Introduction

Modular tantalum augments have been introduced to manage severe bone defects in hip and knee revision surgery. The porous surfaces of tantalum augments are intended to enhance osseointegration and a number of studies have documented their excellent biocompatibility. However, the characteristics of tantalum augment osseointegration on human ex vivo specimens from re-revision procedures have not been reported so far.

Introduction: Periprosthetic fractures have long been recognized as one of the major complications after hip resurfacing arthroplasty. Both biomechanical factors and pathological changes of bone tissue might hypothetically influence its occurrence. We analyzed retrieved femoral remnants to identify possibly different fracture modes.

Material and Methods: 83 hips revised for periprosthetic fracture (134.5 days in situ±159.2) were analyzed macroscopically, contact radiographically and histologically. Most cases (80.7%) were treated for advanced stages of osteoarthritis. Hips with preoperative femoral head necrosis were not included. 49 (59.0%) patients were men (57.8 years old±8.5) and 34 (41.0%) women (55.1 years old±10.0; p=.3445). Occurrence of reactive changes and of avascular necrosis in addition to amount of osteonecrosis were used as the major histological criteria for classification of the fracture as acute biomechanical, acute postnecrotic or chronic.

Statistical analyses were performed using statistical software. Probability of Type I error was set to 5% (alpha=0.05).

Results: 37 (44.6%) femoral neck fractures (83.9 days±87.7) occurred earlier than the remaining 46 (55.4%) head fractures (174.1 days±89.7; p=.0129). 50(60.2%) remnants revealed complete osteonecrosis and were thus classified as acute postnecrotic fractures, 29 (34.9%) chronic fractures were characterized by finding of pseudoarthrosis or preformed callus and the remaining 4 (4.8%) were classified as acute mechanic. Acute mechanic fractures (17.5 days±8.0) failed earlier than both acute postnecrotic (146.3 days±181.7; p=.0049) and chronic (130.8 days±120.6; p=.0017) fractures.

Osteonecrosis was found in 81 (97.6%) hips revised after fracture (p< .0001). The vertical size of avascular necrosis in hips after acute postnecrotic fracture (21.1mm±8.5) was bigger (p< .0001) than in both chronic (7.3mm±7.3) and acute mechanic (0.9 mm±1.2) fractures.

Even though 33 (66.0%) of 50 patients with acute postnecrotic fracture were men (p=.0237), no significant differences between males and females were found with respect to age of patients (p=.3445) or duration of prosthesis implantation (p=.1232).

Conclusion: We analyzed hips revised for periprosthetic fracture after the resurfacing arthroplasty. Three distinct fracture modes of this complication could have been identified morphologically. Osteonecrosis secondary to the hip resurfacing arthroplasty appeared to be causative for more than a half of all fractures in present cohort. Mechanical and biomechanical factors related to the procedure might have possibly influenced the occurrence of both postnecrotic fractures and cases with vital reactive changes of tissues neighbouring the fracture line.

The proposed classification may help to understand causes of periprosthetic fractures after hip resurfacing arthroplasty.

The Gorham-Stout Syndrome (Gorham’s massive osteolysis) is a rare condition in which spontaneous, progressive resorption of bone occurs. The aetiology is poorly understood. We report six cases of the condition and present evidence that osteolysis is due to an increased number of stimulated osteoclasts. This suggests that early potent antiresorptive therapy such as with calcitonin or bisphosphonates may prevent local progressive osteolysis.