Atraumatic compartment syndrome results from prolonged compression of a limb by an obtunded subject. It is most commonly seen in drug abusers and presentation is frequently late. The key factor in the pathogenesis is the fact that muscle necrosis precedes the development of a compartment syndrome. We set out to establish if surgical decompression of these compartment syndromes, as recommended in the literature, was justified. We reviewed 16 patients who underwent decompression of 19 limbs within our unit. Patients presented between 5 and 100 hours following their overdose (mean 30.5 hours) and surgery was performed at a mean time of 64.5 hours after admission. Surgical decompression resulted in the requirement for multiple operations, mean 3.7, and an extremely high complication rate. Infection was particularly prevalent, occurring in 10 of the 19 limbs decompressed. Only one of the 16 patients had normal limb function at follow up. Based on these results and an understanding of the pathogenesis of the condition, we conclude that surgical decompression of atraumatic compartment syndromes is illogical, leads to an increased complication rate and is therefore unjustified.