Total knee arthroplasty (TKA) is a very successful procedure with good clinical outcomes. However, the effects of obesity on TKA outcomes remain controversial and inconclusive. The objective of this study was to quantify the biomechanical effects of simulated obesity on Cruciate Retaining (CR) and Posterior Stabilized (PS) TKA in human cadaveric knees. We hypothesized that biomechanical characteristics of CR TKA will be less dependent on simulated obesity compared to PS TKA. Eight cadaveric knees (4 male, 4 female) average age 68.4 years (range, 40–86 years) underwent TKA and were tested using a custom knee testing system. Specifically, Cruciate Retaining (CR) and Posterior Stabilized (PS) Lospa Knee System (Corentec Inc.) were implanted and tested sequentially using internal control experimental design. The muscle loading was determined based on the physiological cross-sectional area ratio of the quadriceps and hamstring muscles. The ratios were then applied to CDC data representing the average male height and used to simulate a BMI of 25, 30, and 35 at knee flexion angles (KFA) of 15, 30, 45, 60, 75, and 90 degrees. Patellofemoral and tibiofemoral joint contact areas and pressures were measured using the K-scan sensor system (Tekscan Inc, South Boston, MA). Contact area, force, pressure and peak contact pressure were obtained and analyzed for each specimen. Knee kinematics were quantified using a Microscribe 3DLX digitizer (Revware Inc, Raleigh, North Carolina). Repeated measure analysis of variance with a Tukey post hoc test was used to compare loading conditions. Comparisons between the CR and PS TKA groups were made with a paired INTRODUCTION
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