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Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_10 | Pages 32 - 32
1 Jun 2023
Gately S Green C Given J Mahon LM Meleady E O'Brien C
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Introduction. Legg-Calve-Perthes (Perthes Disease) was first recognised by three physicians, Arthur Legg (1874–1939), Jacqui Calve (1875–1954) and George Perthes (1869 – 1927) in 1910. Perthes disease is a rare childhood condition that affects the hip. It occurs when the blood supply to the femoral head is disrupted. Without this blood supply, the bone cells die and avascular necrosis can occur. The Herring classification is used to diagnose the stages of Perthes Disease. It is an important prognostic factor. There are three classifications, Herring A, B and C. Herring A has no involvement of the lateral pillar with no density changes noted on x-ray. Herring B has at least 50% of the lateral pillar height maintained on x-ray. Herring C has less than 50% of the lateral pillar height on x-ray (Herring et al, 1992). Children with Perthes disease require specialist Limb Reconstruction team throughout their treatment journey, this includes Orthopaedic surgery and therapy (Physiotherapy and Occupational Therapy). The National Limb Reconstruction Therapy Team is based at the National Orthopaedic Hospital, Cappagh. The therapy team consists of 1 Clinical Specialist Physiotherapist, 1 Senior Physiotherapist and 1 Senior Occupational Therapist who provide input to this cohort. This study aims to analyse the importance of a comprehensive pre-operative assessment by the therapy team (Physiotherapist and Occupational Therapist) to maximise patient outcomes post operatively. Methodology. This is a quantitative research study conducted by the National Limb Reconstructive Therapy Service of the National Orthopaedic Hospital in Cappagh, Dublin. The inclusion criteria for this study consisted of:. Age – Patient must be part of the Paediatric Service, i.e., under the age of 16. Diagnosis – Patient must have a diagnosis of Perthes Disease with a Herring Classification documented. Application of a Hip Distractor Frame formed part of the patient's surgical management. Surgery was completed by Mr Connor Green. Surgery was completed between January 2021 and December 2022. Patient were required to have their external hip distractor frame removed by December 2022. Exclusion Criteria: Those not meeting the above inclusion criteria. Following the inclusion criteria, a number of cases were identified of which 10 cases were selected at random. A retrospective analysis of these samples was completed. The medical charts were reviewed as well as patient electronic healthcare records. Microsoft Excel was utilised to analyse the data and capture results. Results. From analysing the data, the following results were identified:. 80% of the sample cohort had a length of stay of 5 days following surgery. There were two outliers due to infection who had a length of stay of 14 days. 90% of the sample received a pre-operative Physiotherapy and Occupational Therapy assessment. This assessment included information gathering regarding the child's home and social environment; their functional baseline and anticipated post-operative needs. Standardised and non-standardised assessments were used. 88.89% of those who completed a pre-operative assessment required referral to community Occupational Therapy teams for equipment provision (wheelchair, transfer aids) to allow for timely discharge. On average, each patient in the sample required 17 physiotherapy outpatient sessions prior to handover to the community teams. 100% of our sample required post operation onward referral for MDT input in the community (Occupational Therapy and Physiotherapy). Conclusions. The importance of a multi-disciplinary approach towards family and children was highlighted in this study. A comprehensive pre-operative therapy assessment optimizes care for this cohort by preparing them in terms of equipment provisions, local team input and expectations for therapy. The data suggests future Limb Reconstruction team should include Physiotherapy and Occupational Therapy as part of the multi-disciplinary team, in the treatment of children with Perthe's Disease. We suggest an MDT pre-assessment is completed to optimize patient care, reduce length of stay and improve patient satisfaction in the acute hospital setting


Orthopaedic Proceedings
Vol. 106-B, Issue SUPP_19 | Pages 46 - 46
22 Nov 2024
Mozella A Leal AC Cobra H Costa G
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Aim. Evaluate the metabolites composition of the synovial fluid from patients with PJI or aseptic failure of total knee arthroplasties. Method. The synovial fluids from 21 patients scheduled for revision total knee arthroplasty (11 with the diagnosis of PJI and 10 with aseptic failures) were analyzed using 1D 1H NMR spectroscopy. Univariate and multivariate statistical analyses were used to identify metabolites that were differentially abundant between those groups. Results. A total of 28 metabolites were identified and five of them found to be differentially abundant between infected and non-infected synovial fluids. Lactate, acetate and 3-hydroxybutyrate were found to be in a higher concentration, and glucose and creatine were found reduced in the synovial fluid from PJI patients. Conclusions. Synovial fluid from patients with PJI exhibit a distinct metabolic profile, possibly reflecting metabolic adaptation that occurs in the infected periprosthetic microenvironment. Further research and studies are warranted to gain a broader insight into the metabolic pathways engaged by both pathogen and immune cells in the context of a PJI


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_1 | Pages 51 - 51
1 Feb 2021
Smith L Cates H Freeman M Nachtrab J Komistek R
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Background. While posterior cruciate retaining (PCR) implants are a more common total knee arthroplasty (TKA) design, newer bi-cruciate retaining (BCR) TKAs are now being considered as an option for many patients, especially those that are younger. While PCR TKAs remove the ACL, the BCR TKA designs keep both cruciate ligaments intact, as it is believed that the resection of the ACL greatly affects the overall kinematic patterns of TKA designs. Various fluoroscopic studies have focused on determination of kinematics but haven't defined differentiators that affect motion patterns. This research study assesses the importance of the cruciate ligaments and femoral geometry for Bi-Cruciate Retaining (BCR) and Posterior Cruciate Retaining (PCR) TKAs having the same femoral component, compared to the normal knee. Methods. The in vivo 3D kinematics were determined for 40 subjects having a PCR TKA, 10 having a BCR TKA, and 10 having a normal knee, in a retrospective study. All TKA subjects had the same femoral component. All subjects performed a deep knee bend under fluoroscopic surveillance. The kinematics were determined during early flexion (ACL dominant), mid flexion (ACL/PCL transition) and deep flexion (PCL dominant). Results. During the first 30 degrees of flexion, the ACL played an important role, as subjects having a BCR TKA experienced kinematic patterns more similar to the normal knee. During mid flexion, both TKAs experienced random kinematic patterns, which could be due to the ACL and PCL being less active or resected in PCR TKA. In deeper flexion, both TKAs experienced kinematic patterns similar to the normal knee, thus supporting the assumption that the PCL played a dominant role [Fig. 1, Fig. 2]. All three groups generally experienced progressive axial rotation throughout flexion [Fig. 3]. On average, subjects having a PCR TKA experienced 112.3° of flexion, which was greater than the BCR subjects. Conclusions. Both the BCR TKA and normal groups experienced similar kinematic patterns, but the femoral geometrical differences from the anatomical condition may have influenced decreased motion compared to the normal knee. Both TKAs experienced similar kinematic patterns in deeper flexion, with the PCR TKA experiencing excellent weight-bearing flexion. Results from this study suggest that the cruciate ligaments can play a role in kinematics, but femoral geometry working with the ligaments may be an option to consider


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_1 | Pages 12 - 12
1 Feb 2021
Pianigiani S Verga R
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A common location for radius fracture is the proximal radial head. With the arm in neutral position, the fracture usually happens in the anterolateral quadrant (Lacheta et al., 2019). If traditional surgeries are not enough to induce bone stabilization and vascularization, or the fracture can be defined grade III or grade IV (Mason classification), a radial head prosthesis can be the optimal compromise between bone saving and recovering the “terrible triad”. A commercially available design of radial head prosthesis such as Antea (Adler Ortho, Milan, Italy) is characterized by flexibility in selecting the best matching size for patients and induced osteointegration thanks to the Ti-Por. ®. radial stem realized by 3D printing with laser technique (Figure 1). As demonstrated, Ti-Por. ®. push-out resistance increased 45% between 8 −12 weeks after implantation, hence confirming the ideal bone-osteointegration. Additional features of Antea are: bipolarity, modularity, TiN coating, radiolucency, hypoallergenic, 10° self-aligning. The osteointegration is of paramount importance for radius, in fact the literature is unfortunately reporting several clinical cases for which the fracture of the prosthesis happened after bone-resorption. Even if related to an uncommon activity, the combination of mechanical resistance provided by the prosthesis and the stabilization due to the osteointegration should cover also accidental movements. Based upon Lacheta et al. (2019), after axial compression-load until radii failure, all native specimens survived a compression-load of 500N, while the failure happened for a mean compression force of 2560N. The aim of this research study was to test the mechanical resistance of a radial head prosthesis obtained by 3D printing. In detail, a finite element analysis (FEA) was used to understand the mechanical resistance of the core of the prosthesis and the potential bone fracture induced in the radius with simulated bone- resorption (Figure 2a). The critical level was estimated at the height for which the thickness of the core is the minimum (Figure 2b). Considered boundary conditions:. - Full-length prosthesis plus radius out of the cement block equal to 60mm (Figure 2a);. - Bone inside the cement equal to 60mm (Figure 2b);. - Load inclined 10° epiphysiary component (Figure 2c);. - Radius with physiological or osteoporotic bone conditions;. - Load (concentrated in the sphere simulating full transmission from the articulation) of 500N or 1300N or 2560N. Figure 3 shows the results in terms of maximum stress on the core of the prosthesis and the risk of fracture (Schileo et al., 2008). According to the obtained results, the radial head prosthesis shows promising mechanical resistance despite of the simulated bone-resorption for all applied loads except for 2560N. The estimated mechanical limit for the material in use is 200MPa. The risk of fracture is in agreement with the experimental findings (Lacheta et al. (2019)), in fact bone starts to fail for the minimum reported failure load, but only for osteoporotic conditions. The presented FEA aimed at investigating the behavior of a femoral head prostheses made by 3D printing with simulated bone-resorption. The prosthesis shows to be a skilled solution even during accidental loads. For any figures or tables, please contact the authors directly


Bone & Joint Open
Vol. 5, Issue 11 | Pages 953 - 961
1 Nov 2024
Mew LE Heaslip V Immins T Ramasamy A Wainwright TW

Aims

The evidence base within trauma and orthopaedics has traditionally favoured quantitative research methodologies. Qualitative research can provide unique insights which illuminate patient experiences and perceptions of care. Qualitative methods reveal the subjective narratives of patients that are not captured by quantitative data, providing a more comprehensive understanding of patient-centred care. The aim of this study is to quantify the level of qualitative research within the orthopaedic literature.

Methods

A bibliometric search of journals’ online archives and multiple databases was undertaken in March 2024, to identify articles using qualitative research methods in the top 12 trauma and orthopaedic journals based on the 2023 impact factor and SCImago rating. The bibliometric search was conducted and reported in accordance with the preliminary guideline for reporting bibliometric reviews of the biomedical literature (BIBLIO).


Bone & Joint Open
Vol. 4, Issue 4 | Pages 250 - 261
7 Apr 2023
Sharma VJ Adegoke JA Afara IO Stok K Poon E Gordon CL Wood BR Raman J

Aims

Disorders of bone integrity carry a high global disease burden, frequently requiring intervention, but there is a paucity of methods capable of noninvasive real-time assessment. Here we show that miniaturized handheld near-infrared spectroscopy (NIRS) scans, operated via a smartphone, can assess structural human bone properties in under three seconds.

Methods

A hand-held NIR spectrometer was used to scan bone samples from 20 patients and predict: bone volume fraction (BV/TV); and trabecular (Tb) and cortical (Ct) thickness (Th), porosity (Po), and spacing (Sp).


Bone & Joint Open
Vol. 4, Issue 9 | Pages 696 - 703
11 Sep 2023
Ormond MJ Clement ND Harder BG Farrow L Glester A

Aims

The principles of evidence-based medicine (EBM) are the foundation of modern medical practice. Surgeons are familiar with the commonly used statistical techniques to test hypotheses, summarize findings, and provide answers within a specified range of probability. Based on this knowledge, they are able to critically evaluate research before deciding whether or not to adopt the findings into practice. Recently, there has been an increased use of artificial intelligence (AI) to analyze information and derive findings in orthopaedic research. These techniques use a set of statistical tools that are increasingly complex and may be unfamiliar to the orthopaedic surgeon. It is unclear if this shift towards less familiar techniques is widely accepted in the orthopaedic community. This study aimed to provide an exploration of understanding and acceptance of AI use in research among orthopaedic surgeons.

Methods

Semi-structured in-depth interviews were carried out on a sample of 12 orthopaedic surgeons. Inductive thematic analysis was used to identify key themes.


Bone & Joint Open
Vol. 5, Issue 12 | Pages 1072 - 1080
4 Dec 2024
Tang M Lun KK Lewin AM Harris IA

Aims

Systematic reviews of randomized controlled trials (RCTs) are the highest level of evidence used to inform patient care. However, it has been suggested that the quality of randomization in RCTs in orthopaedic surgery may be low. This study aims to describe the quality of randomization in trials included in systematic reviews in orthopaedic surgery.

Methods

Systematic reviews of RCTs testing orthopaedic procedures published in 2022 were extracted from PubMed, Embase, and the Cochrane Library. A random sample of 100 systematic reviews was selected, and all included RCTs were retrieved. To be eligible for inclusion, systematic reviews must have tested an orthopaedic procedure as the primary intervention, included at least one study identified as a RCT, been published in 2022 in English, and included human clinical trials. The Cochrane Risk of Bias-2 Tool was used to assess random sequence generation as ‘adequate’, ‘inadequate’, or ‘no information’; we then calculated the proportion of trials in each category. We also collected data to test the association between these categories and characteristics of the RCTs and systematic reviews.


Bone & Joint Open
Vol. 3, Issue 10 | Pages 786 - 794
12 Oct 2022
Harrison CJ Plummer OR Dawson J Jenkinson C Hunt A Rodrigues JN

Aims

The aim of this study was to develop and evaluate machine-learning-based computerized adaptive tests (CATs) for the Oxford Hip Score (OHS), Oxford Knee Score (OKS), Oxford Shoulder Score (OSS), and the Oxford Elbow Score (OES) and its subscales.

Methods

We developed CAT algorithms for the OHS, OKS, OSS, overall OES, and each of the OES subscales, using responses to the full-length questionnaires and a machine-learning technique called regression tree learning. The algorithms were evaluated through a series of simulation studies, in which they aimed to predict respondents’ full-length questionnaire scores from only a selection of their item responses. In each case, the total number of items used by the CAT algorithm was recorded and CAT scores were compared to full-length questionnaire scores by mean, SD, score distribution plots, Pearson’s correlation coefficient, intraclass correlation (ICC), and the Bland-Altman method. Differences between CAT scores and full-length questionnaire scores were contextualized through comparison to the instruments’ minimal clinically important difference (MCID).


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_4 | Pages 61 - 61
1 Apr 2019
Ta M LaCour M Sharma A Komistek R
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During the preoperative examination, surgeons determine whether a patient, with a degenerative hip, is a candidate for total hip arthroplasty (THA). Although research studies have been conducted to investigate in vivo kinematics of degenerative hips using fluoroscopy, surgeons do not have assessment tools they can use in their practice to further understand patient assessment. Ideally, if a surgeon could have a theoretical tool that efficiently allows for predictive post-operative assessment after virtual surgery and implantation, they would have a better understanding of joint conditions before surgery. The objectives of this study were (1) to use a validated forward solution hip model to theoretically predict the in vivo kinematics of degenerative hip joints, gaining a better understanding joint conditions leading to THA and (2) compare the predicted kinematic patterns with those derived using fluoroscopy for each subject. A theoretical model, previously evaluated using THA kinematics and telemetry, was used for this study, incorporating numerous muscles and ligaments, including the quadriceps, hamstring, gluteus, iliopsoas, tensor fasciae latae, an adductor muscle groups, and hip capsular ligaments. Ten subjects having a pre-operative degenerative hip were asked to perform gait while under surveillance using a mobile fluoroscopy unit. The hip joint kinematics for ten subjects were initially assessed using in vivo fluoroscopy, and then compared to the predicted kinematics determined using the model. Further evaluations were then conducted varying implanted component position to assess variability. The fluoroscopic evaluation revealed that 33% of the degenerative hips experienced abnormal hip kinematics known as “hip separation” where the femoral head slides within the acetabulum, resulting in a decrease in contact area. Interestingly, the mathematical model produced similar kinematic profiles, where the femoral head was sliding within the acetabulum (Figure 1). During swing phase, it was determined that this femoral head sliding (FHS) is caused by hip capsular laxity resulting in reducing joint tension. At the point of maximum velocity of the foot, the momentum of the lower leg becomes too great for capsule to properly constrain the hip, leading to the femoral component pistoning outwards. During stance phase, kinematics of degenerative hips were similar to kinematics of a THA subject with mal-positioning of the acetabular cup. Further evaluation revealed that if the cup was placed at a position other than its native, anatomical center, abnormal forces and torques acting within the joint lead to the femoral component sliding within the acetabular cup. It was hypothesized that in degenerative hips, similar to THA, the altered center of rotation is a leading influence of FHS (Figure 2). The theoretical model has now been validated for subjects having a THA and degenerative subjects. The model has successfully derived kinematic patterns similar to subjects evaluated using fluoroscopy. The results in this study revealed that altering the native joint center is the most influential factor leading to FHS, or more commonly known as hip separation. A new module for the mathematical model is being implemented to simulate virtual surgery so that the surgery can pre- operatively plan and then simulate post-operative results


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_4 | Pages 64 - 64
1 Apr 2019
Dessinger G Ta M Zeller I Nachtrab J Sharma A Komistek R
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Introduction. Many fluoroscopic studies on total knee arthroplasty (TKA) have identified kinematic variabilities compared to the normal knee, with many subjects experiencing paradoxical motion patterns. The intent of this research study was to investigate the results of customized-individual-made (CIM) and off-the-shelf (OTS) PS and PCR TKA to determine kinematic variabilities and to assess these kinematic patterns with those previously documented for the normal knee. Methods. In vivo kinematics were assessed for 151 subjects – 44 with CIM-PCR, 75 with OTS-PCR, 14 with CIM-PS, and 18 with OTS-PS TKA – using a mobile fluoroscopic system and then evaluated using a 3D-2D registration technique. This was a multicenter evaluation so the group of implants were implanted by two surgeons and selected based on recruitment criteria. Each subject performed a deep knee bend activity (DKB) while under fluoroscopy. The kinematics assessed for each subject were condyle translation (LAP/MAP) and rotation (axial rotation). Results. During the DKB, the average LAP of the CIM-PCR was −2.0 mm (s = 4.0), the OTS-PCR was −2.1 mm (s = 3.0), the CIM-PS was −9.0 mm (s = 6.0), and the OTS-PS was −4.3 mm (s = 3.3) (Figure 1). The average MAP of the CIM-PCR was 2.0 mm (s = 2.9), the OTS-PCR was 2.4 mm (s = 3.3), the CIM-PS was −1.2 mm (s = 5.2), and the OTS-PS was 1.1 mm (s = 1.7) (Figure 2). The average axial rotation of the CIM-PCR was 4.6° (s = 5.8), the OTS-PCR was 5.7° (s = 4.8), the CIM-PS was 9.3° (s = 4.8), and the OTS-PS was 7.5° (s = 3.5) (Figure 3). Eleven of 44 (25%) subjects having a CIM-PCR TKA, 16/75 (21.3%) subjects having an OTS-PCR TKA experienced an anterior slide of their lateral condyle, while no subjects having a CIM-PS TKA and 3/18 (16.6%) of OTS-PS subjects experienced this slide. Nine of 44 (20.5%) CIM- PCR, 8/75 (10.6%) OTS-PCR experienced a reverse axial rotation pattern, while only one subject having a CIM-PS and not OTS-PS subjects experienced this non-normal rotation pattern. Discussion. Subjects having a CIM-PS TKA experienced the greatest amount of lateral condyle posterior femoral rollback and axial rotation, although less in magnitude to the normal knee seen in previous fluoroscopic studies. This was the only group to experience posterior motion of their medial condyle during flexion. More subjects having a PCR TKA experienced a paradoxical anterior lateral condyle sliding pattern and reverse axial rotation pattern, which was not commonly seen in the subjects having a PS TKA. Significance. Subjects that had a CIM-PS TKA demonstrated greater magnitudes of lateral condyle rollback and subjects having a PS TKA experienced more normal axial rotation patterns


The Bone & Joint Journal
Vol. 103-B, Issue 4 | Pages 782 - 787
3 Apr 2021
Mahmood A Rashid F Limb R Cash T Nagy MT Zreik N Reddy G Jaly I As-Sultany M Chan YTC Wilson G Harrison WJ

Aims

Despite the COVID-19 pandemic, incidence of hip fracture has not changed. Evidence has shown increased mortality rates associated with COVID-19 infection. However, little is known about the outcomes of COVID-19 negative patients in a pandemic environment. In addition, the impact of vitamin D levels on mortality in COVID-19 hip fracture patients has yet to be determined.

Methods

This multicentre observational study included 1,633 patients who sustained a hip fracture across nine hospital trusts in North West England. Data were collected for three months from March 2020 and for the same period in 2019. Patients were matched by Nottingham Hip Fracture Score (NHFS), hospital, and fracture type. We looked at the mortality outcomes of COVID-19 positive and COVID-19 negative patients sustaining a hip fracture. We also looked to see if vitamin D levels had an impact on mortality.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_9 | Pages 92 - 92
1 May 2016
Lancaster-Jones O Al-Hajjar M Williams S Jennings L Thompson J Isaac G Fisher J
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Introduction and Aims. In order to improve the longevity and design of an implant, a wide range of pre-clinical testing conditions should be considered including variations in surgical delivery, and patients' anatomy and biomechanics. The aim of this research study was to determine the effect of the acetabular cup inclination angle with different levels of joint centre mismatch on the magnitude of dynamic microseparation, occurrence and severity of edge loading and the resultant wear rates in a hip joint simulator. Methods. The six-station Leeds Mark II Anatomical Physiological Hip Joint Simulator and 36mm diameter ceramic-on-ceramic bearings (BIOLOX® delta) were used in this study. A standard gait cycle, with a twin-peak loading (2.5kN peak load and approximately 70N swing phase load), extension/flexion 15°/+30° and internal/external ±10° rotations, was applied. Translational mismatch in the medial-lateral axis between the centres of rotation of the head and the cup were considered. In this study, mismatches of 2, 3 and 4 (mm) were applied. Two acetabular cup inclination angles were investigated; equivalent to 45° and 65° in-vivo. These resulted in a total of six conditions [Figure 1] with n=6 for each condition. Three million cycles were completed under each condition. The lubricant used was 25% (v/v) new-born calf serum supplemented with 0.03% (w/v) sodium azide to retard bacterial growth. The wear of the ceramic bearings were determined using a microbalance (XP205, Mettler Toledo, UK) and a coordinate measuring machine (Legex 322, Mitutoyo, UK). The stripe wear was analysed using RedLux software. The dynamic microseparation displacement was measured using a linear variable differential transformer. Mean wear rates and 95% confidence limits were determined and statistical analysis (one way ANOVA) completed with significance taken at p<0.05. Results Increasing the medial-lateral joint centre mismatch from 2 to 3 to 4mm resulted in an increased dynamic microseparation [Figure 2]. A similar trend was observed for the wear. A higher level of medial-lateral mismatch increased the wear rate under both 45° and 65° cup inclination angle conditions [Figure 3]. The mean wear rates obtained under 65° were significantly higher compared to those obtained under the 45° cup inclination angle conditions for a given medial-lateral mismatch in the joint centre (p=0.02 for 2mm mismatch, p=0.02 for 3 mm mismatch, and p<0.01 for 4mm mismatch). Conclusions. The condition with the acetabular cups positioned at an inclination of 45° exhibited greater resistance to dynamic microseparation for any given medial-lateral mismatch in the centres of rotation. Higher wear rates correlated with higher levels of dynamic microseparation. These results highlight how different conditions can alter the severity of edge loading, and highlight the necessity of understanding how the surgical positioning can affect the occurrence of edge loading and wear. Future studies will look into the other factors which can influence the microseparation conditions such as joint laxity, swing phase load and version angles


Bone & Joint Open
Vol. 1, Issue 9 | Pages 520 - 529
1 Sep 2020
Mackay ND Wilding CP Langley CR Young J

Aims

COVID-19 represents one of the greatest global healthcare challenges in a generation. Orthopaedic departments within the UK have shifted care to manage trauma in ways that minimize exposure to COVID-19. As the incidence of COVID-19 decreases, we explore the impact and risk factors of COVID-19 on patient outcomes within our department.

Methods

We retrospectively included all patients who underwent a trauma or urgent orthopaedic procedure from 23 March to 23 April 2020. Electronic records were reviewed for COVID-19 swab results and mortality, and patients were screened by telephone a minimum 14 days postoperatively for symptoms of COVID-19.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIX | Pages 21 - 21
1 Sep 2012
Davda K Smyth N Hart A Cobb J
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The radiographic analysis of over 5000 metal on metal (MoM) hips using Ein Bild Roentgen Analyse (EBRA) software have been recently published in an attempt to determine the influence of cup orientation on bearing function. The validation of this software relies one study, conducted in a phantom pelvis without a femoral head in situ. Three dimensional computed tomographic (3D-CT) has been shown to be more accurate for hip and knee arthroplasty than plain radiographs for measurements of component orientation and position. The accuracy of EBRA when compared to 3D-CT for MoM hips specifically is unclear. We measured the cup orientation of 96 large diameter MoM hips using EBRA analysis of plain radiographs and compared this to 3D-CT. All measurements were made using the radiographic definition of cup orientation. The mean difference in version between the two imaging modalities was 8°; with wide limits of agreement of −21.2° and +5.6°. Three retroverted cups were not detected by EBRA. The mean difference in inclination values was 0.3°, but there was up to 9°difference between imaging modalities. When measured by 3D CT, 64% of hips were within a 10° safe zone around 45° inclination and 20° version, compared to only 24% when measured by EBRA (Fishers Exact test, p< 0.0001). The measurement of cup orientation of MoM hips using EBRA software is insufficiently accurate, particularly for the assessment of cup version. The cup rim is obscured by the large diameter femoral head on plain radiographs. Research studies using EBRA analysis for version have limited value if accuracy of more than 20 degrees is required to draw conclusions. This software may not be suitable to measure the performance of a device or surgeon. The limitations of EBRA can be overcome, if 3D-CT with an extended Hounsfield scale for data capture is used


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 70 - 70
1 Mar 2013
Hamel W
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A Tracking Fluoroscope System (TFS), the first of its kind, has been developed and the design of this new technology has been previously presented. The TFS is a unique mobile robot that can acquire real-time x-ray records of hip, knee, or ankle joint motion while a subject walks/maneuvers naturally within a laboratory floor area. By virtue of its mechanizations, test protocols can involve many types maneuvers such as chair rises, stair climbing/descending, ramp crossing, walking, etc. Because the subjects are performing such actions naturally, the resulting fluoroscope images reflect the full functionality of their musculoskeletal anatomy. The goal of this follow-up study is to conduct a comparative analysis with traditional stationary fluoroscopy units to determine if this new technology does offer clinical and research advantages. Technical trials with human subjects and active fluoroscope operation were designed to evaluate and refine the TFS engineering and operational features. These trials have been completed and the key results were compared with the traditional stationary fluoroscopic units. The technical trials verified that the TFS is ready for actual clinical diagnostic use and provides the researcher an opportunity to evaluate in vivo kinematics of subjects while performing normal daily activities at various speeds. Using the mobile fluoroscopic unit, patients performed activities that were not possible to capture with a stationary unit. Also, with the upgrade to an image recording rate of 60 frames per second, the quality of the fluoroscopic images using the TFS were superior to stationary units. Further analyses are now being conducted to compare the kinematic results for a deep knee bend and gait, traditionally analyzed in the past using stationary fluoroscopic units to determine if there are unique advantages. It is hypothesized that the more normal-like gait patterns may produce kinematic patterns that differ from stationary fluoroscopic units. At present, the TFS has proven to be superior over other fluoroscopic units and will allow clinicians to evaluate patients under and unrestricted kinematic environment. Also, future research studies will be able to compare patients with or without a TKA under more challenging kinematic conditions, producing kinematic patterns that may lead to incites pertaining to TKA failure and/or concerns


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_8 | Pages 26 - 26
1 May 2014
Lewallen D
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Over the past 40 years information from large institutional total joint registries have aided in patient clinical care and follow-up efforts, have helped drive improvements in clinical practice, and have been a powerful tool for generating research studies on large well documented populations of patients. Still, these efforts are limited in that they are expensive, usually reflect a single institutional experience, and results can be biased by the larger volumes or experience at the typically large academic centers which have such registries in place. National registry efforts in other countries including Scandinavia, Australia, and the UK have resulted in improved outcomes and a decreased number of revision procedures by a combination of early identification and withdrawal of poorly performing implants, altered surgical techniques, implant choices and behaviors by surgeons, changes in practices by hospitals, and modification in requirements and incentives by payors and regulatory agencies. The American Joint Replacement Registry (AJRR) is a collaborative multi-stakeholder, independent, not-for-profit 501 c3 organisation established in 2009 for data collection and quality improvement initiatives relating to total hip and knee arthroplasty. AJRR is a national registry effort with the goal of enrolling more than 90% of the over 5,000 hospitals performing nearly 1 million hip and knee arthroplasties each year in the US. AJRR is supported by contributions from the American Academy of Orthopedic Surgeons (AAOS), the American Association of Hip and Knee Surgeons (AAHKS), the Hip Society, the Knee Society, Health Insurers, Medical Device Manufacturers, and individual orthopaedic surgeons via designated contributions through the Orthopedic Research and Education Foundation (OREF). The overarching goal of AJRR is to improve arthroplasty care for patients through the collection and sharing of data on all primary and revision total joint replacement procedures in the U.S. The mission of the registry is to enhance patient safety, and improve the value of arthroplasty care. This will be accomplished by providing national benchmarks for implant, surgeon and hospital performance which serves to modify behaviors thereby decreasing the revision burden, improving outcomes and reducing costs. From the time of incorporation in 2009 up to October 2013 the AJRR has secured the participation of 218 hospitals in 47 different states in the formal enrollment process, and have level one data submission from more than 100 institutions on over 63,000 hip and knee procedures. In addition to publicly available annual reports, confidential specific individual reports for hospitals, surgeons and manufacturers will be available by subscription with an option for future confidential online direct data queries by an individual or entity regarding their own individual performance compared to national benchmark values. In summary, registry studies have provided a rich source of information for improving arthroplasty care over the past four decades, with the emergence and increasing interaction of national registries a major factor in current efforts to increase both the quality and value of the health care of entire populations. The development, support and continued expansion of a national registry in the US must remain a central focus if we wish to improve as much as possible the arthroplasty care provided to all patients in our country


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 51 - 51
1 Mar 2013
De Bock T Zingde S Leszko F Tesner R Wasielewski R Mahfouz M Komistek R
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Introduction. The low-cost, no-harm conditions associated with vibroarthography, the study of listening to the vibrations and sound patterns of interaction at the human joints, has made this method a promising tool for diagnosing joint pathologies. This current study focuses on the knee joint and aims to synchronize computational models with vibroarthographic signals via a comprehensive graphical user interface (GUI) to find correlations between kinematics, vibration signals, and joint pathologies. This GUI is the first of its kind to synchronize computational models with vibroarthographic signals and gives researchers a new advantage of analyzing kinematics, vibration signals, and pathologies simultaneously in an easy-to-use software environment. Methods. The GUI (Figure 1) has the option to view live or previously captured fluoroscopic videos, the corresponding computational model, and/or the pre- or post-processed vibration signals. Having more than one signal axes available allows for comparison of different filtering techniques to the same signal, or comparison of signals coming from different sensor placements (ex: medial vs. lateral femoral condyle). Using computational models derived using fluoroscopic data synchronized with the vibration signals, the areas of contact between articulating surfaces can be mapped for the in vivo signal (figure 2). This new method gives the opportunity to find correlations between the different sensor signals and contact maps with the diagnosis and cartilage degeneration map, provided by a surgeon, during arthroscopy or TKA implantation (figure 3). Results. Using previously captured data and newly acquired data for subjects from research studies, several different knee pathologies have been analyzed. The signals were listened to audibly after being processed to add a qualitative side. Sounds coming from knees with pathologies revealed noticeable differences compared to the healthy subjects, and the quantitative analysis further supported our hypothesis (>96% accuracy classification patella arthritic subjects vs. healthy). Discussion. Ideally, transitioning towards real-time kinematic tracking with signal acquisition allows for diagnostic screening tools of the knee joint that will provide feedback of cartilage damage maps as well as potential meniscal or ligament injuries. The method used in this study is multi-faceted in that it allows the subject to perform various daily weight or non-weight bearing activities at his/her own speed which makes it easier to use than if the subject had to be in a very controlled environment


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 532 - 532
1 Dec 2013
Sharma A Carr C Cheng J Mahfouz M Komistek R
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Mathematical modeling provides an efficient and easily reproducible method for the determination of joint forces under in vivo conditions. The need for these new modeling methodologies is needed in the lumbar spine, where an understanding of the loading environment is limited. Few studies using telemetry and pressure sensors have directly measured forces borne by the spine; however, only a very small number of subjects have been studied and experimental conditions were not ideal for giving total forces acting in the spine. As a result, alternative approaches for investigating the lumbar spine across different clinical pathologies are essential. Therefore, the objective of this study was to develop of an inverse dynamic mathematical model for theoretically deriving in-vivo contact forces as well as musculotendon forces in patients having healthy, symptomatic, pathological and post-operative conditions of the lumbar spine. Fluoroscopy and 3D-to-2D image registration were used to obtain kinematic data for patients performing flexion-extension of the lumbar spine. This data served as input into the multi-body, mathematical model. Other inputs included patient-specific bone geometries, recreated from CT, and ground reaction forces. Vertebral bones were represented as rigid bodies, while massless frames symbolized the lower body, torso and abdominal wall (Figure 1). In addition, ligaments were selected and modeled as linear spring elements, along with relevant muscle groups. The muscles were divided into individual fascicles and solved for using a pseudo-inverse algorithm which enabled for decoupling of the derived resultant torques defining the desired kinetic trajectory for the muscles. The largest average contact forces in the model for healthy, symptomatic, pathological, and post-operative lumbar spine conditions occurred at maximum flexion at L4L5 level and were predicted to be 2.47 BW, 2.33 BW, 3.08 BW, and 1.60 BW, respectively. The FE rotation associated with these theoretical force values was 43.0° in healthy, 40.5° in symptomatic, 44.4° in pathological, and 22.8° in post-operative patients. The smallest forces occurred as patients approached the upright, standing position, followed by slight increases in the contact force at full extension. The theoretically derived muscle forces exhibited similar contributory force profiles in the intact spine (healthy, symptomatic, and pathologic); however, surgically implanted spines experienced an increase in the contribution of the external oblique muscles accompanied with decreased slope gradients in the muscle force profiles (Figure 2). These altered force patterns may be associated with the decrease in the predicted contact forces in post-operative patients. In addition, the decreased slope gradients in surgically implanted patients corresponds with the observed difficulty of performing the prescribed motion, possibly due to improper muscle firing, thereby leading to slower motion cycles and less ranges-of-motion. On the contrary, patients having an intact spine performed the activity at a faster speed and to greater ranges-of-motion, which corresponds with the higher contact forces derived in the model. In conclusion, this research study presented the development of a mathematical modeling approach utilizing patient-specific data to generate theoretical in-vivo joint forces. This may serve to help progress the understanding for the kinetic characteristics of the native and surgically implanted lumbar spine


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_21 | Pages 21 - 21
1 Dec 2016
Bhandari M Khan M Ayeni O Madden K Bedi A Ranawat A Kelly B Sancheti P Ejnisman L Tsiridis E
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Femoroacetabular impingement (FAI) is a common cause of hip pain in the young adult. Uncertainty regarding surgical indications, outcome assessment, management preferences and perceptions of the literature exist. We conducted a large international survey assessing the perceptions and demographics of orthopaedic surgeons regarding FAI. A survey was developed using previous literature, focus groups and a sample-to-redundancy strategy. The survey contained forty-six questions and was emailed to national orthopaedic associations and orthopaedic sports medicine societies for member responses. Members were contacted on multiple occasions to increase response rates. Nine hundred orthopaedic surgeons from twenty national and international organisations completed the survey. Surgeons responded across 6 continents, 58.2 % from developed nations with 35.4 % having sports fellowship training. North American and European surgeons reported significantly greater exposure to hip arthroscopy during residency and fellowships in comparison to international respondents (48.0% vs. 44.5% vs. 25.6% respectively; p<0.001). Surgeons performing a higher volume of FAI surgery (over 100 cases per year) were significantly more likely to have practiced for more than 20 years (OR 1.91; 95% CI 1.01 to 3.63), be practicing at an academic hospital (OR 2.25; 95% CI 1.22 to 4.15), and have formal arthroscopy training (OR 46.17; 95% CI 20.28 to 105.15). High volume surgeons were over two-fold more likely to practice in North America and Europe (OR 2.26; 95% CI: 1.08 to 4.72). The exponential rise in the diagnosis and surgical management for FAI appears to be driven largely by experienced surgeons in developed nations. Our analysis suggests that although FAI management is early in the innovation cycle we are at a tipping point towards wider uptake and utilisation. The results of this survey will help guide further research and study