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Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_8 | Pages 88 - 88
1 Apr 2017
Oostlander A Moerman A Zadpoor A Schoeman M Nelissen R Valstar E
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Background

Periprosthetic osteolysis is the most common long-term complication of a total joint arthroplasty, often resulting in aseptic loosening of the implant. As we aim at developing a safe and minimally invasive implant refixation procedure, thorough characterisation of the properties of the periprosthetic tissue is needed.

Methods

In this pilot study, the periprosthetic tissue of eleven patients undergoing hip revision surgery due to aseptic loosening was obtained. Histology, confocal microscopy, atomic force microscopy (AFM) and nanoindentation were performed to structurally and mechanically characterise the tissue. The study was approved by the Medical Ethical Committee of the Leiden University Medical Center.