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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 104 - 104
1 May 2012
M. B D. DT I. VK V. MP G. B D. S J. S S. V
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Background

Identification of novel therapeutics to accelerate acute fracture healing remains critical. A prostaglandin EP-2 receptor agonist (CP-533,536) has demonstrated acceleration of fracture healing in preclinical models. The objective of this study is to assess the efficacy of a single dose of CP-533,536 in subjects with a closed fracture of the tibial shaft using radiographic measurements compared to placebo treatment.

Methods

In a phase II randomised, blinded, placebo-controlled trial, the efficacy of a single local injection of three doses of CP-533,536 (0.5mg, 1.5mg and 15mg) was compared to a placebo and a standard of care arm in patients with closed tibial shaft fractures. The tibial fractures were treated with reamed inter-locked intramedullary nails. Patients were followed at two week intervals to six months with a final evaluation at one year. Fracture healing was independently adjudicated by a radiologist panel and an orthopaedic surgeon panel.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 133 - 133
1 May 2012
M. B C. G E. S G. M B. P
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Purpose

Identifying optimal treatment strategies for inpatients with traumatic foot and ankle injuries has been hampered by a wide variety of outcome measures with unproven reliability and validity. It remains plausible that the choice of functional outcome measures may influence measurement of treatment effects. This prospective observational study aims to measure the correlation and agreement across six functional outcome measures in patients with traumatic foot and ankle injuries.

Methods

Patients 18 years of age or older with a traumatic foot or ankle injury completed the Short Form-12 (SF-12), Short Musculoskeletal Functional Assessment (SMFA), Foot Function Index (FFI), Foot and Ankle Ability Measure (FAAM), American Academy of Orthopaedic Surgeons (AAOS) Foot and Ankle Questionnaire and American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale at a single follow-up visit. Raw scores were calculated and transformed to a functional level of excellent, very good, good, fair or poor. Pearson correlation co-efficients providing measures of correlation and agreement between functional levels were assessed.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 156 - 156
1 May 2012
M. B B. D J. AKA B. WK H. JC R. WP A. VK P. T
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Background

As the number of studies in the literature is increasing, orthopaedic surgeons rely heavily on meta-analyses as their primary source of scientific evidence. The objectives of this review were to assess the scientific quality and number of published meta-analyses on orthopaedic-related topics over time.

Methods

We conducted, in duplicate and independently, a systematic review of published meta-analyses in orthopaedics in the years 2005 and 2008 and compared them with a previous systematic review of meta-analyses from 1969-1999. A search of electronic databases (Medline, EMBASE, and the Cochrane Database of Systematic Reviews (CDSR)) was performed to identify meta-analyses published in 2005 and 2008. We searched bibliographies and contacted content experts to identify additional relevant studies. Two investigators used the Oxman and Guyatt Index to assess the quality of the studies and abstracted relevant data.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 103 - 103
1 May 2012
M. AR M. B K. T A. T J. S A. FGG
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Introduction

Humeral non-union may present a challenging problem. The instability from the un-united fracture leads to pain, disability and significant morbidity. The incidence of humeral shaft non-union as a complication of both operative and non-operative treatment is approximately 8% to 12%. This retrospective study reviews the results of surgical treatment of humeral fracture non-union performed by a single surgeon with a consistent surgical protocol.

Material and Method

We present a retrospective analysis of a series of 51 consecutive cases of humeral fracture non-union treated in our limb reconstruction centre. Data were collected on mechanism of injury, associated co-morbidities, smoking, use of NSAIDs and treatment before referral. Patients were followed up to clinical and radiological union.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 63 - 63
1 May 2012
M. B N. S P. D S. S G.H. G E. S J. D
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Purpose

The objective of this meta-analysis was to compare the effects of early and delayed surgery on the risk of mortality, common post-operative complications, and length of hospital stay among elderly hip fracture patients.

Methods

We searched MEDLINE and EMBASE for relevant prospective studies evaluating surgical delay in patients undergoing surgery for hip fractures published in all languages between 1966 and 2008. Two reviewers independently assessed methodological quality and extracted relevant data.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 36 - 36
1 May 2012
O. B N. D M. L D.G. L M. B
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Background

The new Fassier-Duval Telescopic IM System (FD-rod) has the advantage of a single entry point over the traditional telescopic rods such as the Bailey-Dubow or Sheffield rods. Although encouraging early results were presented by François Fassier, there is no formal publication in the literature as yet.

Methods

The first 24 consecutive cases (age 1.5-12.5 years) with a minimum of 1 year follow-up (1-2.4 years) after femoral and/or tibial FD-rods were reviewed to assess complications involving migration, non-telescoping, joint intrusion, infections and re-operation rates in patients with Osteogenesis imperfecta (OI, 15 cases), congenital tibial pseudarthrosis (CPT) in Neurofibromatosis Type1 (NF1, 2 cases), and Epidermal Naevus syndrome (1 case). In 6 cases of patients with Hypophosphataemic Rickets FD-rods were combined with an Ilizarov frame.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 137 - 137
1 May 2012
R. H T. D M. P M. B J. M
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Aim

The purpose of this clinical series is to prospectively review the mid-term clinical and radiographic outcomes of the Scandinavian Total Ankle Replacement (STAR) performed at two academic Canadian University centres.

Methods

Between 1998 and 2005, 111 STAR were implanted into 98 patients at two Canadian centres. Prospective clinical and radiographic follow-up was performed. Validated and non-validated outcome questionnaires consisting of the AAOS foot and ankle questionnaire, AOFAS Hindfoot score, Foot Function Index (FFI), Ankle Osteoarthritis Scale (AOS) were completed. Sixty four patients were followed with these scores prospectively and 50 retrospectively. Both groups had prospective radiographic follow-up using measures described by Hintermann et al, and Wood et al.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 146 - 146
1 May 2012
M. B K. E D. A
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Study Design

A prospective cohort study was carried out looking at the functional outcome and post-procedure translational segmental instability after multi-level lumbar decompression using a Hinge osteotomy technique.

Objective

The Hinge osteotomy technique involves unilateral subperiosteal muscle dissection with osteotomy of the base of the spinous processes thereby preserving the integrity of the posterior elements. The objective of this study was to demonstrate the results of this technique clinically and radiologically.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 139 - 139
1 May 2012
L. J M. B M. S S. WP
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Background

Subtalar fusion is traditionally an open procedure with potentially significant complications but there is little published on arthroscopic subtalar arthrodesis.

Methods

We present the first UK series of 33 arthroscopic subtalar fusions in 32 patients, with a variety of pathologies


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 67 - 67
1 May 2012
M. B
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The optimal choice of irrigating solution or irrigating pressure in the initial management of open fracture wounds remains controversial. FLOW compared the effect of castile soap versus normal saline, and low versus high pressure pulsatile lavage on one year re-operation rates in patients with open fracture wounds.

We conducted a multicentre, blinded, two-by-two factorial, pilot randomised trial of 111 patients with open fracture wounds receiving either castile soap solution or normal saline and either high or low pressure pulsatile lavage. The primary outcome, re-operation within one year, included infections, wound healing problems, and nonunions. Secondary outcomes included all operative and non-operative infections, wound healing problems, nonunion and functional outcomes. We followed the intention to treat principle.

Eighty-nine patients (80.2%) completed the 12-month follow-up. As anticipated in this small-sample-size pilot study, results were compatible with substantial benefit and substantial harm. The hazard ratio (HR) for re-operation with castile soap was 0.77 (95% Confidence Interval (CI) 0.35 to 1.69, p=0.52). With low pressure lavage, the hazard ratio for the risk of re-operation was 0.56, 95% CI 0.25 to 1.27, p=0.17. Secondary outcomes showed a significant relative risk reduction for nonunion of 63% in favour of castile soap (p=0.036), and a trend for a relative risk reduction for nonunion of 44% in favour of low pressure lavage (p=0.22). Functional outcome scores showed no significant differences at any time point between groups.

The FLOW pilot randomised controlled trial demonstrated the possibility that the use of low pressure may decrease the re-operation rate for infection, wound healing problems, or nonunion. Our findings provide compelling rationale for continued investigation in a pivotal FLOW trial of 2280 patients.


Introduction

Intimate partner violence (IPV) is a pattern of coercive behaviours that include repeated physical, sexual and emotional abuse. Musculoskeletal injuries are common symptoms of IPV. We aimed to determine the proportion of female patients, attending orthopaedic fracture clinics, that have experienced IPV defined as physical, sexual, or emotional abuse within the past 12 months.

Methods

We completed a cross-sectional study of 282 injured women attending two Level I trauma centres in Canada. Female patients presenting to the orthopaedic fracture clinics completed two validated self-reported written questionnaires; the Woman Abuse Screening Tool (WAST) and the Partner Violence Screen (PVS) to determine the prevalence of IPV. The questionnaire also contained questions that pertain to participant demographics, fracture characteristics, and experiences with health care utilisation.