Aims. In the treatment of basal thumb osteoarthritis (OA), intra-articular autologous fat transplantation has become of great interest within recent years as a minimally invasive and effective alternative to surgical intervention with regard to pain reduction. This study aims to assess its long-term effectiveness. Methods. Patients diagnosed with stage one to three OA received a single intra-articular autologous fat transplantation. Fat tissue was harvested from the abdomen and injected into the trapeziometacarpal (TMC) joint under radiological guidance, followed by one week of immobilization. Patients with a minimum three-year post-procedure period were assessed for pain level (numerical rating scale), quality of life (Mental Health Quotient (MHQ)), the abbreviated version of the Disabilities of Arm, Shoulder and Hand questionnaire (QuickDASH)), and grip and pinch strength, as well as their overall impression of the treatment. Wilcoxon tests compared data from pre-intervention, and at one and three years post-intervention. Results. Out of 136 treated joints, the study involved 87 patients (37 patients were loss to follow-up, and 12 patients (9%) who underwent resection arthroplasty) with a median follow-up of 4.9 years (IQR 5.4 to 5.9). Pain, both at rest and during stress, significantly improved at one year and remained stable through three years. Sex, age, and stage of disease were not associated with postoperative pain levels. Patient-reported outcome measures for QuickDASH and MHQ improved up to at least three years post-treatment. Patients reported high satisfaction and willingness to recommend the procedure. Grip and pinch strength did not significantly change over time. Conclusion. The data show that autologous fat transfer has a longer-lasting effect in two-thirds of re-examined patients. If patients had an initial positive response, the pain-reducing effect lasted for at least three years. Therefore, this minimally invasive approach can offer a valuable treatment alternative for basal thumb OA

A huge commitment is required from patients and families who undergo a limb reconstruction procedure using the hexapod frame. This includes turning the struts on the frame, pin site care and intensive rehabilitation. Montpetit et al (2009) discovered that function, participation, engagement in regular activities of daily living is severely impacted during the hexapod lengthening period. Due to the long duration and burden for families, it is imperative that healthcare professionals understand the impact that the hexapod frame has on functional abilities and health related quality of life (HRQL). This project involved a retrospective review of prospectively collected data on function and HRQL during two periods of time: (1) when the hexapod frame is applied on the child's lower extremity and (2) when the lengthening phase is completed, and the hexapod frame is removed. Data from 38 children (mean age: 12 years SD 3.8) who completed lower extremity reconstruction using the hexapod frame and completed either or both the Pediatric Quality of Life Inventory 4.0 Generic Core Scale (PedsQL) and Pediatric Outcomes data Collection Instrument (PODCI) was included. Analysis included, standardized response means, the non-parametric Wilcoxon test and effect size calculation. A Wilcoxon signed rank test for those children who completed pre and post frame PODCI’;s revealed those scores were significantly greater once the hexapod frame was removed (Md=85.10, n=10) compared to during (Md=66.50, n=10) with a large effect size, r= 1.45. Similar, the PedsQL scores improved post frame removal (Md= 66.30, n=10) compared to during treatment (Md = 53.34, n=10), with a medium size effect, r= 0.62. All subtests improved once the frame was removed. This study provides essential insights into the burden of the hexapod frame for children and provides valuable information for all allied healthcare professionals targeted interventions for health domains. This study shows that children's function improves once the hexapod frame is removed. However, this study highlights the importance for all healthcare professional to address health domains for the duration of the hexapod procedure where the child scored lower e.g. sports and physical function, pain and comfort, happiness from the PODCI. The PedsQL identified lower mean scores in physical and emotional function

Instability is a common indication for revision total hip arthroplasty (THA). However, even after the initial revision, some patients continue to have recurrent dislocations. This study investigates those at risk for recurrent dislocation after revision THA for instability at a single institution. Between 2009 and 2019, 163 patients underwent revision THA for instability at a single institution. Thirty-three of these patients required re-revision THA due to recurrent dislocation. Cox proportional hazard models with death as a competing event were used to analyze risk factors, including prosthesis sizing and alignment. Paired t-tests or Wilcoxon signed rank tests were used to assess patient outcomes (Veterans RAND 12 (VR-12) physical score, VR-12 mental score, Harris Hip Score, and hip disability and osteoarthritis outcome score for joint replacement). Duration of follow-up until either re-revision or final follow-up was a mean of 45.3 ± 38.2 months. The 1-year cumulative incidence for recurrent dislocation after revision was 8.7%, which increased to 19.6% at 5 years and 32.9% at 10 years postoperatively. In the multivariable analysis, high ASA score [HR 2.71], being underweight (BMI<18 kg/m. 2. ) [HR 36.26] or overweight/obese (BMI>25 kg/m. 2. ) [HR 4.31], use of specialized liners [HR 5.51–10.71], lumbopelvic stiffness [HR 6.29], and postoperative abductor weakness [HR 7.20] were significant risk factors for recurrent dislocation. Increasing the cup size decreased the dislocation risk [HR 0.89]. The dual mobility construct did not affect the risk for recurrent dislocation in univariate or multivariable analyses. VR-12 physical and HHS (pain and function) scores improved postoperatively at midterm. Patients requiring revision THA for instability are at risk for recurrent dislocation. Higher ASA scores, abnormal BMI, use of special liners, lumbopelvic stiffness, and postoperative abductor weakness are significant risk factors for re-dislocation

Vacuum orthoses are being applied in the care of patients with foot and lower leg conditions, as ankle fractures or sprains. The lower leg is protected and immobilized, which increases mobility. Due to the design, the orthoses lead to a difference in leg length, i.e. the side with the orthosis becomes longer, which changes the gait kinematics. To prevent or mitigate the unfavourable effects of altered gait kinematics, leg length-evening devices (shoe lifts) are offered that are worn under the shoe on the healthy side. Our aim was to evaluate the effect of such a device on the normality of gait kinematics. Gait analysis was conducted with 63 adult, healthy volunteers having signed an informed consent form that were asked to walk on a treadmill at a speed of 4.5km/h in three different conditions:. barefoot - as reference for establishing the normality score baseline. with a vacuum orthosis (VACOPed, OPED GmbH, Germany) and a sport shoe. with a vacuum orthosis and a shoe lift (EVENup, OPED GmbH, Germany). Data was sampled using the gait analysis system MCU 200 (LaiTronic GmbH, Austria). The positions of the joint markers were exported from the software and evaluated for the joint angles during the gait cycle using custom software (implemented in DIAdem 2017, National Instruments). A normality score using a modification of the Gait Profile Score (GPS) was calculated in every 1%-interval of the gait cycle and evaluated with a Wilcoxon signed rank test. The GPS value was reduced by 0.33° (0.66°) (median and IQR) while wearing the shoe lift. The effect was statistically significant, and very large (W = 1535.00, p < .001; r (rank biserial) = 0.52, 95% CI [0.29, 0.70]). The significant reduction of the GPS value indicates a more normal gait kinematics while using the leg length-evening device on the contralateral shoe. This rather simple and inexpensive device thus might improve patient comfort and balance while using the vacuum orthoses

Tenotomy of the iliopsoas tendon has been described as an effective procedure to treat refractive groin pain induced by iliopsoas tendinitis. However, the procedure forces the rectus femoris to act as the primary hip flexor and little is known about the long-term effects of this procedure on the peri-articular muscle envelope (PAME). Studies suggest that iliopsoas tenotomy results in atrophy of the iliopsoas and decreased hip flexion strength with poorer outcomes, increasing the susceptibility for secondary tendinopathy. The aim of this study is to describe changes in the PAME following psoas release. All patients who presented for clinical examination at our hospital between 2016 and 2021 were retrospectively reviewed. Patients who presented after psoas tenotomy with groin pain and who were unable to actively lift the leg against gravity, were included. Pelvic MRI was taken. Qualitative muscle evaluation was done with the Quartile classification system. Quantitative muscle evaluation was done by establishing the cross-sectional area (CSA). Two independent observers evaluated the ipsi- and contralateral PAME twice. The muscles were evaluated on the level: iliacus, psoas, gluteus minimus-medius-maximus, rectus femoris, tensor fasciae lata, piriformis, obturator externus and internus. For the qualitative evaluation, the intra- and inter-observer reliability was calculated by using kappastatistics. A Bland-Altman analysis was used to evaluate the intra- and inter-observer reliability for the quantitative evaluation. The Wilcoxon test was used to evaluate the changes between the ipsi- and contra-lateral side. 17 patients were included in the study. Following psoas tenotomy, CSA reduced in the ipsilateral gluteus maximus, if compared with the contralateral side. Fatty degeneration occurred in the tensor fascia latae. Both CSA reduction and fatty degeneration was seen for psoas, iliacus, gluteus minimus, piriformis, obturator externus and internus. No CSA reduction and fatty degeneration was seen for gluteus medius and rectus femoris. Conclusions/Discussion. Following psoas tenotomy, the PAME of the hip shows atrophy and fatty degeneration. These changes can lead to detrimental functional problems and may be associated with debilitating rectus femoris tendinopathy. In patients with psoas tendinopathy, some caution is advised when considering an iliopsoas tenotomy

Introduction. Survival after contemporary solid organ transplant (SOT) is increasing, and demand for total hip arthroplasty (THA) among SOT recipients is rising accordingly. The purpose of this study is to compare the perioperative outcomes and short-term implant- and patient-survivorship of contemporary THA following the most common types of SOT. Methods. Among SOT recipients, 119 primary THAs (92 patients, 39% female) were performed at a single institution from 2000–2020 and were retrospectively reviewed at a mean follow-up of 3.6yrs. Revisions, conversion to THA and multiple organs transplanted were excluded. The most common SOT was renal (39%), followed by lung (34%), liver (18%) and heart (8%). Demographics, peri-operative outcomes, 90-day re-admissions, re-operations and mortality were compared between SOT groups using chi-squared, Fisher's exact, Wilcoxon tests and Cox proportional hazard ratios. Results. Renal (median: 52yrs, 25–75%ile: 45.1–58.1) and heart transplant patients (55.4, 53.8–68.8) presented for THA at younger ages than liver (62.8, 50.0–67.6) and lung patients (63.1, 55.4–69.0; p<0.001). However, renal patients had the longest duration between SOT and THA (8.2yrs, 2.8–13.7; p=0.002), followed by liver (5.0, 1.2–11.4), heart (4.2, 2.4–9.6) and lung (2.6, 1.3–5.5). LOS was 3.0 days (p=0.31), 16% were discharged to a facility (p=0.87), and 9.4% required transfusion (p=0.43). Eighteen patients required re-admission within 90days (15%; p=0.44), and four underwent revision at 1-yr (3.4%; p=0.42). Mortality was 4.3% at 1yr (95% CI: 1.6–10.9) and 23.1% at 3yrs (95% CI: 15.0–32.9). When adjusted for age, ASA class, and duration from SOT to THA, lung transplant had higher mortality relative to kidney (RR 4.28, 95% CI: 1.79–11.26; p<0.001) and liver (RR 5.84, 95% CI: 1.95–25.29; p<0.001). Conclusion. SOT patients are a medically complex group with substantial requirements for facility placement, transfusions and re-admissions after THA. Short-term implant survivorship is acceptable, but THA in SOT patients is not without mortality risk, especially among lung transplant recipients

INTRODUCTION. Measurement of range of motion is a critical item of any knee scoring system. Conventional measurements used in the clinical settings are not as precise as required. Smartphone technology using either inclinometer application or photographic technology may be more precise with virtually no additional cost when compared to more sophisticated techniques such as gait analysis or image analysis. No comparative analysis between these two techniques has been previously performed. The goal of the study was to compare these two technologies to the navigated measurement considered as the gold standard. MATERIAL. Ten patients were consecutively included. Inclusion criterion was implantation of a TKA with a navigation system. METHODS. Two free angle measurement applications were downloaded to the Smartphone: one using inclinometer technology, the other using camera technology. After navigation assisted TKA and just before wound closure, the operated knee was positioned at full extension, 30±2°, 60±2°, 90±2° and 120±2° according to the navigated measurement. At each step, the knee flexion angle was measured with both Smartphone applications: inclinometer application (figure 1) and camera application (figure 2). For each of the ten patients, 5 navigated, 5 inclinometer and 5 camera measurements were obtained for each patient, giving three sets of 50 repeat measurements. The sample size was calculated to get a significance level of 0.05 and a power of 0.8 to detect a 10° difference. The difference between the three sets of measurements was analyzed with an ANOVA test for repeat measurements, with post-hoc comparisons with a paired Wilcoxon test. The correlation between the three sets of measurements was analyzed with a Kendall test, with post-hoc comparisons with a Spearman test. All tests were performed at a 0.05 level of significance, and post-hoc comparisons were performed at a 0.01 level of significance. RESULTS. The mean paired difference between navigated and camera measurements was 0.7° (SD 1.5°), with one difference greater than 3°. The mean paired difference between navigated and inclinometer measurements was 7.5° (SD 5.3°), with 16 differences greater than 10°. The mean paired difference between inclinometer and camera measurements was −6.8° (SD5.2°), with 7 differences greater than 10°. The ANOVA test for repeat measurements showed a significant difference between the three sets of measurements (p<0.001). The results of post-hoc paired comparisons with the Wilcoxon test are reported in table 2. The Kendall test showed that the distribution of the three sets of measurements was no different. The post-hoc paired correlations with the Spearman test showed a good coherence between all pairs of measurements (R² between 0.02 and 0.12). No pre-operative criteria showed a significant influence on the differences observed. DISCUSSION. Measuring the knee flexion angle with the camera of a smartphone is effective in a routine clinical practice. Accuracy can be better than other conventional measurement techniques. All applications of a smartphone do not have the same precision and must be validated before clinical use. CONCLUSION. Smartphone technology enables a more accurate assessment of the knee range of motion after TKA than conventional measurement techniques. To view tables/figures, please contact authors directly

The treatment of medial knee osteoarthritis (OA) in conjunction with anterior knee laxity is an issue of debate. Current treatment options include knee joint distraction, unicompartmental knee replacement (UKR) or high tibial osteotomy with anterior cruciate ligament (ACL) reconstruction or total knee replacement. Bone-conserving options are preferred for younger and active patients with intact lateral and patello-femoral compartment. However, still limited experience exists in the field of combining medial UKR and ACL reconstruction. The aim of this study is to retrospectively evaluate the results of combined fixed-bearing UKR and ACL reconstruction, specifically with regard to patient satisfaction, activity level, and postoperative functional outcomes. The hypothesis was that this represents a safe and viable procedure leading to improved stability and functional outcome in patients affected by isolated unicompartmental OA and concomitant ACL deficiency. Fourteen patients with ACL deficiency and concomitant medial compartment symptomatic osteoarthritis were treated from 2006 to 2010. Twelve of them were followed up for an average time of 7.8 year (range 6–10 years). Assessment included Knee Osteoarthritis Outcome Score (KOOS), Oxford Knee score (OKS), American Knee Society scores (AKSS), WOMAC index of osteoarthritis, Tegner activity level, objective examination including instrumented laxity test with KT-1000 arthrometer and standard X-rays. Wilcoxon test was utilized to compare the pre-operative and follow-up status. Differences with a p value <0.05 were considered statistically significant. KOOS score, OKS, WOMAC index and the AKSS improved significantly at follow-up (p < 0.05). There was no clinical evidence of instability in any of the knees as evaluated with clinical an instrumented laxity testing (p < 0.05). No pathologic radiolucent lines were observed around the components. In one patient a total knee prosthesis was implanted due to the progression of signs of osteoarthritis in the lateral compartment 3 years after primary surgery. UKR combined with ACL reconstruction is a valid therapeutic option for young and active patients with a primary ACL injury who develop secondary OA and confirms subjective and objective clinical improvement up to 8 years after surgery

Introduction. Component position and overall limb alignment following total knee arthroplasty (TKA) have been shown to influence prosthetic survivorship and clinical outcomes. Robotic-assisted (RA) total knee arthroplasty has demonstrated improved accuracy to plan in cadaver studies compared to conventionally instrumented (manual) TKA, but less clinical evidence has been reported. The objective of this study was to compare the three-dimensional accuracy to plan of RATKA with manual TKA for overall limb alignment and component position. Methods. A non-randomized, prospective multi-center clinical study was conducted to compare RATKA and manual TKA at 4 U.S. centers between July 2016 and August 2018. Computed tomography (CT) scans obtained approximately 6 weeks post-operatively were analyzed using anatomical landmarks. Absolute deviation from surgical plans were defined as the absolute value of the difference between the CT measurements and surgeons’ operative plan for overall limb, femoral and tibial component mechanical varus/valgus alignment, tibial component posterior slope, and femoral component internal/external rotation. We tested the differences of absolute deviation from plan between manual and RATKA groups using stratified Wilcoxon tests, which controlled for study center and accounted for skewed distributions of the absolute values. Alpha was 0.05 two-sided. At the time of this abstract, data collections were completed for two centers (52 manual and 58 RATKA). Results. Comparing absolute deviation from plan between groups, RATKA demonstrated clear benefits for tibial component alignment (median absolute deviation from plan: 1.5° vs. 0.8°, manual vs RATKA, p<.001), tibial slope (2.7° vs. 1.1°, manual vs RATKA, p<.001), and femoral component rotation (1.4° vs. 0.9°, manual vs RATKA, p<0.02). Femoral component and overall limb alignment accuracy were comparable (p>0.10). Discussion and Conclusions. In this study, compared to manual TKA, RATKA cases were 47% more accurate for tibial component alignment, 59% more accurate for tibial slope, and 36% more accurate for femoral component rotation (percent differences of median absolute deviations from plan). Further clinical data is needed to study the longer-term benefits of robotic technologies. Nevertheless, this study supports improved accuracy to plan utilizing RATKA compared to manual TKA. For any figures or tables, please contact authors directly

Aims

The risk of postoperative complications after resection of soft-tissue sarcoma in the medial thigh is higher than in other locations. This study investigated whether a vessel sealing system (VSS) could help reduce the risk of postoperative complications after wide resection of soft-tissue sarcoma in the medial thigh.

Bi-cruciate stabilized (BCS) TKA is the prosthesis that aims to substitute bi-cruciate ligament with post-cam engagement. We estimated to describe the in vivo kinematics during deep knee bending in BCS and Cruciate retaining (CR) TKA with the same articular geometry. We analyzed 26 knees who agreed to the current investigation under institutional review board approval. 17 knees were implanted with BCS (Journey ∥BCS, Smith & Nephew. Memphis, US) and 9 knees with CR (Journey∥CR). Each patient was asked to perform deep knee bending under weight-bearing condition. To estimate the spatial position and orientation of the TKA, 2D/3D registration technique with single fluoroscopy was used. We evaluated anteroposterior (AP) translation of the nearest point from femoral component to tibial axial plane for medial and lateral sides, femoral external rotation relative to tibial component and post-cam engagement in BCS. Measurement results were analyzed using Wilcoxon test. Values of P<0.05 were considered statistically significant. Medial AP translation indicated 11.7±5.1% posterior movement in BCS and 4.0±6.6% anterior movement in CR from minimum flexion to 130°. Lateral AP translation indicated 28.9±11.4% posterior movement in BCS and 18.3±6.2% posterior movement in CR from minimum flexion to 130°. Femoral external rotation were observed in both group and the amount of rotation were 5.2°±4.5° in BCS and 8.2°±4.0° in CR. Anterior post-cam engagement was not observed in all cases (76.5%). But medial AP translation in BCS was anteriorly in shallow flexion angles compared to CR. It suggested that anterior post-cam engagement couldn't work in valid

Introduction. Closed suction intraarticular drain (CSD) use after total knee arthroplasty (TKA) has been studied with regards to wound healing and range of motion, however, no data exist on how CSD use impacts knee joint effusion and quadriceps strength. The primary purpose of this study was to determine whether CSD use influences recovery of quadriceps strength. Secondary outcomes examined effects of CSD on intraarticular effusion, lower limb swelling, knee range of motion (ROM), pain and wound healing complications. Methods. Twenty-nine patients undergoing same-day bilateral TKA were enrolled in a prospective, randomized blinded study. Subjects were randomized to receive a CSD on one lower extremity while the contralateral limb had the use of a subcutaneous drain (SCDRN) without the use of suction. Isometric quadriceps strength was collected as the primary outcome. Secondary outcomes consisted of quadriceps muscle activation, intraarticular effusion measured via ultrasound, lower extremity swelling measured with bioelectrical impendence, lower extremity girth, ROM, and pain. Outcomes were assessed preoperatively and postoperatively at day 2, 2 and 6 weeks and 3 months. Differences in limbs were determined using paired t-tests or Wilcoxon signed rank tests. Results. No significant differences were identified between limbs prior to surgery for the primary or secondary outcomes. No significant differences in quadriceps strength were seen between CSD and SCDRN limbs at postoperative day 2 (p = 0.09), two weeks (p=0.7), six weeks (p=0.3), or three months (p=0.5). Secondary outcomes, of quadriceps activation battery, intraarticular effusion, lower extremity swelling, ROM, and pain were not found to significantly differ at any time point following surgery. Conclusion. The use of CSD during TKA did not influence quadriceps strength, quadriceps activation, intraarticular effusion, bioelectrical measure of swelling, ROM, or pain. The results of this study have limited drain use by the authors in primary uncomplicated TKA

Introduction. Periprosthetic joint infection (PJI) remains the main cause of failure in primary and revision total knee arthroplasties (TKAs). Local delivery of antibiotics, mainly antibiotic-loaded bone cement (ALBC), is commonly employed to prevent PJI. Over the past decade, tantalum and porous titanium have been successfully utilized as metaphyseal fixation devices to address bone loss and improve biologic fixation during revision TKA. However, no study has examined the antimicrobial properties compared to bone cement. The purpose of this study was to compare the ability of tantalum, 3D porous titanium, antibiotic-loaded bone cement (ALBC) and smooth titanium alloy (STA) to inhibit Staphylococci bacterial agents in an in vitro medium environment, based on the evaluation of the zone of inhibition (ZOI) and the antibacterial activity duration. Our study hypothesis was that we will found no significant difference between groups to inhibit Methicillin-Sensitive or Methicillin-Resistant Staphylococcus aureus (MSSA/MRSA) agents. Methods. Thirty beads made of 3 different materials (tantalum/ 3D porous titanium/ STA) were bathed during 1hour inside of a solution made of 1g vancomycin with 20-mL of sterile water for injection (bath concentration: 50 mg/mL). Ten 1cm. 3. cylinders were also created mixing standard surgical cement with 1g of Vancomycin in standardized sterile molds (ALBC beads). Finally, thirty beads made of tantalum/ 3D porous titanium/ STA were bathed in phosphate buffered saline solution to act as a control group. Cylinders were then placed on agar plates inoculated with MSSA and MRSA. Inhibition zone diameters were measured each day and cylinders were transferred onto a new inoculated plate. Inhibition zones were measured with a manual Vernier caliper and with automated software. The mean inhibition zones between groups were compared using the Wilcoxon Test. Results. The inter-class coefficient correlation values indicated an optimal intra-observer and inter-observer reproducibility for ZOI measurement (ICC 0.96 and ICC 0.98). For MSSA and MRSA, no inhibitory effect was found in the control group and antibiotic-loaded STA beads exhibited a short inhibitory effect until day 2. For MSSA, both tantalum and 3D porous titanium beads exhibited larger inhibition zones than cement beads (all p<0.01) each day until day 7 for tantalum and until day 3 for 3D porous titanium. After 6 days, ALBC presented larger inhibition zone than the 3D porous titanium, but no difference was found with tantalum. For MRSA, both tantalum and 3D porous titanium beads had significantly larger inhibition zones than ALBC each day until day 6 for tantalum (all p<0.01) and until day 3 for 3D porous titanium (all p<0.04). ALBC presented larger inhibition zone than tantalum and 3D porous titanium from day 7 to 9 (all p<0.04). Conclusion. Our results demonstrate that porous metal implants can deliver local antibiotics over slightly varying time frames based on our in vitro analysis. Antibiotic-impregnated tantalum and 3D porous titanium constructs exhibited superior antimicrobial properties when compared to STA. Future goals include impregnating porous metals with antibiotics for intraoperative use during revision TKA. For figures, tables, or references, please contact authors directly

In the past decades, titanium-based biomaterials have been broadly used in maxillofacial and periodontology surgery. The main aetiological agents related to complications in this procedures are Porphyromonas gingivalis, a Gram-negative anaerobic bacteria that is also responsible for the development of chronic gingivitis, and Streptococcus oralis, a Gram positive facultative anaerobic bacteria. In previous studies, we have demonstrated that the fluorine doping of titanium-based alloys reduces bacterial adherence. The aim of this study is to evaluate the bacterial adherence on fluorine-doped titanium (TiF) probes compared to chemical polishing titanium (Ti) probes. The P. gingivalis ATCC 33277 and S. oralis ATCC 9811 adherence study was performed by introducing each probe in a well of 6-well plate with 5 ml containing 106 colony forming units (CFU/ml) in sterile 0.9% NaCl and was incubated 37°C 5% CO2 for 90 minutes, in anaerobiosis in the case of P. gingivalis. After incubation, samples were stained with LIVE/DEAD BacLight Bacterial Viability Kit. Proportion of live and dead bacteria was calculated and studied by using ImageJ software. The experiments were performed in triplicate. The statistical data were analyzed by nonparametric Wilcoxon test with a level of statistical significance of 0.05. Our results showed a significant (p<0.0053) 14.41% decrease of the adherence of P. gingivalis on TiF and an increase of 30% of dead cells. For S. oralis we did not get significant results. In conclusion, TiF can be considered a promising approach to prevent and treat infections related to maxillofacial and periodontology surgery

Aims

A local injection may be used as an early option in the treatment of Morton’s neuroma, and can be performed using various medications. The aim of this study was to compare the effects of injections of hyaluronic acid compared with corticosteroid in the treatment of this condition.

Introduction. A careful evaluation of new technologies such as robotic-arm assisted total knee arthroplasty (RATKA) is important to understand the reduction in variability among users. While there is data reviewing the use of RATKA, the data is typically presented for experienced TKA surgeons. Therefore, the purpose of this cadaveric study was to compare the variability for several surgical factors between RATKA and manual TKA (MTKA) for surgeons undergoing orthopaedic fellowship training. Methods. Two operating surgeons undergoing orthopaedic fellowship training, each prepared six cadaveric legs for cruciate retaining TKA, with MTKA on one side (3 knees) and RATKA on the other (3 knees). These surgeons were instructed to execute a full RATKA or MTKA procedure through trialing and achieve a balanced knee. The number of recuts and final poly thickness was intra-operatively recorded. After completion of bone cuts, the operating surgeons were asked if they would perform a cementless knee based on their perception of final bone cut quality as well as rank the amount of mental effort exerted for required surgical tasks. Two additional fellowship trained orthopaedic assessment surgeons, blinded to the method of preparation, each post-operatively graded the resultant bone cuts of the tibia and femur according to the perceived percentage of cut planarity (grade 1, <25%; grade 2, 25–50%; grade 3, 51–75%; and grade 4, >76%). The grade for medial and lateral tibial bone cuts was averaged and a Wilcoxon signed rank test was used for statistical comparisons. Assessment surgeons also determined whether the knee was balanced in flexion and extension. A balanced knee was defined as relatively equal medial and lateral gaps under relatively equal applied load. Results. Operating surgeons used 9mm polys in all 6 RATKA specimens, and 3/6 MTKA specimens. Operating surgeons said they would do cementless in 4/6 RATKA specimens, and 1/6 MTKA specimen. In MTKA specimens, 5/6 cases had a recut on the tibia or femur to obtain knee balance. With RATKA, 1/6 cases had a recut on the tibia. With RATKA, operating surgeons performed a pre-resection balancing workflow, and made plan adjustments prior to resection. The operating surgeons reported reduced mental effort when performing bone measurements, tibial bone cutting, knee balancing, trialing, and post-resection adjustments with RATKA compared to MTKA. Mental effort was equivalent during femoral bone cutting between the two procedures and increased for RATKA during initial exposure and retractor setup. Assessment surgeons considered all 6 RATKA and 2/6 MTKA specimens to be balanced. Assessment surgeons assigned RATKA specimens a higher grade for perceived planarity (3.86 vs. 3.48, p=0.03) than MTKA specimens. DISCUSSION. In this cadaveric study, RATKA resulted in a higher usage of minimum poly thickness, greater tendency to want to use cementless components, higher number of balanced knees, higher perceived planarity, lower number of recuts, and reduced mental effort than MTKA cases. RATKA may give users more confidence in performing cementless TKA, especially for novice surgeons. Robotic-arm assisted TKA may allow for reduced surgical variability, which may improve patient outcomes, and should be investigated in a clinical setting

Twenty patients underwent simultaneous bilateral medial unicompartmental knee arthroplasty. Pre-operative hip-knee-ankle alignment and valgus stress radiographs were used to plan the desired post-operative alignment of the limb in accordance with established principles for unicompartmental arthroplasty. In each patient the planned alignment was the same for both knees. Overall, the mean planned post-operative alignment was to 2.3° of varus (0° to 5°). The side and starting order of surgery were randomised, using conventional instrumentation for one knee and computer-assisted surgery for the opposite side. The mean variation between the pre-operative plan and the achieved correction in the navigated and the non-navigated limb was 0.9° (. sd. 1.1; 0° to 4°) and 2.8° (. sd. 1.4; 1° to 7°), respectively. Using the Wilcoxon signed rank test, we found the difference in variation statistically significant (p < 0.001). Assessment of lower limb alignment in the non-navigated group revealed that 12 (60%) were within ± 2° of the pre-operative plan, compared to 17 (87%) of the navigated cases. Computer-assisted surgery significantly improves the post-operative alignment of medial unicompartmental knee arthroplasty compared to conventional techniques in patients undergoing bilateral simultaneous arthroplasty. Improved alignment after arthroplasty is associated with better function and increased longevity

Introduction. Trabecular Titanium is a biomaterial characterized by a regular three-dimensional hexagonal cell structure imitating trabecular bone morphology. Components are built via Electron Beam Melting technology in aone- step additive manufacturing process. This biomaterial combines the proven mechanical properties of Titanium with the elastic modulus provided by its cellular solid structure (Regis 2015 MRS Bulletin). Several in vitro studies reported promising outcomes on its osteoinductive and osteoconductive properties: Trabecular Titanium showed to significantly affect osteoblast attachment and proliferation while inhibiting osteoclastogenesis (Gastaldi 2010 J Biomed Mater Res A, Sollazzo 2011 ISRN Mater Sci); human adipose stem cells were able to adhere, proliferate and differentiate into an osteoblast-like phenotype in absence of osteogenic factors (Benazzo 2014 J Biomed Mater Res A). Furthermore, in vivo histological and histomorphometric analysis in a sheep model indicated that it provided bone in-growth in cancellous (+68%) and cortical bone (+87%) (Devine 2012 JBJS). A multicentre prospective study was performed to assess mid-term outcomes of acetabular cups in Trabecular Titanium after Total Hip Arthroplasty (THA). Methods. 89 patients (91 hips) underwent primary cementless THA. There were 46 (52%) men and 43 (48%) women, with a median (IQR) age and BMI of 67 (57–70) years and 26 (24–29) kg/m2, respectively. Diagnosis was mostly primary osteoarthritis in 80 (88%) cases. Radiographic and clinical evaluations (Harris Hip Score [HHS], SF-36) were performed preoperatively and at 7 days, 3, 6, 12, 24 and 60 months. Bone Mineral Density (BMD) was determined by dual-emission X-ray absorptiometry (DEXA) according to DeLee &Charnley 3 Regions of Interest (ROI) postoperatively at the same time-points using as baseline the measureat 1 week. Statistical analysis was carried out using Wilcoxon test. Results. Median (IQR) HHS and SF-36 improved significantly from 48 (39–61) and 49 (37–62) preoperatively to 99 (96–100) and 76 (60–85) at 60 mo. (p≤0.0001). Radiographic analysis showed evident signs of bone remodelling and biological fixation, with presence of superolateral and inferomedial bone buttress, and radial trabeculae in ROI I/II. All cups resulted radiographically stable without any radiolucent lines. The macro-porous structure of this biomaterial generates a high coefficient of friction (Marin 2012 Hip Int), promoting a firm mechanical interlocking at the implant-bone interface which could be already observed in the operating room. BMD initially declined from baseline at 7 days to 6 months. Then, BMD slightly increased or stabilized in all ROIs up to 24 months, while showing evidence of partial decline over time with increasing patient' age at 60 months, although without any clinical significance in terms of patients health status or implant stability. Statistical significant correlations in terms of bone remodeling were observed between groups of patients on the basis of gender and age (p≤0.05). No revision or implant failure was reported. Conclusions. All patients reported significant improvements in quality of life, pain relief and functional recovery. Radiographic evaluation confirmed good implant stability at 60 months. These outcomes corroborate the evidence reported on these cups by orthopaedic registries and literature (Perticarini 2015 BMC Musculoskelet Disord; Bistolfi 2014 Min Ortop)

Introduction. Component position and overall limb alignment following total knee arthroplasty (TKA) have been shown to influence prosthetic survivorship and clinical outcomes. 1. The objective of this study was to compare the accuracy to plan of three-dimensional modeled (3D) TKA with manual TKA for component alignment and position. Methods. An open-label prospective clinical study was conducted to compare 3D modeling with manual TKA (non-randomized) at 4 U.S. centers between July 2016 and August 2018. Men and women aged > 18 with body mass index < 40kg/m. 2. scheduled for unilateral primary TKA were recruited for the study. 144 3DTKA and 86 manual TKA (230 patients) were included in the analysis of accuracy outcomes. Seven high-volume, arthroplasty fellowship-trained surgeons performed the surgeries. The surgeon targeted a neutral (0°) mechanical axis for all except 9 patients (4%) for whom the target was within 0°±3°. Computed tomography (CT) scans obtained approximately 6 weeks post-operatively were analyzed using anatomical landmarks to determine femoral and tibial component varus/valgus position, femoral component internal/external rotation, and tibial component posterior slope. Absolute deviation from surgical plan was defined as the absolute value of the difference between the CT measurement and the surgeon's operative plan. Smaller absolute deviation from plan indicated greater accuracy. Mean component positions for manual and 3DTKA groups were compared using two-sample t tests for unequal variances. Differences of absolute deviations from plan were compared using stratified Wilcoxon tests, which controlled for study center and accounted for skewed distributions of the absolute values. Alpha was 0.05 two-sided. At the time of this report, CT measurements of femoral component rotation position referenced from the posterior condylar axis were not yet completed; therefore, the current analysis of femoral component rotation accuracy to plan reflects one center that exclusively used manual instruments referencing the transepicondylar axis (TEA). Results. Coronal positions of the femoral components measured via CT for manual and 3D TKA, respectively, were (mean ± standard deviation) 0.1°±1.6° varus and 0.0°±1.4° varus (p=0.533); positions of the tibial components were 1.9°±2.4° varus and 0.9°±2.0° varus (p=0.002). Positions of external femoral component rotation relative to the TEA were 1.1°±2.3° and 0.5°±2.3°, respectively (p=0.036). Tibial slopes were 3.7°±3.0° and 3.2°±1.8°, respectively (p=0.193). Comparing absolute deviation from plan between groups, 3DTKA demonstrated greater accuracy for tibial component alignment [median (25. th. , 75. th. percentiles) absolute deviation from plan, 1.7° (0.9°, 2.9°) vs. 0.9°(0.4°, 1.9°), p<.001], femoral component rotation [1.4° (0.9°, 2.5°) vs. 0.9° (0.7°, 1.5°), p=0.015], and tibial slope [2.9° (1.5°, 5.0°) vs. 1.1° (0.6°, 2.0°), p<.001] (Table 1). Accuracy for femoral component alignment was comparable [1.0° (0.4°, 1.7°) vs. 0.9° (0.4°, 1.5°), p=0.159] (Table 1). Discussion and Conclusions. Our findings support improved accuracy to the surgical plan utilizing 3DTKA compared with manual TKA. Compared to manual TKA, 3DTKA cases were typically 47% more accurate for tibial component alignment, 62% more accurate for tibial slope, and 36% more accurate for femoral component rotation (calculated as percent reduction of median absolute deviation). The evaluation of femoral component coronal alignment reflected already very good baseline accuracy of the surgeons utilizing the intramedullary femoral guide system (Table 1). As optimal component position in TKA affects joint kinematics and may positively influence implant longevity, it is important for surgeons to maximize the opportunity to direct component positioning. Further clinical data is needed to study potential longer-term benefits of robotic technologies. For figures, tables, or references, please contact authors directly

INTRODUCTION. Navigation systems have proved allowing performing measurement of the lower limb axis with a good accuracy, but the mandatory use of reference pins or screws limit their use to the operating room. The use of non-invasive navigation systems has been suggested to overcome this limitation. We conducted a prospective study to assess the validity of such a measurement system with non-invasive fixation of the reference arrays. The main goal was to compare this method with a standard, invasive navigation system requiring bony fixation of the arrays. The following hypothesis was tested: there will be a significant difference between the simultaneous measurement of the mechanical femoro-tibial angle by a standard navigation system and by the non-invasive navigation system. MATERIAL AND METHODS. 20 patients scheduled for total or partial knee arthroplasty were included after giving their informed consent. There were 7 men and 13 women with a median age of 65 years (range, 55 to 90). The median coronal deformation measured by X-rays was 8° of varus (range, 5° valgus to 22 ° varus). The same navigation system was used for both invasive and non-invasive measurements, but the basic algorithms were adapted for the non-invasive technique. For the non-invasive technique, metallic plates were strapped on the thigh and the calf to allow arrays fixation (fig. 1). Coronal femoro-tibial mechanical angle (CMFA) in maximal extension without stress was recorded by the non invasive system. This non-invasive analysis was immediately followed by surgery, and the same angle was measured intra-operatively with the invasive system. Comparisons between non-invasive and invasive measurements were performed using a Wilcoxon test, after checking that their distribution followed a normal distribution, and an equivalence testing with limits of ±3°. The correlation between the two sets of measurements was analyzed using a correlation test Spearman rank. The analysis of the concordance of the two sets of measurements was performed using Bland and Altman tests. The significance level p was set at 0.05. RESULTS. There was no significant difference between non invasive and invasive measurements of the CMFA in full extension. There was a good correlation (fig. 2) and a good concordance (fig. 3) between both measurements. DISCUSSION. The non invasive measurement technique system seems to be as accurate as conventional, invasive navigation. CONCLUSION. This technique might be a valuable alternative to long leg x-rays, with a good accuracy but without radiation exposure. For any figures or tables, please contact the authors directly