Osteoarthritis continues to be a major cause of pain and disability. The pathological processes leading to the end-stage of joint degeneration remain poorly understood. Advances in radiological imaging have the potential to improve understanding of the structural and functional changes observed in OA. The aim of this study was to describe the microarchitecture of the femoral head in osteoarthritis. Twenty osteoarthritic femoral heads underwent micro-computed tomography scanning at 30µm. Four parameters of micro-architecture and structure were determined: bone volume ratio (BV:TV), trabecular thickness, structural model index and degree of anisotropy. The femoral head was divided into 27 cubic volumes of interest. Analysis of variance (ANOVA) was used to assess differences between regions. Cystic and sclerotic changes were assessed qualitatively.Introduction
Methods
To compare the results of total knee replacement in a consecutive series of morbidly obese patients (body mass index (BMI) > 40 kg/m2) with a matched group of non-obese (BMI< 30 kg/m2) patients. 41 consecutive total knee replacements performed in morbidly obese patients were matched pre-operatively with 41 total knee replacements performed in non-obese patients for age, sex, diagnosis, type of prosthesis, laterality, knee score and function score components of the Knee Society Score (KSS). All patients were prospectively followed up and the post-operative KSS, radiographs, complications (superficial wound infection, deep joint infection, deep venous thrombosis, peri-operative mortality) and five-year survivorship compared for the two groups. No patients were lost to follow-up (mean follow-up in morbidly obese: 38.5 (range 6-66) months; non-obese: 44 (range 6-67) months).Aim
Methods
