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Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 92 - 92
1 Jan 2013
Boutefnouchet T Ashraf M Budair B Porter K Tillman R
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A clinical evaluation of the effect of MRI scan to bring about a change in surgical management of elderly patients who present with hip fracture with no history of trauma or a suspicious looking lesion on x-rays. Many of these patients present with or without history of previous malignancy or bone disorder.

We evaluated that if the delay in treatment within 36 hours as per national guide lines is justified to benefit patients.

Methods

A clinical review of six hundred hip fracture patients where one hundred and four patients who had MRI scan of hip for fracture with either no history of trauma or a fracture with suspected pathological features with or without history of malignancy or bone disorder.

The final outcome of hundred patients who had MRI scans 32 male and 68 female with median age of 65 years. Four patients were excluded as were unable to tolerate the MRI scan.

Statistical analysis software SAS/STAT® was used to conduct data collation and analyses.

A further radiological analysis of MRI scans with positive lesion to the plain X-rays to correlate the finding of a lesion on femoral side on MRI scan to a lesion on acetabular side.

Results

Out of hundred patients who had MRI scan for a suspected metastatic or pathological lesion only 12 showed a metastatic lesion despite the fact 31 had previous history of malignancy, CI 4.03; 101.91, P < 0.0003. No primary lesion detected in any patient.

We also found if the acetabular side was not seen to be involved on pain x-ray, MRI scan did not detect any acetabular lesion, contingency coefficient 0.5632, P < .0001.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IV | Pages 106 - 106
1 Mar 2012
Ellanti P Ashraf M Thakaral R McCarthy T O'Sulllivan K McElwain J
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Introduction

It is recommended that the ankle be held in dorsiflexion at the time of placement of syndesmosis screw. We assessed the validity of this recommendation.

Materials and methods

A two-part roentgenographic and computerised analysis of distal tibiofibular syndesmosis. The first part involved recruitment of 30 healthy adult volunteers. The second part involved 15 ankle fractures with syndesmotic injury requiring syndesmosis screw placement. In the first part individuals maximally dorsiflexed and plantarflexed their ankles in a specialised jig for standardisation. Mortice views were taken and intermalleolar distance measured. In the second part mortice views were taken in plantarflexion and dorsiflexion before and after the placement of syndesmosis screw in theatre. The intermalleolar distance was then measured.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 275 - 276
1 May 2010
Ashraf M Davarinos N Ellanti P Thakral R Nicholson P Morris S Mc elwain J
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Introduction: Weber B fractures are one of the most common fractures of the ankle. Unstable fractures are treated with lateral plating and a lag screw. Another method of fixation is antiglide plating, this concept was first introduced by Brunner and Weber in 1982.

Manoli and Schaeffer in 1987, showed that fixation by antiglide plate demonstrated superior static biomechanical properties compared to lateral plating.

However there are some shortcomings in their study and hence we decided to perform our biomechanical study. The shortcomings of the Manoli study are. They did not use an interfragmentary lag screw for lateral plate fixation. It was a cadaveric study where the bone does not accurately represent the live bone. The quality of the bone ranging from normal to osteoporotic bone varies from cadaver to cadaver and hence there is no uniformity between the samples.

Materials and Methods: We used 4th generation composite bone models validated to closely simulate human bone characteristics for fracture toughness, tensile strength, compressive strength, fatigue crack resistance and implant subsidence. 4th generation composite bone model provides uniformity of test samples which is not achievable in cadaveric studies.

These bones were custom made for the experiment. We used two sets of bones, one representative of normal bone (Set A n=10) and the other of osteoporotic bone quality (Set B n=10). Each of the sets A & B will have two types of fixations for artificially created Weber B Fractures.

Lateral plate with interfragmentary lag screw.

Antiglide plate with interfragmentary lag screw.

The strength of the fixation was measured by restressing the bone until the fixation failed using an Instron machine which simultaneously applied torque and compressive forces to the fibular construct. The resulting data was analysed on a computer and statistical analysis was performed.

Results: When the two fixation constructs were stressed to failure, the lateral plate construct demonstrated less stiffness (3–5Nm/degree) and failed at lower energy levels (250Nm). Similar values obtained for the antiglide system were, stiffness of 12–16Nm/degree and energy absorbed to failure 350–450Nm. Antiglide plating was significantly more stable in the osteoporotic fibula.

Conclusion: Antiglide plating with lag screw is much more stable than lateral plating. It is suitable for treatment without plaster cast post operatively. It results in a more stable fixation in osteoporotic bone.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 276 - 276
1 May 2010
Ashraf M Ellanti P Thakral R McEvoy F Sparkes J Mc Elwain J
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Introduction: Traditionally the fixation of choice as recommended by the AO ASIF group for transverse fractures of the Olecranon and the Patella is the tension band wiring technique.

The concept of tension band wiring is based on the fact that the distractive force applied to one surface of the bone will result in compression on the opposite articular surface.

Clinical outcomes of TBW are not equivocal. It is associated with significant morbidity such as non union, failure of fixation, especially in osteoporotic bone and infection which sometimes leads to amputation. Often a second procedure for removal of prominent metal work is required.

In our biomechanical study we investigated this concept as we believe that the forces generated by TBW construct do not generate significant compressive forces required for healing of fracture.

Materials and Methods: We used 4th generation composite bones (Sawbones®, Malmoe, Sweden.). These bone analogues have been validated to closely simulate human bone characteristics for fracture toughness, tensile strength, compressive strength, fatigue crack resistance and implant subsidence.

The advantage of using 4th generation composite bone model is that it provides uniformity which is not achievable in cadaveric studies. Two different bone models representative of Olecranon and patella were used. Transverse fractures were created in the bones and fixed with TBW technique as described in A.O. manual.

Two 0.062-inch Kirschner wires and figure of eight configuration of 18G Stainless steel wire with single knot technique was used. Micro motion transducers (DVRT: MicroStrain, Williston, Vermont) with an accuracy of ± 1μm were placed across the fracture site both anteriorly and posteriorly. Continuous information regarding fracture distraction and compression, as determined by the transducers was recorded from both sites simultaneously during the experiment.

The tension band wire construct was loaded up to a maximum force of 4000 Newtons for patella and 500 for the olecranon. The fractures were subjected to cyclic loading at 1Hz using a servo hydraulic materials-testing system (model 8500; Instron, Canton, Massachusetts). The results were analysed on a computer and statistical analysis performed.

Results: During the application of cyclical loading, we noted a gap at the articular surface ranging from 1.1± 0.4mm and 2.1± 0.6mm for Olecranon and patella constructs respectively. During most of the duration of the experiment no transducer displacements were recorded at the articular surface.

Conclusion: The concept that distractive forces at one end could be converted to compression at the other end through the TBW does not hold true in our biomechanical study. A simpler construct may suffice for fixation of patellar and Olecranon fractures which can reduce the complications associated with TBW fixation.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 96 - 96
1 Mar 2009
Ashraf M Thakral R McCarthy T Lundon P O’Sullivan K MacElwain J
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Introduction: In clinical practice The Cascade sign is widely used to assess the rotational deformity of the fingers associated with metacarpal and phalangeal fractures. We carried out a scientific study on thirty volunteers to evaluate the validity or otherwise of this standard sign.

Material and Methods: Metal pointers were attached to the dorsum of the fingers, flexed at MCP and PIP joints. These pointers represented the mid longitudinal axis of the phalanges. Standardised AP radiographs of the closed fist were taken in all cases with the wrist placed in neutral position, in a custom made jig. The radiographs were assessed by two different observers using Picture Archiving and Communication System, software version VA42B, to determine the convergence of the metal pointers towards the scaphoid tubercle, as described in the cascade sign and Lister method..

Statistics: Power of the study was determined with an assumption of a type-2 error of 0.05 and a two sided test. Descriptive statistics and confidence limits were calculated using SPSS 11 software.

Results: We observed that the metal pointers did not equivocally converge towards the scaphoid tubercle. The persistent pattern of convergence was within a 2–3cm radius of the scaphoid tubercle. The statistical analysis, two tailed paired t-test of this pattern showed strong association with this latter finding. (p< 0.003).

Conclusion: Our study suggests that the cascade sign is sensitive but not specific to access the rotational deformity of the fingers. Radiological there is significant scatter about the scaphoid tubercle.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 41 - 41
1 Mar 2009
Ashraf M Nugent N O’Sullivan K O’Beirne J O’Sullivan T McCoy G
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Introduction: We performed a clinical and radiological study to determine the functional outcome in terms of union and shoulder function and other related complications associated with treatment of humeral diaphyseal fractures with Intramedullary nailing.

Methods and Patients: A review of 100 consecutive humeral nailing over a period of four years performed solely for diaphyseal fractures using Russell Taylor nails.

51 male and 49 female.

Average age of 48.0 (25.3–63.8IQR)

45 Simple, 46 comminuted and 9 pathological fractures.

70 were isolated and 10 were part of multiple trauma fractures.

91 closed and 9 open fractures.

52 fractures due to simple falls, 30 road traffic accident,9 pathological fracture,8 work related and 1 unknow cause.

Out of 100 nails, 90 were statically locked while 9 were locked proximally and 1 was locked only distally.

The outcomes were assessed clinically, radiologically and using the Disability of Arm Shoulder and Hand (DASH) function scoring system.

Statistically Cronbach’s alphas were calculated for the three scales of the DASH instrument. These scales were the function/symptom scale consisting of 30 items, sports/music module containing 4 items, and work module comprising 4 items.

Medians (interquartile ranges) and ranges are presented for numerical variables.

Mann-Whitney U tests (two-tailed) and Univariate and multivariate regression analysis were used.

Results: 90% fractures united initially and 4% had delayed union, giving cumulative union rate of 94%. Six non unions required a second procedure.

The DASH function scale scores was categorised into good 71 patients 85.5% (Score 0-< 25),

Medium 4 patients 4.8% (Score 25-< 40) and Poor 8 patients 9.6% (Score 40+).

Univariate and multivariate regression analysis showed, Increasing age (adjusted OR=0.96,95%CI 0.93–0.99,P< 0.01) and communited compared to simple fractures (adjusted OR=0.12,95%CI 0.03–0.45,P< 0.01) were associated with reduced likelihood of attaining full range of motion.

Male patients (unadjusted OR=2.37,95%CI 0.90–6.25,P=0.08) and patients involved in RTA compared to falls (unadjusted OR=4.5,95%CI 0.96–21.07,P=0.06) were associated with higher likelihood of attaining full range of motion.

85 % had no complication, while 15 % had complications.

One nerve palsy and one case of infection.

Seven patients required nail removal and 3 required removal of proximal locking screw.

Conclusion: To date, we have the largest series in the literature of antegrade nailing for diaphyseal fractures. In our series the vast majority of patients achieved desired functional outcome and union, hence we recommend the use of intramedullary nailing for humeral diaphyseal fractures. By eliminating surgical technique errors, complications can be reduced further and even higher union rates can be achieved.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 116 - 116
1 Mar 2009
Thakral R Ashraf M Kaar K Brennan W McHugh P
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Background/Aim: A preliminary biomechanical study conducted on cadaver fibulae, was observed to have a significant (p< 0.001) difference between two different methods of interfragmentary screw fixation for oblique fractures.

A further study was undertaken to verify the results on composite material with biomechanical properties similar to human bone.

Material and Methods: Forty, custom designed composite fibular specimens were used for the biomechanical testing. The specimens were divided into two groups of 20 each. Group I comprised of specimens with biomechanical properties similar to young healthy bone and group II comprised of osteoporotic bone quality. The fibular specimens were osteotomised to resemble a short oblique fracture of the lateral malleolus. The fractures were fixed with interfragmentary cortical lag screws placed in antero-posterior and postero anterior directions, 10 samples in each group.

Results: In both groups, the mean force required to disrupt the fracture fixation was observed to be 0.45 kN higher in samples fixed with screws placed in postero anterior direction.

Conclusion: This study further confirms the screw placement in postero- anterior direction provides a stronger biomechanical construct for short oblique fracture of the lateral malleolus.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 280 - 280
1 May 2006
Ashraf M Hussain M Thakral R Corrigan J Kaar K McGuiness A Dolan M
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Aims: Treatment options for proximal humeral fractures are not very clear, specially in osteoporotic bones. Non operative treatment if on one hand leads to unpredicted and poor outcomes, the operative treatment on the other hand leads to devascularization of fractured fragments and implant failure leading to unacceptable results. Newer interlocking plates, which are applied with minimum soft tissue stripping of fractured fragments and better fixation abilities seems a promising alternative. We present our experience with such plates.

Patients and Methods: Over a period of two years 2002 and 2003, we used 50 plates to treat Neer’s two and three parts and surgical neck of humerus fractures. We reviewed our clinical results with PHILOS plates, which is in interlocking plate. Average age was 34 (24–82). 21 Male and 29 Females. We followed them clinically and radiologically for healing. The shoulder function was assesses with DASH scoring system. The DASH system questionnaire was filled by patients before the fracture and after healing of the fractures. We used a regimen of progressive rehabilitation of shoulder from immediate post operative period. All the complications including union issues, shoulder function, wound problems, nerve injuries, infection and implant failure were noted. Two different techniques were used to fix the fracture with the plate.

Statistical analysis was performed on the data collected through DASH questionnaires along with multivariate and univariate analysis and t-tests.

Results: We were able to follow all the patients who filled the pre fracture and post healing DASH system questioner. X-rays and clinical findings were available for all the patients in the study. All the patients united with average length of 6 weeks (5–12 weeks). All the fractures united. There were no deep infections; however, two patients had to have a week of oral antibiotics for superficial wound infection. There were no permanent nerve injuries. Eight patients had transient axillary nerve paresis, which resolved after 10–15 days. Patient satisfaction with the procedure was high.

48 % of patients showed a rise in DASH scores after the fracture healing, indicating decrease shoulder function. This was statistically analysed and failed to reach any significance p=0.867. There was no difference between the two techniques in terms of complications and union rates.

Conclusions: PHILOS interlocking plates in our study showed 100% union rate with no or minimal complications and preservation of shoulder function. They are technically not difficult to apply and allow immediate post operative mobilization. Hence we recommend their use in primary fixation of proximal humerus fractures.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_II | Pages 126 - 126
1 Feb 2004
Ashraf M Soffi S Ali W O’Beirne J Glynn T Kelly I
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Aim: To assess the blood loss in patients undergoing total knee arthroplasty and to determine the effects of surgical technique, duration of surgery and use of tourniquet. To look at the value of patient factors including gender, age, weight, pre-operative haemoglobin as predictive factors for future transfusion. We assessed the complications of wound healing, regaining the range of motion and thromboembolic effects.

Patients and Methods: A prospective review of 150 patients undergoing knee arthroplasty, with a minimum follow-up of 2 years (2–8 years). We divided the patients into three groups (n=50). Group A had no tourniquet applied and haemostasis secured before skin closure, Group B had tourniquet released after cementation to secure haemostasis before skin closure and Group C had tourniquet applied until after the skin closure.

Patients were matched for age, gender, pathology, weight, implant type, pre operative haemoglobin and senior operator in all three groups. We assessed intra-operative and total blood loss, transfusions requirements, postoperative wound complication, regaining of the range of motion, incidence of systemic effects of tourniquet and duration of hospital stay. We also looked at the effects of NSAIDS on blood loss and compared the validity of various factors reported in the literature to be predictive of future transfusion after the surgery. Statistical analysis used were, student’s t-test, univariate and multivariate analysis and regression statistical analysis.

Results: Group A had maximum blood loss (mean 1374 mls.) followed by Group B (mean 774 mls.) The mean blood loss of Group C was 550 mls (p< 0.001, 95% confidence interval range of 527843 mls). Statistically the duration of operation was the most important factor in minimising the blood loss (p< . 0001 R2 =0.68). The association of pre operative haemoglobin and weight as predictors of future transfusions statistically did not show a strong relationship (R2 = 0.17, R2 = 0.13 respectively). Statistically no significant difference was found in wound complications, hospital stay, post operative pain and regaining the range of motion in three groups (R2 0.58). Patients on NSAIDS did not loose more bloods than patients not on NSAIDS.

Conclusions: The use of tourniquet until after the skin closure is statistically the best method for reducing blood loss in total knee arthroplasty. It does not cause significant wound problems and does not significantly affect the regaining of range of motion. Furthermore the usage of NSAIDS does not cause excessive postoperative bleeding.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_II | Pages 134 - 134
1 Feb 2003
Ashraf M Nugent N Kelly IP
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Introduction: The management of humeral diaphyseal fractures is in a state of flux, with humeral plating becoming more popular than humeral nailing. This change of opinion has been stimulated primarily by the American literature, which quotes significant complication rates associated with humeral nailing.

Methods: We undertook a retrospective study, over a consecutive seven year period, to evaluate the complication rate and the functional outcome (American DASH scoring system) following humeral nailing. The study group was composed of 91 patients, with an average age of 50 years (22–90). All cases were performed by a consultant or under their direct supervision. The minimum follow-up was one year.

Results: Of the 91 cases, 7 were lost to follow-up. Non-union was seen in 4 cases, all requiring removal of nail with additional surgical procedures. Delayed union was seen in 2 cases. Nail prominence causing impingement pain was seen in 4 cases, necessitating nail removal. In 3 cases, the proximal screws loosened and in 1 case the distal screw loosened, necessitating removal. One case required an exchange nailing to improve stability and one nail became infected, again demanding removal. Thus significant complications were seen in 16 of 84 (19%) cases. The functional outcome was good to excellent in 51 cases and poor to moderate in 33 cases.

Conclusion: Based on our results, we agree with the current move away from humeral nailing as the procedure of choice for humeral diaphyseal fractures. We are supportive of the move towards humeral plating.