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Orthopaedic Proceedings
Vol. 106-B, Issue SUPP_8 | Pages 14 - 14
10 May 2024
Mooya S Berney M Cleary M Rowan F
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Introduction

The condition of the soft tissues surrounding an ankle fracture influences timing and treatment of injuries. Conventional treatment used an open approach to facilitate anatomical reduction and rigid internal fixation. Intramedullary devices for fibular fractures provide a safe alternative in patients in which the condition of the soft tissue envelope or the patient's co-morbidities may benefit from a less invasive approach. We compared outcomes for patients treated with open reduction internal fixation (ORIF) with those undergoing treatment with fibular nails (FN)

Methods

13 consecutive patients treated with fibular nails (FN) were compared with 13 age-matched patients that underwent open reduction and internal fixation (ORIF). All patients were followed to union. Study outcomes were time from admission to surgery, length of stay, wound failure, implant failure, revision surgery, OMAS and SF-36


Orthopaedic Proceedings
Vol. 106-B, Issue SUPP_6 | Pages 7 - 7
2 May 2024
McCabe P Baxter J O'Connor M McKenna P Murphy T Cleary M Rowan F
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The burden of metastatic disease presenting with axial skeleton lesions is exponentially rising predominantly due to advances in oncological therapies. A large proportion is these lesions are located in the proximal femora, which given its unique biomechanical architecture is problematic.

These patients are frequently comorbid and require prompt and concise decision making regarding their orthopaedic care in line with recent British Orthopaedic Association guidelines.

We present data detailing the outcomes for patients with proximal femoral metastatic disease referred and treated over a three year period in an Regional Cancer Centre.

We retrospectively reviewed a prospectively maintained database of all patients referred for discussion at MDT with axial skeletal metastatic disease. From this we isolated patients with femoral disease. Demographic data along with primary tumour and metastatic disease site were assessed. Treatment regimens were analysed and compared. Finally predicted and actual mortality data was collated.

331 patients were referred over the analysed time period, of which 99 had femoral disease. 66% of patients were managed conservatively with serial monitoring while 34% underwent operative treatment. 65% of those received an intramedullary fixation while 35% had arthroplasty performed. There was a 51:49 split male to female with Prostate, Lung and Breast being the predominant primary tumours. Concurrent spinal metastatic disease was noted in 62% of patients while visceral mets were seen in 37%. Mortality rate was 65% with an average prognosis of 388 days (1.06years) while average mortality was noted within 291 days (0.8 years).

Proximal femoral metastatic disease accounts for a large volume of the overall mets burden. There is an overall tendency towards conservative management and of those requiring surgery IM nailing was the treatment of choice. The data would indicate that outcomes for these patients are guarded and on average worse than those predicted.


Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_8 | Pages 83 - 83
11 Apr 2023
Khojaly R Rowan F Nagle M Shahab M Shah V Dollard M Ahmed A Taylor C Cleary M Niocaill R
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Is Non-Weight-Bearing Necessary? (INWN) is a pragmatic multicentre randomised controlled trial comparing immediate protected weight-bearing (IWB) with non-weight-bearing cast immobilisation (NWB) following ankle fracture fixation (ORIF). This trial compares; functional outcomes, complication rates and performs an economic analysis to estimate cost-utility.

IWB within 24hrs was compared to NWB, following ORIF of all types of unstable ankle fractures. Skeletally immature patients and tibial plafond fractures were excluded. Functional outcomes were assessed by the Olerud-Molander Ankle Score (OMAS) and RAND-36 Item Short Form Survey (SF-36) taken at regular follow-up intervals up to one year. A cost-utility analysis via decision tree modelling was performed to derive an incremental cost effectiveness ratio (ICER). A standard gamble health state valuation model utilising SF-36 scores was used to calculate Quality Adjusted Life Years (QALYs) for each arm.

We recruited 160 patients (80 per arm), aged 15 to 94 years (M = 45.5), 54% female. Complication rates were similar in both groups. IWB demonstrated a consistently higher OMAS score, with significant values at 6 weeks (MD=10.4, p=0.005) and 3 months (MD 12.0, p=0.003). Standard gamble utility values demonstrated consistently higher values (a score of 1 equals perfect health) with IWB, significant at 3 months (Ẋ = 0.75 [IWB] / 0.69 [NWB], p=0.018). Cost-utility analysis demonstrated NWB is €798.02 more expensive and results in 0.04 fewer QALYs over 1 year. This results in an ICER of −€21,682.42/QALY. This negative ICER indicates cost savings of €21,682.42 for every QALY (25 patients = 1 QALY gain) gained implementing an IWB regime.

IWB demonstrates a superior functional outcome, greater cost savings and similar complication rates, compared to NWB following ankle fracture fixation.


Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_4 | Pages 15 - 15
3 Mar 2023
Fahey E Elsheikh M Davey M Rowan F Cassidy T Cleary M
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Aims

The COVID-19 pandemic has triggered transformative change in how clinicians interact with their patients. There has been a shift away from face-to-face toward virtual consultations. However, the evidence to support this change in practice is unclear. The aim of this study was to systematically review the evidence base for virtual consultations for orthopaedics.

Materials and Methods

Two independent reviewers performed a literature search based on PRISMA guidelines, utilizing the MEDLINE, EMBASE and Scopus databases. Only studies reporting outcomes following the use of telemedicine for diagnosis, consultation, rehabilitation, and follow-up were included. Outcomes analyzed were: 1) Patient and clinician satisfaction, 2) Clinical outcome measures, and 3) Cost analysis of traditional vs teleconsultation.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_16 | Pages 8 - 8
1 Dec 2021
Khojaly R Rowan F Nagle M Shahab M Ahmed AS Taylor C Cleary M Mac Niocaill R
Full Access

Abstract

Objectives

The purpose of this trial is to investigate the safety and efficacy of immediate weight-bearing (IWB) and range of motion exercise regimes following ORIF of unstable ankle fractures with a particular focus on functional outcomes and complication rates.

Methods

A pragmatic randomised controlled multicentre trial, comparing IWB in a walking boot and ROM within 24 hours versus NWB and immobilisation in a cast for six weeks, following ORIF of all types of unstable adult ankle fractures. The exclusion criteria are skeletal immaturity and tibial plafond fractures. The primary outcome measure is the functional Olerud-Molander Ankle Score (OMAS). Secondary outcomes include wound infection, displacement of osteosynthesis, the full arc of ankle motion, RAND-36 Item Short Form Survey (SF-36) scoring, time to return to work and postoperative hospital length of stay.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 490 - 491
1 Nov 2011
Rowan F O’Malley N Poynton A
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Introduction: Recombinant human bone morphogenic protein-2 (rhBMP-2) eliminates the need for iliac crest bone graft and has superior fusion rates in anterior interbody fusion1. Post-operative neck swelling has precluded its use in cervical fusion2. Peri-rhBMP-2 oedema is a proposed cause of neuropathic leg pain in posterolateral lumbar fusion. We aimed to compare the incidence of leg pain in a rhBMP-2 treated cohort with a control group following posterolateral lumbar fusion and to determine radiological evidence of a mechanical cause for leg pain in either group.

Methods and Results: A single surgeon, multi-centre elective practice was retrospectively reviewed over a four-year period. All rhBMP-2 treated patients were included. Control patients included all primary instrumented lumbar fusions. Endpoints included single observer recorded leg pain. There were 64 and 40 patients in the rhBMP-2 treated and control group respectively. Pre-operative demographics and diagnoses were similar. Inter-body cages were used equally. Three patients had non-mechanical leg pain in the control group versus eleven in the rhBMP-2 group of which 6 were revision surgeries. None of the control group had previous lumbar fusion (p< 0.05). Within the rhBMP-2 group, cage use was similar for leg pain (31%) and non-leg pain (29%).

Conclusion: In primary lumbar fusion surgery, there is no significant difference in post-operative MRI-identifiable mechanical leg pain between rhBMP-2 treated and non-treated groups. RhBMP-2 loaded cages do not increase the risk of leg pain. Recombinant hBMP-2 is safe to use in posterolateral lumbar surgery.

Conflicts of Interest: None

Source of Funding: None