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Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 584 - 584
1 Nov 2011
Nadeau M Arellano MPRR Gurr K Bailey SI Taylor B Grewal R Lawlor K Bailey CS
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Purpose: Claudication is a common complaint of elderly patients. Lumbar spinal stenosis (LSS) and peripheral arterial disease (PAD) are the two main etiologies, producing neurogenic and vascular claudication respectively. Physicians initially diagnose claudication based on a “typical” symptom profile. The reliability of this symptom profile to accurately diagnose LSS or PAD as a cause of claudication is unknown, leading to the potentially unnecessary utilization of expensive and overly sensitive imaging modalities. Furthermore, clinicians rely on this symptom profile when directing treatment for patients with concurrent imaging positive for LSS and PAD. This study evaluates the reliability of various symptom attributes, which classically have characterized and differentiated the two.

Method: Patients presenting at a tertiary care center’s vascular or spine clinics with a primary complaint of claudication were enrolled in the study. Diagnosis of either LSS or PAD was confirmed with imaging for each patient. They answered 14 questions characterizing their symptoms. Sensitivity, specificity, positive and negative likelihood ratio (PLR and NLR) was determined for each symptom attribute.

Results: The most sensitive symptom attribute to rule out LSS is “triggering of pain with standing alone” (0.96). Four symptom attributes demonstrated a high PLR and three had low NLR for diagnosing neurogenic claudication (PLR= 3.08, 2.51, 2.14, 2.9; NLR=0.06, 0.29, 0.15). In vascular patients, calf symptoms and alleviation of pain with simply standing had a high PLR and NLR (PLR= 3.08 and 4.85; NLR= 0.31 and 0.36).

Conclusion: Only four of 14 “classic” symptom attributes are highly sensitive for ruling out LSS, and should be considered by primary care physicians before pursing expensive diagnostic imaging. Six symptom attributes should be relied upon to differentiate LSS and NLR. Numbness, pain triggered with standing alone, located in the buttock and thigh, and relieved following sitting, are symptom attributes which reliably characterize neurogenic claudication.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 562 - 563
1 Nov 2011
Hundt H Fleming J Lawendy A Gurr K Bailey SI Sanders D McGarr G Bihari R Bailey CS
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Purpose: Recent studies have examined the systemic inflammation that occurs following spinal cord injury (SCI) (Gris et al. 2008). It is believed that this systemic inflammation plays a role in the respiratory, renal and hepatic morbidity of SCI patients, ultimately contributing to mortality post-injury. Evidence of this inflammatory response has been shown as early as two hours post SCI (Gris et al. 2008) Intravital microscopy is a powerful tool for assessing inflammation acutely and in ‘real-time’ (Brock et al. 1999). This tool would be useful for demonstrating the acuteness of a systemic inflammatory response post-SCI, and for assessing the degree of inflammation to different severities of SCI. The liver has been shown to play a particularly important role in the initiation and progression of the early systemic inflammatory response to spinal cord injury (SCI), therefore the purpose was to evaluate hepatic inflammation immediately after SCI. We hypothesized that SCI would cause immediate leukocyte recruitment and that the magnitude of inflammation would increase with increasing severity of cord injury.

Method: Male Wistar rats (200–225g) were randomly assigned to one of the following groups: uninjured, trauma-injured (laminectomy and no cord injury), cord compressed or cord transected. Spinal cord-injured rats were anesthetized by isoflurane, a dorsal laminectomy was performed, and the 4th thoracic spinal segment was injured by a moderately severe clip-compression injury or by a severe complete cord transection injury. Uninjured rats and trauma-injured rats served as controls. At 0.5 and 1.5 h after SCI rats had the left lobe of their livers externalized and visualized using intravital video microscopy.

Results: At 0.5 hours the total number of leukocytes per post-sinusoidal venule was significantly increased after cord compression and cord transection compared to that in uninjured and trauma-injured rats (P< 0.05). Of these leukocytes significantly more were either adherent or rolling along venule walls compared to uninjured and trauma-injured rats (P< 0.05). Of the rolling leukocytes 2–fold more were observed after cord transection compared to cord compression. At 1.5 h the total number of leukocytes per post-sinusoidal venule and the number of adherent leukocytes was significantly increased only after cord transection.

Conclusion: Injury to the spinal cord but not trauma alone causes immediate leukocyte recruitment to the liver within 0.5 h after injury. Also, leukocyte recruitment increases with increasing severity of injury. This is the first study to use intravital microscopy to visualize systemic inflammation in the liver following SCI.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 380 - 380
1 Jul 2010
Katsimihas M Bailey C Issa K Rosas-Arellano P Bailey S Gurr K
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Purpose: To report the clinical and radiographic prospective results of a consecutive series of patient with a minimum two year follow-up with the Charite Total Disc Arthroplasty (TDA).

Methods: Between 2001 and 2005 sixty patients underwent a Charite TDA (Depuy Spine, Raynham, MA) at either L4–5 or L5-S1. The primary indication for surgery was discogenic low back pain confirmed by provocative discography. Clinical assessment was carried out preoperatively and postoperatively at 3, 6, 12 months, and once a year thereafter using the Oswestry Disability Index (ODI), Visual Analogue Scale (VAS) for back and leg pain, and SF-36. Radiographic analysis included: angle of sagittal rotation, translation of the rostral vertebra onto the caudal vertebra, anterior vertical motion (AVM), middle vertical motion (MVM), posterior vertical motion (PVM), pre- and post-operative lumbar lordosis, disc height and subsidence of the TDA. The radiographic measurements were performed using the GE Medical Systems Centricity PACS Software Version 1.0.

Results: There were 36 female and 24 male patients with a mean age of 39 (range 21–59). The mean duration of low back pain was 70 months. Twenty-five percent claimed work compensation status. The mean post-operative hospital stay was 4.8 days. A statistical significant improvement was demonstrated between the mean pre-operative ODI (50) and all post-operative intervals (p< 0.0001) which had declined to 27.7 by one year. Similarly, pre-operative VAS back pain (8.0), leg pain (6.1), SF-36 physical component summary score (33.5) and mental component summary score (41.8) remained improved (p< 0.0001) by three months (4.1, 3.1, 51.7, 62.0 respectively).

The mean pre and post-operative lumbar lordosis was 34.58 and 53.48 respectively. The mean sagittal rotation was 6.5 degrees at 5 year follow-up, while the mean translation was 0.83 mm. The mean AVM, MVM and PVM were 0.59 mm, −3.96 mm and 3.69 mm respectively at 5 year follow-up.

Conclusion: This study demonstrates satisfactory clinical results in carefully selected patients. The radiographic assessment confirmed preservation of movement at the replaced disc during flexion and extension of the lumbar spine.

Interest Statement: No financial benefits or funding has been received for the completion of this study.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 381 - 381
1 Jul 2010
Katsimihas M Bailey C Ignitiuk A Fleming J Issa K Rosas-Arellano P Bailey S Gurr K
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Purpose: To investigate subsidence of the Charite total disc arthroplasty (TDA) and to identify if a discrepancy between vertebral endplate and the Charite footprint predispose to subsidence.

Methods: Between July 2001 and May 2008 64 patients underwent a Charite TDA (DePuy Spine, Raynham, MA). They were prospectively followed at 3, 6, 12 months, and once a year thereafter.

The following measurements were performed on the replaced motion segment using a lateral radiograph:

The anterior-posterior (AP) dimension of the end plates.

Amount of subsidence.

The distance between the TDA and the posterior and anterior borders of the vertebra bodies (to represent the extent of uncoverage of the endplate by the TDA).

The AP dimension of the TDA metal endplate.

The ratio between the actual and radiographic AP length of the metal endplate was calculated and utilized as the correction factor for the error of magnification on all other radiographic measurements.

Results: At L5-S1 the mean subsidence was 1.87 mm and occurred exclusively at the posterior part of the inferior end plate of L5. The mean posterior uncoverage was 3.5 mm (L5) and 0.27 mm (S1).

At L4–L5 the mean subsidence was 1.48 mm (L4) and 0.56 mm (L5). Posterior uncoverage of L4 and L5 vertebrae were 4.81 and 2.22 mm, respectively.

Subsidence of more than 1 mm was present in all cases where the posterior uncoverage of the end plate with the TDA was more than 2 mm (odds ratio: 5.7). Subsidence was non – progressive in all cases.

An anatomic mismatch exists between L5 and S1 endplates in the AP dimension; in more than half the patients S1 is shorter than L5.

Conclusion: The radiographic measurements suggest an increased likelihood of subsidence with more than 2 mm of posterior uncoverage of the end plate by the TDA. The endplate AP length of S1 is frequently less than that of L5. Implant selection based on the smaller S1 endplate may produce worrisome uncoverage of the L5 inferior endplate leading to an increased risk of subsidence and possible catastrophic failure. TDA design should afford modularity to compensate.

No financial benefits or funding has been received for the completion of this study.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 124 - 124
1 Mar 2008
Beggs A Gurr K
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We are reporting our case series of lumbar total disc endoprostheses. Oswestry and SF-36 scores were obtained from patients preoperatively and postoperatively for discs in situ for six, twelve and twenty-four months. Oswestry scores improved from fifty-three to thirty-two at six months (N=34); fifty-five to thirty-one at twelve months (N=28); and fifty-two to twenty-five at twenty-four months (N=17). SF-36 scores improved from thirty to fifty-four (physical) and forty to sixty-two (mental) at six months; twenty-nine to fifty-five (physical) and thirty-eight to sixty-three (mental) at twelve months; and twenty-nine to sixty-two (physical) and forty-one to sixty-seven (mental) at twenty-four months.

We report our results using the Charité III Endprosthesis in the treatment of degenerative disc disease.

Short term outcome for patients having undergone total disk arthroplasty support cautious optimism for continued implantation. Continued close follow-up is essential

Total disk arthroplasty for the treatment of degenerative disc disease is increasing in popularity. Expected FDA approval of several implants make accurate functional outcome reports essential to guide practice.

Disc replacements in situ for six months (N=34) improved in Oswestry scores from fifty-three to thirty-two. SF-36 physical scores for the same cohort improved from a mean of thirty to fifty-four and mental scores from forty to sixty-two. At one year (N=28), Oswestry scores improved from fifty-five to thirty-one. SF-36 physical scores improved from twenty-nine to fifty-five, and mental scores from thirty-eight to sixty-three. At two years (N=17), Oswestry scores improved from fifty-two to twenty-five. SF-36 physical scores improved from twenty-nine to sixty-two, and mental scores from forty-one to sixty-seven.

Using very narrow indications for application of this technique we have implanted fifty-one total disc arthroplasties. Cohorts were analyzed for outcome based on duration in situ of the implant. Through careful follow-up we have identified the following trends based on validated objective outcome measures including the Oswestry low back index and the Short Form 36. These outcome measures in addition to data reported separately demonstrating clear maintenance of interdiscal lumbar range of motion allow for cautious optimism regarding the continued application of total disc arthroplasty.