Purpose of the Study. To assess the test-retest reliability, construct validity and determine the cut-off scoret of BACKonLINE™ for people with LBP. Background. Appropriate treatment for Low back pain (LBP) is vital, however patients can wait for 14–24 weeks on NHS Physiotherapy lists. Many factors contribute to LBP and initially can be due to peripheral tissue damage. However, persistent LBP is associated with amplification in pain processing in the central nervous system (central sensitisation-CS). CS often results in poorer outcomes and often requires longer management making timely assessment and appropriate management crucial. An online self-assessment and self-management tool (BACKonLINE™) for discerning between characteristics of predominantly centrally (CD) or peripherally (PD) driven LBP was developed using a Delphi study. Method. Same subject, test-retest reliability and construct validity study (two sessions). Sample of 35 volunteers with LBP. In session 1, participants completed BACKonLINE™ and validated questionnaires (Oswestry Disability Index, StartBack, Tampa scale for Kinesiophobia, Pain Anxiety Symptom Scale Short Form 20). Participants repeated the process one week later. BACKonLINE's Cut-off score was determined by plotting results against StartBack using ROC curve analysis. Results. BACKonLINE™ showed excellent test-retest reliability (ICC= 0.913; 95%CI=0.832–0.956). When assessing construct validity, the aforementioned questionnaires demonstrated moderate correlation with BACKonLINE™ (Pearson's r range= 0.42–0.67, p-value<0.005). ROC analysis determined that scores higher than 42 in BACKonLINE™ indicate CD LBP while scores ≤42 indicate PD LBP. Conclusion. The study shows that BACKonLINE™ has excellent test-retest reliability, and good construct validity within a LBP population. However, further studies with larger sample sizes should be conducted before the implementation of BACKonLINE™. Conflicts of interest: No conflicts of interest. Sources of funding: Civil Service Commission, Kuwait

Purpose. Posterior lumbar fusion using minimally invasive surgical (MIS) techniques are reported to minimise postoperative pain, soft tissue damage and length of hospital stay when compared to the traditional open procedure. Methods. This is a review of patients who underwent MIS for posterolateral lumbar fusion in a single practice over a 2-year period. Results. Twenty-eight patients underwent this procedure. The median age was 57 (range 34-80). Male:female ratio was 1:1. The most common symptom was radicular pain (n=26). Two patients had back pain without radicular symptoms. Primary degenerative spondylolisthesis was seen in 22 patients and post-laminectomy spondylolisthesis in 3 patients. Transforaminal interbody fusion (TLIF) with pedicle screw fixation was the commonest procedure (20) while the rest had pedicle screw fixation and inter-transverse fusion. Along with fusion, nerve root decompression alone was performed in 19, while 5 had decompression of the central spinal canal. Intra-operative navigation was used to assist screw placement in 5 patients. The typical hospital stay was 3 days. All but two patients were mobilised the same or the following day. Twenty-one patients with radiculopathy (80%) reported improvement in VAS at 6-months. One patient suffered irreversible nerve root injury (L5). Significant pedicle breach without nerve injury by a screw was seen in one patient. Conclusion. Minimally invasive TLIF and pedicle screw fixation lumbar degenerative condition is a safe procedure with complications comparable to traditional open techniques. Minimal muscle dissection and soft tissue damage allows for earlier ambulation and reduced hospital stay. The procedure however required longer operative time and increased exposure to intra-operative x-rays

Purpose of the Study. To develop an online self-assessment and self-management tool (BACKonLINE™) for discerning between people with characteristics of predominantly centrally (CD) or peripherally (PD) driven LBP. Background. Low back pain (LBP) may worsen with time, making appropriate treatment important. In the NHS Physiotherapy services LBP patients may wait for 14–24 weeks for treatments. Many factors contribute to LBP, but it is predominantly initially viewed as a result of peripheral tissue damage. However, evidence show that persistent LBP is associated with amplification in pain processing in the central nervous system (central sensitisation). Sometimes, this may drive symptoms, resulting in poorer outcomes and requiring longer management. Timely assessment and appropriate management is therefore paramount. Method. Design: 2-round Delphi study. Sample: Purposive sample of international LBP physiotherapy experts. For Round1, series of questions were developed using literature search on characterising clinical features of LBP with predominantly CD or PD pain. Participants were asked to score questions on a 7-point Likert scale on their importance in differentiating between CD and PD pain. Round2, sent to Round1 participants, aimed to reach final consensus on BACKonLINE™. Consensus for both rounds was pre-set at ≥70%. Results. In Round1, 38 experts participated. Out of 55 questions, 33 (60%) reached consensus. Participants added 11 new questions. Round2 included 44 questions and sent to Round1 participants. In Round2, 40 (90.9%) questions reached final consensus. Conclusion. This study displays an agreement among LBP physiotherapy experts on the importance of characterising CD and PD pain. Forty (90.9%) questions reached final consensus and formulated BACKonLINE™. Conflicts of interest. No conflicts of interest. Sources of funding. Civil Service Commission, Kuwait

Aims

CRP is an acute-phase protein that is used as a biomarker to follow severity and progression in infectious and inflammatory diseases. Its pathophysiological mechanisms of action are still poorly defined. CRP in its pentameric form exhibits weak anti-inflammatory activity. The monomeric isoform (mCRP) exerts potent proinflammatory properties in chondrocytes, endothelial cells, and leucocytes. No data exist regarding mCRP effects in human intervertebral disc (IVD) cells. This work aimed to verify the pathophysiological relevance of mCRP in the aetiology and/or progression of IVD degeneration.

The purpose of this retrospective study, is to demonstrate the survivorship and clinical effectiveness of the Wallis implant, against low back pain and functional disability in patients with degenerative lumbar spine disease. The Wallis Interspinous implant, was developed as a minimally invasive and anatomically conserving procedure, without recourse to rigid fusion procedures. The initial finite element analysis and cadaver biomechanical studies showed that the Wallis ligament improves stability in the degenerate lumbar motion segment. Unloading the disc and facet joints reduces intradiscal pressures at same and adjacent levels allowing for the potential of the disc to repair itself. A total of 157 patients who had wallis ligament insertion between 2003 and 2009 were reviewed, with a mean age of 54 and were followed for 48 months on average. Patients were assessed pre-operatively and post-operatively every 6 months by VAS pain score, Oswestry Disability Index and SF-36. 90% of patients improved, to show a minimal clinical difference, compared to the pre-operative evaluation. There is overall 75-80% good clinical outcome. Low infection rate of 1.1%. Two cases of prolapsed discs at the same level requiring further discectomy, 7 required fusion. No fractures or expulsions. The Wallis implant represents a safe non-fusion stabilisation device in the treatment of degenerative lumbar spine disease with canal stenosis. There is less soft tissue damage, quick rehabilitation, less morbidity and associated low complication rate

This study evaluates the long-term survival of spinal implants after surgical site infection (SSI) and the risk factors associated with treatment failure.

A Kaplan-Meier survival analysis was carried out on 43 patients who had undergone a posterior spinal fusion with instrumentation between January 2006 and December 2008, and who consecutively developed an acute deep surgical site infection. All were appropriately treated by surgical debridement with a tailored antibiotic program based on culture results for a minimum of eight weeks.

A ‘terminal event’ or failure of treatment was defined as implant removal or death related to the SSI. The mean follow-up was 26 months (1.03 to 50.9). A total of ten patients (23.3%) had a terminal event. The rate of survival after the first debridement was 90.7% (95% confidence interval (CI) 82.95 to 98.24) at six months, 85.4% (95% CI 74.64 to 96.18) at one year, and 73.2% (95% CI 58.70 to 87.78) at two, three and four years. Four of nine patients required re-instrumentation after implant removal, and two of the four had a recurrent infection at the surgical site. There was one recurrence after implant removal without re-instrumentation.

Multivariate analysis revealed a significant risk of treatment failure in patients who developed sepsis (hazard ratio (HR) 12.5 (95% confidence interval (CI) 2.6 to 59.9); p < 0.001) or who had > three fused segments (HR 4.5 (95% CI 1.25 to 24.05); p = 0.03). Implant survival is seriously compromised even after properly treated surgical site infection, but progressively decreases over the first 24 months.

Cite this article: Bone Joint J 2013;95-B:1121–6.

The purpose of this study was to determine whether patients with a burst fracture of the thoracolumbar spine treated by short segment pedicle screw fixation fared better clinically and radiologically if the affected segment was fused at the same time. A total of 50 patients were enrolled in a prospective study and assigned to one of two groups. After the exclusion of three patients, there were 23 patients in the fusion group and 24 in the non-fusion group. Follow-up was at a mean of 23.9 months (18 to 30). Functional outcome was evaluated using the Greenough Low Back Outcome Score. Neurological function was graded using the American Spinal Injury Association Impairment Scale. Radiological outcome was assessed on the basis of the angle of kyphosis.

Peri-operative blood transfusion requirements and duration of surgery were significantly higher in the fusion group (p = 0.029 and p < 0.001, respectively). There were no clinical or radiological differences in outcome between the groups (all outcomes p > 0.05). The results of this study suggest that adjunctive fusion is unnecessary when managing patients with a burst fracture of the thoracolumbar spine with short segment pedicle screw fixation.

Objectives

In order to elucidate the influence of sympathetic nerves on lumbar radiculopathy, we investigated whether sympathectomy attenuated pain behaviour and altered the electrical properties of the dorsal root ganglion (DRG) neurons in a rat model of lumbar root constriction.