The antibiotic prophylaxis for orthopaedic and trauma patients undergoing metal work implantation was changed in our unit to specifically reduce the incidence of C.difficile. The aim of this study was to determine whether this change did reduce the incidence of post-operative C.difficile infections presenting on the orthopaedic ward. The secondary aim was to ensure that the change in prophylaxis did not increase the incidence of deep wound infections.