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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_III | Pages 9 - 9
1 Feb 2012
Kalra S Thiruvengada M Khanna A Parker M
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In order to define the optimum timing of surgery for a hip fracture, we undertook a systematic review of all previously published studies on this topic. Data from the retrieved studies were extracted by two independent reviews and the methodology of each study assessed. In total, 43 studies involving 265,137 patients were identified. Outcomes considered were mortality, post-operative complications, length of hospital stay and return of patients back home.

There were no randomised trials on this topic. Six studies of 8535 patients have the most appropriate methodology, which was prospective collection of data with adjustment for confounding variables. These studies found no effect on mortality for any delays in surgery. One of these studies found fewer complications for those operated on early but this was not found in the other study to report on these outcomes. Two of these studies reported on hospital stay, which was reduced for those operated on early. Six studies of 229,418 patients were retrospective reviews of patient administration databases with an attempt at adjusting for confounding factors. They reported a reduced mortality, hospital stay and complications for those operated on early. Thirty-one other studies of variable methodology reported similar findings of reduced complications with early surgery, apart from one study of 399 patients which reported an increased mortality and morbidity for those operated on within 24 hours of admission.

In conclusion those studies with more careful methodology were less likely to report a beneficial effect of early surgery, particularly in relation to mortality. But early surgery (within 48 hours of admission) does seem to reduce complications such as pressure sores and reduces hospital stay.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 548 - 549
1 Oct 2010
Haleem S Clifton R Gaskin J Khanna A Parker M
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Introduction: Fractures of the neck of femurs in amputees have been reported sporadically in literature. We reviewed a series of 19 amputees who presented with a fracture neck of femur to analyse their mobility and pain scores at the end of one year and compared them with other patients presenting with the same condition.

Methods: We retrospectively analysed prospectively collected data for fractures of the proximal femur on all patients with amputations of the lower limb. Details on admission of all consecutive admission to one hospital were recorded from 1989 onwards including age, sex, type of amputation, fracture type, mechanism of injury, peri-operative mobility and rehabilitative status up to 1 year post operatively.

Results: Nineteen (19) patients with 22 amputations, sustaining 20 fractures of the neck of femurs were treated among approximately 6500 neck of femur fractures in our hip fracture database. Of these 7 were male and 12 were female. The mean age was 79 years with a range of 50–89 years. 17 patients had undergone below knee amputations (BKA) and 5 above knee amputations (AKA). Thirteen patients came from their own homes with thirteen patients being mobile pre-operatively while 6 were bed bound. All patients were alert and scored well on mental test scores. Intracapsular fractures were the most common type with AO Screw fixation being the most common operative management. Hospital stay was an average of 7 days with a range of 1–90 days. Thirteen of our cohort of patients survived more than a year after the fracture operation. Post operative mobility scoring revealed that most of our patients returned to their preoperative mobility level except for those that did not survive for the first year.

Discussion: Fractures of the neck of femurs have an increasing incidence in an expanding aging population with nearly 60000 fractures treated in the United Kingdom every year. Amputees suffer from accelerated bone density loss and are at an increased risk for osteoporosis and fragility fractures in the hip. The future prospect with an increasing population of amputees with fracture neck of femurs must be addressed so that appropriate management plans can be implemented to allow such patients to return to full mobility and active lifestyle. This also decreases other co-morbidities such as pressure sores and infection.

Approximately one third of our patients survived between 1 to 4 years and another third survived between 5 to 10 years with one patient surviving over 10 years with nearly returning to their pre-injury status. We suggest that satisfactory post operative function is achievable with either internal fixation or hemiarthroplasty.

We conclude that these fractures should be treated with the same urgency and expertise as similar fractures in non-amputees as long term survival and good quality of life can be expected.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 596 - 596
1 Oct 2010
Khanna A Emery D Lowndes S Maffulli N
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Introduction: The management of the small unstable subgroup of slipped upper femoral epiphysis is controversial. This group has a high risk of developing avascular necrosis. Clinicians are keen to treat in a way as to not contribute to this risk, but the optimum treatment pathway is unclear in the literature.

Meta analysis of the available data was done to address two main areas of concern with regards to treatment: Reduction and the timing of treatment.

Methods: Review of the literature revealed 4 relevant studies (with 85 patients) that met the inclusion criteria, which contained adequate data allowing comparison between two patient groups regarding the role of reduction and 5 studies (with 130 patients) regarding the timing of treatment.

Results: All studies were retrospective reviews; no relevant randomised controlled trials have been performed. Analysis of the collected data gave an odds ratio of 2.204 with regards to reduction. Compilation of the data available therefore favoured the unreduced group. They had a lower risk of developing avascular necrosis. In the analysis relating to timing of treatment, there was an odds ratio of 0.591. This showed the evidence in the literature to favour the group treated in less than 24 hours from symptom onset.

Conclusions: Following discussion of the results, it was concluded that reduction should always be undertaken cautiously as it has an association with increased AVN. The ideal time for management is within 24 hours of symptom onset. There are suggestions in the literature that if this is not possible, it should be postponed for one week.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 538 - 539
1 Oct 2010
Khanna A Gougoulias N Maffulli N
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Introduction: The concept of minimally invasive total knee arthroplasty surgery evolved to reduce quadriceps muscle strength loss and improve clinical outcome following total knee replacement. We performed a systematic review of the published literature on Minimally Invasive Total Knee Arthroplasty (MITKA) and to analyse the reported surgical outcomes.

Material and Methods: A comprehensive search of databases using various combinations of the keywords: minimally invasive total knee arthroplasty, mini-incision total knee replacement and minimally invasive arthroplasty was performed. 28 studies published from January 2003 to June 2008 meeting the inclusion criteria were evaluated using the Coleman Methodology Score (CMS).

Results: AT A mean CMS of 60, most studies reporting on outcome of MITKA are of moderate scientific quality. Patients undergoing MITKA tend to have decreased post operative pain, rapid recovery of quadriceps function, reduced blood loss, improved range of motion (mostly reported as a short term gain) and shorter hospital stay in comparison to patients undergoing standard total knee arthroplasty. These benefits however need to be balanced against the incidence of increased tourniquet time and increased incidence of component malaligment in the MITKA group.

Conclusion: Evidence based knowledge regarding results of MITKA comes from prospective studies of moderate quality with short follow up periods. Multicenter studies with longer follow ups are needed to justify the long term advantages of MITKA over standard total knee arthroplasty.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 303 - 303
1 May 2010
Khan S Haleem S Khanna A Parker M
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Background: Numerous researchers have documented posterior comminution to confer an increased incidence of non-union and avascular necrosis after internal fixation of both displaced and undisplaced intracpasular hip fractures. This prospective study of 1247 patients questions this association and shows that comminution does not cause a statistically significant increase in these complications of fracture healing.

Methods: Twelve hundred and forty-seven patients with 1247 intracapsular hip fractures (568 undisplaced and 679 displaced fractures) were treated with open reduction and internal fixation. All these had preoperative radiographs, which were evaluated for posterior comminution. All of them were followed up post-operatively for clinical and radiographic evidence of non-union and avascular necrosis. The incidence of complications in comminuted versus non-comminuted fractures was calculated in both undisplaced and displaced groups. These rates were then compared for statistical significance (p value =0.05).

Results: The undisplaced cases (n=568) comprised 557 non-comminuted and 11 comminuted fractures. The complication rates were 10.9% and 18.2% respectively. The difference was not significant, with a p value of 0.38. Displaced fractures (n=679) consisted of 588 non-comminuted and 91 comminuted cases. In this group, complication rates were 33% and 35% respectively, with a p value of 0.82.

Conclusions: For the 1247 patients studied, there was no association between the observation of comminution of the fracture on the pre-operative x-rays and the later development of fracture healing complications.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 303 - 303
1 May 2010
Khanna A Khanna A Khan S Parker M
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Hip fractures are one of the leading causes of morbidity in the elderly population. A large reduction in morbidity can be achieved if these individuals can have definitive treatment rapidly. However, this is not always achievable to a multi factorial host of contributing factors. Therefore, to enable us to understand some aspect of why these delays, if any occur, the following study was undertaken.

The purpose of the study is to relate the place at which the patient fell, to the time of day for admission to casualty. This will enable us to ascertain whether there is a relationship between the location of injury and the time taken to admission into hospital; if there is such a correlation, then it will enable us to identify factors which will expedite an individuals attendance to hospital.

Designs: Retrospective analysis of prospectively collected data for 5273 consecutive admission to one centre with a confirmed proximal femoral fracture from January 1989 to November 2006.

Setting: Peterborough District Hospital

Results: Individuals who sustained an injury inside their own home living alone were more likely to suffer a delay in attendance to the hospital with a fracture (Median 8 hours), compared to individuals who live in there own home living with one or more individual (Median 3 hours) or those who fell indoors at other locations (Median 5 hours) or outside (Median 2 hours) were their falls were witnessed. Also it was noticed that patients living in there own homes fell during the early hours of the day, while patients who had a fall outside fell mainly during ‘working hours’ where as patients in hospital mainly had a fall during night time or mid day.

Conclusion: There is a quantifiable correlation demonstrated between place of injury and the delay in attendance to hospital.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 242 - 243
1 Mar 2010
Gougoulias N McBride DJ Khanna A Maffulli N
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Introduction: The optimal treatment of intra-articular calcaneal fractures remains controversial.

Material and Methods: Electronic databases were searched for randomised trials comparing interventions for treating patients with calcaneal fractures. Two reviewers independently assessed trial quality, using a 12-item scale, and extracted data. Where appropriate results were pooled.

Results: Six trials met the inclusion criteria. Two reports reported on the same group of patients at differing follow-up intervals. All six included trials had methodological flaws. Another two trials are ongoing. Four trials (134 patients) compared open reduction and internal fixation (ORIF) with non-operative management. Pooled results showed no difference in residual pain (24/40 versus 24/42; OR 0.90, 95% CI 0.34 to 2.36), but a lower proportion of the operative group was unable to return to the same work (11/45 vs 23/45; OR 0.30, 95% CI 0.13 to 0.71), and was unable to wear the same shoes as before (12/52 vs 24/54; OR 0.37, 95% CI 0.17 to 0.84). One large-scale study showed that the outcomes (SF-36, visual analogue scale (VAS), Bohler’s angle) after non-operative treatment were not different to those after ORIF. ORIF gave superior results for return to work, return to normal activities and ability to wear the same shoes. The subtalar fusion rate was reduced after ORIF. Excluding patients receiving Workers’ Compensation, the outcomes were significantly better in some groups of surgically treated patients. One trial (23 patients), evaluated impulse compression therapy. At one year there was a mean difference of 1.40 pain VAS units (95% CI 0.02 to 2.82) in favour of the treated group. The impulse compression group had greater subtalar movement at three months, and patients returned to work three months earlier.

Conclusions: The relatively poor quality of existing trials means that current evidence is only tentative. It remains unclear whether the possible advantages of surgery are worth its risks.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 240 - 240
1 Mar 2010
Gougoulias N Khanna A McBride DJ Maffulli N
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Introduction: The use of total ankle arthroplasty for the management of end stage arthritis of the ankle is gaining in popularity. We performed a review of the literature on Total Ankle Arthroplasty to assess the methodology of studies and to detect possible variation in the reported surgical outcomes.

Material and Methods: All relevant articles in peer-reviewed journals were retrieved except those not mentioning outcomes, case reports, review of literature and letters to editors. Studies reporting on implants presently used, with at least 20 subjects followed for a mean of at least two years were included. Two authors independently scored the quality of the studies using the Coleman Methodology Score (CMS). We collected data for type of study, patient numbers, length of follow-up, complications, outcome and prosthesis survival with revision or fusion as an endpoint. Where appropriate, pooling of data was performed.

Results: Twenty-one level IV studies, published from 2003 to 2008, reporting on 2167 ankle replacements followed for a mean of 5.6 years, were included. The CMS was 65 (SD 15), with substantial agreement between the two examiners. Inflammatory arthropathy was present in 31% of ankles. The intra-operative fracture rate was 10.5%. Superficial wound healing complication rate was 6.4%, and deep infections occurred in 1.2% of ankles. Patients’ satisfaction rate was 94%. The failure rate of the primary ankle prosthesis was 11.6% (Agility: 12.2% at 4 years, STAR: 11.7% at 4.6 years and Buechel-Pappas (BP): 12.8% at 7.3 years). Pooling the data the six-year survivorship for the Agility was 0.70 (CI 95%, 0.50–0.90), whereas the 10-year survivorship for the STAR was 0.79 (CI 95%, 0.56–1.00) and for the BP 0.87 (CI 95%, 0.69–1.00).

Conclusions: Studies reporting on total ankle arthroplasty are of overall moderate quality. Survivorship analysis revealed superior results for mobile-bearing implants. Patients’ satisfaction rate was high.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 424 - 424
1 Sep 2009
Indluru R Khanna A Kumar A
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Aim: To evaluate results of fully congruent Mobile bearing knee arthroplasty for valgus arthritic knees using lateral capsular approach and realignment of vastus lateralis.

Material and Method: We reviewed results of 50 mobile bearing total knee arthroplasties performed consecutively between 2001 and 2006 for Valgus arthritic knees, using lateral capsular approach and realignment of vastus lateralis. Patients were evaluated using oxford and International knee society Score. Radiographs were examined for alignment of the component, evidence of loosening and scanograms assessed to evaluate the restoration of mechanical axis.

Results: The study group consisted of 47 patients, 20 men and 27 women who received fifty knees. The mean age at the primary operation was 71.57 years (range 47–82 years; SD, 9.5). The mean follow up was 4.2 years (range 1–6 years; SD, 1.35). The mean Valgus deformity was 15.92° (rang from 15–20 SD 1.89). Fixed flexion deformity was seen in 15 knees.

The mean Oxford Knee Society ratings was 52 (range 47–55; SD, 3.18) preoperatively, and 19 (range 14–24; SD, 3.72) at final follow up. The pre op mean range motion was 84.28° (range 45°–120°; SD 21.73). At final follow up the average range of motion was 107.5° (range 95°–120°; SD 8.93). According to the system of the Knee Society, the average knee score was 94 points and the average functional score was 89 points at final follow up.

There were no clinical failures or cases of postoperative instability and no cases of radiographic loosening or wear.

Radiological evaluation: None of these knees had radiographic evidence of loosening or osteolysis. Mechanical axis was restored in all the patients.

Conclusion: This study demonstrates satisfactory results of Mobile bearing knee arthroplasty using lateral parapatellar with proximal realignment of vastus lateralis for Valgus arthritic knees.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 499 - 500
1 Sep 2009
Spurrier E Khanna A Pathak G
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It is common practice in wrist arthroscopy to suspend the patient’s arm using Chinese finger traps and to distract the wrist joint by applying weight to the arm at the elbow. It is possible that this may cause significant pressure to be applied to the fingers, and potentially damage the digital nerves. We examined the pressure applied by finger traps and consider the risk this poses to the digital nerves.

Standard finger traps were suspended from a spring balance and the author’s fingers inserted along with a length of rubber tubing. The tubing was filled with saline and connected to a digital compartment pressure monitor. The hanging mass was gradually increased and the pressure in the rubber tubing noted. This pressure was taken as analogous to the pressure affecting the neurovascular bundle.

Pressure increases linearly with increasing mass. A pressure of 500mmHg has been suggested as necessary to cause nerve injury1. Using non-invasive technique it was not possible to accurately measure the absolute pressure acting on the digital nerves. However the increase in pressure was noted.

Using weight to distract the wrist during arthroscopy has potential to cause nerve injury. We suggest that pressure insufflation combined with Chinese finger traps with minimum weight traction provides a more than satisfactory view at wrist arthroscopy and can avoid potential digital nerve injury. However traction through finger traps for other purposes such as fracture reduction may be used with caution.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 166 - 166
1 Mar 2009
Kalra S Thiruvengada M Khanna A Parker M
Full Access

In order to define the optimum timing of surgery for a hip fracture, we undertook a systematic review of all previously published studies on this topic. Data from the retrieved studies was extracted by two independent reviews and the methodology of each study assessed. In total, 43 studies involving 265137 patients were identified. Outcomes considered were mortality, post-operative complications, length of hospital stay and return of patients back home.

There were no randomised trials on this topic. Six studies of 8535 patients have the most appropriate methodology, which was prospective collection of data with adjustment for confounding variables. These studies found no effect on mortality for any delays in surgery. One of these studies found fewer complications for those operated on early but this was not found in the other study to report on these outcomes. Two of these studies reported on hospital stay, which was reduced for those operated on early. Six studies of 229418 patients were retrospective reviews of patient administration databases with an attempt at adjusting for confounding factors. They reported a reduce mortality, hospital stay and complications for those operated on early. Thirty-one other studies of variable methodology reported similar findings of reduced complications with early surgery apart from one study of 399 patients, which reported an increased mortality and morbidity for those operated on within 24 hours of admission.

In conclusion those studies with more careful methodology were less likely to report a beneficial effect of early surgery, particularly in relation to mortality. But early surgery (within 48 hours of admission) does seem to reduce complications such as pressure sores and reduces hospital stay.