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Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 104 - 104
1 Dec 2013
Szubski C Klika A Myers T Schold J Barsoum W
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Introduction:

Over the last several decades, life expectancy following solid organ transplant (i.e. kidney, liver, heart, lung, and pancreas) has increased significantly, largely due to improvements in surgical technique, immunosuppressive regimens, patient selection, and postoperative care. As this population ages, many of these transplant patients become candidates for total knee arthroplasty (TKA). However, these patients may be at greater risk of complications following TKA due to immunosuppression and metabolic derangements secondary to organ dysfunction. The purpose of this study was to use a large, nationally representative database to compare morbidity, mortality, length of stay (LOS), and charges for TKA patients with and without a history of solid organ transplant.

Methods:

This retrospective study was a review of the Nationwide Inpatient Sample (NIS; the largest all-payer inpatient care United States database representing a 20% stratified sample) from 1998 to 2010. Patients who had a primary TKA (ICD-9-CM 81.54) were included (n = 5,706,675, weighted national frequency). A total of 763,924 cases were excluded for the following: age <18 years, pathologic fracture of lower extremity, malignant neoplasm and/or metastatic cancer, previous and/or bilateral arthroplasty, admission type other than “elective”. The remaining 4,942,751 patients were categorized as transplant (n = 5,245; included only liver, kidney, heart, lung and/or pancreas transplant) or non-transplant group (n = 4,931,017; no history of any transplant including solid organ or tissue). A multivariable regression model was used to identify any association(s) between a history of solid organ transplant and morbidity, mortality, LOS and hospital charges, while adjusting for patient and hospital characteristics.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 308 - 308
1 May 2006
Myers T Saleh K Mont M Cui Q Kuskowski M
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Introduction: The authors systematically reviewed the available literature in order to define the outcomes for avascular necrosis (AVN) and spontaneous osteonecrosis of the knee (SPONK) after unicompartmental knee arthroplasty (UKA) or total knee arthroplasty (TKA).

Materials and Methods: A literature review yielded seven reports with Hospital for Special Surgery (HSS) or Knee Society Score (KSS) outcomes for arthroplasty secondary to either AVN or SPONK. The mean pre-operative, post-operative, and difference in KSS or HSS scores plus the mean revision rates for the arthroplasties for each underlying disease (AVN and. SPONK) were tabulated and reported in this order. The reported means were weighted by the number of knees in each study.

Results: A total of 63 TKAs were performed for AVN and 85 TKAs were performed for SPONK. Additionally, 74 UKAs were performed for SPONK. TKAs performed secondary to AVN had mean KSS scores of 50.6, 90.2, and 39.4 points. The revision rate was 12.5% (SD=10.45). TKAs performed for SPONK had mean HSS scores of 55.6, 82.5, and 27 points. The revision rate was 5.9% (SD=2.79). UKAs performed for SPONK had mean HSS scores of 54, 83.1, and 29.1 points with a revision rate was 9.7% (SD=5.9).

Discussion: Although the KSS for TKAs performed for AVN match the KSS performed in osteoarthritic patient populations receiving TKAs, the revision rate is higher in the AVN group. The HSS scores for patients with SPONK receiving TKAs or UKAs are similar although the revision rate is higher for UKAs.