Image-guided intra-articular hip injection of local-anaesthetic and steroid is commonly used in the management of hip pain. It can be used as a diagnostic and/or therapeutic tool and is of low cost (£75). The aim of this study was to assess how often a hip injection has a therapeutic effect.

This is a retrospective, consecutive, case series of intra-articular hip injections performed in a tertiary referral hospital over a 2-year period (2013–4). Patients were identified from the radiology department's prospectively entered database. Clinical information, reason for injection and subsequent management was obtained from hospital records. All patients prospectively reported their pain levels in a numeric pain scale diary (out of 10) at various time points; pre-, immediately post-, 1st day-, 2nd day- and 2 weeks- post-injection. Only patients with complete pain scores at all time points were included (n=200, of the 250 injections performed over study period, 80%).

The majority of injections were performed for osteoarthritis (OA) treatment (82%). The pain was significantly reduced from a pre-injection score of 7.5 (SD:2) to 5.0 (SD:3) immediately post-injection(p<0.001); only 24 (11%) reported any worsening of pain immediately post-injection. Pain significantly reduced further to 3.8(SD:3) at 2-weeks post-injection (p<0.001). 50% of patients had at least a 3 point drop in reported pain. No improvement was seen in 18 patients and 10 (5%) reported worse pain at 2-weeks compared to pre-injection. Of the OA cohort, 10% have required repeat injections, 45% required no further intervention and 45% underwent or are due for hip replacement. No immediate complications occurred.

Intra-articular hip injection reduced pain in 86% of cases and has delayed any further surgical treatment for at least 2 years in over 50% of OA cases. It is hence a cost-effective treatment modality. Further work is necessary to describe factors predicting response.

Summary Statement

Service industry metrics (the net promoter score) are being introduced as a measure of UK healthcare satisfaction. Lower limb arthroplasty, as a ‘service’, scores comparably with the most successful commercial organisations.

Many psychological factors have been associated with function after joint replacement. Personality is a stable pattern of responses to external conditions and stimuli. The aim of this study was to investigate the relationship between personality, joint function, and general physical in patients undergoing total hip (THR) and knee replacement (TKR).

We undertook a prospective cohort study of 184 patients undergoing THA and 205 undergoing TKA. Personality was assesed using the Eysneck Personality Questionaire, brief version (EPQ-BV). Physical health was measured using the EuroQol (EQ-5D). Joint function was measured using the relevant Oxford Score. Outcomes were assessed at six months. Multivariable models were constructed.

The stable introvert personality was most common. Unstable introverts had poorer pre-operative function with hip arthrosis, but not knee arthrosis. Personality was not directly associated with post-operative function – the only independent predictors were pre-operative function (p=0.002) and comorbidity (p<0.001). While satisfaction after TKR was associated with personality (p=0.026), there was no association after THR (p=0.453). The poorest satisfaction was in those with the unstable introvert personality type.

Personality was a predictor of preoperative status. It did not have a direct association with postoperative status, but may have as preoperative function was the main predictor of postoperative function, personality may have had an indirect effect. Personality was also a predictor of satisfaction after TKR. This suggests that predicting satisfaction after knee replacement is more complex. Therefore certain patient may benefit from a tailored preoperative education to explore and manage expectations.

Introduction/Background: Significant limitations exist in the treatment of segmental defects or non-unions. Several investigators have developed methods in rats to synthesize ‘neo-bone’ within a mold for transfer and bone replacement in vivo. To better understand the critical biologic steps, it is desirable to use murine knockout models. Consequently, there is a need for a murine model of molded bone formation.

Materials/Methods: Biocompatible silicone chambers were implanted over the distal portion of the inferior epigastric artery in each recipient mouse. Bone marrow was implanted into these chambers along with 10 microliters of BMP-7. At two weeks the animals were euthanized and the chambers explanted. Both faxitron and histological analysis was performed to characterize the contents of the chambers.

Results: In this model, ossicle formation required the combination of viable donor marrow cells, an osteoinductive signal (BMP-7), and a patent vascular pedicle. Ossicle size and shape reflected the shape and dimensions of the interior of the chamber. De novo bone was produced in nine of nine chambers.

Discussion: Currently no commercially available genetically labelled rat allows the tracking of specific cells in bone formation. Crucially, this study establishes the feasibility and reproducibility of the bone chamber model in a mouse.

Conclusion: In this study we have established the vascularized neo-ossicle model in a murine model. This model may be used to track cell populations and develop a greater understanding of the critical biological steps in de novo bone formation.

Aims: 1) to create a new and reproducible animal model to produce heterotopic ossification (HO) 2) to be able to exactly quantify the amount of HO using a microCT scan and 3) to prove the hypothesis that COX-2 inhibitors are efficacious in the prevention of HO. Methods: We developed a IACUC-approved Lewis rat model, in which the ventral side of the right femur was scraped to mechanically disrupt the periosteum. By clamping the vastus intermedius ischemic injury to the muscle was produced to enhance HO. Finally homologous bone marrow from a donor rat was placed on the anterior surface of the femur. Half of the study group (8 rats) received chow mixed with a COX-2 inhibitor, while the other half received normal chow. After 6 weeks the animals were sacrificed, the femurs removed and imaged by microCT. Grading of HO was based on the thickness of ectopic bone as evaluated in a blinded fashion by 3 independent observers. Results: All animals developed bilateral HO. Rats treated with COX-2 inhibitors developed significantly less ectopic bone than the control group rats. Conclusions: The results suggest that we have created a very reliable, reproducible model to form ectopic bone in rats. Using the microCT we can precisely quantify the amount of HO. We have been able to show that COX-2 inhibitors significantly decrease the amount of HO formation and are thus a good alternative to non-specific NSAIDs with their potential serious side effects on the gastrointestinal tract and on hemo-stastis.

Nitric oxide (NO) is a free radical labile gas which has important physiological functions and is synthesised by the action of a group of enzymes called nitric oxide synthases (NOS) on L- arginine. We have shown that nitric oxide modulates fracture healing¹. Bone morphogenic proteins (BMP) are potent differentiating factors that augment the process of new bone formation. Recombinant human BMP-2 (rhBMP-2) enhances spinal fusion². With progression of fusion there is a remodelling of the fusion mass bone accompanied with a decrease in the fusion mass size. It is not known whether nitric oxide has a role in spinal fusion or rhBMP-2 enhanced spinal fusion.

We studied this in a novel rat intertransverse fusion model using a defined volume of bone graft (7 caudal vertebrae) along with 157 mm3 of absorbable Type-1 collagen sponge (Helistat®) carrier, which was compacted and delivered using a custom jig for achieving a similar graft density from sample to sample. The control groups consisted of a sham operated group (S, n=20), an autograft + carrier group (AC, n=28) and a group consisting of 43 μg of rhBMP-2 (Genetics Institute, Andover, MA) mixed with autograft + carrier (ACB, n=28). Two experimental groups received a nitric oxide synthase (NOS) inhibitor, N^G-nitro L-arginine methyl ester (L-NAME, Sigma Chemicals, St Louis, MO) in a dose of 1 mg/ml ad lib in the drinking water (ACL, n=28) and one of these experimental groups had rhBMP-2 added to the graft mixture at the time of surgery (ACLB, n=28). Rats were sacrificed at 22 days and 44 days, spinal columns dissected and subjected to high density radiology (faxitron) and decalcified histology. The faxitrons were subjected to image analysis (MetaMorph).

On a radiographic score (0–4) indicating progressive maturation of bone fusion mass, no difference was found between the AC and ACL groups, however, there was a significant enhancement of fusion when rhBMP-2 was added (ACB group, 3.3±0.2) when compared to the AC group (1±0) (p< .001). However, on day 44, the ACLB group (3.3±0.2) showed significantly less fusion progression when compared to the ACB group (4±0) (p< 0.01). There was a 25% (p< 0.05) more fusion-mass-area in day 44 of ACLB group (297±26 mm³) when compared to day 44 of the ACB group (225±16 mm³) indicating that NOS inhibition delayed the remodelling of the fusion mass. Undecalcified histology demonstrated that there was a delay in graft incorporation whenever NOS was inhibited (ACL and ACLB groups).

Our results show that the biology of autograft spinal fusion and rhBMP-2 enhanced spinal fusion can be potentially manipulated by nitric oxide pathways.

Introduction: The stress and strain in the proximal femur after total hip arthroplasty are influenced by the geometry of the implant in addition to its materials properties and applied loading. The addition of a third taper in the medio-lateral plane may provide additional stability and improved load transmission.

Aim: To examine the relative stability of double and triple tapered stems in two finite element (FE) models.

Methods: The geometry of a polished, double-tapered and a triple-tapered stem were scanned using a three dimensional technique. Two FE models of the stems were created using PATRAN. The models were analysed using the ABAQUS. Tied and sliding contact conditions were allowed between the implants and the cement mantle. The interface at the distal tip of the stem was removed to represent the scenario with a distal centraliser present.

Results: When tied contact was assumed, both stems displayed similar von Mises’ stress distributions. The peak stresses remained constant in the double tapered stem, with a marked translation of regions of high stress towards the distal tip with the introduction of sliding contact conditions. Peak stresses in the triple tapered stem decreased, but displayed a more continuous distribution along the implant with sliding contact. Torsional loading of the stems reduced the magnitude of the distal tip stresses.

Conclusions: The triple-tapered geometry displayed a more even distribution of stresses along the length of the implant. The double-tapered geometry displayed a high stress state at the distal tip of the implant.

Aim: To report our experience of revision knee arthroplasty with respect to surgical technique, joint line restoration and clinical outcome.

Methods: A clinical and radiological review was made of 45 knee revisions performed between 1996 to1998 using the Kinemax system. The reasons for revisions were infection (19), wear (11), loosening (seven), base-plate fracture (four) and instability (five). A primary prosthesis was used in 10 (22%), a posterior stabiliser in 24 (53%) and a superstabiliser in 11 (24%). WOMAC pain and function scores, arc of motion and measurements of joint line and patellar height were made.

Results: Three patients had died. Three knees had been revised a second time for instability and one had been arthrodesed for infection. The mean joint line elevation was 1.3mm compared with the primary and depressed 1.6mm when compared with the natural knee. Twenty-seven percent had patella infera and 13% had patella alta. A significant correlation was found between the change in patellar tendon length and the change in the joint line. The flexion arc was significantly improved from 83 degrees to 95 degrees. No relationship was found between the clinical outcomes and the changes in the joint-line. There were two deep infections (4.4%) and five knees were unstable. The three cases of flexion instability were due to failure to reconstruct adequately the antero-posterior (AP) diameter of the femur.

Conclusions: By restoring the level of the joint-line, a less constrained prostheses can be used in revision surgery with good functional results. The AP diameter of the femur must also be reconstructed to avoid flexion instability.

Twenty-three of 46 patients, aged 56 to 95 years, with fracture of the femoral neck (FNF) completed the first trial of 10 months treatment with oral sodium fluoride 60 mg and calcium 1800 mg on alternate days and 1 micrograms of vitamin D1 daily. Pre-treatment and post-treatment biopsy specimens and microradiographs of the iliac crest and metacarpal and spinal radiographs were evaluated together with biopsy material from seven untreated age-matched controls with FNF. In 17 patients the treatment improved the amount and quality of trabecular bone. Cortical thickness increased in nine patients and there were no losses of amount or mineralisation. The treatment was well tolerated by most patients and there were no major side-effects or signs of bone demineralisation. The study also revealed an unexpected rapid post-fracture deterioration of bone tissue in untreated FNF patients; thus there is an increased risk of further fractures which calls for the use of an effective treatment to increase bone mass.