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Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 194 - 194
1 Jul 2014
Poldervaart M Gremmels H van Deventer K Fledderus J Oner FC Verhaar M Dhert W Alblas J
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Summary Statement

Prolonged presence of VEGF (released from gelatin microspheres) led to a significant increase in scaffold vascularization when applied in vivo. Bioprinted scaffolds with regional VEGF presence retained their architecture and regional vessel formation occurred.

Introduction

Tissue-engineered bone constructs need timely vascularization for optimal performance in regeneration. A potent stimulus of vascularization is vascular endothelial growth factor (VEGF), a factor with a short half-life time. Controlled release of VEGF from gelatin microparticles (GMPs) was investigated as a means to prolong VEGF presence at the preferred location within bioprinted scaffolds, and study subsequent vascularization.