plastic limit of UHMWPe. Changes in the femoral condylar shape after TKA were small based on alignment analysis of the medial and lateral condyles. Kinematic analysis revealed an average 16.9 degrees tibial internal rotation with flexion to 90 degrees. Condylar translations exhibited a medial pivot pattern from 0 to 90 degrees of flexion, with an average of 0.9 mm anterior translation of the medial condyle and 9.0 mm posterior translation of the lateral condyle. As a result, tibial internal rotation with medial pivot pattern was accepted. Conclusions. The novel TKA design based on restoration of articular surface orientation and bony geometry exhibits in vivo kinematics and alignment, contact mechanics that are compatible with excellent functional performance and implant longevity for Asian

Introduction. Forward solution joint models (FSMs) can be powerful tools, leading to fast and cost-efficient simulation revealing in vivo mechanics that can be used to predict implant longevity. Unlike most joint analysis methods, mathematical modeling allows for nearly instantaneous evaluations, yielding more rapid surgical technique and implant design iterations as well as earlier insight into the follow-up outcomes used to better assess potential success. The current knee FSM has been developed to analyze both the kinematics and kinetics of commercial TKA designs as well as novel implant designs. Objective. The objective of this study was to use the knee FSM to predict the condylar translations and axial rotation of both fixed- and mobile-bearing TKA designs during a deep knee bend activity and to compare these kinematics to known fluoroscopy evaluations. Methods. The knee joint is modeled mathematically using Kane's dynamics, incorporating muscle controllers to predict the muscle forces, contact detection algorithms to compute the knee joint forces, and nonlinear ligaments at the knee joint. The tibiofemoral kinematics data for 20 subjects implanted with fixed-bearing (FB) PS TKA and 20 subjects implanted with mobile-bearing (MB) PS TKA were collected using fluoroscopy data during a deep knee bend (DKB) activity from full extension to 120° of flexion. All subjects were implanted by the same surgeon. The same CAD models for these implanted were incorporated in the FSM to predict the tibiofemoral kinematics. The average component placement from fluoroscopy data were used as an initial condition for the placement of the component in the mathematical model. Results. Overall, fluoroscopy results showed patients experienced 6.8 mm and 6.4 mm posterior rollback of the lateral femoral condyle for FB and MB PS TKA groups, respectively. The FSM predicted 5.9 mm and 6.3 mm of lateral posterior rollback for FB and MB PS TKA models, respectively (Figure 1). On average, media condyle translated posteriorly −2.9 mm and −2.5 mm, for FB and MB subjects, respectively. The mathematical model prediction for FB and MB models was −1.4 mm and −2.4 mm, respectively (Figure 2). The overall axial rotation was 5.1° and 4.5°, for FB and MB subjects from fluoroscopy, respectively. The axial rotation prediction using the FSM was 6.0° and 4.2°, for FB and MB models, respectively (Figure 3). Conclusion. Overall, it is clear that the FSM can accurately predict both the patterns and magnitudes of fixed- and mobile-bearing TKA condylar translations and axial rotations, showing consistent rollback of the lateral condyle, less translation of the medial condyle, and consistent axial rotation throughout flexion, all of which were also observed in the fluoroscopy data. The correlation between the theoretically predicted and experimentally confirmed kinematic patterns demonstrates the viability of forward solution modeling as a valuable and accurate method to evaluate total joint replacement mechanics. For any figures or tables, please contact the authors directly

Introduction. Robotic TKA allows for quantifiable precision performing bone resections for implant realignment within acceptable final component and limb alignments. One of the early steps in this robotic technique is after initial exposure and removal of medial and lateral osteophytes, a “pose-capture” is performed with varus and valgus stress applied to the knee in near full extension and 90° of flexion to assess gaps. Component alignment adjustments can be made on the preoperative plan to balance the gaps. At this point in the procedure any posterior osteophytes will still be present, which could after removal change the flexion and extension gaps by 1–3mm. This must be taken into consideration, or changes in component alignment could result in over-correction of gaps can occur. Objective. The purpose of this study was to identify what effect the posterior osteophyte's size and location and their removal had on gap measurements between pose-capture and after bone cuts are made and gaps assessed during implant trialing. Methods. This was a retrospective, single center cohort study comparing 100 robotic-assisted TKAs. Preoperative computer tomography was assessed for the presence, size and location of posterior osteophytes. Robotic-assessed gaps at pose capture and trialing were collected. Paired t-tests, independent t-tests and Pearson's correlation were used to examine this relationship. Results. Posterior osteophytes were present in 87% of cases with 59.3% isolated to the posterior medial femoral condyle. In the sagittal plane, posterior medial femoral condyle (pMFC), posterior lateral femoral condyle (pLFC) and posterior tibial (pT) osteophytes measured 6.75 ± 2.7mm, 5.77 ± 2.8mm, and 6.52 ± 3.14mm respectively. There was a significant increase in medial (17.4 ± 2.7mm vs 19.7 ± 2.2mm, p<0.01) and lateral (19.2 ± 2.2mm vs 20.5 ± 1.9mm, p<0.01) extension gaps from pose-capture to trialing. There was no difference in the delta of medial extension gaps from pose-change to trialing for knees with pMFC osteophytes > or < 5mm (2.1 ± 2.3 mm vs 2.4 ± 2.1mm, p=0.56). Similarly, there was no difference in the change in lateral extension gaps from pose-capture to trialing for knees with lateral posterior osteophytes > or < 5mm (1.2 ± 2.0mm vs 1.73 ± 1.53mm, p = 0.37). There was no statistically significant correlation between medial or lateral osteophyte size and change in medial (r=0.12, p=0.27) or lateral (r=0.11, p=0.36) extension gaps respectively. Conclusion. While there is a significant change in robotically assessed gaps at pose-capture and trialing, this change is small, our study findings are not able to substantiate that it is solely due to the presence, size or location of posterior osteophytes. A post-hoc power analysis indicates that, in order to detect a difference in gap between pose-capture and trialing of 1mm, over 75 knees with and without posterior osteophytes would be needed

The purpose of this study was to compare intra-operative, clinical, functional, and patient-reported outcomes following revision anterior cruciate ligament reconstruction (ACL-R) with a matched cohort of primary isolated ACL-R. A secondary purpose was to compare patient-reported outcomes within revision ACL-R based on intra-operative cartilage pathology. Between January 2010 and August 2017, 396 patients underwent revision ACL-R, and were matched to primary isolated ACL-R patients using sex, age, body mass index (BMI), and Beighton score. Intra-operative assessments including meniscal and chondral pathology, and graft diameter were recorded. Lachman and pivot shift tests were completed independently on each patient at two-years post-operative by a physiotherapist and orthopaedic surgeon. A battery of functional tests was assssed including single-leg Bosu balance, and four single-leg hop tests. The Anterior Cruciate Ligament-Quality of Life Questionnaire (ACL-QOL) was completed pre-operatively and two-years post-operatively. Descriptive statistics including means (M) and standard deviations (SD), and as appropriate paired t-tests were used to compare between-groups demographics, the degree and frequency of meniscal and chondral pathology, graft diameter, rate of post-operative ACL graft laxity, the surgical failure rate, and ACL-QOL scores. Comparative assessment of operative to non-operative limb performance on the functional tests was used to assess limb symmetry indices (LSI). Revision ACL-R patients were 52.3% male, mean age 30.7 years (SD=10.2), mean BMI 25.3 kg/m2 (SD=3.79), and mean Beighton score 3.52 (SD=2.51). In the revision group, meniscal (83%) and chondral pathology (57.5%) was significantly more frequent than in the primary group (68.2% and 32.1%) respectively, (p < 0 .05). Mean graft diameter (mm) in the revision ACL-R group for hamstring (M=7.89, SD=0.99), allograft (M=8.42, SD=0.82), and patellar or quadriceps tendon (M=9.56, SD=0.69) was larger than in the primary ACL-R group (M=7.54, SD=0.76, M=8.06, SD=0.55, M=9, SD=1) respectively. The presence of combined positive Lachman and pivot shift tests was significantly more frequent in the revision (21.5%) than primary group (4.89%), (p < 0 .05). Surgical failure rate was higher in the revision (10.3%) than primary group (5.9%). Seventy-three percent of revision patients completed functional testing. No significant LSI differences were demonstrated between the revision and primary ACL-R groups on any of the functional tests. No statistically significant differences were demonstrated in mean preoperative ACL-QOL scores between the revision (M=28.5/100, SD=13.5) and primary groups (M=28.5/100, SD=14.4). Mean two-year scores demonstrated statistically significant and minimally clinically important differences between the revision (M=61.1/100, SD=20.4) and primary groups (M=76.0/100, SD=18.9), (p < 0 .05). Mean two-year scores for revision patients with repair of the medial (M=59.4/100, SD=21.7) or lateral meniscus (M=59.4/100, SD=23.6), partial medial meniscectomy (M=59.7/100, SD=20), grade three or four osteoarthritis (M=55.9/100, SD=19.5), and medial femoral condyle osteoarthritis (M=59.1/100, SD=18) were lower compared with partial lateral meniscectomy (M=67.1/100, SD=19.1), grade one or two osteoarthritis (M=63.8/100, SD=18.9), and lateral femoral condyle osteoarthritis (M=62, SD=21). Revision ACL-R patients demonstrated a greater amount of meniscal and chondral pathology at the time of surgery. Two-years post-operative these patients demonstrated higher rates of graft laxity and lower ACL-QOL scores compared with the primary ACL-R group. Higher grade and medial sided osteoarthritis was associated with inferior ACL-QOL scores in revision ACL-R

Each of the seven cuts required for a total knee arthroplasty has its own science, and can affect the outcome of surgery. Distal Femur. Sets the axial alignment (along with the tibial cut), and too little or too much depth affects ligament tension in extension. Anterior Femur. Sets the rotation of the femoral component, which affects patellar tracking. Internal rotation results in patellar maltracking. External rotation will either notch the femur, or cause too large a femoral component to be selected. Anterior and posterior femoral cuts also determine femoral component size selection. Too small a femoral component causes notching, flexion instability, and mismatch to the tibial component. Too big a femoral component causes overstuffing, periarticular pain, and patellar maltracking. Posterior Femur. Posterior referencing usually works, and the typical knee requires 3 degrees of external rotation to align with the transepicondylar axis. In valgus knees, there may be significant hypoplasia of the lateral femoral condyle, and posterior referencing has to be adjusted to avoid internal rotation. Posterior chamfer. A 4-in-one block saves time. Anterior chamfer. Deeper anterior chamfer allows a deeper trochlear groove, for patellar tracking. Tibia. Sets axial alignment with distal femoral cut. Posterior slope loosens flexion gap. Oversizing results in painful medial overhang. Lateral overhang usually not a problem. Undersizing results in inadequate bone support and subsidence. Patella. Inset or onset. Central peg associated with fracture. Err to medial and superior to assist tracking and avoid impingement on the tibial insert

Deformity correction is a fundamental goal in total knee arthroplasty. Severe valgus deformities often present the surgeon with a complex challenge. These deformities are associated with abnormal bone anatomy, ligament laxity and soft tissue contractures. Distorted bone anatomy is due to bone loss on the lateral femoral condyle, especially posteriorly. To a lesser extent bone loss occurs from the lateral tibia plateau. The AP axis (Whiteside's Line) or epicondylar axis must be used as a rotational landmark in the severely valgus knee. Gap balancing techniques can be helpful in the severely valgus knee, but good extension balance must be obtained before setting femoral rotation with this technique. Coronal alignment is generally corrected to neutral or 2- to 3-degree overcorrection to mild mechanical varus to unload the attenuated medial ligaments. The goal of soft tissue releases is to obtain rectangular flexion and extension gaps. Soft tissue releases involve the IT band, posterolateral corner/arcuate complex, posterior capsule, LCL, and popliteus tendon. Assessment of which structures is made and then releases are performed. In general, pie crust release of the IT band is sufficient for mild deformity. More severe deformities require release of the posterolateral corner / arcuate and posterior capsule. I prefer a pie crust technique, while Ranawat has described the use of electrocautery to perform these posterior/ posterolateral releases. In most cases the LCL is not released, however, this can be released from the lateral epicondyle, if necessary. Good ligament balance can be obtained in most cases, however, some cases with severe medial ligament attenuation require additional ligament constraint such as a constrained condylar implant