Prosthetic joint infection (PJI) concerns up to 20% of all prosthesis revision procedures. The IDSA recommends at least 2 weeks of intravenous antimicrobial therapy while most of the appropriate antibiotics in these settings have very high oral bioavailability (e.g., rifampicin, cotrimoxazole, fluoroquinolone, clindamycin, fusidic acid, linezolid and doxycycline). AVAPOM is a monocentric retrospective non-inferiority study which included patients who received at least one of the highly bioavailable antibiotics listed above as a documented treatment (i.e., following the intravenous empirical post-operative antibiotic treatment) for PJIs in order to compare the remission rate of infection and the length of hospital stay (LOS). Patients were split between intravenous group (IV, from 1st January 2013 to 31st December 2014) and complete oral group (PO; since 1st January 2015) and were compared on both the PJI outcome regarding the last news available and the length of stay (LOS).Aim
Method
Among elderly Caucasians, fractures of the femoral neck are a common cause of disability. Intertrochanteric and intra-capsular fractures occur equally often, and both are about three times more common in women than in men. Risk factors include neurological impairment, malnutrition, impaired vision, malignancy and decreased activity. We found that in black South Africans femoral neck fractures occur equally often in men and in women. Intracapsular fractures are comparatively rare, occurring in one of every eight female patients and one of every 3.5 male patients. Further, we found that in both black men and black women the femoral neck was consistently and significantly shorter than in whites. These results suggest that a short femoral neck may offer protection not only against intracapsular fracture, but also possibly against fracture of the femoral neck in general. In addition, greater cortical thickness in black people probably offers further protection.
