The femoral antero-posterior axis (AP or Whiteside’s Line) is one of the frequently used landmarks during total knee arthroplasty for determining rotation of the femoral component. Femoral morphology is assumed to be relatively constant and bone cuts made to prepare the distal femur are referenced from this landmark. Few studies have confirmed the consistency or reproducibility of this axis in normal femora even though the effect of malrotation on patella tracking and valgusvarus knee stability has been well documented. Fifty normal (non-degenerate) cadaveric femora (27 right, 23 left) were studied. The AP axis was identified and marked on each. An end-on photograph was taken to give a two dimensional image. The transepicondylar axis (TEA) was then drawn on each image. The angle between these two axes was recorded. Measurement of the TEA referenced from the AP axis gave a mean angle of 90.82 degrees (range 80–102; standard deviation=4.72). This study shows that the femoral AP axis is a reasonable method of determining femoral component rotation during total knee arthroplasty. However the variance in the results would suggest that other landmarks should also be used as a means of cross-checking femoral component rotation

Aims. This study aimed to evaluate if total knee arthroplasty (TKA) femoral components aligned in either mechanical alignment (MA) or kinematic alignment (KA) are more biomimetic concerning trochlear sulcus orientation and restoration of trochlear height. Methods. Bone surfaces from 1,012 CT scans of non-arthritic femora were segmented using a modelling and analytics system. TKA femoral components (Triathlon; Stryker) were virtually implanted in both MA and KA. Trochlear sulcus orientation was assessed by measuring the distal trochlear sulcus angle (DTSA) in native femora and in KA and MA prosthetic femoral components. Trochlear anatomy restoration was evaluated by measuring the differences in medial, lateral, and sulcus trochlear height between native femora and KA and MA prosthetic femoral components. Results. Femoral components in both MA and KA alignments exhibited a more valgus DTSA compared to native femora. However, DTSA deviation from native was significantly less in KA than in MA (4.8° (SD 2.2°) vs 8.8° (SD 1.8°); p < 0.001). DTSA deviation from native orientation correlated positively with the mechanical lateral distal femoral angle (mLDFA) in KA and negatively in MA (r = 0.53, p < 0.001; r = -0.18, p < 0.001). Medial trochlear height was not restored with either MA or KA, with MA resulting in lower medial trochlear height than KA in the proximal 20% of the trochlea. Lateral and sulcus trochlear height was not restored with either alignment in the proximal 80% of the trochlea. At the terminal arc point, KA replicated sulcus and lateral trochlear height, while MA led to over-restoration. Conclusion. Femoral components aligned in KA demonstrated greater biomimetic qualities than those in MA regarding trochlear sulcus orientation and trochlear height restoration, particularly in valgus femora. Variability across knees was observed, warranting further research to evaluate the clinical implications of these findings. Cite this article: Bone Joint J 2024;106-B(8):817–825

Introduction and Aims: Bone cement (Polymethylmethacrylate) is commonly used to augment internal fixation in osteoporotic bone. An inconsistency exists among surgeons regarding the appropriate mixing time for bone cement to achieve optimal screw purchase. The study addresses the effect of cement viscosity on fixation augmentation in both healthy and simulated osteoporotic canine bone. Method: Fourteen canine femora were plated using eight-hole DC plates and 3.5mm screws, repairing transverse diaphyseal osteotomies with and without a gap. In the left femora, cement was mixed for one minute (liquid) prior to injection into drilled and tapped holes that were either properly sized (2.5mm) or over-drilled (3.2mm) to simulate osteoporotic bone. In the right femora, cement was mixed for five minutes prior to injection (thick paste). Four-point bending stiffness for each plated construct was normalised to baseline stiffness, followed by failure loading. Results: Within the properly sized holes, there were no significant differences in bending stiffness with or without a gap at the fracture site. The liquid cement had a force to failure 77% greater than that of cement as a paste (p< 0.05). Within the over-sized holes simulating osteoporotic bone, there was no difference between liquid and paste without a gap. With a gap, liquid cement demonstrated an increased bending stiffness of 24% (p< 0.05) and force to failure was 92% higher (p< 0.05). Bone cement in its liquid state may provide increased structural support in the setting of an osteoporotic fracture, possibly due to increased interdigitation of the cement with the screw threads and bone. Conclusion: In a canine diaphyseal fracture model, screw insertion into liquid cement achieves greater bending stiffness and resists a greater load to failure than insertion into cement with the consistency of a paste

The purpose of this study was to determine the effect of cement mixing time on fixation augmentation in both healthy and simulated osteoporotic canine bone. In a canine diaphyseal model, screw insertion into liquid cement achieves greater bending stiffness and resists a greater load to failure than cement inserted as a paste. Bone cement in its liquid state may provide increased structural support in the setting of an osteoporotic fracture, possibly due to increased interdigitation of the cement with the screw threads and bone. An inconsistency exists among orthopaedic surgeons with regards to the appropriate mixing time for bone cement to achieve optimal results. The purpose of this study was to determine the effect of cement mixing time on fixation augmentation in both healthy and simulated osteoporotic canine bone. In a canine diaphyseal fracture model, screw insertion into liquid cement achieves greater bending stiffness and resists a greater load to failure than insertion into cement with the consistency of a paste. Bone cement in its liquid state may provide increased structural support in the setting of an osteoporotic fracture, possibly due to increased interdigitation of the cement with the screw threads and bone. Baseline stiffness for fourteen pairs of cadaveric canine femora was determined. A transverse diaphyseal osteotomy was created and fixed using an eight-hole DC plate and 3.5 mm screws. A 1cm gap was created at the osteotomy site simulating loss of bone. In the left femora, cement was mixed for one minute (liquid) prior to injection into pre-drilled holes; in the right femora, cement was mixed for five minutes prior to injection (thick paste). In each mixing time group, seven specimens were treated with a plate and properly sized pre-drilled and tapped holes (2.5mm), and seven received over-drilled holes (3.2 mm) to simulate osteoporotic bone. Four-point bending stiffness was determined for each plated construct, and normalized to baseline stiffness. Specimens were then loaded to failure. Within the properly sized holes, there were no statistically significant differences (SSD) in bending stiffness with or without a gap. The liquid cement had a force to failure 77% greater than that of cement as a paste (p< 0.05). Within the over-sized holes, there was no SSD between liquid and paste without a gap. With a gap, liquid cement demonstrated an increased bending stiffness of 24 % (p< 0.05) and force to failure was 92% higher (p< 0.05)

Aims. The Exeter short stem was designed for patients with Dorr type A femora and short-term results are promising. The aim of this study was to evaluate the minimum five-year stem migration pattern of Exeter short stems in comparison with Exeter standard stems. Methods. In this case-control study, 25 patients (22 female) at mean age of 78 years (70 to 89) received cemented Exeter short stem (case group). Cases were selected based on Dorr type A femora and matched first by Dorr type A and then age to a control cohort of 21 patients (11 female) at mean age of 74 years (70 to 89) who received with cemented Exeter standard stems (control group). Preoperatively, all patients had primary hip osteoarthritis and no osteoporosis as confirmed by dual X-ray absorptiometry scanning. Patients were followed with radiostereometry for evaluation of stem migration (primary endpoint), evaluation of cement quality, and Oxford Hip Score. Measurements were taken preoperatively, and at three, 12, and 24 months and a minimum five-year follow-up. Results. At three months, subsidence of the short stem -0.87 mm (95% confidence interval (CI) -1.07 to -0.67) was lower compared to the standard stem -1.59 mm (95% CI -1.82 to -1.36; p < 0.001). Both stems continued a similar pattern of subsidence until five-year follow-up. At five-year follow-up, the short stem had subsided mean -1.67 mm (95% CI -1.98 to -1.36) compared to mean -2.67 mm (95% CI -3.03 to -2.32) for the standard stem (p < 0.001). Subsidence was not influenced by preoperative bone quality (osteopenia vs normal) or cement mantle thickness. Conclusion. The standard Exeter stem had more early subsidence compared with the short Exeter stem in patients with Dorr type A femora, but thereafter a similar migration pattern of subsidence until minimum five years follow-up. Both the standard and the short Exeter stems subside. The standard stem subsides more compared to the short stem in Dorr type A femurs. Subsidence of the Exeter stems was not affected by cement mantle thickness. Cite this article: Bone Jt Open 2023;4(7):507–515

Intramedullary devices have been used since 1989 for fractures around the trochanter. Standard PFN has been shown to be one of the stable and successful intramedullary devices for pertrochanteric fractures. In order to minimise the intra-operative complications, small PFN has been designed to fit the Asian femora. Before performing a clinical documentation series, the authors with the computer assisstance performed virtual templating of 60 asian femora. After standardising the magnification of the radiograph with that of the template, best possible fit of the latter was achevied. Various parameters such as:. Width of the remaining neck from the surface of femoral neck screw and hip pin. Height of the proximal end of the nail from the tip of greater trochanter. The distance between the actual and proposed take-off point of medio-lateral angulation. Width of intramedullary canal at distal end of the nail were measured. After analysis of the measurements, we propose to further modify the small PFN in order to get best fit and minimal intra-operative complications

1. An experimental study of the healing mechanism in circumscribed defects in femora of albino rats of the Wistar strain is described. 2. Only the outer one-fifth of the defect is repaired by subperiosteal bony callus, the rest of the defect being repaired by endosteal callus. 3. Subperiosteal callus does not bridge the defect until endosteal callus is developed fully. 4. As peripheral callus matures the greater part of the endosteal callus is resorbed, with the exception of trabeculae attached to the margin of the defect. 5. The resorbed area in the medullary part of the defect is gradually obliterated by deposition of inner circumferential lamellae. 6. There appear to be differences between the mechanism responsible for repair of fractures of a long bone and that which heals circumscribed bone defects

Pre-operative and postoperative radiographs of both hips and pelvis of 160 Malaysian and Australian patients who had undergone Total Hip Replacement (THR) were reviewed. The purpose of the study was to determine morphometric differences in each group that could influence sizing and positioning of cemented total hip implants. In order to measure distances and diameters, we used OSIRIS, a digital radiographic analysis tool provided on the internet by the Department of Medical Imaging, University of Geneva. The known head sizes of the implants were used to calibrate OSIRIS. The patient groups were subdivided into three. We discovered that in general the sizes of the Malaysian population began 1 size below that of the Australian patients. The dimensionally larger 2 groups of the Malaysian patients were similar to the smaller 2 groups of the Australian population leaving a group of small Malaysian femora for whom there were fewer suitable implants. We conclude that more work needs to be done to provide suitable implants for South East Asian patients

Introduction. Iatrogenic proximal femur hoop-stress fracture is a recognised complication of uncemented hip arthroplasty. It has a reported incidence of two to three percent and increases patient morbidity. We describe a novel technology that predicts fracture in real-time by less than one minute. Method. Four proximal femora from red deer (Cervus elaphus), similar size to human proximal femora, were prepared to accept an uncemented hip arthroplasty femoral rasp (Finsbury Orthopaedics) and then mounted in a loading machine. The femora were fresh-frozen, defrosted and kept at room temperature in 0.9% saline swabs. The rasp was forced into each femur in repeated loading cycles every 10 seconds, in steps of 100N increasing from 200N to over 2000N until fracture, in a manner to simulate surgery. One sensor was attached to the surface of the proximal femur and one to the femoral rasp. The sensor outputs were recorded, analysed and displayed on a PC using a software algorithm to show signal energy (joules) and amplitude (decibels). The proximal femur was coated with specular marking paint to permit real-time 3-D digital image correlation (DIC) analysis. DIC is an established tool in engineering fracture analysis and utilises two spatially orientated video cameras to measure surface strain and fracture. The femur was observed by the human eye and loaded in cycles until a fracture was seen. The moment of fracture was marked in the recording timeline. DIC was used to confirm fracture. Results. All femora fractured in the anterior proximal cortex. Signals from both sensors were identical in form and differed by less than five percent in strength during loading. Both signals demonstrated significant increases in energy and amplitude shortly prior to fracture. Early during loading cycles the femoral rasp subsided and became well-fixed within the femur; this was associated with signals of 60-70dB. During later loading cycles the rasp ceased to subside in the femur and was well-fixed in a press-fit; subsequent loading caused fracture and this was preceded by a greater number of stronger signals of over 90dB. The increase occurred 1 to 3 loading cycles prior to fracture, or less than 30 seconds. DIC was used to confirm the presence of a fracture visible to the human eye. At the time of the first significant increase in signal there was no crack visible to the eye or to DIC analysis and the femoral rasp did not subside further into the femur. Conclusions. During press-fitting of an uncemented femoral rasp in a deer femur a significant change in signal characteristics occurs shortly prior to a fracture being visible to the eye and detectable by DIC analysis. The almost identical signal output from both sensors suggests that one single sensor mounted on a femoral rasp will suffice, thereby removing the need to expose more of the proximal femur during surgery. This technology may be able to predict and therefore prevent femur fracture during uncemented hip arthroplasty. Further research is necessary in animal and human cadavers to explore and validate this research

We have developed a bioactive bone cement (BA cement) consisting of Bis-GMA resin and bioactive glass powder. It has high compressive and tensile strengths, a low curing temperature and its bioactivity allows it to bond directly with bone. We operated on the 18 femora of nine mongrel dogs for intercalary replacement of part of the bone by a metal prosthesis using either PMMA cement or BA cement for fixation. Three dogs were killed at each of 4, 12 and 26 weeks after surgery for the evaluation of fixation strength by a push-out test and for histological examination by Giemsa surface staining and SEM. Fixation strengths with PMMA cement at 4, 12 and 26 weeks after surgery were 46.8 ± 18.9, 50.0 ± 24.7, and 58.2 ± 28.9 kgf (mean ±SD), respectively. Those with BA cement were 56.8 ± 26.1, 67.2 ± 19.2, and 72.8 ± 22.2 kgf, respectively. Fibrous tissue intervened between bone and PMMA cement but BA cement had bonded directly to bone at 12 and 26 weeks. This suggests that BA cement will be useful in providing long-lasting fixation of implants to bone under weight-bearing conditions

Aims. To evaluate how abnormal proximal femoral anatomy affects different femoral version measurements in young patients with hip pain. Methods. First, femoral version was measured in 50 hips of symptomatic consecutively selected patients with hip pain (mean age 20 years (SD 6), 60% (n = 25) females) on preoperative CT scans using different measurement methods: Lee et al, Reikerås et al, Tomczak et al, and Murphy et al. Neck-shaft angle (NSA) and α angle were measured on coronal and radial CT images. Second, CT scans from three patients with femoral retroversion, normal femoral version, and anteversion were used to create 3D femur models, which were manipulated to generate models with different NSAs and different cam lesions, resulting in eight models per patient. Femoral version measurements were repeated on manipulated femora. Results. Comparing the different measurement methods for femoral version resulted in a maximum mean difference of 18° (95% CI 16 to 20) between the most proximal (Lee et al) and most distal (Murphy et al) methods. Higher differences in proximal and distal femoral version measurement techniques were seen in femora with greater femoral version (r > 0.46; p < 0.001) and greater NSA (r > 0.37; p = 0.008) between all measurement methods. In the parametric 3D manipulation analysis, differences in femoral version increased 11° and 9° in patients with high and normal femoral version, respectively, with increasing NSA (110° to 150°). Conclusion. Measurement of femoral version angles differ depending on the method used to almost 20°, which is in the range of the aimed surgical correction in derotational femoral osteotomy and thus can be considered clinically relevant. Differences between proximal and distal measurement methods further increase by increasing femoral version and NSA. Measurement methods that take the entire proximal femur into account by using distal landmarks may produce more sensitive measurements of these differences. Cite this article: Bone Jt Open 2022;3(10):759–766

Aims

We have evaluated the survivorship, outcomes, and failures of an interlocking, reconstruction-mode stem-sideplate implant used to preserve the native hip joint and achieve proximal fixation when there is little residual femur during large endoprosthetic reconstruction of the distal femur.

Aims. When performing revision total hip arthroplasty using diaphyseal-engaging titanium tapered stems (TTS), the recommended 3 to 4 cm of stem-cortical diaphyseal contact may not be available. In challenging cases such as these with only 2 cm of contact, can sufficient axial stability be achieved and what is the benefit of a prophylactic cable? This study sought to determine, first, whether a prophylactic cable allows for sufficient axial stability when the contact length is 2 cm, and second, if differing TTS taper angles (2° vs 3.5°) impact these results. Methods. A biomechanical matched-pair cadaveric study was designed using six matched pairs of human fresh cadaveric femora prepared so that 2 cm of diaphyseal bone engaged with 2° (right femora) or 3.5° (left femora) TTS. Before impaction, three matched pairs received a single 100 lb-tensioned prophylactic beaded cable; the remaining three matched pairs received no cable adjuncts. Specimens underwent stepwise axial loading to 2600 N or until failure, defined as stem subsidence > 5 mm. Results. All specimens without cable adjuncts (6/6 femora) failed during axial testing, while all specimens with a prophylactic cable (6/6) successfully resisted axial load, regardless of taper angle. In total, four of the failed specimens experienced proximal longitudinal fractures, three of which occurred with the higher 3.5° TTS. One fracture occurred in a 3.5° TTS with a prophylactic cable yet passed axial testing, subsiding < 5 mm. Among specimens with a prophylactic cable, the 3.5° TTS resulted in lower mean subsidence (0.5 mm (SD 0.8)) compared with the 2° TTS (2.4 mm (SD 1.8)). Conclusion. A single prophylactic beaded cable dramatically improved initial axial stability when stem-cortex contact length was 2 cm. All implants failed secondary to fracture or subsidence > 5 mm when a prophylactic cable was not used. A higher taper angle appears to decrease the magnitude of subsidence but increased the fracture risk. The fracture risk was mitigated by the use of a prophylactic cable. Cite this article: Bone Jt Open 2023;4(7):472–477

Introduction The AO/ASIF 3.5 mm STS is increasingly used for internal fixation of large bones with the recent introduction of the 3.5 mm periarticular plating system. Our study aims to compare the insertion torque and mechanical properties of the screw after insertion into bovine femora using non tapped and pretapped methods. Methods Three groups of ten 3.5 mm AO/ASIF STSs of variable lengths were used. One group was put aside as the control. One group was inserted into fresh bovine femora using pre-tapped drill holes and the final group using non-tapped drill holes. The insetion torques were measured and compared using an analogue torque screw driver. All screws were removed. The three groups were then tested for mechanical strength. The results of the groups were compared we found the insertion torque to be six times greater in the non tapped group compared to the pre tapped group. We noted the non tapped group failed later than the pre-tapped group, this was statistically not significant however. The mechanical strength of the screw was not statistically altered. Conclusions We conclude that the 3.5 mm STS is easier to insert when pre tapped. However pre tapping is not necessary to preserve the mechanical strength of the screw

Aims. Electromagnetic induction heating has demonstrated in vitro antibacterial efficacy over biofilms on metallic biomaterials, although no in vivo studies have been published. Assessment of side effects, including thermal necrosis of adjacent tissue, would determine transferability into clinical practice. Our goal was to assess bone necrosis and antibacterial efficacy of induction heating on biofilm-infected implants in an in vivo setting. Methods. Titanium-aluminium-vanadium (Ti6Al4V) screws were implanted in medial condyle of New Zealand giant rabbit knee. Study intervention consisted of induction heating of the screw head up to 70°C for 3.5 minutes after implantation using a portable device. Both knees were implanted, and induction heating was applied unilaterally keeping contralateral knee as paired control. Sterile screws were implanted in six rabbits, while the other six received screws coated with Staphylococcus aureus biofilm. Sacrifice and sample collection were performed 24, 48, or 96 hours postoperatively. Retrieved screws were sonicated, and adhered bacteria were estimated via drop-plate. Width of bone necrosis in retrieved femora was assessed through microscopic examination. Analysis was performed using non-parametric tests with significance fixed at p ≤ 0.05. Results. The width of necrosis margin in induction heating-treated knees ranged from 0 to 650 μm in the sterile-screw group, and 0 to 517 μm in the biofilm-infected group. No significant differences were found between paired knees. In rabbits implanted with sterile screws, no bacteria were detected. In rabbits implanted with infected screws, a significant bacterial load reduction with median 0.75 Log10 colony-forming units/ml was observed (p = 0.016). Conclusion. Induction heating was not associated with any demonstrable thermal bone necrosis in our rabbit knee model, and might reduce bacterial load in S. aureus biofilms on Ti6Al4V implants. Cite this article: Bone Joint Res 2024;13(12):695–702

Aims. The cemented Oxford unicompartmental knee arthroplasty (OUKA) features two variants: single and twin peg OUKA. The purpose of this study was to assess the stability of both variants in a worst-case scenario of bone defects and suboptimal cementation. Methods. Single and twin pegs were implanted randomly allocated in 12 pairs of human fresh-frozen femora. We generated 5° bone defects at the posterior condyle. Relative movement was simulated using a servohydraulic pulser, and analyzed at 70°/115° knee flexion. Relative movement was surveyed at seven points of measurement on implant and bone, using an optic system. Results. At the main fixation zone, the twin peg shows less relative movement at 70°/115°. At the transition zone, relative movements are smaller for the single peg for both angles. The single peg shows higher compression at 70° flexion, whereas the twin peg design shows higher compression at 115°. X-displacement is significantly higher for the single peg at 115°. Conclusion. Bony defects should be avoided in OUKA. The twin peg shows high resilience against push-out force and should be preferred over the single peg. Cite this article: Bone Joint Res 2022;11(2):82–90

Introduction. Within the reconstruction of unicondylar femoral bone defects with morselized bone grafts in revision total knee arthroplasty (TKA), a stem extension appears to be critical to obtain adequate mechanical stability. Whether the stability is still secured by this reconstruction technique in bicondylar defects has not been assessed. Long, rigid stem extensions have been advocated to maximize the stability in revision TKAs. The disadvantage of relatively stiff stem extensions is that bone resorption is promoted due to stress shielding. Therefore, we developed a relatively thin intramedullary stem which allowed for axial sliding movements of the articulating part relative to the intramedullary stem. The hypothesis behind the design is that compressive contact forces are directly transmitted to the distal femoral bone, whereas adequate stability is provided by the sliding intramedullary stem. A prototype was made of this new knee revision design and applied to the reconstruction of uncontained bicondylar femoral bone defects. Materials and Methods. Five synthetic distal femora with a bicondylar defect were reconstructed with impacted bone grafting (IBG) and this new knee revision design. A custom-made screw connection between the stem and the intercondylar box was designed to lock or initiate the sliding mechanism, another screw (dis)connected the stem. A cyclically axial load of 500 N was applied to the prosthetic condyles to assess the stability of the reconstruction. Radiostereometry was used to determine the migrations of the femoral component with a rigidly connected stem, a sliding stem and no stem extension. Results. We found a stable reconstruction of the bicondylar femoral defects with IBG in case of a rigidly connected stem. After disconnecting the stem, the femoral component showed substantially more migrations. With a sliding stem rotational migrations were similar to those of a rigidly connected stem. However, the sliding stem allowed proximal migration of the condylar component, thereby compressing the IBG. Discussion. A stable reconstruction of uncontained bicondylar femoral defects could be created with IBG and a TKA with a thin stem extension. It appeared that the presence of a functional stem extension was important for the stability of the bicondylar reconstruction. In an effort to reduce stress shielding, we developed a sliding stem mechanism. This sliding stem provided adequate stability, while compressive contact forces are still transmitted to the distal femoral bone. Clinical studies have to confirm that our sliding stem mechanism leads to long term bone maintenance after revision TKAs

Aims. The association of auraptene (AUR), a 7-geranyloxycoumarin, on osteoporosis and its potential pathway was predicted by network pharmacology and confirmed in experimental osteoporotic mice. Methods. The network of AUR was constructed and a potential pathway predicted by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) terms enrichment. Female ovariectomized (OVX) Institute of Cancer Research mice were intraperitoneally injected with 0.01, 0.1, and 1 mM AUR for four weeks. The bone mineral density (BMD) level was measured by dual-energy X-ray absorptiometry. The bone microstructure was determined by histomorphological changes in the femora. In addition, biochemical analysis of the serum and assessment of the messenger RNA (mRNA) levels of osteoclastic markers were performed. Results. In total, 65.93% of the genes of the AUR network matched with osteoporosis-related genes. Osteoclast differentiation was predicted to be a potential pathway of AUR in osteoporosis. Based on the network pharmacology, the BMD and bone mineral content levels were significantly (p < 0.05) increased in the whole body, femur, tibia, and lumbar spine by AUR. AUR normalized the bone microstructure and the serum alkaline phosphatase (ALP), bone-specific alkaline phosphatase (bALP), osteocalcin, and calcium in comparison with the OVX group. In addition, AUR treatment reduced TRAP-positive osteoclasts and receptor activator of nuclear factor kappa-B ligand (RANKL). +. nuclear factor of activated T cells 1 (NFATc1). +. expression in the femoral body. Moreover, the expressions of initiators for osteoclastic resorption and bone matrix degradation were significantly (p < 0.05) regulated by AUR in the lumbar spine of the osteoporotic mice. Conclusion. AUR ameliorated bone loss by downregulating the RANKL/NFATc1 pathway, resulting in improvement of osteoporosis. In conclusion, AUR might be an ameliorative cure that alleviates bone loss in osteoporosis via inhibition of osteoclastic activity. Cite this article: Bone Joint Res 2022;11(5):304–316

Primary total hip replacement (THR) in patients with abnormal/altered proximal femoral anatomy/narrow canals presents a technical challenge. There are only limited standard prosthetic stems available to deal with narrow canals or abnormal morphology. Many prefer to use expensive custom implants which often have a lag time to manufacture and do not always have long term published outcomes.

We present results of the Asian C-stem (which is a standard implant available on the shelf) used in patients predominantly of Caucasian origin with abnormal proximal femoral anatomy.

We retrospectively reviewed clinic-radiological results of 131 patients (131 stems) who underwent primary THR using Asian C-stem at Wrightington Hospital till their latest follow up. Revision for any reason was considered as primary end point.

Mean age at surgery was 50.8 years (16 – 80). The 2 commonest indications were primary osteoarthritis (66 patients) and hip dysplasia (54 patients). Mean follow up was 43.5 months with a minimum follow up of 12 months and maximum follow up of 97 months. There were 2 recurrent dislocations and 1 hip subluxed twice. One dislocation needed revision surgery. 1 patient underwent acetabular revision for loosening. There was no stem failure, obvious loosening or loss of fixation in any patients in our series with regards to the Asian C-stem. There were no infections and intra-operative perforations or fractures.

C-stem Asian is a reliable implant for patients undergoing THR with abnormal proximal femoral anatomy or narrow canals. Long term follow up is essential.

Aims. This study was designed to characterize the recurrence incidence and risk factors of antibiotic-loaded cement spacer (ALCS) for definitive bone defect treatment in limb osteomyelitis. Methods. We included adult patients with limb osteomyelitis who received debridement and ALCS insertion into the bone defect as definitive management between 2013 and 2020 in our clinical centre. The follow-up time was at least two years. Data on patients’ demographics, clinical characteristics, and infection recurrence were retrospectively collected and analyzed. Results. In total, 314 patients with a mean age of 52.1 years (SD 12.1) were enrolled. After a mean of 50 months’ (24 to 96) follow-up, 53 (16.9%) patients had infection recurrence including 32 tibiae, ten femora, ten calcanea, and one humerus. Of all patients with recurrence, 30 (9.6%) occurred within one year and 39 (12.4%) within two years. Among them, 41 patients needed reoperation, five received antibiotics treatment only, and seven ultimately required amputations. Following multivariable analysis, we found that patients infected with Gram-negative bacilli were more likely to have a recurrence (odds ratio (OR) 2.38, 95% confidence interval (CI) 1.20 to 6.94; p = 0.046) compared to Staphylococcus aureus; segmental bone defects (OR 5.25, 95% CI 1.80 to 15.26; p = 0.002) and smoking (OR 3.00, 95% CI 1.39 to 6.50; p = 0.005) were also independent risk factors for recurrence after treatment. Conclusion. Permanent ALCS might be an alternative strategy for definitive bone defect management in selected osteomyelitis cases. However, the overall high recurrence found suggests that it should be cautiously treated. Additionally, segmental defects, Gram-negative infections, and smoking were associated with an increased risk of infection recurrence. Cite this article: Bone Joint Res 2023;12(8):467–475